Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | single_gel_24h |
| GeneSet | HSA05212_PANCREATIC_CANCER |
| Enrichment Score (ES) | -0.41001716 |
| Normalized Enrichment Score (NES) | -1.5316621 |
| Nominal p-value | 0.022123894 |
| FDR q-value | 0.2695873 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | VEGFB | VEGFB Entrez, Source | vascular endothelial growth factor B | 106 | 0.175 | 0.0473 | No |
| 2 | EGF | EGF Entrez, Source | epidermal growth factor (beta-urogastrone) | 392 | 0.126 | 0.0657 | No |
| 3 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 763 | 0.101 | 0.0700 | No |
| 4 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 2228 | 0.057 | -0.0223 | No |
| 5 | TGFB2 | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 2282 | 0.056 | -0.0086 | No |
| 6 | RALGDS | RALGDS Entrez, Source | ral guanine nucleotide dissociation stimulator | 2347 | 0.055 | 0.0039 | No |
| 7 | ERBB2 | ERBB2 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 2456 | 0.053 | 0.0124 | No |
| 8 | EGFR | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 2716 | 0.048 | 0.0080 | No |
| 9 | STAT3 | STAT3 Entrez, Source | signal transducer and activator of transcription 3 (acute-phase response factor) | 2887 | 0.045 | 0.0094 | No |
| 10 | PGF | PGF Entrez, Source | placental growth factor, vascular endothelial growth factor-related protein | 2920 | 0.044 | 0.0210 | No |
| 11 | FIGF | FIGF Entrez, Source | c-fos induced growth factor (vascular endothelial growth factor D) | 3423 | 0.036 | -0.0053 | No |
| 12 | RAC2 | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 3877 | 0.030 | -0.0299 | No |
| 13 | MAP2K1 | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 4172 | 0.026 | -0.0438 | No |
| 14 | BCL2L1 | BCL2L1 Entrez, Source | BCL2-like 1 | 4653 | 0.020 | -0.0736 | No |
| 15 | RAF1 | RAF1 Entrez, Source | v-raf-1 murine leukemia viral oncogene homolog 1 | 4811 | 0.018 | -0.0796 | No |
| 16 | TGFA | TGFA Entrez, Source | transforming growth factor, alpha | 4880 | 0.018 | -0.0791 | No |
| 17 | BRCA2 | BRCA2 Entrez, Source | breast cancer 2, early onset | 5213 | 0.014 | -0.0998 | No |
| 18 | SMAD4 | SMAD4 Entrez, Source | SMAD, mothers against DPP homolog 4 (Drosophila) | 5961 | 0.005 | -0.1545 | No |
| 19 | PIK3R2 | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 6716 | -0.003 | -0.2103 | No |
| 20 | MAPK1 | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 6842 | -0.004 | -0.2184 | No |
| 21 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 6874 | -0.004 | -0.2193 | No |
| 22 | MAPK9 | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 7208 | -0.008 | -0.2420 | No |
| 23 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 7260 | -0.008 | -0.2432 | No |
| 24 | AKT3 | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 7266 | -0.008 | -0.2410 | No |
| 25 | PIK3R3 | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 7359 | -0.009 | -0.2450 | No |
| 26 | TGFBR1 | TGFBR1 Entrez, Source | transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) | 7514 | -0.011 | -0.2532 | No |
| 27 | STAT1 | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 7778 | -0.013 | -0.2688 | No |
| 28 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 7869 | -0.014 | -0.2711 | No |
| 29 | RALA | RALA Entrez, Source | v-ral simian leukemia viral oncogene homolog A (ras related) | 7900 | -0.015 | -0.2687 | No |
| 30 | AKT2 | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 8477 | -0.020 | -0.3056 | No |
| 31 | JAK1 | JAK1 Entrez, Source | Janus kinase 1 (a protein tyrosine kinase) | 8495 | -0.021 | -0.3004 | No |
| 32 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 8761 | -0.023 | -0.3129 | No |
| 33 | CASP9 | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 8779 | -0.024 | -0.3067 | No |
| 34 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 9174 | -0.028 | -0.3276 | No |
| 35 | BAD | BAD Entrez, Source | BCL2-antagonist of cell death | 9214 | -0.028 | -0.3215 | No |
| 36 | CDK6 | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 9381 | -0.030 | -0.3246 | No |
| 37 | PIK3CA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 9438 | -0.031 | -0.3191 | No |
| 38 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 9542 | -0.032 | -0.3167 | No |
| 39 | SMAD2 | SMAD2 Entrez, Source | SMAD, mothers against DPP homolog 2 (Drosophila) | 10127 | -0.039 | -0.3484 | No |
| 40 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 10753 | -0.047 | -0.3805 | No |
| 41 | ACVR1C | ACVR1C Entrez, Source | activin A receptor, type IC | 10894 | -0.050 | -0.3754 | No |
| 42 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 11355 | -0.058 | -0.3917 | Yes |
| 43 | BRAF | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 11372 | -0.058 | -0.3745 | Yes |
| 44 | ARAF | ARAF Entrez, Source | v-raf murine sarcoma 3611 viral oncogene homolog | 11403 | -0.059 | -0.3581 | Yes |
| 45 | KRAS | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 11456 | -0.060 | -0.3431 | Yes |
| 46 | PLD1 | PLD1 Entrez, Source | phospholipase D1, phosphatidylcholine-specific | 11478 | -0.060 | -0.3257 | Yes |
| 47 | MAPK10 | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 11586 | -0.062 | -0.3141 | Yes |
| 48 | RALBP1 | RALBP1 Entrez, Source | ralA binding protein 1 | 11641 | -0.063 | -0.2980 | Yes |
| 49 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 11704 | -0.065 | -0.2822 | Yes |
| 50 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 11928 | -0.071 | -0.2766 | Yes |
| 51 | RALB | RALB Entrez, Source | v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) | 12089 | -0.076 | -0.2647 | Yes |
| 52 | IKBKB | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 12168 | -0.078 | -0.2458 | Yes |
| 53 | MAPK3 | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 12184 | -0.079 | -0.2219 | Yes |
| 54 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 12416 | -0.088 | -0.2116 | Yes |
| 55 | PIK3CB | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 12588 | -0.096 | -0.1941 | Yes |
| 56 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 12607 | -0.097 | -0.1646 | Yes |
| 57 | NFKB2 | NFKB2 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 12794 | -0.110 | -0.1438 | Yes |
| 58 | TGFBR2 | TGFBR2 Entrez, Source | transforming growth factor, beta receptor II (70/80kDa) | 13036 | -0.137 | -0.1184 | Yes |
| 59 | TGFB3 | TGFB3 Entrez, Source | transforming growth factor, beta 3 | 13109 | -0.151 | -0.0759 | Yes |
| 60 | CCND1 | CCND1 Entrez, Source | cyclin D1 | 13302 | -0.295 | 0.0030 | Yes |
