Datasetdouble_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls
#double_gel_24h_versus_single_gel_24h.class.cls
#double_gel_24h_versus_single_gel_24h_repos
Phenotypeclass.cls#double_gel_24h_versus_single_gel_24h_repos
Upregulated in classdouble_gel_24h
GeneSetHSIAO_LIVER_SPECIFIC_GENES
Enrichment Score (ES)0.39649412
Normalized Enrichment Score (NES)1.787636
Nominal p-value0.0
FDR q-value0.0867072
FWER p-Value0.989
Table: GSEA Results Summary



Fig 1: Enrichment plot: HSIAO_LIVER_SPECIFIC_GENES   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1G6PCG6PC
Entrez,  Source
glucose-6-phosphatase, catalytic subunit140.2950.0250Yes
2SLC10A1SLC10A1
Entrez,  Source
solute carrier family 10 (sodium/bile acid cotransporter family), member 1190.2660.0482Yes
3NR0B2NR0B2
Entrez,  Source
nuclear receptor subfamily 0, group B, member 2380.2270.0669Yes
4HRGHRG
Entrez,  Source
histidine-rich glycoprotein500.2110.0847Yes
5ACAT2ACAT2
Entrez,  Source
acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase)570.2020.1021Yes
6PCK1PCK1
Entrez,  Source
phosphoenolpyruvate carboxykinase 1 (soluble)590.2010.1198Yes
7TFTF
Entrez,  Source
transferrin620.1970.1370Yes
8FABP1FABP1
Entrez,  Source
fatty acid binding protein 1, liver630.1970.1543Yes
9HMGCS2HMGCS2
Entrez,  Source
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)800.1870.1696Yes
10ACAA2ACAA2
Entrez,  Source
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)830.1850.1858Yes
11BDH1BDH1
Entrez,  Source
3-hydroxybutyrate dehydrogenase, type 11210.1690.1979Yes
12ARG1ARG1
Entrez,  Source
arginase, liver2170.1460.2036Yes
13PLGPLG
Entrez,  Source
plasminogen2290.1440.2155Yes
14SC4MOLSC4MOL
Entrez,  Source
sterol-C4-methyl oxidase-like2660.1400.2251Yes
15CYP3A4CYP3A4
Entrez,  Source
cytochrome P450, family 3, subfamily A, polypeptide 42900.1370.2354Yes
16DHCR24DHCR24
Entrez,  Source
24-dehydrocholesterol reductase3080.1340.2460Yes
17BHMTBHMT
Entrez,  Source
betaine-homocysteine methyltransferase3170.1330.2571Yes
18SULT2A1SULT2A1
Entrez,  Source
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 13670.1280.2647Yes
19MTTPMTTP
Entrez,  Source
microsomal triglyceride transfer protein4400.1220.2701Yes
20RBP4RBP4
Entrez,  Source
retinol binding protein 4, plasma4870.1190.2771Yes
21FSTFST
Entrez,  Source
follistatin5030.1170.2863Yes
22TDO2TDO2
Entrez,  Source
tryptophan 2,3-dioxygenase5040.1170.2966Yes
23APOA1APOA1
Entrez,  Source
apolipoprotein A-I5520.1130.3031Yes
24ABCC6ABCC6
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 65670.1120.3119Yes
25IGFBP1IGFBP1
Entrez,  Source
insulin-like growth factor binding protein 15780.1120.3210Yes
26CYP2E1CYP2E1
Entrez,  Source
cytochrome P450, family 2, subfamily E, polypeptide 16010.1100.3291Yes
27C4BPAC4BPA
Entrez,  Source
complement component 4 binding protein, alpha7120.1040.3299Yes
28FGBFGB
Entrez,  Source
fibrinogen beta chain8000.1000.3320Yes
29SERPIND1SERPIND1
Entrez,  Source
serpin peptidase inhibitor, clade D (heparin cofactor), member 18120.0990.3400Yes
30SERPINF2SERPINF2
Entrez,  Source
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 29280.0940.3396Yes
31CDO1CDO1
Entrez,  Source
cysteine dioxygenase, type I9960.0910.3425Yes
32ADFPADFP
Entrez,  Source
adipose differentiation-related protein10460.0900.3467Yes
33CFHR1CFHR1
Entrez,  Source
complement factor H-related 110680.0880.3529Yes
34IL8RBIL8RB
Entrez,  Source
