Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | double_gel_24h |
| GeneSet | ALCOHOL_METABOLIC_PROCESS |
| Enrichment Score (ES) | 0.41580623 |
| Normalized Enrichment Score (NES) | 1.5678546 |
| Nominal p-value | 0.012121212 |
| FDR q-value | 0.23284148 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | NR0B2 | NR0B2 Entrez, Source | nuclear receptor subfamily 0, group B, member 2 | 38 | 0.227 | 0.0842 | Yes |
| 2 | PDK4 | PDK4 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 4 | 44 | 0.215 | 0.1663 | Yes |
| 3 | ADH7 | ADH7 Entrez, Source | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide | 214 | 0.147 | 0.2098 | Yes |
| 4 | GCK | GCK Entrez, Source | glucokinase (hexokinase 4, maturity onset diabetes of the young 2) | 287 | 0.137 | 0.2568 | Yes |
| 5 | DHCR24 | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 308 | 0.134 | 0.3066 | Yes |
| 6 | IL4 | IL4 Entrez, Source | interleukin 4 | 824 | 0.098 | 0.3056 | Yes |
| 7 | MIOX | MIOX Entrez, Source | myo-inositol oxygenase | 881 | 0.096 | 0.3382 | Yes |
| 8 | GFPT1 | GFPT1 Entrez, Source | glutamine-fructose-6-phosphate transaminase 1 | 950 | 0.094 | 0.3689 | Yes |
| 9 | GFPT2 | GFPT2 Entrez, Source | glutamine-fructose-6-phosphate transaminase 2 | 1368 | 0.078 | 0.3675 | Yes |
| 10 | SPHK1 | SPHK1 Entrez, Source | sphingosine kinase 1 | 1584 | 0.073 | 0.3792 | Yes |
| 11 | AKR1D1 | AKR1D1 Entrez, Source | aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) | 1770 | 0.068 | 0.3914 | Yes |
| 12 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 1791 | 0.068 | 0.4158 | Yes |
| 13 | TGFB2 | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 2282 | 0.056 | 0.4003 | No |
| 14 | HK1 | HK1 Entrez, Source | hexokinase 1 | 2841 | 0.045 | 0.3757 | No |
| 15 | GMDS | GMDS Entrez, Source | GDP-mannose 4,6-dehydratase | 3421 | 0.036 | 0.3460 | No |
| 16 | ATF4 | ATF4 Entrez, Source | activating transcription factor 4 (tax-responsive enhancer element B67) | 3467 | 0.036 | 0.3563 | No |
| 17 | IPPK | IPPK Entrez, Source | inositol 1,3,4,5,6-pentakisphosphate 2-kinase | 3506 | 0.035 | 0.3669 | No |
| 18 | FBP2 | FBP2 Entrez, Source | fructose-1,6-bisphosphatase 2 | 3572 | 0.034 | 0.3751 | No |
| 19 | SOAT1 | SOAT1 Entrez, Source | sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 | 3594 | 0.034 | 0.3865 | No |
| 20 | PPARD | PPARD Entrez, Source | peroxisome proliferative activated receptor, delta | 3654 | 0.033 | 0.3947 | No |
| 21 | PFKL | PFKL Entrez, Source | phosphofructokinase, liver | 4248 | 0.025 | 0.3598 | No |
| 22 | GAPDHS | GAPDHS Entrez, Source | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | 4347 | 0.024 | 0.3616 | No |
| 23 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 4607 | 0.021 | 0.3500 | No |
| 24 | ALDOC | ALDOC Entrez, Source | aldolase C, fructose-bisphosphate | 4791 | 0.019 | 0.3433 | No |
| 25 | GALT | GALT Entrez, Source | galactose-1-phosphate uridylyltransferase | 4837 | 0.018 | 0.3469 | No |
| 26 | ALDOB | ALDOB Entrez, Source | aldolase B, fructose-bisphosphate | 5260 | 0.013 | 0.3201 | No |
| 27 | MBTPS2 | MBTPS2 Entrez, Source | membrane-bound transcription factor peptidase, site 2 | 5428 | 0.011 | 0.3117 | No |
| 28 | UGP2 | UGP2 Entrez, Source | UDP-glucose pyrophosphorylase 2 | 5449 | 0.011 | 0.3144 | No |
| 29 | ALDOA | ALDOA Entrez, Source | aldolase A, fructose-bisphosphate | 5499 | 0.010 | 0.3146 | No |
