Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | single_gel_24h |
| GeneSet | APOPTOSIS |
| Enrichment Score (ES) | -0.43437964 |
| Normalized Enrichment Score (NES) | -1.5346835 |
| Nominal p-value | 0.017475728 |
| FDR q-value | 0.27189893 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CASP1 | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 1348 | 0.079 | -0.0667 | No |
| 2 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 1411 | 0.077 | -0.0374 | No |
| 3 | GZMB | GZMB Entrez, Source | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 1567 | 0.073 | -0.0169 | No |
| 4 | BCL2L11 | BCL2L11 Entrez, Source | BCL2-like 11 (apoptosis facilitator) | 1935 | 0.064 | -0.0164 | No |
| 5 | FASLG | FASLG Entrez, Source | Fas ligand (TNF superfamily, member 6) | 3426 | 0.036 | -0.1125 | No |
| 6 | LTA | LTA Entrez, Source | lymphotoxin alpha (TNF superfamily, member 1) | 3561 | 0.034 | -0.1074 | No |
| 7 | IRF3 | IRF3 Entrez, Source | interferon regulatory factor 3 | 4204 | 0.026 | -0.1444 | No |
| 8 | BCL2L1 | BCL2L1 Entrez, Source | BCL2-like 1 | 4653 | 0.020 | -0.1693 | No |
| 9 | IRF7 | IRF7 Entrez, Source | interferon regulatory factor 7 | 4680 | 0.020 | -0.1625 | No |
| 10 | JUN | JUN Entrez, Source | jun oncogene | 4841 | 0.018 | -0.1666 | No |
| 11 | BIRC5 | BIRC5 Entrez, Source | baculoviral IAP repeat-containing 5 (survivin) | 5083 | 0.015 | -0.1781 | No |
| 12 | BIRC2 | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 5286 | 0.013 | -0.1877 | No |
| 13 | TNFRSF1A | TNFRSF1A Entrez, Source | tumor necrosis factor receptor superfamily, member 1A | 5475 | 0.010 | -0.1973 | No |
| 14 | BCL2 | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 6812 | -0.004 | -0.2961 | No |
| 15 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 6874 | -0.004 | -0.2987 | No |
| 16 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 7260 | -0.008 | -0.3240 | No |
| 17 | DFFB | DFFB Entrez, Source | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) | 7293 | -0.009 | -0.3227 | No |
| 18 | CASP3 | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 7301 | -0.009 | -0.3194 | No |
| 19 | MAP2K4 | MAP2K4 Entrez, Source | mitogen-activated protein kinase kinase 4 | 7416 | -0.010 | -0.3237 | No |
| 20 | CYCS | CYCS Entrez, Source | cytochrome c, somatic | 7500 | -0.010 | -0.3254 | No |
| 21 | BAX | BAX Entrez, Source | BCL2-associated X protein | 7784 | -0.013 | -0.3408 | No |
| 22 | CASP7 | CASP7 Entrez, Source | caspase 7, apoptosis-related cysteine peptidase | 8153 | -0.017 | -0.3609 | No |
| 23 | TNF | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 8457 | -0.020 | -0.3748 | No |
| 24 | NFKBIB | NFKBIB Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 8711 | -0.023 | -0.3837 | No |
| 25 | CASP9 | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 8779 | -0.024 | -0.3784 | No |
| 26 | PRF1 | PRF1 Entrez, Source | perforin 1 (pore forming protein) | 8817 | -0.024 | -0.3705 | No |
| 27 | BIRC4 | BIRC4 Entrez, Source | baculoviral IAP repeat-containing 4 | 8879 | -0.025 | -0.3642 | No |
| 28 | TRADD | TRADD Entrez, Source | TNFRSF1A-associated via death domain | 9040 | -0.026 | -0.3646 | No |
| 29 | BNIP3L | BNIP3L Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 9084 | -0.027 | -0.3561 | No |
| 30 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 9174 | -0.028 | -0.3505 | No |
| 31 | CASP4 | CASP4 Entrez, Source | caspase 4, apoptosis-related cysteine peptidase | 9198 | -0.028 | -0.3399 | No |
| 32 | BAD | BAD Entrez, Source | BCL2-antagonist of cell death | 9214 | -0.028 | -0.3287 | No |
| 33 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 10368 | -0.041 | -0.3971 | No |
| 34 | CASP6 | CASP6 Entrez, Source | caspase 6, apoptosis-related cysteine peptidase | 10649 | -0.045 | -0.3982 | No |
| 35 | DFFA | DFFA Entrez, Source | DNA fragmentation factor, 45kDa, alpha polypeptide | 11119 | -0.053 | -0.4101 | Yes |
| 36 | MAP3K1 | MAP3K1 Entrez, Source | mitogen-activated protein kinase kinase kinase 1 | 11443 | -0.059 | -0.4082 | Yes |
| 37 | MAPK10 | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 11586 | -0.062 | -0.3916 | Yes |
| 38 | BID | BID Entrez, Source | BH3 interacting domain death agonist | 12134 | -0.077 | -0.3988 | Yes |
| 39 | FADD | FADD Entrez, Source | Fas (TNFRSF6)-associated via death domain | 12156 | -0.078 | -0.3661 | Yes |
| 40 | IKBKB | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 12168 | -0.078 | -0.3325 | Yes |
| 41 | CASP2 | CASP2 Entrez, Source | caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) | 12178 | -0.079 | -0.2986 | Yes |
| 42 | FAS | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 12841 | -0.114 | -0.2982 | Yes |
| 43 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 12964 | -0.127 | -0.2514 | Yes |
| 44 | BIRC3 | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 13071 | -0.143 | -0.1963 | Yes |
| 45 | IRF1 | IRF1 Entrez, Source | interferon regulatory factor 1 | 13267 | -0.235 | -0.1075 | Yes |
| 46 | APAF1 | APAF1 Entrez, Source | apoptotic peptidase activating factor | 13280 | -0.257 | 0.0047 | Yes |
