Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | single_gel_24h |
| GeneSet | HSA05220_CHRONIC_MYELOID_LEUKEMIA |
| Enrichment Score (ES) | -0.4400485 |
| Normalized Enrichment Score (NES) | -1.6101929 |
| Nominal p-value | 0.018907564 |
| FDR q-value | 0.23166895 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 491 | 0.118 | -0.0007 | No |
| 2 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 763 | 0.101 | 0.0100 | No |
| 3 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 1411 | 0.077 | -0.0150 | No |
| 4 | GAB2 | GAB2 Entrez, Source | GRB2-associated binding protein 2 | 1477 | 0.075 | 0.0032 | No |
| 5 | SHC1 | SHC1 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 1 | 1493 | 0.075 | 0.0251 | No |
| 6 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 2228 | 0.057 | -0.0128 | No |
| 7 | TGFB2 | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 2282 | 0.056 | 0.0003 | No |
| 8 | CRKL | CRKL Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 2336 | 0.055 | 0.0131 | No |
| 9 | CTBP2 | CTBP2 Entrez, Source | C-terminal binding protein 2 | 2635 | 0.049 | 0.0058 | No |
| 10 | CBLC | CBLC Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence c | 2857 | 0.045 | 0.0030 | No |
| 11 | MAP2K1 | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 4172 | 0.026 | -0.0879 | No |
| 12 | CBLB | CBLB Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence b | 4550 | 0.021 | -0.1098 | No |
| 13 | BCL2L1 | BCL2L1 Entrez, Source | BCL2-like 1 | 4653 | 0.020 | -0.1113 | No |
| 14 | RAF1 | RAF1 Entrez, Source | v-raf-1 murine leukemia viral oncogene homolog 1 | 4811 | 0.018 | -0.1175 | No |
| 15 | SMAD4 | SMAD4 Entrez, Source | SMAD, mothers against DPP homolog 4 (Drosophila) | 5961 | 0.005 | -0.2024 | No |
| 16 | PTPN11 | PTPN11 Entrez, Source | protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | 6041 | 0.004 | -0.2071 | No |
| 17 | STAT5A | STAT5A Entrez, Source | signal transducer and activator of transcription 5A | 6535 | -0.001 | -0.2438 | No |
| 18 | PIK3R2 | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 6716 | -0.003 | -0.2565 | No |
| 19 | GRB2 | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 6805 | -0.004 | -0.2619 | No |
| 20 | MAPK1 | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 6842 | -0.004 | -0.2634 | No |
| 21 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 6874 | -0.004 | -0.2644 | No |
| 22 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 7260 | -0.008 | -0.2908 | No |
| 23 | AKT3 | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 7266 | -0.008 | -0.2887 | No |
| 24 | HDAC2 | HDAC2 Entrez, Source | histone deacetylase 2 | 7306 | -0.009 | -0.2890 | No |
| 25 | PIK3R3 | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 7359 | -0.009 | -0.2901 | No |
| 26 | TGFBR1 | TGFBR1 Entrez, Source | transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) | 7514 | -0.011 | -0.2984 | No |
| 27 | AKT2 | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 8477 | -0.020 | -0.3646 | No |
| 28 | MAP2K2 | MAP2K2 Entrez, Source | mitogen-activated protein kinase kinase 2 | 8874 | -0.025 | -0.3868 | No |
| 29 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 9056 | -0.027 | -0.3922 | No |
| 30 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 9174 | -0.028 | -0.3925 | No |
| 31 | BAD | BAD Entrez, Source | BCL2-antagonist of cell death | 9214 | -0.028 | -0.3868 | No |
| 32 | CDK6 | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 9381 | -0.030 | -0.3901 | No |
| 33 | PIK3CA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 9438 | -0.031 | -0.3849 | No |
| 34 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 9542 | -0.032 | -0.3829 | No |
| 35 | HRAS | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 9624 | -0.033 | -0.3789 | No |
| 36 | STAT5B | STAT5B Entrez, Source | signal transducer and activator of transcription 5B | 9889 | -0.036 | -0.3877 | No |
| 37 | CTBP1 | CTBP1 Entrez, Source | C-terminal binding protein 1 | 10344 | -0.041 | -0.4092 | No |
| 38 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 10753 | -0.047 | -0.4255 | Yes |
| 39 | ACVR1C | ACVR1C Entrez, Source | activin A receptor, type IC | 10894 | -0.050 | -0.4208 | Yes |
| 40 | CRK | CRK Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian) | 10930 | -0.050 | -0.4081 | Yes |
| 41 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 11355 | -0.058 | -0.4223 | Yes |
| 42 | NRAS | NRAS Entrez, Source | neuroblastoma RAS viral (v-ras) oncogene homolog | 11369 | -0.058 | -0.4055 | Yes |
| 43 | BRAF | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 11372 | -0.058 | -0.3878 | Yes |
| 44 | ARAF | ARAF Entrez, Source | v-raf murine sarcoma 3611 viral oncogene homolog | 11403 | -0.059 | -0.3720 | Yes |
| 45 | KRAS | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 11456 | -0.060 | -0.3577 | Yes |
| 46 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 11704 | -0.065 | -0.3564 | Yes |
| 47 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 11928 | -0.071 | -0.3515 | Yes |
| 48 | IKBKB | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 12168 | -0.078 | -0.3455 | Yes |
| 49 | MAPK3 | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 12184 | -0.079 | -0.3224 | Yes |
| 50 | PIK3CB | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 12588 | -0.096 | -0.3233 | Yes |
| 51 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 12607 | -0.097 | -0.2949 | Yes |
| 52 | NFKB2 | NFKB2 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 12794 | -0.110 | -0.2751 | Yes |
| 53 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 12964 | -0.127 | -0.2488 | Yes |
| 54 | TGFBR2 | TGFBR2 Entrez, Source | transforming growth factor, beta receptor II (70/80kDa) | 13036 | -0.137 | -0.2121 | Yes |
| 55 | TGFB3 | TGFB3 Entrez, Source | transforming growth factor, beta 3 | 13109 | -0.151 | -0.1711 | Yes |
| 56 | RUNX1 | RUNX1 Entrez, Source | runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) | 13119 | -0.153 | -0.1249 | Yes |
| 57 | SOS2 | SOS2 Entrez, Source | son of sevenless homolog 2 (Drosophila) | 13162 | -0.167 | -0.0769 | Yes |
| 58 | CCND1 | CCND1 Entrez, Source | cyclin D1 | 13302 | -0.295 | 0.0030 | Yes |
