Datasetdouble_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls
#double_gel_24h_versus_single_gel_24h.class.cls
#double_gel_24h_versus_single_gel_24h_repos
Phenotypeclass.cls#double_gel_24h_versus_single_gel_24h_repos
Upregulated in classsingle_gel_24h
GeneSetICHIBA_GVHD
Enrichment Score (ES)-0.3434269
Normalized Enrichment Score (NES)-1.5359051
Nominal p-value0.0
FDR q-value0.27360126
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: ICHIBA_GVHD   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1IFIT3IFIT3
Entrez,  Source
interferon-induced protein with tetratricopeptide repeats 380.3570.0255No
2G6PCG6PC
Entrez,  Source
glucose-6-phosphatase, catalytic subunit140.2950.0467No
3CYP26A1CYP26A1
Entrez,  Source
cytochrome P450, family 26, subfamily A, polypeptide 1270.2390.0633No
4FABP1FABP1
Entrez,  Source
fatty acid binding protein 1, liver630.1970.0750No
5HMGCS2HMGCS2
Entrez,  Source
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)800.1870.0874No
6USP18USP18
Entrez,  Source
ubiquitin specific peptidase 18940.1800.0996No
7NR1D1NR1D1
Entrez,  Source
nuclear receptor subfamily 1, group D, member 1960.1800.1127No
8VEGFBVEGFB
Entrez,  Source
vascular endothelial growth factor B1060.1750.1248No
9MMP12MMP12
Entrez,  Source
matrix metallopeptidase 12 (macrophage elastase)1260.1680.1356No
10RELNRELN
Entrez,  Source
reelin2840.1370.1337No
11CD14CD14
Entrez,  Source
CD14 molecule3270.1320.1402No
12CCL5CCL5
Entrez,  Source
chemokine (C-C motif) ligand 53470.1300.1482No
13IFIT1IFIT1
Entrez,  Source
interferon-induced protein with tetratricopeptide repeats 13660.1280.1563No
14TYROBPTYROBP
Entrez,  Source
TYRO protein tyrosine kinase binding protein3760.1280.1649No
15CTSSCTSS
Entrez,  Source
cathepsin S4620.1200.1673No
16BTG2BTG2
Entrez,  Source
BTG family, member 26770.1050.1587No
17PPP1R3CPPP1R3C
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 3C7210.1030.1630No
18CYP8B1CYP8B1
Entrez,  Source
cytochrome P450, family 8, subfamily B, polypeptide 17250.1030.1703No
19LRG1LRG1
Entrez,  Source
leucine-rich alpha-2-glycoprotein 17690.1010.1744No
20GIMAP4GIMAP4
Entrez,  Source
GTPase, IMAP family member 47720.1010.1816No
21LPHN1LPHN1
Entrez,  Source
latrophilin 19900.0920.1718No
22LPLLPL
Entrez,  Source
lipoprotein lipase11160.0870.1687No
23UBDUBD
Entrez,  Source
ubiquitin D12080.0830.1678No
24LAPTM5LAPTM5
Entrez,  Source
lysosomal associated multispanning membrane protein 512120.0830.1737No
25CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog12830.0810.1743No
26CASP1CASP1
Entrez,  Source
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)13480.0790.1752No
27PKLRPKLR
Entrez,  Source
pyruvate kinase, liver and RBC14490.0760.1732No
28HBA-A114730.0750.1769No
29MT1AMT1A
Entrez,  Source
metallothionein 1A (functional)17340.0690.1622No
30ACSL1ACSL1
Entrez,  Source
acyl-CoA synthetase long-chain family member 117610.0680.1652No
31VNN1VNN1
Entrez,  Source
vanin 117800.0680.1688No
32CYP7B1CYP7B1
Entrez,  Source
cytochrome P450, family 7, subfamily B, polypeptide 117960.0680.1726No
33KLF10KLF10
