Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | double_gel_24h |
| GeneSet | GATED_CHANNEL_ACTIVITY |
| Enrichment Score (ES) | 0.51368535 |
| Normalized Enrichment Score (NES) | 2.1328351 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.01116375 |
| FWER p-Value | 0.061 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CHRNA7 | CHRNA7 Entrez, Source | cholinergic receptor, nicotinic, alpha 7 | 107 | 0.175 | 0.0351 | Yes |
| 2 | KCNB2 | KCNB2 Entrez, Source | potassium voltage-gated channel, Shab-related subfamily, member 2 | 483 | 0.119 | 0.0362 | Yes |
| 3 | KCNJ4 | KCNJ4 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 4 | 546 | 0.114 | 0.0597 | Yes |
| 4 | NOX1 | NOX1 Entrez, Source | NADPH oxidase 1 | 560 | 0.113 | 0.0867 | Yes |
| 5 | SCN2B | SCN2B Entrez, Source | sodium channel, voltage-gated, type II, beta | 689 | 0.105 | 0.1029 | Yes |
| 6 | CACNG2 | CACNG2 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 2 | 693 | 0.104 | 0.1285 | Yes |
| 7 | CLCNKB | CLCNKB Entrez, Source | chloride channel Kb | 710 | 0.104 | 0.1529 | Yes |
| 8 | CLCN1 | CLCN1 Entrez, Source | chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant) | 715 | 0.103 | 0.1782 | Yes |
| 9 | RYR2 | RYR2 Entrez, Source | ryanodine receptor 2 (cardiac) | 917 | 0.095 | 0.1865 | Yes |
| 10 | KCNJ14 | KCNJ14 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 14 | 936 | 0.094 | 0.2084 | Yes |
| 11 | CHRNA3 | CHRNA3 Entrez, Source | cholinergic receptor, nicotinic, alpha 3 | 992 | 0.092 | 0.2269 | Yes |
| 12 | KCNN3 | KCNN3 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 | 1040 | 0.090 | 0.2457 | Yes |
| 13 | CACNA2D1 | CACNA2D1 Entrez, Source | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 1054 | 0.089 | 0.2668 | Yes |
| 14 | KCNJ6 | KCNJ6 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 6 | 1102 | 0.087 | 0.2848 | Yes |
| 15 | P2RX1 | P2RX1 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 1 | 1200 | 0.084 | 0.2981 | Yes |
| 16 | ACCN1 | ACCN1 Entrez, Source | amiloride-sensitive cation channel 1, neuronal (degenerin) | 1306 | 0.080 | 0.3100 | Yes |
| 17 | TRPC3 | TRPC3 Entrez, Source | transient receptor potential cation channel, subfamily C, member 3 | 1352 | 0.079 | 0.3261 | Yes |
| 18 | P2RX7 | P2RX7 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 7 | 1500 | 0.075 | 0.3335 | Yes |
| 19 | CACNA1H | CACNA1H Entrez, Source | calcium channel, voltage-dependent, alpha 1H subunit | 1737 | 0.069 | 0.3327 | Yes |
| 20 | SCNN1G | SCNN1G Entrez, Source | sodium channel, nonvoltage-gated 1, gamma | 1742 | 0.069 | 0.3494 | Yes |
| 21 | CACNA1C | CACNA1C Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1C subunit | 1939 | 0.064 | 0.3504 | Yes |
| 22 | CFTR | CFTR Entrez, Source | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | 1946 | 0.064 | 0.3657 | Yes |
| 23 | SCN4B | SCN4B Entrez, Source | sodium channel, voltage-gated, type IV, beta | 1965 | 0.063 | 0.3800 | Yes |
| 24 | CHRNB2 | CHRNB2 Entrez, Source | cholinergic receptor, nicotinic, beta 2 (neuronal) | 2101 | 0.060 | 0.3846 | Yes |
| 25 | SCNN1B | SCNN1B Entrez, Source | sodium channel, nonvoltage-gated 1, beta (Liddle syndrome) | 2267 | 0.056 | 0.3860 | Yes |
| 26 | CACNA1S | CACNA1S Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1S subunit | 2440 | 0.053 | 0.3861 | Yes |
| 27 | CACNB3 | CACNB3 Entrez, Source | calcium channel, voltage-dependent, beta 3 subunit | 2538 | 0.051 | 0.3914 | Yes |
| 28 | CACNA1E | CACNA1E Entrez, Source | calcium channel, voltage-dependent, alpha 1E subunit | 2545 | 0.051 | 0.4035 | Yes |
| 29 | KCNH3 | KCNH3 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 3 | 2561 | 0.050 | 0.4149 | Yes |
| 30 | KCNH4 | KCNH4 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 4 | 2628 | 0.049 | 0.4221 | Yes |
| 31 | KCNMB1 | KCNMB1 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, beta member 1 | 2672 | 0.049 | 0.4309 | Yes |
| 32 | KCNK15 | KCNK15 Entrez, Source | potassium channel, subfamily K, member 15 | 2726 | 0.048 | 0.4386 | Yes |
