Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | double_gel_24h |
| GeneSet | HSA00650_BUTANOATE_METABOLISM |
| Enrichment Score (ES) | 0.5981882 |
| Normalized Enrichment Score (NES) | 1.9940417 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.028613709 |
| FWER p-Value | 0.355 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | EHHADH | EHHADH Entrez, Source | enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | 7 | 0.362 | 0.1614 | Yes |
| 2 | HMGCS1 | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 36 | 0.229 | 0.2617 | Yes |
| 3 | ACAT2 | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 57 | 0.202 | 0.3506 | Yes |
| 4 | HMGCS2 | HMGCS2 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | 80 | 0.187 | 0.4325 | Yes |
| 5 | BDH1 | BDH1 Entrez, Source | 3-hydroxybutyrate dehydrogenase, type 1 | 121 | 0.169 | 0.5050 | Yes |
| 6 | HADH | HADH Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase | 379 | 0.127 | 0.5428 | Yes |
| 7 | GAD1 | GAD1 Entrez, Source | glutamate decarboxylase 1 (brain, 67kDa) | 655 | 0.107 | 0.5699 | Yes |
| 8 | AACS | AACS Entrez, Source | acetoacetyl-CoA synthetase | 1115 | 0.087 | 0.5742 | Yes |
| 9 | AKR1B10 | AKR1B10 Entrez, Source | aldo-keto reductase family 1, member B10 (aldose reductase) | 1279 | 0.081 | 0.5982 | Yes |
| 10 | ACAT1 | ACAT1 Entrez, Source | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | 1732 | 0.069 | 0.5951 | No |
| 11 | DDHD1 | DDHD1 Entrez, Source | DDHD domain containing 1 | 3539 | 0.035 | 0.4749 | No |
| 12 | PDHB | PDHB Entrez, Source | pyruvate dehydrogenase (lipoamide) beta | 3903 | 0.030 | 0.4609 | No |
| 13 | GAD2 | GAD2 Entrez, Source | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) | 4673 | 0.020 | 0.4120 | No |
| 14 | ALDH5A1 | ALDH5A1 Entrez, Source | aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) | 5161 | 0.014 | 0.3818 | No |
| 15 | ALDH3A1 | ALDH3A1 Entrez, Source | aldehyde dehydrogenase 3 family, memberA1 | 5228 | 0.013 | 0.3829 | No |
| 16 | HADHA | HADHA Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit | 5790 | 0.007 | 0.3438 | No |
| 17 | ECHS1 | ECHS1 Entrez, Source | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | 5819 | 0.007 | 0.3446 | No |
| 18 | ACADS | ACADS Entrez, Source | acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain | 6143 | 0.003 | 0.3217 | No |
| 19 | HSD17B4 | HSD17B4 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 4 | 6653 | -0.002 | 0.2846 | No |
| 20 | PPME1 | PPME1 Entrez, Source | protein phosphatase methylesterase 1 | 6973 | -0.005 | 0.2630 | No |
| 21 | HMGCL | HMGCL Entrez, Source | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) | 7395 | -0.009 | 0.2356 | No |
| 22 | ALDH2 | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 8031 | -0.016 | 0.1950 | No |
| 23 | RDH11 | RDH11 Entrez, Source | retinol dehydrogenase 11 (all-trans/9-cis/11-cis) | 8080 | -0.017 | 0.1988 | No |
| 24 | ALDH1B1 | ALDH1B1 Entrez, Source | aldehyde dehydrogenase 1 family, member B1 | 8208 | -0.018 | 0.1972 | No |
| 25 | PRDX6 | PRDX6 Entrez, Source | peroxiredoxin 6 | 8269 | -0.018 | 0.2010 | No |
| 26 | HSD3B7 | HSD3B7 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 8441 | -0.020 | 0.1971 | No |
| 27 | PDHA1 | PDHA1 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 1 | 8834 | -0.024 | 0.1785 | No |
| 28 | ABAT | ABAT Entrez, Source | 4-aminobutyrate aminotransferase | 8902 | -0.025 | 0.1847 | No |
| 29 | PDHA2 | PDHA2 Entrez, Source | pyruvate dehydrogenase (lipoamide) alpha 2 | 8903 | -0.025 | 0.1959 | No |
| 30 | AADAC | AADAC Entrez, Source | arylacetamide deacetylase (esterase) | 9121 | -0.027 | 0.1918 | No |
| 31 | PLA1A | PLA1A Entrez, Source | phospholipase A1 member A | 10432 | -0.042 | 0.1123 | No |
| 32 | ALDH7A1 | ALDH7A1 Entrez, Source | aldehyde dehydrogenase 7 family, member A1 | 12088 | -0.076 | 0.0218 | No |
| 33 | ALDH3A2 | ALDH3A2 Entrez, Source | aldehyde dehydrogenase 3 family, member A2 | 12137 | -0.077 | 0.0527 | No |
| 34 | ALDH9A1 | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 12333 | -0.084 | 0.0758 | No |
