Datasetdouble_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls
#double_gel_24h_versus_single_gel_24h.class.cls
#double_gel_24h_versus_single_gel_24h_repos
Phenotypeclass.cls#double_gel_24h_versus_single_gel_24h_repos
Upregulated in classdouble_gel_24h
GeneSetG_PROTEIN_COUPLED_RECEPTOR_ACTIVITY
Enrichment Score (ES)0.46778232
Normalized Enrichment Score (NES)2.0187078
Nominal p-value0.0
FDR q-value0.024513228
FWER p-Value0.279
Table: GSEA Results Summary



Fig 1: Enrichment plot: G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1TAS2R13TAS2R13
Entrez,  Source
taste receptor, type 2, member 13170.2710.0314Yes
2GPR64GPR64
Entrez,  Source
G protein-coupled receptor 64390.2270.0572Yes
3GNRHRGNRHR
Entrez,  Source
gonadotropin-releasing hormone receptor1560.1570.0673Yes
4GLP2RGLP2R
Entrez,  Source
glucagon-like peptide 2 receptor1660.1550.0854Yes
5MAS1MAS1
Entrez,  Source
MAS1 oncogene2010.1490.1007Yes
6IL8RAIL8RA
Entrez,  Source
interleukin 8 receptor, alpha2280.1450.1162Yes
7TAS2R10TAS2R10
Entrez,  Source
taste receptor, type 2, member 102800.1380.1290Yes
8OPRM1OPRM1
Entrez,  Source
opioid receptor, mu 12970.1360.1441Yes
9ADRA1AADRA1A
Entrez,  Source
adrenergic, alpha-1A-, receptor3120.1340.1592Yes
10LPHN3LPHN3
Entrez,  Source
latrophilin 33480.1300.1722Yes
11CRHR1CRHR1
Entrez,  Source
corticotropin releasing hormone receptor 14730.1200.1773Yes
12CCKBRCCKBR
Entrez,  Source
cholecystokinin B receptor6320.1080.1783Yes
13TRHRTRHR
Entrez,  Source
thyrotropin-releasing hormone receptor6390.1080.1909Yes
14MCHR1MCHR1
Entrez,  Source
melanin-concentrating hormone receptor 17020.1040.1987Yes
15CRHR2CRHR2
Entrez,  Source
corticotropin releasing hormone receptor 27170.1030.2101Yes
16VIPR2VIPR2
Entrez,  Source
vasoactive intestinal peptide receptor 27930.1000.2165Yes
17GRM6GRM6
Entrez,  Source
glutamate receptor, metabotropic 68300.0980.2256Yes
18CCKARCCKAR
Entrez,  Source
cholecystokinin A receptor8990.0950.2319Yes
19LPHN1LPHN1
Entrez,  Source
latrophilin 19900.0920.2362Yes
20TAS1R3TAS1R3
Entrez,  Source
taste receptor, type 1, member 310150.0910.2453Yes
21DRD3DRD3
Entrez,  Source
dopamine receptor D310480.0900.2537Yes
22CNR1CNR1
Entrez,  Source
cannabinoid receptor 1 (brain)10850.0880.2616Yes
23PTHR1PTHR1
Entrez,  Source
parathyroid hormone receptor 110950.0870.2714Yes
24F2RL3F2RL3
Entrez,  Source
coagulation factor II (thrombin) receptor-like 311340.0860.2789Yes
25OPRK1OPRK1
Entrez,  Source
opioid receptor, kappa 111420.0860.2887Yes
26IL8RBIL8RB
Entrez,  Source
interleukin 8 receptor, beta11700.0850.2969Yes
27OPRD1OPRD1
Entrez,  Source
opioid receptor, delta 112670.0810.2995Yes
28ELTD1ELTD1
Entrez,  Source
EGF, latrophilin and seven transmembrane domain containing 113390.0790.3036Yes
29GPR56GPR56
Entrez,  Source
G protein-coupled receptor 5613810.0780.3099Yes
30ADRA2AADRA2A
Entrez,  Source