| 33 | CACNA1D | CACNA1D Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1D subunit | 3122 | 0.041 | 0.4190 | Yes |
| 34 | CACNG5 | CACNG5 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 5 | 3203 | 0.040 | 0.4228 | Yes |
| 35 | KCNA2 | KCNA2 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 2 | 3251 | 0.039 | 0.4290 | Yes |
| 36 | KCNH2 | KCNH2 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 2 | 3257 | 0.039 | 0.4383 | Yes |
| 37 | CNGA3 | CNGA3 Entrez, Source | cyclic nucleotide gated channel alpha 3 | 3305 | 0.038 | 0.4442 | Yes |
| 38 | KCNS1 | KCNS1 Entrez, Source | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 | 3324 | 0.038 | 0.4522 | Yes |
| 39 | KCNK1 | KCNK1 Entrez, Source | potassium channel, subfamily K, member 1 | 3345 | 0.037 | 0.4600 | Yes |
| 40 | KCNN4 | KCNN4 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 | 3482 | 0.035 | 0.4585 | Yes |
| 41 | CACNA1A | CACNA1A Entrez, Source | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 3570 | 0.034 | 0.4604 | Yes |
| 42 | KCNE2 | KCNE2 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 2 | 3669 | 0.033 | 0.4611 | Yes |
| 43 | SCN5A | SCN5A Entrez, Source | sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) | 3775 | 0.032 | 0.4610 | Yes |
| 44 | KCNC3 | KCNC3 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 3 | 3788 | 0.031 | 0.4679 | Yes |
| 45 | KCND3 | KCND3 Entrez, Source | potassium voltage-gated channel, Shal-related subfamily, member 3 | 3813 | 0.031 | 0.4737 | Yes |
| 46 | SCN7A | SCN7A Entrez, Source | sodium channel, voltage-gated, type VII, alpha | 3851 | 0.030 | 0.4784 | Yes |
| 47 | KCNA1 | KCNA1 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) | 3853 | 0.030 | 0.4858 | Yes |
| 48 | KCNA6 | KCNA6 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 6 | 3892 | 0.030 | 0.4903 | Yes |
| 49 | KCNA5 | KCNA5 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 5 | 3911 | 0.030 | 0.4963 | Yes |
| 50 | CACNG1 | CACNG1 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 1 | 3925 | 0.029 | 0.5026 | Yes |
| 51 | CACNA1G | CACNA1G Entrez, Source | calcium channel, voltage-dependent, alpha 1G subunit | 3937 | 0.029 | 0.5090 | Yes |
| 52 | CHRNA6 | CHRNA6 Entrez, Source | cholinergic receptor, nicotinic, alpha 6 | 4014 | 0.028 | 0.5102 | Yes |
| 53 | KCNMB4 | KCNMB4 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, beta member 4 | 4059 | 0.028 | 0.5137 | Yes |
| 54 | KCNQ2 | KCNQ2 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 2 | 4151 | 0.026 | 0.5133 | No |
| 55 | TRPC5 | TRPC5 Entrez, Source | transient receptor potential cation channel, subfamily C, member 5 | 4328 | 0.024 | 0.5060 | No |
| 56 | GLRA1 | GLRA1 Entrez, Source | glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome) | 4330 | 0.024 | 0.5119 | No |
| 57 | CHRNA2 | CHRNA2 Entrez, Source | cholinergic receptor, nicotinic, alpha 2 (neuronal) | 4515 | 0.022 | 0.5034 | No |
| 58 | P2RX3 | P2RX3 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 3 | 4544 | 0.021 | 0.5065 | No |
| 59 | TRPC4 | TRPC4 Entrez, Source | transient receptor potential cation channel, subfamily C, member 4 | 4722 | 0.019 | 0.4980 | No |
| 60 | HTR3A | HTR3A Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 3A | 4785 | 0.019 | 0.4979 | No |
| 61 | KCNJ3 | KCNJ3 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 3 | 4792 | 0.019 | 0.5021 | No |
| 62 | KCNH1 | KCNH1 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 1 | 4830 | 0.018 | 0.5038 | No |
| 63 | GLRA2 | GLRA2 Entrez, Source | glycine receptor, alpha 2 | 4835 | 0.018 | 0.5079 | No |
| 64 | KCNA3 | KCNA3 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 3 | 4844 | 0.018 | 0.5118 | No |
| 65 | KCNQ3 | KCNQ3 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 3 | 4990 | 0.016 | 0.5048 | No |
| 66 | KCNS3 | KCNS3 Entrez, Source | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 | 5174 | 0.014 | 0.4945 | No |
| 67 | KCNA4 | KCNA4 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 4 | 5299 | 0.013 | 0.4882 | No |
| 68 | NMUR2 | NMUR2 Entrez, Source | neuromedin U receptor 2 | 5367 | 0.012 | 0.4861 | No |
| 69 | SCN11A | SCN11A Entrez, Source | sodium channel, voltage-gated, type XI, alpha | 5399 | 0.011 | 0.4865 | No |
| 70 | CACNG4 | CACNG4 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 4 | 5484 | 0.010 | 0.4828 | No |
| 71 | SCN4A | SCN4A Entrez, Source | sodium channel, voltage-gated, type IV, alpha | 5567 | 0.009 | 0.4789 | No |
| 72 | RYR1 | RYR1 Entrez, Source | ryanodine receptor 1 (skeletal) | 5589 | 0.009 | 0.4796 | No |
| 73 | CLCN2 | CLCN2 Entrez, Source | chloride channel 2 | 5847 | 0.006 | 0.4617 | No |
| 74 | KCNIP2 | KCNIP2 Entrez, Source | Kv channel interacting protein 2 | 5898 | 0.006 | 0.4593 | No |
| 75 | CHRNA4 | CHRNA4 Entrez, Source | cholinergic receptor, nicotinic, alpha 4 | 5906 | 0.005 | 0.4601 | No |
| 76 | KCNJ15 | KCNJ15 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 15 | 6003 | 0.005 | 0.4540 | No |
| 77 | KCNE1 | KCNE1 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 1 | 6053 | 0.004 | 0.4513 | No |
| 78 | P2RX2 | P2RX2 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 2 | 6139 | 0.003 | 0.4457 | No |
| 79 | SCN9A | SCN9A Entrez, Source | sodium channel, voltage-gated, type IX, alpha | 6177 | 0.003 | 0.4435 | No |
| 80 | KCNG2 | KCNG2 Entrez, Source | potassium voltage-gated channel, subfamily G, member 2 | 6206 | 0.002 | 0.4420 | No |
| 81 | KCNJ5 | KCNJ5 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 5 | 6426 | -0.000 | 0.4254 | No |
| 82 | SCN1B | SCN1B Entrez, Source | sodium channel, voltage-gated, type I, beta | 6455 | -0.000 | 0.4234 | No |
| 83 | CACNB2 | CACNB2 Entrez, Source | calcium channel, voltage-dependent, beta 2 subunit | 6462 | -0.000 | 0.4231 | No |
| 84 | CACNA1B | CACNA1B Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1B subunit | 6647 | -0.002 | 0.4098 | No |
| 85 | CHRNE | CHRNE Entrez, Source | cholinergic receptor, nicotinic, epsilon | 6825 | -0.004 | 0.3974 | No |
| 86 | KCNC1 | KCNC1 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 1 | 6848 | -0.004 | 0.3967 | No |
| 87 | KCNQ1 | KCNQ1 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 1 | 6895 | -0.005 | 0.3944 | No |
| 88 | CHRNB4 | CHRNB4 Entrez, Source | cholinergic receptor, nicotinic, beta 4 | 7214 | -0.008 | 0.3723 | No |
| 89 | CHRND | CHRND Entrez, Source | cholinergic receptor, nicotinic, delta | 7510 | -0.011 | 0.3527 | No |
| 90 | CACNB4 | CACNB4 Entrez, Source | calcium channel, voltage-dependent, beta 4 subunit | 7521 | -0.011 | 0.3545 | No |
| 91 | CHRNA1 | CHRNA1 Entrez, Source | cholinergic receptor, nicotinic, alpha 1 (muscle) | 7580 | -0.011 | 0.3530 | No |
| 92 | KCNJ10 | KCNJ10 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 10 | 7799 | -0.014 | 0.3398 | No |
| 93 | CNGB1 | CNGB1 Entrez, Source | cyclic nucleotide gated channel beta 1 | 7881 | -0.014 | 0.3373 | No |
| 94 | CHRNB3 | CHRNB3 Entrez, Source | cholinergic receptor, nicotinic, beta 3 | 8039 | -0.016 | 0.3294 | No |
| 95 | KCNJ1 | KCNJ1 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 1 | 8394 | -0.020 | 0.3075 | No |
| 96 | KCNJ12 | KCNJ12 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 12 | 8416 | -0.020 | 0.3108 | No |
| 97 | GLRB | GLRB Entrez, Source | glycine receptor, beta | 8597 | -0.022 | 0.3026 | No |
| 98 | CACNB1 | CACNB1 Entrez, Source | calcium channel, voltage-dependent, beta 1 subunit | 8689 | -0.023 | 0.3014 | No |
| 99 | KCNN2 | KCNN2 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 | 8839 | -0.024 | 0.2961 | No |
| 100 | P2RX4 | P2RX4 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 4 | 9274 | -0.029 | 0.2705 | No |
| 101 | HTR3B | HTR3B Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 3B | 10347 | -0.041 | 0.1997 | No |
| 102 | CLCN3 | CLCN3 Entrez, Source | chloride channel 3 | 10689 | -0.046 | 0.1853 | No |
| 103 | TRPC1 | TRPC1 Entrez, Source | transient receptor potential cation channel, subfamily C, member 1 | 11504 | -0.060 | 0.1388 | No |
