Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | single_gel_24h |
| GeneSet | HSA00600_SPHINGOLIPID_METABOLISM |
| Enrichment Score (ES) | -0.5862966 |
| Normalized Enrichment Score (NES) | -1.7143011 |
| Nominal p-value | 0.008130081 |
| FDR q-value | 0.15144418 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SPTLC1 | SPTLC1 Entrez, Source | serine palmitoyltransferase, long chain base subunit 1 | 1401 | 0.078 | -0.0469 | No |
| 2 | SPHK1 | SPHK1 Entrez, Source | sphingosine kinase 1 | 1584 | 0.073 | -0.0059 | No |
| 3 | NEU2 | NEU2 Entrez, Source | sialidase 2 (cytosolic sialidase) | 1804 | 0.067 | 0.0283 | No |
| 4 | SGPP1 | SGPP1 Entrez, Source | sphingosine-1-phosphate phosphatase 1 | 4322 | 0.024 | -0.1423 | No |
| 5 | SMPD1 | SMPD1 Entrez, Source | sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) | 4806 | 0.018 | -0.1647 | No |
| 6 | NEU3 | NEU3 Entrez, Source | sialidase 3 (membrane sialidase) | 5842 | 0.006 | -0.2377 | No |
| 7 | ARSA | ARSA Entrez, Source | arylsulfatase A | 7270 | -0.008 | -0.3386 | No |
| 8 | DEGS2 | DEGS2 Entrez, Source | degenerative spermatocyte homolog 2, lipid desaturase (Drosophila) | 7304 | -0.009 | -0.3346 | No |
| 9 | PPAP2B | PPAP2B Entrez, Source | phosphatidic acid phosphatase type 2B | 7532 | -0.011 | -0.3435 | No |
| 10 | DEGS1 | DEGS1 Entrez, Source | degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) | 9137 | -0.027 | -0.4434 | No |
| 11 | NEU1 | NEU1 Entrez, Source | sialidase 1 (lysosomal sialidase) | 9433 | -0.031 | -0.4425 | No |
| 12 | SMPD2 | SMPD2 Entrez, Source | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) | 9847 | -0.036 | -0.4468 | No |
| 13 | PPAP2A | PPAP2A Entrez, Source | phosphatidic acid phosphatase type 2A | 11707 | -0.065 | -0.5376 | Yes |
| 14 | B4GALT6 | B4GALT6 Entrez, Source | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 | 11834 | -0.068 | -0.4957 | Yes |
| 15 | SPHK2 | SPHK2 Entrez, Source | sphingosine kinase 2 | 11926 | -0.071 | -0.4495 | Yes |
| 16 | UGCG | UGCG Entrez, Source | UDP-glucose ceramide glucosyltransferase | 12641 | -0.099 | -0.4287 | Yes |
| 17 | PPAP2C | PPAP2C Entrez, Source | phosphatidic acid phosphatase type 2C | 12644 | -0.099 | -0.3544 | Yes |
| 18 | UGT8 | UGT8 Entrez, Source | UDP glycosyltransferase 8 (UDP-galactose ceramide galactosyltransferase) | 12767 | -0.108 | -0.2821 | Yes |
| 19 | ASAH1 | ASAH1 Entrez, Source | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | 12784 | -0.110 | -0.2009 | Yes |
| 20 | ARSE | ARSE Entrez, Source | arylsulfatase E (chondrodysplasia punctata 1) | 12894 | -0.120 | -0.1186 | Yes |
| 21 | SMPD3 | SMPD3 Entrez, Source | sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) | 13215 | -0.202 | 0.0095 | Yes |