Entrez,  Source
Kruppel-like factor 1018370.0670.1745No
34ACTL7BACTL7B
Entrez,  Source
actin-like 7B18560.0660.1779No
35MARVELD1MARVELD1
Entrez,  Source
MARVEL domain containing 118770.0650.1812No
36LBPLBP
Entrez,  Source
lipopolysaccharide binding protein19400.0640.1811No
37HES6HES6
Entrez,  Source
hairy and enhancer of split 6 (Drosophila)21130.0600.1724No
38LIFRLIFR
Entrez,  Source
leukemia inhibitory factor receptor alpha21790.0580.1717No
39PAX3PAX3
Entrez,  Source
paired box gene 3 (Waardenburg syndrome 1)21900.0580.1752No
40C1QCC1QC
Entrez,  Source
complement component 1, q subcomponent, C chain22080.0570.1781No
41FKBP5FKBP5
Entrez,  Source
FK506 binding protein 522480.0560.1792No
42S100A9S100A9
Entrez,  Source
S100 calcium binding protein A924270.0530.1696No
43CD53CD53
Entrez,  Source
CD53 molecule25260.0510.1659No
44NAT8NAT8
Entrez,  Source
N-acetyltransferase 8 (camello like)25340.0510.1691No
45SLC1A2SLC1A2
Entrez,  Source
solute carrier family 1 (glial high affinity glutamate transporter), member 225580.0510.1710No
46CRYAACRYAA
Entrez,  Source
crystallin, alpha A25980.0500.1717No
47RND2RND2
Entrez,  Source
Rho family GTPase 226000.0500.1753No
48ITGB2ITGB2
Entrez,  Source
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)26950.0480.1717No
49IGFALSIGFALS
Entrez,  Source
insulin-like growth factor binding protein, acid labile subunit29970.0430.1519No
50IL1RNIL1RN
Entrez,  Source
interleukin 1 receptor antagonist34000.0370.1241No
51RBM13RBM13
Entrez,  Source
RNA binding motif protein 1334190.0360.1254No
52SOCS1SOCS1
Entrez,  Source
suppressor of cytokine signaling 134700.0360.1242No
53CYBACYBA
Entrez,  Source
cytochrome b-245, alpha polypeptide34710.0360.1268No
54MUP534850.0350.1284No
55PRLRPRLR
Entrez,  Source
prolactin receptor36080.0340.1216No
56CD68CD68
Entrez,  Source
CD68 molecule36710.0330.1192No
57ELA1ELA1
Entrez,  Source
elastase 1, pancreatic36850.0330.1206No
58ADRB3ADRB3
Entrez,  Source
adrenergic, beta-3-, receptor37430.0320.1186No
59POM121POM121
Entrez,  Source
POM121 membrane glycoprotein (rat)37450.0320.1209No
60PTGS1PTGS1
Entrez,  Source
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)37600.0320.1222No
61PTPRCPTPRC
Entrez,  Source
protein tyrosine phosphatase, receptor type, C39400.0290.1107No
62PBEF1PBEF1
Entrez,  Source
pre-B-cell colony enhancing factor 139750.0290.1102No
63XDHXDH
Entrez,  Source
xanthine dehydrogenase39800.0290.1120No
64CD74CD74
Entrez,  Source
CD74 molecule, major histocompatibility complex, class II invariant chain41000.0270.1050No
65ELOVL6ELOVL6
Entrez,  Source
ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)41580.0260.1025No
66HPHP
Entrez,  Source
haptoglobin41950.0260.1017No
67FGL2FGL2
Entrez,  Source
fibrinogen-like 242530.0250.0992No
68EIF1EIF1
Entrez,  Source
eukaryotic translation initiation factor 144710.0220.0844No
69SC5DLSC5DL
Entrez,  Source
sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like44740.0220.0858No
70HSD17B2HSD17B2
Entrez,  Source
hydroxysteroid (17-beta) dehydrogenase 244810.0220.0870No
71IRF7IRF7
Entrez,  Source
interferon regulatory factor 746800.0200.0734No
72IRF8IRF8
Entrez,  Source
interferon regulatory factor 847500.0190.0696No
73GPX3GPX3
Entrez,  Source
glutathione peroxidase 3 (plasma)48420.0180.0640No
74VCAM1VCAM1
Entrez,  Source
vascular cell adhesion molecule 148680.0180.0634No
75C1QBC1QB
Entrez,  Source
complement component 1, q subcomponent, B chain48910.0180.0630No
76RETSATRETSAT
Entrez,  Source
retinol saturase (all-trans-retinol 13,14-reductase)50250.0160.0540No
77CYBBCYBB
Entrez,  Source
cytochrome b-245, beta polypeptide (chronic granulomatous disease)50280.0160.0550No
78ELAC2ELAC2
Entrez,  Source
elaC homolog 2 (E. coli)50310.0160.0560No
79NRP1NRP1
Entrez,  Source
neuropilin 150470.0150.0560No
80PRM3PRM3
Entrez,  Source
protamine 350510.0150.0569No
81HCKHCK
Entrez,  Source
hemopoietic cell kinase50800.0150.0559No
82BIRC5BIRC5
Entrez,  Source
baculoviral IAP repeat-containing 5 (survivin)50830.0150.0568No
83ALAS2ALAS2
Entrez,  Source
aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia)51490.0140.0529No
84LCP2LCP2
Entrez,  Source
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)52260.0130.0481No
85ORM1ORM1
Entrez,  Source
orosomucoid 155390.0100.0252No
86SULT4A1SULT4A1
Entrez,  Source
sulfotransferase family 4A, member 158810.006-0.0003No
87ATP1B3ATP1B3
Entrez,  Source
ATPase, Na+/K+ transporting, beta 3 polypeptide62380.002-0.0272No
88FKBP11FKBP11
Entrez,  Source
FK506 binding protein 11, 19 kDa62740.002-0.0298No
89PDZK1PDZK1
Entrez,  Source
PDZ domain containing 163460.001-0.0351No
90LITAFLITAF
Entrez,  Source
lipopolysaccharide-induced TNF factor63760.000-0.0373No
91CTSECTSE
Entrez,  Source
cathepsin E6446-0.000-0.0425No
92IL18BPIL18BP
Entrez,  Source
interleukin 18 binding protein6672-0.003-0.0594No
93PLK1PLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)6701-0.003-0.0613No
94C1QAC1QA
Entrez,  Source
complement component 1, q subcomponent, A chain6809-0.004-0.0692No
95PPP1R2PPP1R2
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 26926-0.005-0.0776No
96CDC5LCDC5L
Entrez,  Source
CDC5 cell division cycle 5-like (S. pombe)6966-0.005-0.0802No
97SH3GL1SH3GL1
Entrez,  Source
SH3-domain GRB2-like 17167-0.007-0.0949No
98CAMPCAMP
Entrez,  Source
cathelicidin antimicrobial peptide7261-0.008-0.1013No
99APBB1IPAPBB1IP
Entrez,  Source
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein7296-0.009-0.1033No
100SNX10SNX10
Entrez,  Source
sorting nexin 107325-0.009-0.1048No
101RPL22RPL22
Entrez,  Source
ribosomal protein L227527-0.011-0.1192No
102TFF3TFF3
Entrez,  Source
trefoil factor 3 (intestinal)7570-0.011-0.1216No
103STAT1STAT1
Entrez,  Source
signal transducer and activator of transcription 1, 91kDa7778-0.013-0.1364No
104WARSWARS
Entrez,  Source
tryptophanyl-tRNA synthetase7827-0.014-0.1390No
105OATOAT
Entrez,  Source
ornithine aminotransferase (gyrate atrophy)7916-0.015-0.1446No
106MKLN1MKLN1
Entrez,  Source
muskelin 1, intracellular mediator containing kelch motifs8067-0.016-0.1548No
107RPS6KC1RPS6KC1
Entrez,  Source
ribosomal protein S6 kinase, 52kDa, polypeptide 18070-0.016-0.1538No
