Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | single_gel_24h |
| GeneSet | AGEING_BRAIN_UP |
| Enrichment Score (ES) | -0.4238973 |
| Normalized Enrichment Score (NES) | -1.7934167 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.1328472 |
| FWER p-Value | 0.98 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | DDIT4 | DDIT4 Entrez, Source | DNA-damage-inducible transcript 4 | 25 | 0.248 | 0.0285 | No |
| 2 | SEPT4 | SEPT4 Entrez, Source | septin 4 | 58 | 0.201 | 0.0507 | No |
| 3 | ACAA2 | ACAA2 Entrez, Source | acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) | 83 | 0.185 | 0.0717 | No |
| 4 | VEGFB | VEGFB Entrez, Source | vascular endothelial growth factor B | 106 | 0.175 | 0.0914 | No |
| 5 | LPIN1 | LPIN1 Entrez, Source | lipin 1 | 182 | 0.151 | 0.1043 | No |
| 6 | RAMP1 | RAMP1 Entrez, Source | receptor (calcitonin) activity modifying protein 1 | 485 | 0.119 | 0.0960 | No |
| 7 | CYP1B1 | CYP1B1 Entrez, Source | cytochrome P450, family 1, subfamily B, polypeptide 1 | 895 | 0.096 | 0.0768 | No |
| 8 | CLK1 | CLK1 Entrez, Source | CDC-like kinase 1 | 1018 | 0.091 | 0.0787 | No |
| 9 | SPON1 | SPON1 Entrez, Source | spondin 1, extracellular matrix protein | 1239 | 0.082 | 0.0721 | No |
| 10 | GAB2 | GAB2 Entrez, Source | GRB2-associated binding protein 2 | 1477 | 0.075 | 0.0634 | No |
| 11 | DHRS3 | DHRS3 Entrez, Source | dehydrogenase/reductase (SDR family) member 3 | 1479 | 0.075 | 0.0725 | No |
| 12 | ADD3 | ADD3 Entrez, Source | adducin 3 (gamma) | 1701 | 0.070 | 0.0644 | No |
| 13 | CD302 | CD302 Entrez, Source | CD302 molecule | 2125 | 0.059 | 0.0397 | No |
| 14 | ICAM2 | ICAM2 Entrez, Source | intercellular adhesion molecule 2 | 2246 | 0.056 | 0.0375 | No |
| 15 | FGF2 | FGF2 Entrez, Source | fibroblast growth factor 2 (basic) | 2253 | 0.056 | 0.0439 | No |
| 16 | EDG1 | EDG1 Entrez, Source | endothelial differentiation, sphingolipid G-protein-coupled receptor, 1 | 2463 | 0.052 | 0.0345 | No |
| 17 | GFAP | GFAP Entrez, Source | glial fibrillary acidic protein | 2549 | 0.051 | 0.0343 | No |
| 18 | GATM | GATM Entrez, Source | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 2899 | 0.045 | 0.0134 | No |
| 19 | LRP4 | LRP4 Entrez, Source | low density lipoprotein receptor-related protein 4 | 3530 | 0.035 | -0.0300 | No |
| 20 | SFRP1 | SFRP1 Entrez, Source | secreted frizzled-related protein 1 | 3533 | 0.035 | -0.0259 | No |
| 21 | TGM2 | TGM2 Entrez, Source | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 3735 | 0.032 | -0.0372 | No |
| 22 | UNG | UNG Entrez, Source | uracil-DNA glycosylase | 3887 | 0.030 | -0.0450 | No |
| 23 | CEBPD | CEBPD Entrez, Source | CCAAT/enhancer binding protein (C/EBP), delta | 4222 | 0.026 | -0.0671 | No |
| 24 | SEPP1 | SEPP1 Entrez, Source | selenoprotein P, plasma, 1 | 4239 | 0.025 | -0.0652 | No |