interleukin 8 receptor, beta11700.0850.3528Yes
35ALAS1ALAS1
Entrez,  Source
aminolevulinate, delta-, synthase 112520.0820.3538Yes
36FGAFGA
Entrez,  Source
fibrinogen alpha chain13020.0800.3572Yes
37ASGR2ASGR2
Entrez,  Source
asialoglycoprotein receptor 214630.0760.3517Yes
38PZPPZP
Entrez,  Source
pregnancy-zone protein16180.0720.3464Yes
39FGGFGG
Entrez,  Source
fibrinogen gamma chain16190.0720.3527Yes
40ACSM3ACSM3
Entrez,  Source
acyl-CoA synthetase medium-chain family member 316990.0700.3529Yes
41ACAT1ACAT1
Entrez,  Source
acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)17320.0690.3565Yes
42ACSL1ACSL1
Entrez,  Source
acyl-CoA synthetase long-chain family member 117610.0680.3604Yes
43AKR1D1AKR1D1
Entrez,  Source
aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)17700.0680.3659Yes
44SERPINE1SERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 118050.0670.3692Yes
45GSTA2GSTA2
Entrez,  Source
glutathione S-transferase A218360.0670.3728Yes
46LBPLBP
Entrez,  Source
lipopolysaccharide binding protein19400.0640.3706Yes
47SERPINA5SERPINA5
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 520420.0610.3683Yes
48HSD11B1HSD11B1
Entrez,  Source
hydroxysteroid (11-beta) dehydrogenase 120440.0610.3737Yes
49CES1CES1
Entrez,  Source
carboxylesterase 1 (monocyte/macrophage serine esterase 1)20570.0610.3782Yes
50LCATLCAT
Entrez,  Source
lecithin-cholesterol acyltransferase20890.0600.3811Yes
51AGTR1AGTR1
Entrez,  Source
angiotensin II receptor, type 120900.0600.3864Yes
52OTCOTC
Entrez,  Source
ornithine carbamoyltransferase21520.0590.3870Yes
53CFBCFB
Entrez,  Source
complement factor B21640.0580.3913Yes
54TATTAT
Entrez,  Source
tyrosine aminotransferase21650.0580.3965Yes
55ASLASL
Entrez,  Source
argininosuccinate lyase22930.0560.3917No
56KLKB1KLKB1
Entrez,  Source
kallikrein B, plasma (Fletcher factor) 125710.0500.3751No
57SEPHS2SEPHS2
Entrez,  Source
selenophosphate synthetase 225850.0500.3785No
58GLUD1GLUD1
Entrez,  Source
glutamate dehydrogenase 127090.0480.3734No
59APOC1APOC1
Entrez,  Source
apolipoprotein C-I28290.0460.3684No
60GATMGATM
Entrez,  Source
glycine amidinotransferase (L-arginine:glycine amidinotransferase)28990.0450.3671No
61NR1H4NR1H4
Entrez,  Source
nuclear receptor subfamily 1, group H, member 429570.0440.3666No
62ASGR1ASGR1
Entrez,  Source
asialoglycoprotein receptor 130230.0430.3655No
63CATCAT
Entrez,  Source
catalase31290.0410.3611No
64AOX1AOX1
Entrez,  Source
aldehyde oxidase 131480.0410.3634No
65KCNH2KCNH2
Entrez,  Source
potassium voltage-gated channel, subfamily H (eag-related), member 232570.0390.3586No
66SERPINC1SERPINC1
Entrez,  Source
serpin peptidase inhibitor, clade C (antithrombin), member 133030.0380.3586No
67SAA4SAA4
Entrez,  Source
serum amyloid A4, constitutive33710.0370.3567No
68PON3PON3
Entrez,  Source
paraoxonase 333950.0370.3582No
69GCH1GCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)34810.0350.3549No
70F2F2
Entrez,  Source
coagulation factor II (thrombin)34960.0350.3570No
71FGL1FGL1
Entrez,  Source
fibrinogen-like 137130.0320.3434No
72CDH2CDH2
Entrez,  Source
cadherin 2, type 1, N-cadherin (neuronal)37140.0320.3462No
73SLC38A3SLC38A3
Entrez,  Source
solute carrier family 38, member 337280.0320.3481No
74SERPINA4SERPINA4
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 438810.0300.3392No
75CPCP
Entrez,  Source
ceruloplasmin (ferroxidase)39120.0300.3395No
76CYP2C9CYP2C9
Entrez,  Source
cytochrome P450, family 2, subfamily C, polypeptide 939200.0290.3416No
77PBEF1PBEF1
Entrez,  Source
pre-B-cell colony enhancing factor 139750.0290.3400No
78AHSGAHSG
Entrez,  Source
alpha-2-HS-glycoprotein40360.0280.3379No
79APOBAPOB
Entrez,  Source
apolipoprotein B (including Ag(x) antigen)41170.0270.3342No
80HPHP
Entrez,  Source
haptoglobin41950.0260.3306No
81SEPP1SEPP1
Entrez,  Source
selenoprotein P, plasma, 142390.0250.3296No
82F10F10
Entrez,  Source
coagulation factor X42780.0250.3289No
83PROCPROC
Entrez,  Source
protein C (inactivator of coagulation factors Va and VIIIa)42840.0250.3307No
84AGTAGT
Entrez,  Source
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)43530.0240.3277No
85F9F9
Entrez,  Source
coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)43850.0230.3274No
86PCSK6PCSK6
Entrez,  Source
proprotein convertase subtilisin/kexin type 644050.0230.3280No
87VTNVTN
Entrez,  Source
vitronectin44130.0230.3295No
88LAMP2LAMP2
Entrez,  Source
lysosomal-associated membrane protein 244160.0230.3314No
89APOC3APOC3
Entrez,  Source
apolipoprotein C-III47150.0190.3105No
90PYGLPYGL
Entrez,  Source
phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)47600.0190.3088No
91CPB2CPB2
Entrez,  Source
carboxypeptidase B2 (plasma, carboxypeptidase U)49750.0160.2940No
92SERPINA1SERPINA1
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 150980.0150.2860No
93HALHAL
Entrez,  Source
histidine ammonia-lyase51200.0150.2857No
94CASC3CASC3
Entrez,  Source
cancer susceptibility candidate 351750.0140.2828No
95APOA2APOA2
Entrez,  Source
apolipoprotein A-II52140.0140.2811No
96CYP4F2CYP4F2
Entrez,  Source
cytochrome P450, family 4, subfamily F, polypeptide 252340.0130.2809No
97ALDOBALDOB
Entrez,  Source
aldolase B, fructose-bisphosphate52600.0130.2801No
98LTB4DHLTB4DH
Entrez,  Source
leukotriene B4 12-hydroxydehydrogenase52790.0130.2799No
99APOHAPOH
Entrez,  Source
apolipoprotein H (beta-2-glycoprotein I)53860.0110.2728No
100ITIH3ITIH3
Entrez,  Source
inter-alpha (globulin) inhibitor H353920.0110.2735No
101DAB2DAB2
Entrez,  Source
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)54420.0110.2707No
102ORM1ORM1
Entrez,  Source
orosomucoid 155390.0100.2643No
103HNMTHNMT
Entrez,  Source
histamine N-methyltransferase55500.0100.2644No
104PORPOR
Entrez,  Source
P450 (cytochrome) oxidoreductase55560.0100.2648No
105HGDHGD
Entrez,  Source
homogentisate 1,2-dioxygenase (homogentisate oxidase)57310.0080.2523No
106AGXTAGXT
Entrez,  Source
alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase)57430.0070.2521No
107SERPING1SERPING1
Entrez,  Source
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)58080.0070.2478No
108C3C3
Entrez,  Source
complement component 359620.0050.2366No
109HPXHPX
Entrez,  Source
hemopexin59640.0050.2370No
110FN1FN1
Entrez,  Source
fibronectin 160640.0040.2298No
111FBP1FBP1
Entrez,  Source
fructose-1,6-bisphosphatase 160670.0040.2300No
112CFICFI
Entrez,  Source
complement factor I61860.0030.2212No
113ALBALB
Entrez,  Source
albumin62130.0020.2195No
114DECR1DECR1
Entrez,  Source
2,4-dienoyl CoA reductase 1, mitochondrial62900.0010.2138No
115HRSP12HRSP12
Entrez,  Source
heat-responsive protein 1263450.0010.2098No
116RNASE4RNASE4
Entrez,  Source
ribonuclease, RNase A family, 463800.0000.2072No
117HPNHPN
Entrez,  Source
hepsin (transmembrane protease, serine 1)63940.0000.2063No
