Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | single_gel_24h |
| GeneSet | HSA04210_APOPTOSIS |
| Enrichment Score (ES) | -0.47441444 |
| Normalized Enrichment Score (NES) | -1.7789853 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.13196334 |
| FWER p-Value | 0.99 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | IL3 | IL3 Entrez, Source | interleukin 3 (colony-stimulating factor, multiple) | 866 | 0.097 | -0.0310 | No |
| 2 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 2228 | 0.057 | -0.1133 | No |
| 3 | PRKAR1B | PRKAR1B Entrez, Source | protein kinase, cAMP-dependent, regulatory, type I, beta | 2459 | 0.052 | -0.1121 | No |
| 4 | NTRK1 | NTRK1 Entrez, Source | neurotrophic tyrosine kinase, receptor, type 1 | 3308 | 0.038 | -0.1624 | No |
| 5 | FASLG | FASLG Entrez, Source | Fas ligand (TNF superfamily, member 6) | 3426 | 0.036 | -0.1584 | No |
| 6 | PPP3R2 | PPP3R2 Entrez, Source | protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, beta isoform (calcineurin B, type II) | 3931 | 0.029 | -0.1859 | No |
| 7 | PPP3CC | PPP3CC Entrez, Source | protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma) | 4631 | 0.020 | -0.2314 | No |
| 8 | BCL2L1 | BCL2L1 Entrez, Source | BCL2-like 1 | 4653 | 0.020 | -0.2259 | No |
| 9 | PRKACA | PRKACA Entrez, Source | protein kinase, cAMP-dependent, catalytic, alpha | 4870 | 0.018 | -0.2358 | No |
| 10 | PRKAR2A | PRKAR2A Entrez, Source | protein kinase, cAMP-dependent, regulatory, type II, alpha | 4888 | 0.018 | -0.2309 | No |
| 11 | BIRC2 | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 5286 | 0.013 | -0.2563 | No |
| 12 | PPP3CB | PPP3CB Entrez, Source | protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta) | 5416 | 0.011 | -0.2621 | No |
| 13 | TNFRSF1A | TNFRSF1A Entrez, Source | tumor necrosis factor receptor superfamily, member 1A | 5475 | 0.010 | -0.2628 | No |
| 14 | IL1R1 | IL1R1 Entrez, Source | interleukin 1 receptor, type I | 5860 | 0.006 | -0.2896 | No |
| 15 | PIK3R2 | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 6716 | -0.003 | -0.3529 | No |
| 16 | BCL2 | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 6812 | -0.004 | -0.3587 | No |
| 17 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 6874 | -0.004 | -0.3617 | No |
| 18 | PRKAR1A | PRKAR1A Entrez, Source | protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) | 7099 | -0.007 | -0.3762 | No |
| 19 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 7260 | -0.008 | -0.3854 | No |
| 20 | AKT3 | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 7266 | -0.008 | -0.3828 | No |
| 21 | DFFB | DFFB Entrez, Source | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) | 7293 | -0.009 | -0.3818 | No |
| 22 | CASP3 | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 7301 | -0.009 | -0.3792 | No |
| 23 | PIK3R3 | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 7359 | -0.009 | -0.3803 | No |
| 24 | CYCS | CYCS Entrez, Source | cytochrome c, somatic | 7500 | -0.010 | -0.3871 | No |
| 25 | BAX | BAX Entrez, Source | BCL2-associated X protein | 7784 | -0.013 | -0.4037 | No |
| 26 | ENDOG | ENDOG Entrez, Source | endonuclease G | 7979 | -0.015 | -0.4128 | No |
| 27 | CASP7 | CASP7 Entrez, Source | caspase 7, apoptosis-related cysteine peptidase | 8153 | -0.017 | -0.4198 | No |
| 28 | TNF | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 8457 | -0.020 | -0.4354 | No |
| 29 | AKT2 | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 8477 | -0.020 | -0.4296 | No |
| 30 | MYD88 | MYD88 Entrez, Source | myeloid differentiation primary response gene (88) | 8694 | -0.023 | -0.4378 | No |
| 31 | CASP9 | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 8779 | -0.024 | -0.4358 | No |
| 32 | BIRC4 | BIRC4 Entrez, Source | baculoviral IAP repeat-containing 4 | 8879 | -0.025 | -0.4345 | No |
| 33 | PPP3R1 | PPP3R1 Entrez, Source | protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) | 8891 | -0.025 | -0.4265 | No |
| 34 | TRADD | TRADD Entrez, Source | TNFRSF1A-associated via death domain | 9040 | -0.026 | -0.4282 | No |
| 35 | IL3RA | IL3RA Entrez, Source | interleukin 3 receptor, alpha (low affinity) | 9102 | -0.027 | -0.4233 | No |
| 36 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 9174 | -0.028 | -0.4188 | No |
| 37 | BAD | BAD Entrez, Source | BCL2-antagonist of cell death | 9214 | -0.028 | -0.4117 | No |
| 38 | PIK3CA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 9438 | -0.031 | -0.4177 | No |
| 39 | CHP | CHP Entrez, Source | - | 9731 | -0.034 | -0.4275 | No |
| 40 | CAPN2 | CAPN2 Entrez, Source | calpain 2, (m/II) large subunit | 9763 | -0.035 | -0.4176 | No |
| 41 | PPP3CA | PPP3CA Entrez, Source | protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha) | 9796 | -0.035 | -0.4076 | No |
| 42 | PRKAR2B | PRKAR2B Entrez, Source | protein kinase, cAMP-dependent, regulatory, type II, beta | 9892 | -0.036 | -0.4020 | No |
| 43 | CAPN1 | CAPN1 Entrez, Source | calpain 1, (mu/I) large subunit | 10030 | -0.037 | -0.3990 | No |
| 44 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 10368 | -0.041 | -0.4097 | No |
| 45 | CASP6 | CASP6 Entrez, Source | caspase 6, apoptosis-related cysteine peptidase | 10649 | -0.045 | -0.4147 | No |
| 46 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 10753 | -0.047 | -0.4057 | No |
| 47 | DFFA | DFFA Entrez, Source | DNA fragmentation factor, 45kDa, alpha polypeptide | 11119 | -0.053 | -0.4144 | No |
| 48 | CFLAR | CFLAR Entrez, Source | CASP8 and FADD-like apoptosis regulator | 11917 | -0.070 | -0.4496 | Yes |
| 49 | IL1RAP | IL1RAP Entrez, Source | interleukin 1 receptor accessory protein | 12123 | -0.077 | -0.4379 | Yes |
| 50 | BID | BID Entrez, Source | BH3 interacting domain death agonist | 12134 | -0.077 | -0.4113 | Yes |
| 51 | FADD | FADD Entrez, Source | Fas (TNFRSF6)-associated via death domain | 12156 | -0.078 | -0.3853 | Yes |
| 52 | IKBKB | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 12168 | -0.078 | -0.3584 | Yes |
| 53 | IL1B | IL1B Entrez, Source | interleukin 1, beta | 12206 | -0.080 | -0.3331 | Yes |
| 54 | PIK3CB | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 12588 | -0.096 | -0.3278 | Yes |
| 55 | NFKB2 | NFKB2 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 12794 | -0.110 | -0.3043 | Yes |
| 56 | FAS | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 12841 | -0.114 | -0.2673 | Yes |
| 57 | IRAK2 | IRAK2 Entrez, Source | interleukin-1 receptor-associated kinase 2 | 12849 | -0.115 | -0.2272 | Yes |
| 58 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 12964 | -0.127 | -0.1907 | Yes |
| 59 | BIRC3 | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 13071 | -0.143 | -0.1479 | Yes |
| 60 | IL1A | IL1A Entrez, Source | interleukin 1, alpha | 13241 | -0.218 | -0.0835 | Yes |
| 61 | APAF1 | APAF1 Entrez, Source | apoptotic peptidase activating factor | 13280 | -0.257 | 0.0047 | Yes |