| 25 | HBB | HBB Entrez, Source | hemoglobin, beta | 4244 | 0.025 | -0.0624 | No |
| 26 | AGT | AGT Entrez, Source | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 4353 | 0.024 | -0.0676 | No |
| 27 | ITPKB | ITPKB Entrez, Source | inositol 1,4,5-trisphosphate 3-kinase B | 4358 | 0.024 | -0.0650 | No |
| 28 | ANKRD15 | ANKRD15 Entrez, Source | ankyrin repeat domain 15 | 4389 | 0.023 | -0.0644 | No |
| 29 | VEGF | VEGF Entrez, Source | vascular endothelial growth factor | 4407 | 0.023 | -0.0629 | No |
| 30 | LAMP2 | LAMP2 Entrez, Source | lysosomal-associated membrane protein 2 | 4416 | 0.023 | -0.0606 | No |
| 31 | FXYD1 | FXYD1 Entrez, Source | FXYD domain containing ion transport regulator 1 (phospholemman) | 4502 | 0.022 | -0.0644 | No |
| 32 | SDC2 | SDC2 Entrez, Source | syndecan 2 (heparan sulfate proteoglycan 1, cell surface-associated, fibroglycan) | 4569 | 0.021 | -0.0668 | No |
| 33 | IRF7 | IRF7 Entrez, Source | interferon regulatory factor 7 | 4680 | 0.020 | -0.0727 | No |
| 34 | BBOX1 | BBOX1 Entrez, Source | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 4701 | 0.020 | -0.0718 | No |
| 35 | GNE | GNE Entrez, Source | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 4730 | 0.019 | -0.0716 | No |
| 36 | DPYSL3 | DPYSL3 Entrez, Source | dihydropyrimidinase-like 3 | 4815 | 0.018 | -0.0757 | No |
| 37 | CREB3L2 | CREB3L2 Entrez, Source | cAMP responsive element binding protein 3-like 2 | 4834 | 0.018 | -0.0748 | No |
| 38 | EDD1 | EDD1 Entrez, Source | E3 ubiquitin protein ligase, HECT domain containing, 1 | 4878 | 0.018 | -0.0759 | No |
| 39 | GJA1 | GJA1 Entrez, Source | gap junction protein, alpha 1, 43kDa (connexin 43) | 4902 | 0.017 | -0.0755 | No |
| 40 | TGIF | TGIF Entrez, Source | TGFB-induced factor (TALE family homeobox) | 5050 | 0.015 | -0.0848 | No |
| 41 | CSPG2 | CSPG2 Entrez, Source | chondroitin sulfate proteoglycan 2 (versican) | 5062 | 0.015 | -0.0837 | No |
| 42 | PHLPP | PHLPP Entrez, Source | PH domain and leucine rich repeat protein phosphatase | 5073 | 0.015 | -0.0826 | No |
| 43 | SLC4A4 | SLC4A4 Entrez, Source | solute carrier family 4, sodium bicarbonate cotransporter, member 4 | 5747 | 0.007 | -0.1327 | No |
| 44 | NFE2L2 | NFE2L2 Entrez, Source | nuclear factor (erythroid-derived 2)-like 2 | 5811 | 0.007 | -0.1366 | No |
| 45 | SLC14A1 | SLC14A1 Entrez, Source | solute carrier family 14 (urea transporter), member 1 (Kidd blood group) | 5901 | 0.005 | -0.1427 | No |
| 46 | EPM2A | EPM2A Entrez, Source | epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) | 6058 | 0.004 | -0.1540 | No |
| 47 | MFAP3L | MFAP3L Entrez, Source | microfibrillar-associated protein 3-like | 6130 | 0.003 | -0.1590 | No |
| 48 | TMED10 | TMED10 Entrez, Source | transmembrane emp24-like trafficking protein 10 (yeast) | 6170 | 0.003 | -0.1616 | No |