adrenergic, alpha-2A-, receptor13990.0780.3180Yes
31GALR1GALR1
Entrez,  Source
galanin receptor 114950.0750.3198Yes
32CHRM5CHRM5
Entrez,  Source
cholinergic receptor, muscarinic 515580.0730.3240Yes
33PTGFRPTGFR
Entrez,  Source
prostaglandin F receptor (FP)16610.0710.3248Yes
34CMKLR1CMKLR1
Entrez,  Source
chemokine-like receptor 116810.0700.3318Yes
35HTR7HTR7
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)17570.0680.3344Yes
36CHRM2CHRM2
Entrez,  Source
cholinergic receptor, muscarinic 217710.0680.3416Yes
37HTR4HTR4
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 417760.0680.3495Yes
38GRPRGRPR
Entrez,  Source
gastrin-releasing peptide receptor18480.0660.3521Yes
39CHRM4CHRM4
Entrez,  Source
cholinergic receptor, muscarinic 418510.0660.3600Yes
40AVPR1BAVPR1B
Entrez,  Source
arginine vasopressin receptor 1B18700.0660.3665Yes
41OPCMLOPCML
Entrez,  Source
opioid binding protein/cell adhesion molecule-like19880.0630.3652Yes
42DRD1DRD1
Entrez,  Source
dopamine receptor D120050.0620.3715Yes
43SSTR2SSTR2
Entrez,  Source
somatostatin receptor 220140.0620.3784Yes
44CHRM1CHRM1
Entrez,  Source
cholinergic receptor, muscarinic 120920.0600.3799Yes
45HPGDHPGD
Entrez,  Source
hydroxyprostaglandin dehydrogenase 15-(NAD)21100.0600.3858Yes
46TACR3TACR3
Entrez,  Source
tachykinin receptor 321220.0600.3921Yes
47ADRB1ADRB1
Entrez,  Source
adrenergic, beta-1-, receptor21310.0590.3987Yes
48OXTROXTR
Entrez,  Source
oxytocin receptor21840.0580.4017Yes
49PTAFRPTAFR
Entrez,  Source
platelet-activating factor receptor22860.0560.4008Yes
50ADRA2CADRA2C
Entrez,  Source
adrenergic, alpha-2C-, receptor23130.0550.4055Yes
51GABBR2GABBR2
Entrez,  Source
gamma-aminobutyric acid (GABA) B receptor, 223210.0550.4116Yes
52CELSR3CELSR3
Entrez,  Source
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)23260.0550.4179Yes
53HTR5AHTR5A
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 5A23340.0550.4240Yes
54HRH2HRH2
Entrez,  Source
histamine receptor H223870.0540.4265Yes
55C5AR1C5AR1
Entrez,  Source
complement component 5a receptor 124770.0520.4261Yes
56HTR1AHTR1A
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 1A25150.0510.4294Yes
57SCTRSCTR
Entrez,  Source
secretin receptor25160.0510.4356Yes
58AGTR2AGTR2
Entrez,  Source
angiotensin II receptor, type 225190.0510.4416Yes
59ADRA1DADRA1D
Entrez,  Source
adrenergic, alpha-1D-, receptor25540.0510.4452Yes
60TAS2R1TAS2R1
Entrez,  Source
taste receptor, type 2, member 125870.0500.4488Yes
61HRH1HRH1
Entrez,  Source
histamine receptor H126010.0500.4538Yes
62GRM8GRM8
Entrez,  Source
glutamate receptor, metabotropic 826650.0490.4549Yes
63HTR2AHTR2A
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 2A27000.0480.4581Yes
64PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide27270.0480.4619Yes
65CRY1CRY1
Entrez,  Source
cryptochrome 1 (photolyase-like)27400.0470.4666Yes
66CALCRLCALCRL
