Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | double_gel_24h |
| GeneSet | CHOLESTEROL_BIOSYNTHESIS |
| Enrichment Score (ES) | 0.7840065 |
| Normalized Enrichment Score (NES) | 2.1113617 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.012196386 |
| FWER p-Value | 0.079 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 29 | 0.238 | 0.1606 | Yes |
| 2 | HMGCS1 | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 36 | 0.229 | 0.3165 | Yes |
| 3 | HMGCR | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 250 | 0.141 | 0.3971 | Yes |
| 4 | SC4MOL | SC4MOL Entrez, Source | sterol-C4-methyl oxidase-like | 266 | 0.140 | 0.4914 | Yes |
| 5 | SQLE | SQLE Entrez, Source | squalene epoxidase | 634 | 0.108 | 0.5376 | Yes |
| 6 | MVD | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 658 | 0.107 | 0.6087 | Yes |
| 7 | LSS | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 797 | 0.100 | 0.6664 | Yes |
| 8 | FDFT1 | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 952 | 0.094 | 0.7188 | Yes |
| 9 | CYP51A1 | CYP51A1 Entrez, Source | cytochrome P450, family 51, subfamily A, polypeptide 1 | 1345 | 0.079 | 0.7433 | Yes |
| 10 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 1791 | 0.068 | 0.7562 | Yes |
| 11 | PMVK | PMVK Entrez, Source | phosphomevalonate kinase | 1994 | 0.063 | 0.7840 | Yes |
| 12 | MVK | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 3344 | 0.038 | 0.7085 | No |
| 13 | SC5DL | SC5DL Entrez, Source | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like | 4474 | 0.022 | 0.6390 | No |
| 14 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 4607 | 0.021 | 0.6432 | No |
| 15 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 8206 | -0.018 | 0.3854 | No |