| 49 | CLDN5 | CLDN5 Entrez, Source | claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) | 6273 | 0.002 | -0.1691 | No |
| 50 | ACTL6A | ACTL6A Entrez, Source | actin-like 6A | 6365 | 0.001 | -0.1759 | No |
| 51 | LITAF | LITAF Entrez, Source | lipopolysaccharide-induced TNF factor | 6376 | 0.000 | -0.1766 | No |
| 52 | ANP32B | ANP32B Entrez, Source | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 6549 | -0.001 | -0.1895 | No |
| 53 | PDLIM3 | PDLIM3 Entrez, Source | PDZ and LIM domain 3 | 6622 | -0.002 | -0.1947 | No |
| 54 | PICALM | PICALM Entrez, Source | phosphatidylinositol binding clathrin assembly protein | 6743 | -0.003 | -0.2033 | No |
| 55 | BCL2 | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 6812 | -0.004 | -0.2080 | No |
| 56 | TOR1AIP1 | TOR1AIP1 Entrez, Source | torsin A interacting protein 1 | 6907 | -0.005 | -0.2146 | No |
| 57 | TOB1 | TOB1 Entrez, Source | transducer of ERBB2, 1 | 6990 | -0.006 | -0.2201 | No |
| 58 | CEP170 | CEP170 Entrez, Source | centrosomal protein 170kDa | 7086 | -0.006 | -0.2265 | No |
| 59 | VWF | VWF Entrez, Source | von Willebrand factor | 7140 | -0.007 | -0.2296 | No |
| 60 | PON2 | PON2 Entrez, Source | paraoxonase 2 | 7149 | -0.007 | -0.2294 | No |
| 61 | BAMBI | BAMBI Entrez, Source | BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) | 7218 | -0.008 | -0.2336 | No |
| 62 | PMP22 | PMP22 Entrez, Source | peripheral myelin protein 22 | 7414 | -0.010 | -0.2471 | No |
| 63 | HTRA1 | HTRA1 Entrez, Source | HtrA serine peptidase 1 | 7663 | -0.012 | -0.2644 | No |
| 64 | OGG1 | OGG1 Entrez, Source | 8-oxoguanine DNA glycosylase | 7683 | -0.012 | -0.2643 | No |
| 65 | NDRG1 | NDRG1 Entrez, Source | N-myc downstream regulated gene 1 | 7738 | -0.013 | -0.2668 | No |
| 66 | RPS21 | RPS21 Entrez, Source | ribosomal protein S21 | 7759 | -0.013 | -0.2667 | No |
| 67 | PRDX6 | PRDX6 Entrez, Source | peroxiredoxin 6 | 8269 | -0.018 | -0.3030 | No |
| 68 | INSR | INSR Entrez, Source | insulin receptor | 8403 | -0.020 | -0.3106 | No |
| 69 | EXOSC7 | EXOSC7 Entrez, Source | exosome component 7 | 8427 | -0.020 | -0.3099 | No |
| 70 | HCRTR2 | HCRTR2 Entrez, Source | hypocretin (orexin) receptor 2 | 8532 | -0.021 | -0.3152 | No |
| 71 | WFS1 | WFS1 Entrez, Source | Wolfram syndrome 1 (wolframin) | 8712 | -0.023 | -0.3260 | No |
| 72 | ABCG1 | ABCG1 Entrez, Source | ATP-binding cassette, sub-family G (WHITE), member 1 | 8730 | -0.023 | -0.3244 | No |
| 73 | BMP7 | BMP7 Entrez, Source | bone morphogenetic protein 7 (osteogenic protein 1) | 9066 | -0.027 | -0.3465 | No |
| 74 | FGFR2 | FGFR2 Entrez, Source | ffer syndrome, Jackson-Weiss syndrome) | 9074 | -0.027 | -0.3437 | No |
| 75 | TLN1 | TLN1 Entrez, Source | talin 1 | 9094 | -0.027 | -0.3419 | No |
| 76 | TST | TST Entrez, Source | thiosulfate sulfurtransferase (rhodanese) | 9328 | -0.029 | -0.3559 | No |
| 77 | SH3GLB1 | SH3GLB1 Entrez, Source | SH3-domain GRB2-like endophilin B1 | 9390 | -0.030 | -0.3568 | No |
| 78 | MTRR | MTRR Entrez, Source | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | 9403 | -0.030 | -0.3540 | No |
| 79 | KNS2 | KNS2 Entrez, Source | kinesin 2 | 9501 | -0.031 | -0.3575 | No |
| 80 | PTK9 | PTK9 Entrez, Source | PTK9 protein tyrosine kinase 9 | 9524 | -0.032 | -0.3553 | No |
| 81 | VAT1 | VAT1 Entrez, Source | vesicle amine transport protein 1 homolog (T californica) | 9603 | -0.033 | -0.3572 | No |
| 82 | NIPBL | NIPBL Entrez, Source | Nipped-B homolog (Drosophila) | 9627 | -0.033 | -0.3549 | No |
| 83 | RAPGEF4 | RAPGEF4 Entrez, Source | Rap guanine nucleotide exchange factor (GEF) 4 | 9637 | -0.033 | -0.3515 | No |
| 84 | CETN3 | CETN3 Entrez, Source | centrin, EF-hand protein, 3 (CDC31 homolog, yeast) | 10040 | -0.038 | -0.3773 | No |
| 85 | PTP4A2 | PTP4A2 Entrez, Source | protein tyrosine phosphatase type IVA, member 2 | 10102 | -0.038 | -0.3772 | No |
| 86 | CAST | CAST Entrez, Source | calpastatin | 10118 | -0.039 | -0.3736 | No |
| 87 | SMC3 | SMC3 Entrez, Source | structural maintenance of chromosomes 3 | 10429 | -0.042 | -0.3919 | No |
| 88 | ZBTB1 | ZBTB1 Entrez, Source | zinc finger and BTB domain containing 1 | 10853 | -0.049 | -0.4179 | Yes |
| 89 | RAP1B | RAP1B Entrez, Source | RAP1B, member of RAS oncogene family | 10907 | -0.050 | -0.4158 | Yes |
| 90 | NTRK2 | NTRK2 Entrez, Source | neurotrophic tyrosine kinase, receptor, type 2 | 10909 | -0.050 | -0.4098 | Yes |
| 91 | PLEKHC1 | PLEKHC1 Entrez, Source | pleckstrin homology domain containing, family C (with FERM domain) member 1 | 10973 | -0.051 | -0.4083 | Yes |
| 92 | APOD | APOD Entrez, Source | apolipoprotein D | 11002 | -0.051 | -0.4042 | Yes |
| 93 | ITGB1 | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 11016 | -0.051 | -0.3989 | Yes |
| 94 | GNG11 | GNG11 Entrez, Source | guanine nucleotide binding protein (G protein), gamma 11 | 11142 | -0.054 | -0.4018 | Yes |
| 95 | HEPH | HEPH Entrez, Source | hephaestin | 11160 | -0.054 | -0.3964 | Yes |
| 96 | TAX1BP3 | TAX1BP3 Entrez, Source | Tax1 (human T-cell leukemia virus type I) binding protein 3 | 11278 | -0.056 | -0.3984 | Yes |
| 97 | DNASE1L1 | DNASE1L1 Entrez, Source | deoxyribonuclease I-like 1 | 11279 | -0.057 | -0.3914 | Yes |
| 98 | VAMP3 | VAMP3 Entrez, Source | vesicle-associated membrane protein 3 (cellubrevin) | 11346 | -0.058 | -0.3894 | Yes |
| 99 | ZFHX1B | ZFHX1B Entrez, Source | zinc finger homeobox 1b | 11458 | -0.060 | -0.3904 | Yes |
| 100 | HIF1A | HIF1A Entrez, Source | hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 11568 | -0.062 | -0.3911 | Yes |
| 101 | PPAP2A | PPAP2A Entrez, Source | phosphatidic acid phosphatase type 2A | 11707 | -0.065 | -0.3936 | Yes |
| 102 | MAOA | MAOA Entrez, Source | monoamine oxidase A | 11749 | -0.066 | -0.3886 | Yes |
| 103 | GNG12 | GNG12 Entrez, Source | guanine nucleotide binding protein (G protein), gamma 12 | 12090 | -0.076 | -0.4051 | Yes |
| 104 | TPD52L2 | TPD52L2 Entrez, Source | tumor protein D52-like 2 | 12160 | -0.078 | -0.4007 | Yes |
| 105 | FADS1 | FADS1 Entrez, Source | fatty acid desaturase 1 | 12169 | -0.078 | -0.3917 | Yes |
| 106 | TMEM123 | TMEM123 Entrez, Source | transmembrane protein 123 | 12255 | -0.081 | -0.3882 | Yes |
| 107 | ALDH9A1 | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 12333 | -0.084 | -0.3837 | Yes |
| 108 | CLIC4 | CLIC4 Entrez, Source | chloride intracellular channel 4 | 12392 | -0.087 | -0.3775 | Yes |
| 109 | CBS | CBS Entrez, Source | cystathionine-beta-synthase | 12395 | -0.087 | -0.3670 | Yes |
| 110 | CALD1 | CALD1 Entrez, Source | caldesmon 1 | 12565 | -0.095 | -0.3682 | Yes |
| 111 | CSRP1 | CSRP1 Entrez, Source | cysteine and glycine-rich protein 1 | 12660 | -0.100 | -0.3630 | Yes |
| 112 | STK3 | STK3 Entrez, Source | serine/threonine kinase 3 (STE20 homolog, yeast) | 12679 | -0.101 | -0.3520 | Yes |
| 113 | PODXL | PODXL Entrez, Source | podocalyxin-like | 12713 | -0.104 | -0.3417 | Yes |
| 114 | PDLIM5 | PDLIM5 Entrez, Source | PDZ and LIM domain 5 | 12904 | -0.122 | -0.3411 | Yes |
| 115 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 12964 | -0.127 | -0.3300 | Yes |
| 116 | RBL2 | RBL2 Entrez, Source | retinoblastoma-like 2 (p130) | 13031 | -0.136 | -0.3183 | Yes |
| 117 | EFEMP1 | EFEMP1 Entrez, Source | EGF-containing fibulin-like extracellular matrix protein 1 | 13077 | -0.144 | -0.3041 | Yes |
| 118 | CAV2 | CAV2 Entrez, Source | caveolin 2 | 13082 | -0.146 | -0.2865 | Yes |
| 119 | TLE4 | TLE4 Entrez, Source | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 13153 | -0.163 | -0.2718 | Yes |
| 120 | RGN | RGN Entrez, Source | regucalcin (senescence marker protein-30) | 13176 | -0.172 | -0.2523 | Yes |
| 121 | SERINC5 | SERINC5 Entrez, Source | serine incorporator 5 | 13200 | -0.190 | -0.2307 | Yes |
| 122 | ANXA3 | ANXA3 Entrez, Source | annexin A3 | 13255 | -0.224 | -0.2073 | Yes |
| 123 | FGFR3 | FGFR3 Entrez, Source | fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) | 13275 | -0.244 | -0.1788 | Yes |
| 124 | SERPINH1 | SERPINH1 Entrez, Source | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | 13285 | -0.265 | -0.1470 | Yes |
| 125 | AHNAK | AHNAK Entrez, Source | AHNAK nucleoprotein (desmoyokin) | 13307 | -0.312 | -0.1103 | Yes |
| 126 | LTBP1 | LTBP1 Entrez, Source | latent transforming growth factor beta binding protein 1 | 13317 | -0.347 | -0.0685 | Yes |
| 127 | ASCL1 | ASCL1 Entrez, Source | achaete-scute complex-like 1 (Drosophila) | 13337 | -0.574 | 0.0004 | Yes |