Entrez,  Source
calcitonin receptor-like28680.0450.4625Yes
67HTR6HTR6
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 629400.0440.4624Yes
68CYSLTR1CYSLTR1
Entrez,  Source
cysteinyl leukotriene receptor 129720.0430.4653Yes
69GRM4GRM4
Entrez,  Source
glutamate receptor, metabotropic 430140.0430.4673Yes
70GALR3GALR3
Entrez,  Source
galanin receptor 330770.0420.4677Yes
71TACR2TACR2
Entrez,  Source
tachykinin receptor 231420.0410.4678Yes
72SSTR4SSTR4
Entrez,  Source
somatostatin receptor 432230.0400.4665No
73PTGER2PTGER2
Entrez,  Source
prostaglandin E receptor 2 (subtype EP2), 53kDa34780.0360.4516No
74HTR2BHTR2B
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 2B36840.0330.4400No
75F2RL2F2RL2
Entrez,  Source
coagulation factor II (thrombin) receptor-like 237080.0320.4422No
76ADRB3ADRB3
Entrez,  Source
adrenergic, beta-3-, receptor37430.0320.4434No
77PAX8PAX8
Entrez,  Source
paired box gene 837920.0310.4436No
78PDGFRLPDGFRL
Entrez,  Source
platelet-derived growth factor receptor-like38660.0300.4417No
79VIPR1VIPR1
Entrez,  Source
vasoactive intestinal peptide receptor 139430.0290.4394No
80DRD2DRD2
Entrez,  Source
dopamine receptor D240820.0270.4323No
81TBXA2RTBXA2R
Entrez,  Source
thromboxane A2 receptor41130.0270.4332No
82DRD4DRD4
Entrez,  Source
dopamine receptor D442200.0260.4283No
83AVPR2AVPR2
Entrez,  Source
arginine vasopressin receptor 2 (nephrogenic diabetes insipidus)44890.0220.4107No
84GRM2GRM2
Entrez,  Source
glutamate receptor, metabotropic 244990.0220.4126No
85GRM5GRM5
Entrez,  Source
glutamate receptor, metabotropic 545090.0220.4146No
86C3AR1C3AR1
Entrez,  Source
complement component 3a receptor 145270.0210.4159No
87GRM1GRM1
Entrez,  Source
glutamate receptor, metabotropic 145580.0210.4162No
88TACR1TACR1
Entrez,  Source
tachykinin receptor 146580.0200.4111No
89ADRA2BADRA2B
Entrez,  Source
adrenergic, alpha-2B-, receptor47510.0190.4064No
90HTR1BHTR1B
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 1B47670.0190.4075No
91DRD5DRD5
Entrez,  Source
dopamine receptor D548950.0170.4000No
92OPN4OPN4
Entrez,  Source
opsin 4 (melanopsin)51060.0150.3859No
93NMUR2NMUR2
Entrez,  Source
neuromedin U receptor 253670.0120.3676No
94PTGER3PTGER3
Entrez,  Source
prostaglandin E receptor 3 (subtype EP3)56340.0090.3485No
95BDKRB1BDKRB1
Entrez,  Source
bradykinin receptor B157010.0080.3445No
96GPR116GPR116
Entrez,  Source
G protein-coupled receptor 11658180.0070.3365No
97HRH3HRH3
Entrez,  Source
histamine receptor H358510.0060.3348No
98TSHRTSHR
Entrez,  Source
thyroid stimulating hormone receptor59690.0050.3266No
99LANCL1LANCL1
Entrez,  Source
LanC lantibiotic synthetase component C-like 1 (bacterial)60330.0040.3223No
100GRK1GRK1
Entrez,  Source
G protein-coupled receptor kinase 161420.0030.3145No
101NMUR1NMUR1
Entrez,  Source
neuromedin U receptor 163040.0010.3025No
102GHRHRGHRHR
Entrez,  Source