118ADH4ADH4
Entrez,  Source
alcohol dehydrogenase 4 (class II), pi polypeptide6634-0.0020.1883No
119HSD17B4HSD17B4
Entrez,  Source
hydroxysteroid (17-beta) dehydrogenase 46653-0.0020.1872No
120AZGP1AZGP1
Entrez,  Source
alpha-2-glycoprotein 1, zinc6721-0.0030.1823No
121HPDHPD
Entrez,  Source
4-hydroxyphenylpyruvate dioxygenase6761-0.0030.1797No
122APCSAPCS
Entrez,  Source
amyloid P component, serum6912-0.0050.1687No
123MST1MST1
Entrez,  Source
macrophage stimulating 1 (hepatocyte growth factor-like)7046-0.0060.1591No
124SPP2SPP2
Entrez,  Source
secreted phosphoprotein 2, 24kDa7334-0.0090.1381No
125SOD1SOD1
Entrez,  Source
superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))7350-0.0090.1377No
126HMGCLHMGCL
Entrez,  Source
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)7395-0.0090.1352No
127GJB1GJB1
Entrez,  Source
gap junction protein, beta 1, 32kDa (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked)7457-0.0100.1315No
128F12F12
Entrez,  Source
coagulation factor XII (Hageman factor)7631-0.0120.1194No
129MGST1MGST1
Entrez,  Source
microsomal glutathione S-transferase 17644-0.0120.1195No
130SORDSORD
Entrez,  Source
sorbitol dehydrogenase7689-0.0120.1172No
131GGCXGGCX
Entrez,  Source
gamma-glutamyl carboxylase7783-0.0130.1114No
132SERPINF1SERPINF1
Entrez,  Source
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 17864-0.0140.1065No
133PCBD1PCBD1
Entrez,  Source
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)7882-0.0140.1065No
134ALDH2ALDH2
Entrez,  Source
aldehyde dehydrogenase 2 family (mitochondrial)8031-0.0160.0967No
135GSTO1GSTO1
Entrez,  Source
glutathione S-transferase omega 18085-0.0170.0941No
136C2C2
Entrez,  Source
complement component 28163-0.0170.0898No
137DDTDDT
Entrez,  Source
D-dopachrome tautomerase8226-0.0180.0866No
138IL13IL13
Entrez,  Source
interleukin 138256-0.0180.0861No
139ASS1ASS1
Entrez,  Source
argininosuccinate synthetase 18332-0.0190.0820No
140BZW1BZW1
Entrez,  Source
basic leucine zipper and W2 domains 18476-0.0200.0730No
141PGRMC1PGRMC1
Entrez,  Source
progesterone receptor membrane component 18487-0.0210.0740No
142IL13RA1IL13RA1
Entrez,  Source
interleukin 13 receptor, alpha 18528-0.0210.0728No
143PCCBPCCB
Entrez,  Source
propionyl Coenzyme A carboxylase, beta polypeptide8561-0.0210.0723No
144SSRP1SSRP1
Entrez,  Source
structure specific recognition protein 18587-0.0220.0723No
145ALDH1A1ALDH1A1
Entrez,  Source
aldehyde dehydrogenase 1 family, member A18802-0.0240.0582No
146HGFACHGFAC
Entrez,  Source
HGF activator8869-0.0250.0553No
147TOMM40TOMM40
Entrez,  Source
translocase of outer mitochondrial membrane 40 homolog (yeast)8940-0.0250.0522No
148TAF6TAF6
Entrez,  Source
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa8996-0.0260.0503No
149NAT2NAT2
Entrez,  Source
N-acetyltransferase 2 (arylamine N-acetyltransferase)9028-0.0260.0503No
150AADACAADAC
Entrez,  Source
arylacetamide deacetylase (esterase)9121-0.0270.0457No
151SDSSDS
Entrez,  Source
serine dehydratase9204-0.0280.0420No
152TSTTST
Entrez,  Source
thiosulfate sulfurtransferase (rhodanese)9328-0.0290.0352No
153MTHFD1MTHFD1
Entrez,  Source
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase9334-0.0290.0374No
154FMO5FMO5
Entrez,  Source
flavin containing monooxygenase 59549-0.0320.0240No
155FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 49601-0.0330.0230No
156FAHFAH
