Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | double_gel_24h |
| GeneSet | HSA00100_BIOSYNTHESIS_OF_STEROIDS |
| Enrichment Score (ES) | 0.7065894 |
| Normalized Enrichment Score (NES) | 2.1664684 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.011044942 |
| FWER p-Value | 0.036 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 29 | 0.238 | 0.1354 | Yes |
| 2 | HMGCR | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 250 | 0.141 | 0.2006 | Yes |
| 3 | SC4MOL | SC4MOL Entrez, Source | sterol-C4-methyl oxidase-like | 266 | 0.140 | 0.2801 | Yes |
| 4 | DHCR24 | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 308 | 0.134 | 0.3546 | Yes |
| 5 | HSD17B7 | HSD17B7 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 7 | 313 | 0.134 | 0.4316 | Yes |
| 6 | SQLE | SQLE Entrez, Source | squalene epoxidase | 634 | 0.108 | 0.4699 | Yes |
| 7 | MVD | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 658 | 0.107 | 0.5298 | Yes |
| 8 | LSS | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 797 | 0.100 | 0.5770 | Yes |
| 9 | FDFT1 | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 952 | 0.094 | 0.6195 | Yes |
| 10 | CYP51A1 | CYP51A1 Entrez, Source | cytochrome P450, family 51, subfamily A, polypeptide 1 | 1345 | 0.079 | 0.6357 | Yes |
| 11 | NQO1 | NQO1 Entrez, Source | NAD(P)H dehydrogenase, quinone 1 | 1457 | 0.076 | 0.6713 | Yes |
| 12 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 1791 | 0.068 | 0.6855 | Yes |
| 13 | PMVK | PMVK Entrez, Source | phosphomevalonate kinase | 1994 | 0.063 | 0.7066 | Yes |
| 14 | MVK | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 3344 | 0.038 | 0.6270 | No |
| 15 | TM7SF2 | TM7SF2 Entrez, Source | transmembrane 7 superfamily member 2 | 3630 | 0.033 | 0.6249 | No |
| 16 | EBP | EBP Entrez, Source | emopamil binding protein (sterol isomerase) | 4120 | 0.027 | 0.6037 | No |
| 17 | VKORC1 | VKORC1 Entrez, Source | vitamin K epoxide reductase complex, subunit 1 | 4247 | 0.025 | 0.6089 | No |
| 18 | SC5DL | SC5DL Entrez, Source | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like | 4474 | 0.022 | 0.6047 | No |
| 19 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 4607 | 0.021 | 0.6068 | No |
| 20 | CYP27B1 | CYP27B1 Entrez, Source | cytochrome P450, family 27, subfamily B, polypeptide 1 | 5553 | 0.010 | 0.5414 | No |
| 21 | GGCX | GGCX Entrez, Source | gamma-glutamyl carboxylase | 7783 | -0.013 | 0.3818 | No |
| 22 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 8206 | -0.018 | 0.3603 | No |
| 23 | GGPS1 | GGPS1 Entrez, Source | geranylgeranyl diphosphate synthase 1 | 10510 | -0.044 | 0.2126 | No |
