Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | double_gel_24h |
| GeneSet | ION_CHANNEL_ACTIVITY |
| Enrichment Score (ES) | 0.4754806 |
| Normalized Enrichment Score (NES) | 1.9980505 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.02934108 |
| FWER p-Value | 0.343 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CHRNA7 | CHRNA7 Entrez, Source | cholinergic receptor, nicotinic, alpha 7 | 107 | 0.175 | 0.0280 | Yes |
| 2 | KCNB2 | KCNB2 Entrez, Source | potassium voltage-gated channel, Shab-related subfamily, member 2 | 483 | 0.119 | 0.0243 | Yes |
| 3 | KCNJ4 | KCNJ4 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 4 | 546 | 0.114 | 0.0431 | Yes |
| 4 | NOX1 | NOX1 Entrez, Source | NADPH oxidase 1 | 560 | 0.113 | 0.0655 | Yes |
| 5 | SCN2B | SCN2B Entrez, Source | sodium channel, voltage-gated, type II, beta | 689 | 0.105 | 0.0775 | Yes |
| 6 | CACNG2 | CACNG2 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 2 | 693 | 0.104 | 0.0989 | Yes |
| 7 | CLCNKB | CLCNKB Entrez, Source | chloride channel Kb | 710 | 0.104 | 0.1191 | Yes |
| 8 | CLCN1 | CLCN1 Entrez, Source | chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant) | 715 | 0.103 | 0.1402 | Yes |
| 9 | TRPV5 | TRPV5 Entrez, Source | transient receptor potential cation channel, subfamily V, member 5 | 903 | 0.095 | 0.1457 | Yes |
| 10 | RYR2 | RYR2 Entrez, Source | ryanodine receptor 2 (cardiac) | 917 | 0.095 | 0.1644 | Yes |
| 11 | KCNJ14 | KCNJ14 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 14 | 936 | 0.094 | 0.1825 | Yes |
| 12 | CHRNA3 | CHRNA3 Entrez, Source | cholinergic receptor, nicotinic, alpha 3 | 992 | 0.092 | 0.1973 | Yes |
| 13 | KCNN3 | KCNN3 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 | 1040 | 0.090 | 0.2123 | Yes |
| 14 | CACNA2D1 | CACNA2D1 Entrez, Source | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 1054 | 0.089 | 0.2298 | Yes |
| 15 | KCNJ6 | KCNJ6 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 6 | 1102 | 0.087 | 0.2443 | Yes |
| 16 | P2RX1 | P2RX1 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 1 | 1200 | 0.084 | 0.2542 | Yes |
| 17 | ACCN1 | ACCN1 Entrez, Source | amiloride-sensitive cation channel 1, neuronal (degenerin) | 1306 | 0.080 | 0.2629 | Yes |
| 18 | TRPC3 | TRPC3 Entrez, Source | transient receptor potential cation channel, subfamily C, member 3 | 1352 | 0.079 | 0.2758 | Yes |
| 19 | P2RX7 | P2RX7 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 7 | 1500 | 0.075 | 0.2801 | Yes |
| 20 | TRPV2 | TRPV2 Entrez, Source | transient receptor potential cation channel, subfamily V, member 2 | 1634 | 0.072 | 0.2848 | Yes |
| 21 | CACNA1H | CACNA1H Entrez, Source | calcium channel, voltage-dependent, alpha 1H subunit | 1737 | 0.069 | 0.2914 | Yes |
| 22 | SCNN1G | SCNN1G Entrez, Source | sodium channel, nonvoltage-gated 1, gamma | 1742 | 0.069 | 0.3053 | Yes |
| 23 | CACNA1C | CACNA1C Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1C subunit | 1939 | 0.064 | 0.3037 | Yes |
| 24 | CFTR | CFTR Entrez, Source | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | 1946 | 0.064 | 0.3164 | Yes |
| 25 | SCN4B | SCN4B Entrez, Source | sodium channel, voltage-gated, type IV, beta | 1965 | 0.063 | 0.3281 | Yes |
| 26 | CHRNB2 | CHRNB2 Entrez, Source | cholinergic receptor, nicotinic, beta 2 (neuronal) | 2101 | 0.060 | 0.3303 | Yes |
| 27 | KCNK3 | KCNK3 Entrez, Source | potassium channel, subfamily K, member 3 | 2132 | 0.059 | 0.3403 | Yes |