108FCGR18384-0.019-0.1761No
109GRNGRN
Entrez,  Source
granulin8678-0.023-0.1967No
110CYP2B138964-0.026-0.2165No
111AIF1AIF1
Entrez,  Source
allograft inflammatory factor 19000-0.026-0.2173No
112PROM1PROM1
Entrez,  Source
prominin 19081-0.027-0.2214No
113SERPINA10SERPINA10
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 109091-0.027-0.2201No
114STX3STX3
Entrez,  Source
syntaxin 39160-0.028-0.2232No
115IFI35IFI35
Entrez,  Source
interferon-induced protein 359166-0.028-0.2216No
116SLC26A1SLC26A1
Entrez,  Source
solute carrier family 26 (sulfate transporter), member 19210-0.028-0.2228No
117SLC25A10SLC25A10
Entrez,  Source
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 109394-0.030-0.2345No
118COL4A1COL4A1
Entrez,  Source
collagen, type IV, alpha 19777-0.035-0.2610No
119RPAP1RPAP1
Entrez,  Source
RNA polymerase II associated protein 19798-0.035-0.2599No
120NCOA3NCOA3
Entrez,  Source
nuclear receptor coactivator 39861-0.036-0.2620No
121IL6STIL6ST
Entrez,  Source
interleukin 6 signal transducer (gp130, oncostatin M receptor)9951-0.037-0.2661No
122PSME1PSME1
Entrez,  Source
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)10072-0.038-0.2724No
123PSMB8PSMB8
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)10133-0.039-0.2742No
124PTPN1PTPN1
Entrez,  Source
protein tyrosine phosphatase, non-receptor type 110210-0.040-0.2770No
125KRT1-1810325-0.041-0.2827No
126GHRGHR
Entrez,  Source
growth hormone receptor10389-0.042-0.2845No
127IRGMIRGM
Entrez,  Source
immunity-related GTPase family, M10433-0.042-0.2846No
128CASP6CASP6
Entrez,  Source
caspase 6, apoptosis-related cysteine peptidase10649-0.045-0.2976No
129LIPCLIPC
Entrez,  Source
lipase, hepatic10652-0.046-0.2945No
130CCR1CCR1
Entrez,  Source
chemokine (C-C motif) receptor 110676-0.046-0.2928No
131NR2F6NR2F6
Entrez,  Source
nuclear receptor subfamily 2, group F, member 610711-0.046-0.2920No
132BMPR2BMPR2
Entrez,  Source
bone morphogenetic protein receptor, type II (serine/threonine kinase)10795-0.048-0.2948No
133CD52CD52
Entrez,  Source
CD52 molecule10867-0.049-0.2966No
134PLD3PLD3
Entrez,  Source
phospholipase D family, member 310926-0.050-0.2974No
135TSPAN4TSPAN4
Entrez,  Source
tetraspanin 410966-0.051-0.2967No
136CXCL9CXCL9
Entrez,  Source
chemokine (C-X-C motif) ligand 910997-0.051-0.2952No
137CCL611015-0.051-0.2928No
138SNX27SNX27
Entrez,  Source
sorting nexin family member 2711154-0.054-0.2993No
139CDC91L1CDC91L1
Entrez,  Source
CDC91 cell division cycle 91-like 1 (S. cerevisiae)11375-0.058-0.3118No
140QSCN6QSCN6
Entrez,  Source
quiescin Q611386-0.058-0.3083No
141PSME2PSME2
Entrez,  Source
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)11462-0.060-0.3096No
142CCL7CCL7
Entrez,  Source
chemokine (C-C motif) ligand 711508-0.061-0.3086No
143S100A8S100A8
Entrez,  Source
S100 calcium binding protein A811562-0.062-0.3081No
144TAP1TAP1
Entrez,  Source
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)11710-0.065-0.3145No
145ICAM1ICAM1
Entrez,  Source
intercellular adhesion molecule 1 (CD54), human rhinovirus receptor11718-0.065-0.3103No
