Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | single_gel_24h |
| GeneSet | BREAST_CANCER_ESTROGEN_SIGNALING |
| Enrichment Score (ES) | -0.39655504 |
| Normalized Enrichment Score (NES) | -1.5361699 |
| Nominal p-value | 0.016563147 |
| FDR q-value | 0.2751014 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | HSPB1 | HSPB1 Entrez, Source | heat shock 27kDa protein 1 | 5 | 0.389 | 0.0906 | No |
| 2 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 491 | 0.118 | 0.0818 | No |
| 3 | IL6R | IL6R Entrez, Source | interleukin 6 receptor | 695 | 0.104 | 0.0909 | No |
| 4 | CYP19A1 | CYP19A1 Entrez, Source | cytochrome P450, family 19, subfamily A, polypeptide 1 | 960 | 0.093 | 0.0928 | No |
| 5 | KLF5 | KLF5 Entrez, Source | Kruppel-like factor 5 (intestinal) | 1027 | 0.091 | 0.1091 | No |
| 6 | THBS4 | THBS4 Entrez, Source | thrombospondin 4 | 1222 | 0.083 | 0.1138 | No |
| 7 | PGR | PGR Entrez, Source | progesterone receptor | 1712 | 0.069 | 0.0932 | No |
| 8 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 1805 | 0.067 | 0.1021 | No |
| 9 | MT3 | MT3 Entrez, Source | metallothionein 3 (growth inhibitory factor (neurotrophic)) | 1858 | 0.066 | 0.1136 | No |
| 10 | STC2 | STC2 Entrez, Source | stanniocalcin 2 | 1937 | 0.064 | 0.1226 | No |
| 11 | CCNA1 | CCNA1 Entrez, Source | cyclin A1 | 2415 | 0.053 | 0.0992 | No |
| 12 | ERBB2 | ERBB2 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 2456 | 0.053 | 0.1085 | No |
| 13 | ITGB4 | ITGB4 Entrez, Source | integrin, beta 4 | 2487 | 0.052 | 0.1183 | No |
| 14 | EGFR | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 2716 | 0.048 | 0.1123 | No |
| 15 | IL6 | IL6 Entrez, Source | interleukin 6 (interferon, beta 2) | 3035 | 0.043 | 0.0983 | No |
| 16 | GSN | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 3475 | 0.036 | 0.0735 | No |
| 17 | ESR1 | ESR1 Entrez, Source | estrogen receptor 1 | 3787 | 0.031 | 0.0574 | No |
| 18 | RAC2 | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 3877 | 0.030 | 0.0577 | No |
| 19 | IL2RA | IL2RA Entrez, Source | interleukin 2 receptor, alpha | 4057 | 0.028 | 0.0507 | No |
| 20 | VEGF | VEGF Entrez, Source | vascular endothelial growth factor | 4407 | 0.023 | 0.0298 | No |
| 21 | SLC7A5 | SLC7A5 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 | 4803 | 0.018 | 0.0044 | No |
| 22 | DLC1 | DLC1 Entrez, Source | deleted in liver cancer 1 | 4824 | 0.018 | 0.0071 | No |
| 23 | JUN | JUN Entrez, Source | jun oncogene | 4841 | 0.018 | 0.0102 | No |
| 24 | TGFA | TGFA Entrez, Source | transforming growth factor, alpha | 4880 | 0.018 | 0.0114 | No |
| 25 | NGFR | NGFR Entrez, Source | nerve growth factor receptor (TNFR superfamily, member 16) | 4983 | 0.016 | 0.0075 | No |
| 26 | IGFBP2 | IGFBP2 Entrez, Source | insulin-like growth factor binding protein 2, 36kDa | 5034 | 0.016 | 0.0074 | No |
| 27 | TFF1 | TFF1 Entrez, Source | trefoil factor 1 (breast cancer, estrogen-inducible sequence expressed in) | 5116 | 0.015 | 0.0048 | No |
| 28 | ESR2 | ESR2 Entrez, Source | estrogen receptor 2 (ER beta) | 5212 | 0.014 | 0.0008 | No |
| 29 | PLAU | PLAU Entrez, Source | plasminogen activator, urokinase | 5422 | 0.011 | -0.0124 | No |
| 30 | NFYB | NFYB Entrez, Source | nuclear transcription factor Y, beta | 5644 | 0.009 | -0.0271 | No |
| 31 | GATA3 | GATA3 Entrez, Source | GATA binding protein 3 | 5682 | 0.008 | -0.0279 | No |
| 32 | C3 | C3 Entrez, Source | complement component 3 | 5962 | 0.005 | -0.0478 | No |
| 33 | ATF2 | ATF2 Entrez, Source | activating transcription factor 2 | 6021 | 0.004 | -0.0511 | No |
| 34 | BCL2L2 | BCL2L2 Entrez, Source | BCL2-like 2 | 6379 | 0.000 | -0.0779 | No |
| 35 | AR | AR Entrez, Source | androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) | 6572 | -0.002 | -0.0920 | No |
| 36 | CDH1 | CDH1 Entrez, Source | cadherin 1, type 1, E-cadherin (epithelial) | 6620 | -0.002 | -0.0951 | No |
| 37 | AZGP1 | AZGP1 Entrez, Source | alpha-2-glycoprotein 1, zinc | 6721 | -0.003 | -0.1019 | No |
| 38 | BCL2 | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 6812 | -0.004 | -0.1078 | No |
| 39 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 6874 | -0.004 | -0.1113 | No |
| 40 | KIT | KIT Entrez, Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 7251 | -0.008 | -0.1378 | No |
| 41 | RPL27 | RPL27 Entrez, Source | ribosomal protein L27 | 7475 | -0.010 | -0.1522 | No |
| 42 | CTSD | CTSD Entrez, Source | cathepsin D (lysosomal aspartyl peptidase) | 7549 | -0.011 | -0.1551 | No |
| 43 | TFF3 | TFF3 Entrez, Source | trefoil factor 3 (intestinal) | 7570 | -0.011 | -0.1540 | No |
| 44 | PPIA | PPIA Entrez, Source | peptidylprolyl isomerase A (cyclophilin A) | 7751 | -0.013 | -0.1645 | No |
| 45 | THBS2 | THBS2 Entrez, Source | thrombospondin 2 | 7976 | -0.015 | -0.1778 | No |
| 46 | ACTB | ACTB Entrez, Source | actin, beta | 8105 | -0.017 | -0.1835 | No |
| 47 | HMGB1 | HMGB1 Entrez, Source | high-mobility group box 1 | 8126 | -0.017 | -0.1811 | No |
| 48 | CTSB | CTSB Entrez, Source | cathepsin B | 8382 | -0.019 | -0.1957 | No |
| 49 | CTNNB1 | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 8471 | -0.020 | -0.1976 | No |
| 50 | GABRP | GABRP Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, pi | 8657 | -0.022 | -0.2063 | No |
| 51 | RPL13A | RPL13A Entrez, Source | ribosomal protein L13a | 8692 | -0.023 | -0.2035 | No |
| 52 | FOSL1 | FOSL1 Entrez, Source | FOS-like antigen 1 | 8863 | -0.025 | -0.2106 | No |
| 53 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 9056 | -0.027 | -0.2188 | No |
| 54 | MUC1 | MUC1 Entrez, Source | mucin 1, cell surface associated | 9106 | -0.027 | -0.2162 | No |
| 55 | BAD | BAD Entrez, Source | BCL2-antagonist of cell death | 9214 | -0.028 | -0.2176 | No |
| 56 | TOP2A | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 9337 | -0.029 | -0.2199 | No |
| 57 | CCNE1 | CCNE1 Entrez, Source | cyclin E1 | 9404 | -0.030 | -0.2178 | No |
| 58 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 9542 | -0.032 | -0.2207 | No |
| 59 | IL6ST | IL6ST Entrez, Source | interleukin 6 signal transducer (gp130, oncostatin M receptor) | 9951 | -0.037 | -0.2428 | No |
| 60 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 10560 | -0.044 | -0.2783 | No |
| 61 | CLU | CLU Entrez, Source | clusterin | 10667 | -0.046 | -0.2756 | No |
| 62 | NME1 | NME1 Entrez, Source | non-metastatic cells 1, protein (NM23A) expressed in | 10783 | -0.048 | -0.2731 | No |
| 63 | PTGS2 | PTGS2 Entrez, Source | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 12422 | -0.088 | -0.3760 | Yes |
| 64 | GNAS | GNAS Entrez, Source | GNAS complex locus | 12462 | -0.089 | -0.3580 | Yes |
| 65 | SERPINB5 | SERPINB5 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 12574 | -0.095 | -0.3441 | Yes |
| 66 | SCGB1D2 | SCGB1D2 Entrez, Source | secretoglobin, family 1D, member 2 | 12662 | -0.100 | -0.3273 | Yes |
| 67 | ID2 | ID2 Entrez, Source | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 13084 | -0.146 | -0.3248 | Yes |
| 68 | CLDN7 | CLDN7 Entrez, Source | claudin 7 | 13101 | -0.150 | -0.2909 | Yes |
| 69 | CD44 | CD44 Entrez, Source | CD44 molecule (Indian blood group) | 13165 | -0.168 | -0.2563 | Yes |
| 70 | ITGA6 | ITGA6 Entrez, Source | integrin, alpha 6 | 13167 | -0.169 | -0.2168 | Yes |
| 71 | FGF1 | FGF1 Entrez, Source | fibroblast growth factor 1 (acidic) | 13172 | -0.171 | -0.1771 | Yes |
| 72 | CCNA2 | CCNA2 Entrez, Source | cyclin A2 | 13194 | -0.185 | -0.1354 | Yes |
| 73 | CCND1 | CCND1 Entrez, Source | cyclin D1 | 13302 | -0.295 | -0.0744 | Yes |
| 74 | F3 | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 13312 | -0.331 | 0.0023 | Yes |