Entrez,  Source
fumarylacetoacetate hydrolase (fumarylacetoacetase)9998-0.037-0.0038No
157CYP27A1CYP27A1
Entrez,  Source
cytochrome P450, family 27, subfamily A, polypeptide 110158-0.039-0.0125No
158GYS2GYS2
Entrez,  Source
glycogen synthase 2 (liver)10212-0.040-0.0130No
159PROS1PROS1
Entrez,  Source
protein S (alpha)10274-0.040-0.0141No
160GHRGHR
Entrez,  Source
growth hormone receptor10389-0.042-0.0191No
161ALDH6A1ALDH6A1
Entrez,  Source
aldehyde dehydrogenase 6 family, member A110628-0.045-0.0332No
162LIPCLIPC
Entrez,  Source
lipase, hepatic10652-0.046-0.0309No
163PRDX4PRDX4
Entrez,  Source
peroxiredoxin 410666-0.046-0.0279No
164ACOX2ACOX2
Entrez,  Source
acyl-Coenzyme A oxidase 2, branched chain10680-0.046-0.0248No
165CPS1CPS1
Entrez,  Source
carbamoyl-phosphate synthetase 1, mitochondrial10727-0.047-0.0242No
166C1RC1R
Entrez,  Source
complement component 1, r subcomponent10838-0.049-0.0282No
167EPHX1EPHX1
Entrez,  Source
epoxide hydrolase 1, microsomal (xenobiotic)10955-0.050-0.0326No
168CES2CES2
Entrez,  Source
carboxylesterase 2 (intestine, liver)10980-0.051-0.0299No
169SHMT1SHMT1
Entrez,  Source
serine hydroxymethyltransferase 1 (soluble)11060-0.052-0.0314No
170DPYSDPYS
Entrez,  Source
dihydropyrimidinase11440-0.059-0.0549No
171LSRLSR
Entrez,  Source
lipolysis stimulated lipoprotein receptor11509-0.061-0.0548No
172BAATBAAT
Entrez,  Source
bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)11730-0.065-0.0657No
173KYNUKYNU
Entrez,  Source
kynureninase (L-kynurenine hydrolase)11987-0.072-0.0788No
174TFPITFPI
Entrez,  Source
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)12015-0.073-0.0743No
175CYB5ACYB5A
Entrez,  Source
cytochrome b5 type A (microsomal)12147-0.078-0.0774No
176SLC2A2SLC2A2
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 212210-0.080-0.0751No
177ABCB4ABCB4
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 412353-0.085-0.0784No
178CBSCBS
Entrez,  Source
cystathionine-beta-synthase12395-0.087-0.0738No
179CRPCRP
Entrez,  Source
C-reactive protein, pentraxin-related12453-0.089-0.0703No
180FMO3FMO3
Entrez,  Source
flavin containing monooxygenase 312657-0.100-0.0769No
181CRHBPCRHBP
Entrez,  Source
corticotropin releasing hormone binding protein12709-0.104-0.0717No
182GPTGPT
Entrez,  Source
glutamic-pyruvate transaminase (alanine aminotransferase)12724-0.105-0.0635No
183MBL2MBL2
Entrez,  Source
mannose-binding lectin (protein C) 2, soluble (opsonic defect)12928-0.124-0.0679No
184LGALS4LGALS4
Entrez,  Source
lectin, galactoside-binding, soluble, 4 (galectin 4)12949-0.126-0.0583No
185ABCC2ABCC2
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 212994-0.131-0.0501No
186RGL2RGL2
Entrez,  Source
ral guanine nucleotide dissociation stimulator-like 213026-0.136-0.0404No
187SERPINA7SERPINA7
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 713141-0.159-0.0350No
188ACADSBACADSB
Entrez,  Source
acyl-Coenzyme A dehydrogenase, short/branched chain13150-0.162-0.0214No
189RGNRGN
Entrez,  Source
regucalcin (senescence marker protein-30)13176-0.172-0.0080No
190TM4SF4TM4SF4
Entrez,  Source
transmembrane 4 L six family member 413263-0.2330.0060No
Table: GSEA details [plain text format]



Fig 2: HSIAO_LIVER_SPECIFIC_GENES   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HSIAO_LIVER_SPECIFIC_GENES: Random ES distribution   
Gene set null distribution of ES for HSIAO_LIVER_SPECIFIC_GENES