| 28 | SCNN1B | SCNN1B Entrez, Source | sodium channel, nonvoltage-gated 1, beta (Liddle syndrome) | 2267 | 0.056 | 0.3418 | Yes |
| 29 | CACNA1S | CACNA1S Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1S subunit | 2440 | 0.053 | 0.3397 | Yes |
| 30 | TRPV1 | TRPV1 Entrez, Source | transient receptor potential cation channel, subfamily V, member 1 | 2478 | 0.052 | 0.3477 | Yes |
| 31 | CACNB3 | CACNB3 Entrez, Source | calcium channel, voltage-dependent, beta 3 subunit | 2538 | 0.051 | 0.3538 | Yes |
| 32 | CACNA1E | CACNA1E Entrez, Source | calcium channel, voltage-dependent, alpha 1E subunit | 2545 | 0.051 | 0.3638 | Yes |
| 33 | KCNH3 | KCNH3 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 3 | 2561 | 0.050 | 0.3731 | Yes |
| 34 | BSND | BSND Entrez, Source | Bartter syndrome, infantile, with sensorineural deafness (Barttin) | 2593 | 0.050 | 0.3811 | Yes |
| 35 | MS4A2 | MS4A2 Entrez, Source | membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) | 2608 | 0.050 | 0.3903 | Yes |
| 36 | KCNH4 | KCNH4 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 4 | 2628 | 0.049 | 0.3990 | Yes |
| 37 | KCNMB1 | KCNMB1 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, beta member 1 | 2672 | 0.049 | 0.4058 | Yes |
| 38 | KCNK15 | KCNK15 Entrez, Source | potassium channel, subfamily K, member 15 | 2726 | 0.048 | 0.4117 | Yes |
| 39 | CACNA1D | CACNA1D Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1D subunit | 3122 | 0.041 | 0.3903 | Yes |
| 40 | CACNG5 | CACNG5 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 5 | 3203 | 0.040 | 0.3926 | Yes |
| 41 | KCNK10 | KCNK10 Entrez, Source | potassium channel, subfamily K, member 10 | 3239 | 0.040 | 0.3981 | Yes |
| 42 | KCNA2 | KCNA2 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 2 | 3251 | 0.039 | 0.4054 | Yes |
| 43 | KCNH2 | KCNH2 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 2 | 3257 | 0.039 | 0.4131 | Yes |
| 44 | CNGA3 | CNGA3 Entrez, Source | cyclic nucleotide gated channel alpha 3 | 3305 | 0.038 | 0.4174 | Yes |
| 45 | KCNS1 | KCNS1 Entrez, Source | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 | 3324 | 0.038 | 0.4239 | Yes |
| 46 | KCNK1 | KCNK1 Entrez, Source | potassium channel, subfamily K, member 1 | 3345 | 0.037 | 0.4302 | Yes |
| 47 | KCNN4 | KCNN4 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 | 3482 | 0.035 | 0.4272 | Yes |
| 48 | CACNA1A | CACNA1A Entrez, Source | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 3570 | 0.034 | 0.4277 | Yes |
| 49 | KCNE2 | KCNE2 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 2 | 3669 | 0.033 | 0.4271 | Yes |
| 50 | SCN5A | SCN5A Entrez, Source | sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) | 3775 | 0.032 | 0.4257 | Yes |
| 51 | TRPM1 | TRPM1 Entrez, Source | transient receptor potential cation channel, subfamily M, member 1 | 3784 | 0.031 | 0.4316 | Yes |
| 52 | KCNC3 | KCNC3 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 3 | 3788 | 0.031 | 0.4378 | Yes |
| 53 | KCND3 | KCND3 Entrez, Source | potassium voltage-gated channel, Shal-related subfamily, member 3 | 3813 | 0.031 | 0.4424 | Yes |
| 54 | SCN7A | SCN7A Entrez, Source | sodium channel, voltage-gated, type VII, alpha | 3851 | 0.030 | 0.4459 | Yes |
| 55 | KCNA1 | KCNA1 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) | 3853 | 0.030 | 0.4521 | Yes |
| 56 | KCNA6 | KCNA6 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 6 | 3892 | 0.030 | 0.4554 | Yes |
| 57 | KCNA5 | KCNA5 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 5 | 3911 | 0.030 | 0.4601 | Yes |
| 58 | CACNG1 | CACNG1 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 1 | 3925 | 0.029 | 0.4652 | Yes |
| 59 | CACNA1G | CACNA1G Entrez, Source | calcium channel, voltage-dependent, alpha 1G subunit | 3937 | 0.029 | 0.4704 | Yes |
| 60 | CHRNA6 | CHRNA6 Entrez, Source | cholinergic receptor, nicotinic, alpha 6 | 4014 | 0.028 | 0.4705 | Yes |
| 61 | KCNMB4 | KCNMB4 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, beta member 4 | 4059 | 0.028 | 0.4729 | Yes |
| 62 | KCNQ2 | KCNQ2 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 2 | 4151 | 0.026 | 0.4714 | Yes |
| 63 | TRPC5 | TRPC5 Entrez, Source | transient receptor potential cation channel, subfamily C, member 5 | 4328 | 0.024 | 0.4631 | Yes |
| 64 | GLRA1 | GLRA1 Entrez, Source | glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome) | 4330 | 0.024 | 0.4681 | Yes |
| 65 | FXYD3 | FXYD3 Entrez, Source | FXYD domain containing ion transport regulator 3 | 4367 | 0.024 | 0.4702 | Yes |
| 66 | FXYD1 | FXYD1 Entrez, Source | FXYD domain containing ion transport regulator 1 (phospholemman) | 4502 | 0.022 | 0.4646 | Yes |
| 67 | CHRNA2 | CHRNA2 Entrez, Source | cholinergic receptor, nicotinic, alpha 2 (neuronal) | 4515 | 0.022 | 0.4682 | Yes |
| 68 | P2RX3 | P2RX3 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 3 | 4544 | 0.021 | 0.4705 | Yes |
| 69 | ACCN4 | ACCN4 Entrez, Source | amiloride-sensitive cation channel 4, pituitary | 4630 | 0.020 | 0.4682 | Yes |
| 70 | TRPC4 | TRPC4 Entrez, Source | transient receptor potential cation channel, subfamily C, member 4 | 4722 | 0.019 | 0.4654 | Yes |
| 71 | HTR3A | HTR3A Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 3A | 4785 | 0.019 | 0.4645 | Yes |
| 72 | KCNJ3 | KCNJ3 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 3 | 4792 | 0.019 | 0.4679 | Yes |
| 73 | KCNH1 | KCNH1 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 1 | 4830 | 0.018 | 0.4689 | Yes |
| 74 | GLRA2 | GLRA2 Entrez, Source | glycine receptor, alpha 2 | 4835 | 0.018 | 0.4724 | Yes |
| 75 | KCNA3 | KCNA3 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 3 | 4844 | 0.018 | 0.4755 | Yes |
| 76 | KCNQ3 | KCNQ3 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 3 | 4990 | 0.016 | 0.4678 | No |
| 77 | KCNS3 | KCNS3 Entrez, Source | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 | 5174 | 0.014 | 0.4569 | No |
| 78 | KCNA4 | KCNA4 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 4 | 5299 | 0.013 | 0.4501 | No |
| 79 | NMUR2 | NMUR2 Entrez, Source | neuromedin U receptor 2 | 5367 | 0.012 | 0.4475 | No |
| 80 | SCN11A | SCN11A Entrez, Source | sodium channel, voltage-gated, type XI, alpha | 5399 | 0.011 | 0.4475 | No |
| 81 | CACNG4 | CACNG4 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 4 | 5484 | 0.010 | 0.4433 | No |
| 82 | SCN4A | SCN4A Entrez, Source | sodium channel, voltage-gated, type IV, alpha | 5567 | 0.009 | 0.4390 | No |
| 83 | RYR1 | RYR1 Entrez, Source | ryanodine receptor 1 (skeletal) | 5589 | 0.009 | 0.4394 | No |
| 84 | CLCN2 | CLCN2 Entrez, Source | chloride channel 2 | 5847 | 0.006 | 0.4212 | No |
| 85 | KCNIP2 | KCNIP2 Entrez, Source | Kv channel interacting protein 2 | 5898 | 0.006 | 0.4185 | No |
| 86 | CHRNA4 | CHRNA4 Entrez, Source | cholinergic receptor, nicotinic, alpha 4 | 5906 | 0.005 | 0.4191 | No |
| 87 | KCNJ15 | KCNJ15 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 15 | 6003 | 0.005 | 0.4128 | No |
| 88 | KCNE1 | KCNE1 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 1 | 6053 | 0.004 | 0.4100 | No |
| 89 | P2RX2 | P2RX2 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 2 | 6139 | 0.003 | 0.4042 | No |
| 90 | SCN9A | SCN9A Entrez, Source | sodium channel, voltage-gated, type IX, alpha | 6177 | 0.003 | 0.4020 | No |
| 91 | KCNG2 | KCNG2 Entrez, Source | potassium voltage-gated channel, subfamily G, member 2 | 6206 | 0.002 | 0.4003 | No |
| 92 | KCNJ5 | KCNJ5 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 5 | 6426 | -0.000 | 0.3838 | No |
| 93 | SCN1B | SCN1B Entrez, Source | sodium channel, voltage-gated, type I, beta | 6455 | -0.000 | 0.3817 | No |
| 94 | CACNB2 | CACNB2 Entrez, Source | calcium channel, voltage-dependent, beta 2 subunit | 6462 | -0.000 | 0.3813 | No |
| 95 | CACNA1B | CACNA1B Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1B subunit | 6647 | -0.002 | 0.3679 | No |
| 96 | CHRNE | CHRNE Entrez, Source | cholinergic receptor, nicotinic, epsilon | 6825 | -0.004 | 0.3554 | No |
| 97 | KCNC1 | KCNC1 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 1 | 6848 | -0.004 | 0.3546 | No |
| 98 | KCNQ1 | KCNQ1 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 1 | 6895 | -0.005 | 0.3520 | No |
| 99 | CHRNB4 | CHRNB4 Entrez, Source | cholinergic receptor, nicotinic, beta 4 | 7214 | -0.008 | 0.3296 | No |
| 100 | CHRND | CHRND Entrez, Source | cholinergic receptor, nicotinic, delta | 7510 | -0.011 | 0.3095 | No |
| 101 | CACNB4 | CACNB4 Entrez, Source | calcium channel, voltage-dependent, beta 4 subunit | 7521 | -0.011 | 0.3109 | No |
| 102 | CHRNA1 | CHRNA1 Entrez, Source | cholinergic receptor, nicotinic, alpha 1 (muscle) | 7580 | -0.011 | 0.3089 | No |
| 103 | KCNJ10 | KCNJ10 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 10 | 7799 | -0.014 | 0.2952 | No |
| 104 | CNGB1 | CNGB1 Entrez, Source | cyclic nucleotide gated channel beta 1 | 7881 | -0.014 | 0.2921 | No |
| 105 | CHRNB3 | CHRNB3 Entrez, Source | cholinergic receptor, nicotinic, beta 3 | 8039 | -0.016 | 0.2835 | No |
| 106 | CLCA2 | CLCA2 Entrez, Source | chloride channel, calcium activated, family member 2 | 8169 | -0.017 | 0.2773 | No |
| 107 | KCNJ1 | KCNJ1 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 1 | 8394 | -0.020 | 0.2644 | No |
| 108 | KCNJ12 | KCNJ12 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 12 | 8416 | -0.020 | 0.2670 | No |
| 109 | GLRB | GLRB Entrez, Source | glycine receptor, beta | 8597 | -0.022 | 0.2578 | No |
| 110 | CACNB1 | CACNB1 Entrez, Source | calcium channel, voltage-dependent, beta 1 subunit | 8689 | -0.023 | 0.2557 | No |
| 111 | KCNN2 | KCNN2 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 | 8839 | -0.024 | 0.2494 | No |
| 112 | P2RX4 | P2RX4 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 4 | 9274 | -0.029 | 0.2226 | No |
| 113 | TRPV6 | TRPV6 Entrez, Source | transient receptor potential cation channel, subfamily V, member 6 | 10024 | -0.037 | 0.1737 | No |
| 114 | TRPM2 | TRPM2 Entrez, Source | transient receptor potential cation channel, subfamily M, member 2 | 10275 | -0.040 | 0.1631 | No |
| 115 | HTR3B | HTR3B Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 3B | 10347 | -0.041 | 0.1663 | No |
| 116 | CLCN3 | CLCN3 Entrez, Source | chloride channel 3 | 10689 | -0.046 | 0.1500 | No |
| 117 | TRPC1 | TRPC1 Entrez, Source | transient receptor potential cation channel, subfamily C, member 1 | 11504 | -0.060 | 0.1010 | No |
| 118 | CUL5 | CUL5 Entrez, Source | cullin 5 | 11698 | -0.065 | 0.0997 | No |
| 119 | P2RX5 | P2RX5 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 5 | 12877 | -0.118 | 0.0352 | No |