growth hormone releasing hormone receptor63300.0010.3007No
103MC5RMC5R
Entrez,  Source
melanocortin 5 receptor6584-0.0020.2817No
104BDKRB2BDKRB2
Entrez,  Source
bradykinin receptor B27014-0.0060.2500No
105PTGER1PTGER1
Entrez,  Source
prostaglandin E receptor 1 (subtype EP1), 42kDa7055-0.0060.2477No
106TAS2R16TAS2R16
Entrez,  Source
taste receptor, type 2, member 167161-0.0070.2406No
107LPHN2LPHN2
Entrez,  Source
latrophilin 27314-0.0090.2301No
108CD97CD97
Entrez,  Source
CD97 molecule7419-0.0100.2234No
109TAS2R7TAS2R7
Entrez,  Source
taste receptor, type 2, member 77805-0.0140.1959No
110NMBRNMBR
Entrez,  Source
neuromedin B receptor7890-0.0140.1913No
111GHSRGHSR
Entrez,  Source
growth hormone secretagogue receptor8118-0.0170.1762No
112KISS1RKISS1R
Entrez,  Source
KISS1 receptor8190-0.0180.1729No
113HCRTR2HCRTR2
Entrez,  Source
hypocretin (orexin) receptor 28532-0.0210.1496No
114HTR1FHTR1F
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 1F8917-0.0250.1236No
115PTGER4PTGER4
Entrez,  Source
prostaglandin E receptor 4 (subtype EP4)8928-0.0250.1259No
116GALR2GALR2
Entrez,  Source
galanin receptor 29407-0.0300.0933No
117TAS2R5TAS2R5
Entrez,  Source
taste receptor, type 2, member 59646-0.0330.0793No
118SSTR5SSTR5
Entrez,  Source
somatostatin receptor 59703-0.0340.0792No
119CHRM3CHRM3
Entrez,  Source
cholinergic receptor, muscarinic 39961-0.0370.0642No
120SSTR1SSTR1
Entrez,  Source
somatostatin receptor 110304-0.0410.0432No
121HTR3BHTR3B
Entrez,  Source
5-hydroxytryptamine (serotonin) receptor 3B10347-0.0410.0450No
122GRM7GRM7
Entrez,  Source
glutamate receptor, metabotropic 710566-0.0440.0338No
123CNR2CNR2
Entrez,  Source
cannabinoid receptor 2 (macrophage)10772-0.0480.0240No
124NPYNPY
Entrez,  Source
neuropeptide Y10886-0.0490.0214No
125GCGRGCGR
Entrez,  Source
glucagon receptor11253-0.0560.0005No
126GPR175GPR175
Entrez,  Source
G protein-coupled receptor 17511554-0.061-0.0148No
127MC4RMC4R
Entrez,  Source
melanocortin 4 receptor11608-0.063-0.0113No
128GABBR1GABBR1
Entrez,  Source
gamma-aminobutyric acid (GABA) B receptor, 111865-0.069-0.0224No
129ADRA1BADRA1B
Entrez,  Source
adrenergic, alpha-1B-, receptor12029-0.074-0.0258No
130F2RF2R
Entrez,  Source
coagulation factor II (thrombin) receptor12839-0.114-0.0733No
131GRM3GRM3
Entrez,  Source
glutamate receptor, metabotropic 313128-0.156-0.0763No
132EMR1EMR1
Entrez,  Source
egf-like module containing, mucin-like, hormone receptor-like 113220-0.205-0.0585No
133AVPR1AAVPR1A
Entrez,  Source
arginine vasopressin receptor 1A13282-0.262-0.0315No
134ADRB2ADRB2
Entrez,  Source
adrenergic, beta-2-, receptor, surface13304-0.2980.0029No
Table: GSEA details [plain text format]



Fig 2: G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY: Random ES distribution   
Gene set null distribution of ES for G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY