Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | single_gel_24h |
| GeneSet | LH_GRANULOSA_DN |
| Enrichment Score (ES) | -0.57564324 |
| Normalized Enrichment Score (NES) | -1.9701177 |
| Nominal p-value | 0.0020325202 |
| FDR q-value | 0.058369964 |
| FWER p-Value | 0.441 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | RGS5 | RGS5 Entrez, Source | regulator of G-protein signalling 5 | 283 | 0.137 | 0.0252 | No |
| 2 | CDKN1C | CDKN1C Entrez, Source | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 1287 | 0.081 | -0.0229 | No |
| 3 | DHRS3 | DHRS3 Entrez, Source | dehydrogenase/reductase (SDR family) member 3 | 1479 | 0.075 | -0.0118 | No |
| 4 | FLNC | FLNC Entrez, Source | filamin C, gamma (actin binding protein 280) | 1809 | 0.067 | -0.0138 | No |
| 5 | AXL | AXL Entrez, Source | AXL receptor tyrosine kinase | 2505 | 0.051 | -0.0486 | No |
| 6 | RGS4 | RGS4 Entrez, Source | regulator of G-protein signalling 4 | 2623 | 0.049 | -0.0407 | No |
| 7 | RANGAP1 | RANGAP1 Entrez, Source | Ran GTPase activating protein 1 | 3033 | 0.043 | -0.0570 | No |
| 8 | CAP2 | CAP2 Entrez, Source | CAP, adenylate cyclase-associated protein, 2 (yeast) | 3198 | 0.040 | -0.0558 | No |
| 9 | MAPK6 | MAPK6 Entrez, Source | mitogen-activated protein kinase 6 | 3705 | 0.032 | -0.0829 | No |
| 10 | PRKD1 | PRKD1 Entrez, Source | protein kinase D1 | 4700 | 0.020 | -0.1510 | No |
| 11 | TRIB1 | TRIB1 Entrez, Source | tribbles homolog 1 (Drosophila) | 5150 | 0.014 | -0.1799 | No |
| 12 | AKAP12 | AKAP12 Entrez, Source | A kinase (PRKA) anchor protein (gravin) 12 | 5303 | 0.013 | -0.1871 | No |
| 13 | NPC2 | NPC2 Entrez, