Details for gene set HSA04530_TIGHT

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos
Phenotype	class.cls#double_gel_24h_versus_single_gel_24h_repos
Upregulated in class	single_gel_24h
GeneSet	HSA04530_TIGHT_JUNCTION
Enrichment Score (ES)	-0.3772313
Normalized Enrichment Score (NES)	-1.4858048
Nominal p-value	0.023157895
FDR q-value	0.28200647
FWER p-Value	1.0

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	PRKCQ	PRKCQ Entrez, Source	protein kinase C, theta	147	0.160	0.0211	No
2	PRKCE	PRKCE Entrez, Source	protein kinase C, epsilon	467	0.120	0.0212	No
3	MYH11	MYH11 Entrez, Source	myosin, heavy chain 11, smooth muscle	500	0.118	0.0425	No
4	SRC	SRC Entrez, Source	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	729	0.103	0.0461	No
5	PPP2R2C	PPP2R2C Entrez, Source	protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform	1166	0.085	0.0303	No
6	CLDN19	CLDN19 Entrez, Source	claudin 19	1243	0.082	0.0411	No
7	CLDN4	CLDN4 Entrez, Source	claudin 4	1370	0.078	0.0474	No
8	CLDN14	CLDN14 Entrez, Source	claudin 14	1450	0.076	0.0568	No
9	PRKCH	PRKCH Entrez, Source	protein kinase C, eta	1557	0.073	0.0635	No
10	MAGI2	MAGI2 Entrez, Source	membrane associated guanylate kinase, WW and PDZ domain containing 2	1563	0.073	0.0779	No
11	MYH7	MYH7 Entrez, Source	myosin, heavy chain 7, cardiac muscle, beta	2024	0.062	0.0557	No
12	PRKCB1	PRKCB1 Entrez, Source	protein kinase C, beta 1	2052	0.061	0.0659	No
13	PARD3	PARD3 Entrez, Source	par-3 partitioning defective 3 homolog (C. elegans)	2421	0.053	0.0489	No
14	MYH2	MYH2 Entrez, Source	myosin, heavy chain 2, skeletal muscle, adult	2757	0.047	0.0331	No
15	CLDN11	CLDN11 Entrez, Source	claudin 11 (oligodendrocyte transmembrane protein)	3791	0.031	-0.0385	No
16	CLDN16	CLDN16 Entrez, Source	claudin 16	4001	0.028	-0.0486	No
17	JAM2	JAM2 Entrez, Source	junctional adhesion molecule 2	4133	0.027	-0.0531	No
18	MYH4	MYH4 Entrez, Source	myosin, heavy chain 4, skeletal muscle	4255	0.025	-0.0572	No
19	HCLS1	HCLS1 Entrez, Source	hematopoietic cell-specific Lyn substrate 1	4310	0.025	-0.0563	No
20	MYH6	MYH6 Entrez, Source	myosin, heavy chain 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1)	4670	0.020	-0.0794	No
21	PRKCA	PRKCA Entrez, Source	protein kinase C, alpha	4883	0.018	-0.0918	No
22	VAPA	VAPA Entrez, Source	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa	5075	0.015	-0.1032	No
23	PARD6A	PARD6A Entrez, Source	par-6 partitioning defective 6 homolog alpha (C.elegans)	5346	0.012	-0.1211	No
24	MYH8	MYH8 Entrez, Source	myosin, heavy chain 8, skeletal muscle, perinatal	5444	0.011	-0.1263	No
25	PPP2R2A	PPP2R2A Entrez, Source	protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform	5448	0.011	-0.1243	No
26	RAB3B	RAB3B Entrez, Source	RAB3B, member RAS oncogene family	5708	0.008	-0.1423	No
27	CSNK2B	CSNK2B Entrez, Source	casein kinase 2, beta polypeptide	6090	0.004	-0.1703	No
28	CLDN5	CLDN5 Entrez, Source	claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)	6273	0.002	-0.1837	No
29	CSNK2A1	CSNK2A1 Entrez, Source	casein kinase 2, alpha 1 polypeptide	6396	0.000	-0.1928	No
30	CLDN3	CLDN3 Entrez, Source	claudin 3	6913	-0.005	-0.2308	No
31	GNAI3	GNAI3 Entrez, Source	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	6944	-0.005	-0.2320	No
32	MYH13	MYH13 Entrez, Source	myosin, heavy chain 13, skeletal muscle	7145	-0.007	-0.2457	No
33	AKT3	AKT3 Entrez, Source	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)	7266	-0.008	-0.2531	No
34	MYH1	MYH1 Entrez, Source	myosin, heavy chain 1, skeletal muscle, adult	7518	-0.011	-0.2699	No
35	MYH3	MYH3 Entrez, Source	myosin, heavy chain 3, skeletal muscle, embryonic	7568	-0.011	-0.2713	No
36	CDC42	CDC42 Entrez, Source	cell division cycle 42 (GTP binding protein, 25kDa)	7869	-0.014	-0.2911	No
37	CRB3	CRB3 Entrez, Source	crumbs homolog 3 (Drosophila)	7987	-0.016	-0.2968	No
38	ACTB	ACTB Entrez, Source	actin, beta	8105	-0.017	-0.3022	No
39	RHOA	RHOA Entrez, Source	ras homolog gene family, member A	8143	-0.017	-0.3016	No
40	PPP2CA	PPP2CA Entrez, Source	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	8183	-0.017	-0.3010	No
41	EXOC4	EXOC4 Entrez, Source	exocyst complex component 4	8337	-0.019	-0.3087	No
42	PRKCZ	PRKCZ Entrez, Source	protein kinase C, zeta	8458	-0.020	-0.3137	No
43	CTNNB1	CTNNB1 Entrez, Source	catenin (cadherin-associated protein), beta 1, 88kDa	8471	-0.020	-0.3105	No
44	AKT2	AKT2 Entrez, Source	v-akt murine thymoma viral oncogene homolog 2	8477	-0.020	-0.3067	No
45	CSDA	CSDA Entrez, Source	cold shock domain protein A	8491	-0.021	-0.3036	No
46	PPP2CB	PPP2CB Entrez, Source	protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform	8641	-0.022	-0.3103	No
47	EXOC3	EXOC3 Entrez, Source	exocyst complex component 3	8748	-0.023	-0.3136	No
48	PPP2R1B	PPP2R1B Entrez, Source	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform	9012	-0.026	-0.3282	No
49	JAM3	JAM3 Entrez, Source	junctional adhesion molecule 3	9183	-0.028	-0.3354	No
50	TJP2	TJP2 Entrez, Source	tight junction protein 2 (zona occludens 2)	9217	-0.028	-0.3322	No
51	PPM1J	PPM1J Entrez, Source	protein phosphatase 1J (PP2C domain containing)	9432	-0.031	-0.3422	No
52	PPP2R1A	PPP2R1A Entrez, Source	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	9468	-0.031	-0.3386	No
53	HRAS	HRAS Entrez, Source	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	9624	-0.033	-0.3436	No
54	RAB13	RAB13 Entrez, Source	RAB13, member RAS oncogene family	9626	-0.033	-0.3371	No
55	CTTN	CTTN Entrez, Source	cortactin	9710	-0.034	-0.3364	No
56	MYL2	MYL2 Entrez, Source	myosin, light chain 2, regulatory, cardiac, slow	9897	-0.036	-0.3432	No
57	MYH14	MYH14 Entrez, Source	myosin, heavy chain 14	10087	-0.038	-0.3498	No
58	SYMPK	SYMPK Entrez, Source	symplekin	10246	-0.040	-0.3536	No
59	PTEN	PTEN Entrez, Source	phosphatase and tensin homolog (mutated in multiple advanced cancers 1)	10560	-0.044	-0.3683	Yes
60	GNAI2	GNAI2 Entrez, Source	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	10617	-0.045	-0.3635	Yes
61	AKT1	AKT1 Entrez, Source	v-akt murine thymoma viral oncogene homolog 1	10753	-0.047	-0.3642	Yes
62	CLDN8	CLDN8 Entrez, Source	claudin 8	10771	-0.048	-0.3559	Yes
63	MYH9	MYH9 Entrez, Source	myosin, heavy chain 9, non-muscle	10920	-0.050	-0.3570	Yes
64	PPP2R2B	PPP2R2B Entrez, Source	protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform	10989	-0.051	-0.3519	Yes
65	MPDZ	MPDZ Entrez, Source	multiple PDZ domain protein	11206	-0.055	-0.3571	Yes
66	ACTN3	ACTN3 Entrez, Source	actinin, alpha 3	11323	-0.057	-0.3543	Yes
67	NRAS	NRAS Entrez, Source	neuroblastoma RAS viral (v-ras) oncogene homolog	11369	-0.058	-0.3460	Yes
68	MLLT4	MLLT4 Entrez, Source	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	11391	-0.059	-0.3358	Yes
69	KRAS	KRAS Entrez, Source	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	11456	-0.060	-0.3286	Yes
70	PRKCD	PRKCD Entrez, Source	protein kinase C, delta	11467	-0.060	-0.3173	Yes
71	CDK4	CDK4 Entrez, Source	cyclin-dependent kinase 4	11704	-0.065	-0.3221	Yes
72	ACTN4	ACTN4 Entrez, Source	actinin, alpha 4	11817	-0.068	-0.3169	Yes
73	F11R	F11R Entrez, Source	F11 receptor	11977	-0.072	-0.3144	Yes
74	CASK	CASK Entrez, Source	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	12444	-0.088	-0.3317	Yes
75	PRKCI	PRKCI Entrez, Source	protein kinase C, iota	12564	-0.095	-0.3216	Yes
76	CLDN1	CLDN1 Entrez, Source	claudin 1	12658	-0.100	-0.3086	Yes
77	MRAS	MRAS Entrez, Source	muscle RAS oncogene homolog	12754	-0.107	-0.2941	Yes
78	RRAS2	RRAS2 Entrez, Source	related RAS viral (r-ras) oncogene homolog 2	13088	-0.147	-0.2896	Yes
79	CLDN7	CLDN7 Entrez, Source	claudin 7	13101	-0.150	-0.2603	Yes
80	MYH10	MYH10 Entrez, Source	myosin, heavy chain 10, non-muscle	13185	-0.179	-0.2306	Yes
81	MAGI3	MAGI3 Entrez, Source	membrane associated guanylate kinase, WW and PDZ domain containing 3	13229	-0.212	-0.1912	Yes
82	ACTN1	ACTN1 Entrez, Source	actinin, alpha 1	13295	-0.275	-0.1408	Yes
83	GNAI1	GNAI1 Entrez, Source	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	13318	-0.354	-0.0711	Yes
84	PPP2R3A	PPP2R3A Entrez, Source	protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha	13320	-0.362	0.0017	Yes