| 30 | ADH6 | ADH6 Entrez, Source | alcohol dehydrogenase 6 (class V) | 5527 | 0.010 | 0.3164 | No |
| 31 | CHST1 | CHST1 Entrez, Source | carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 | 5606 | 0.009 | 0.3139 | No |
| 32 | PDK1 | PDK1 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 1 | 5686 | 0.008 | 0.3111 | No |
| 33 | PPARGC1A | PPARGC1A Entrez, Source | peroxisome proliferative activated receptor, gamma, coactivator 1, alpha | 5868 | 0.006 | 0.2997 | No |
| 34 | FBP1 | FBP1 Entrez, Source | fructose-1,6-bisphosphatase 1 | 6067 | 0.004 | 0.2863 | No |
| 35 | HDLBP | HDLBP Entrez, Source | high density lipoprotein binding protein (vigilin) | 6097 | 0.004 | 0.2855 | No |
| 36 | GALK1 | GALK1 Entrez, Source | galactokinase 1 | 6282 | 0.001 | 0.2722 | No |
| 37 | CLN8 | CLN8 Entrez, Source | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) | 6600 | -0.002 | 0.2491 | No |
| 38 | ADH4 | ADH4 Entrez, Source | alcohol dehydrogenase 4 (class II), pi polypeptide | 6634 | -0.002 | 0.2475 | No |
| 39 | HPRT1 | HPRT1 Entrez, Source | hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome) | 6770 | -0.004 | 0.2387 | No |
| 40 | PFKFB1 | PFKFB1 Entrez, Source | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 6867 | -0.004 | 0.2331 | No |
| 41 | CNBP | CNBP Entrez, Source | CCHC-type zinc finger, nucleic acid binding protein | 7098 | -0.007 | 0.2183 | No |
| 42 | SOD1 | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 7350 | -0.009 | 0.2029 | No |
| 43 | UGDH | UGDH Entrez, Source | UDP-glucose dehydrogenase | 7513 | -0.011 | 0.1948 | No |
| 44 | ALDH2 | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 8031 | -0.016 | 0.1620 | No |
| 45 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 8206 | -0.018 | 0.1557 | No |
| 46 | SULT1B1 | SULT1B1 Entrez, Source | sulfotransferase family, cytosolic, 1B, member 1 | 8221 | -0.018 | 0.1615 | No |
| 47 | AKR1A1 | AKR1A1 Entrez, Source | aldo-keto reductase family 1, member A1 (aldehyde reductase) | 8240 | -0.018 | 0.1671 | No |
| 48 | ABCG1 | ABCG1 Entrez, Source | ATP-binding cassette, sub-family G (WHITE), member 1 | 8730 | -0.023 | 0.1391 | No |
| 49 | SLC25A10 | SLC25A10 Entrez, Source | solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 | 9394 | -0.030 | 0.1008 | No |
| 50 | ARPP-19 | ARPP-19 Entrez, Source | - | 9567 | -0.032 | 0.1002 | No |
| 51 | CEL | CEL Entrez, Source | carboxyl ester lipase (bile salt-stimulated lipase) | 9883 | -0.036 | 0.0902 | No |
| 52 | ALDH3B1 | ALDH3B1 Entrez, Source | aldehyde dehydrogenase 3 family, member B1 | 9992 | -0.037 | 0.0963 | No |
| 53 | PDK2 | PDK2 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 2 | 10117 | -0.039 | 0.1017 | No |
| 54 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 10560 | -0.044 | 0.0854 | No |
| 55 | FPGT | FPGT Entrez, Source | fucose-1-phosphate guanylyltransferase | 11272 | -0.056 | 0.0534 | No |
| 56 | COQ3 | COQ3 Entrez, Source | coenzyme Q3 homolog, methyltransferase (S. cerevisiae) | 11276 | -0.056 | 0.0748 | No |
| 57 | SCARB1 | SCARB1 Entrez, Source | scavenger receptor class B, member 1 | 11542 | -0.061 | 0.0783 | No |
| 58 | PFKM | PFKM Entrez, Source | phosphofructokinase, muscle | 12050 | -0.074 | 0.0686 | No |
| 59 | ACN9 | ACN9 Entrez, Source | ACN9 homolog (S. cerevisiae) | 12063 | -0.075 | 0.0963 | No |