146OSBPL5OSBPL5
Entrez,  Source
oxysterol binding protein-like 511832-0.068-0.3139No
147CRYL1CRYL1
Entrez,  Source
crystallin, lambda 111907-0.070-0.3144No
148CTSCCTSC
Entrez,  Source
cathepsin C11993-0.073-0.3155No
149KEG112025-0.074-0.3125No
150TAPBPTAPBP
Entrez,  Source
TAP binding protein (tapasin)12433-0.088-0.3370Yes
151CCL4CCL4
Entrez,  Source
chemokine (C-C motif) ligand 412509-0.092-0.3360Yes
152SIRPASIRPA
Entrez,  Source
signal-regulatory protein alpha12585-0.096-0.3347Yes
153LGMNLGMN
Entrez,  Source
legumain12629-0.098-0.3307Yes
154LGALS3LGALS3
Entrez,  Source
lectin, galactoside-binding, soluble, 3 (galectin 3)12649-0.099-0.3249Yes
155FLOT1FLOT1
Entrez,  Source
flotillin 112744-0.106-0.3243Yes
156PSMB9PSMB9
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)12830-0.113-0.3225Yes
157FASFAS
Entrez,  Source
Fas (TNF receptor superfamily, member 6)12841-0.114-0.3149Yes
158LGALS3BPLGALS3BP
Entrez,  Source
lectin, galactoside-binding, soluble, 3 binding protein12844-0.115-0.3067Yes
159TMSB10TMSB10
Entrez,  Source
thymosin, beta 1012891-0.120-0.3014Yes
160CXCL1CXCL1
Entrez,  Source
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)12901-0.121-0.2932Yes
161AKAP9AKAP9
Entrez,  Source
A kinase (PRKA) anchor protein (yotiao) 912906-0.122-0.2846Yes
162TMSB4XTMSB4X
Entrez,  Source
thymosin, beta 4, X-linked12959-0.127-0.2793Yes
163NFKBIANFKBIA
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha12964-0.127-0.2703Yes
164PSMB10PSMB10
Entrez,  Source
proteasome (prosome, macropain) subunit, beta type, 1012966-0.128-0.2611Yes
165CD5LCD5L
Entrez,  Source
CD5 molecule-like13064-0.142-0.2580Yes
166TAP2TAP2
Entrez,  Source
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)13120-0.153-0.2510Yes
167S100A11S100A11
Entrez,  Source
S100 calcium binding protein A1113140-0.159-0.2409Yes
168EMR1EMR1
Entrez,  Source
egf-like module containing, mucin-like, hormone receptor-like 113220-0.205-0.2318Yes
169CLIC1CLIC1
Entrez,  Source
chloride intracellular channel 113242-0.218-0.2175Yes
170IRF1IRF1
Entrez,  Source
interferon regulatory factor 113267-0.235-0.2022Yes
171AVPR1AAVPR1A
Entrez,  Source
arginine vasopressin receptor 1A13282-0.262-0.1840Yes
172SCD5SCD5
Entrez,  Source
stearoyl-CoA desaturase 513289-0.269-0.1649Yes
173CES3CES3
Entrez,  Source
carboxylesterase 3 (brain)13290-0.269-0.1452Yes
174CCL2CCL2
Entrez,  Source
chemokine (C-C motif) ligand 213292-0.273-0.1254Yes
175PROCRPROCR
Entrez,  Source
protein C receptor, endothelial (EPCR)13305-0.301-0.1043Yes
176S100A4S100A4
Entrez,  Source
S100 calcium binding protein A413306-0.310-0.0816Yes
177CXCL10CXCL10
Entrez,  Source
chemokine (C-X-C motif) ligand 1013310-0.321-0.0584Yes
178GBP2GBP2
Entrez,  Source
guanylate binding protein 2, interferon-inducible13323-0.371-0.0321Yes
179S100A6S100A6
Entrez,  Source
S100 calcium binding protein A613330-0.4580.0009Yes
Table: GSEA details [plain text format]



Fig 2: ICHIBA_GVHD   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: ICHIBA_GVHD: Random ES distribution   
Gene set null distribution of ES for ICHIBA_GVHD