Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | single_gel_24h |
| GeneSet | HSA05222_SMALL_CELL_LUNG_CANCER |
| Enrichment Score (ES) | -0.49979702 |
| Normalized Enrichment Score (NES) | -1.8155689 |
| Nominal p-value | 0.0021008404 |
| FDR q-value | 0.11807829 |
| FWER p-Value | 0.959 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | NOS3 | NOS3 Entrez, Source | nitric oxide synthase 3 (endothelial cell) | 489 | 0.118 | -0.0015 | No |
| 2 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 1411 | 0.077 | -0.0478 | No |
| 3 | COL4A4 | COL4A4 Entrez, Source | collagen, type IV, alpha 4 | 1561 | 0.073 | -0.0372 | No |
| 4 | LAMA5 | LAMA5 Entrez, Source | laminin, alpha 5 | 1975 | 0.063 | -0.0495 | No |
| 5 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 2228 | 0.057 | -0.0516 | No |
| 6 | RARB | RARB Entrez, Source | retinoic acid receptor, beta | 3752 | 0.032 | -0.1567 | No |
| 7 | BCL2L1 | BCL2L1 Entrez, Source | BCL2-like 1 | 4653 | 0.020 | -0.2185 | No |
| 8 | RXRB | RXRB Entrez, Source | retinoid X receptor, beta | 4872 | 0.018 | -0.2296 | No |
| 9 | BIRC2 | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 5286 | 0.013 | -0.2569 | No |
| 10 | NOS1 | NOS1 Entrez, Source | nitric oxide synthase 1 (neuronal) | 5453 | 0.011 | -0.2662 | No |
| 11 | RXRA | RXRA Entrez, Source | retinoid X receptor, alpha | 5744 | 0.007 | -0.2858 | No |
| 12 | LAMA3 | LAMA3 Entrez, Source | laminin, alpha 3 | 5828 | 0.006 | -0.2901 | No |
| 13 | FN1 | FN1 Entrez, Source | fibronectin 1 | 6064 | 0.004 | -0.3066 | No |
| 14 | PIK3R2 | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 6716 | -0.003 | -0.3548 | No |
| 15 | BCL2 | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 6812 | -0.004 | -0.3608 | No |
| 16 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 6874 | -0.004 | -0.3640 | No |
| 17 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 7260 | -0.008 | -0.3906 | No |
| 18 | AKT3 | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 7266 | -0.008 | -0.3885 | No |
| 19 | PIK3R3 | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 7359 | -0.009 | -0.3927 | No |
| 20 | CYCS | CYCS Entrez, Source | cytochrome c, somatic | 7500 | -0.010 | -0.4001 | No |
| 21 | LAMB3 | LAMB3 Entrez, Source | laminin, beta 3 | 7845 | -0.014 | -0.4218 | No |
| 22 | RXRG | RXRG Entrez, Source | retinoid X receptor, gamma | 7990 | -0.016 | -0.4280 | No |
| 23 | PIAS3 | PIAS3 Entrez, Source | protein inhibitor of activated STAT, 3 | 8024 | -0.016 | -0.4258 | No |
| 24 | AKT2 | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 8477 | -0.020 | -0.4537 | No |
| 25 | LAMB2 | LAMB2 Entrez, Source | laminin, beta 2 (laminin S) | 8617 | -0.022 | -0.4576 | No |
| 26 | CASP9 | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 8779 | -0.024 | -0.4627 | No |
| 27 | BIRC4 | BIRC4 Entrez, Source | baculoviral IAP repeat-containing 4 | 8879 | -0.025 | -0.4628 | No |
| 28 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 9056 | -0.027 | -0.4681 | No |
| 29 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 9174 | -0.028 | -0.4687 | No |
| 30 | CDK6 | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 9381 | -0.030 | -0.4753 | No |
| 31 | CCNE1 | CCNE1 Entrez, Source | cyclin E1 | 9404 | -0.030 | -0.4679 | No |
| 32 | PIK3CA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 9438 | -0.031 | -0.4612 | No |
| 33 | PIAS2 | PIAS2 Entrez, Source | protein inhibitor of activated STAT, 2 | 9496 | -0.031 | -0.4562 | No |
| 34 | FHIT | FHIT Entrez, Source | fragile histidine triad gene | 9754 | -0.034 | -0.4653 | No |
| 35 | COL4A1 | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 9777 | -0.035 | -0.4566 | No |
| 36 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 10352 | -0.041 | -0.4875 | Yes |
| 37 | MAX | MAX Entrez, Source | MYC associated factor X | 10440 | -0.042 | -0.4814 | Yes |
| 38 | PIAS4 | PIAS4 Entrez, Source | protein inhibitor of activated STAT, 4 | 10464 | -0.043 | -0.4704 | Yes |
| 39 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 10560 | -0.044 | -0.4644 | Yes |
| 40 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 10753 | -0.047 | -0.4648 | Yes |
| 41 | ITGB1 | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 11016 | -0.051 | -0.4692 | Yes |
| 42 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 11355 | -0.058 | -0.4775 | Yes |
| 43 | PTK2 | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 11607 | -0.063 | -0.4777 | Yes |
| 44 | LAMC1 | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 11666 | -0.064 | -0.4630 | Yes |
| 45 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 11704 | -0.065 | -0.4465 | Yes |
| 46 | IKBKB | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 12168 | -0.078 | -0.4580 | Yes |
| 47 | CDKN2B | CDKN2B Entrez, Source | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | 12350 | -0.085 | -0.4462 | Yes |
| 48 | PTGS2 | PTGS2 Entrez, Source | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 12422 | -0.088 | -0.4254 | Yes |
| 49 | PIK3CB | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 12588 | -0.096 | -0.4093 | Yes |
| 50 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 12607 | -0.097 | -0.3817 | Yes |
| 51 | NFKB2 | NFKB2 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 12794 | -0.110 | -0.3629 | Yes |
| 52 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 12964 | -0.127 | -0.3377 | Yes |
| 53 | BIRC3 | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 13071 | -0.143 | -0.3030 | Yes |
| 54 | ITGA6 | ITGA6 Entrez, Source | integrin, alpha 6 | 13167 | -0.169 | -0.2598 | Yes |
| 55 | APAF1 | APAF1 Entrez, Source | apoptotic peptidase activating factor | 13280 | -0.257 | -0.1916 | Yes |
| 56 | CCND1 | CCND1 Entrez, Source | cyclin D1 | 13302 | -0.295 | -0.1054 | Yes |
| 57 | LAMC2 | LAMC2 Entrez, Source | laminin, gamma 2 | 13321 | -0.364 | 0.0016 | Yes |
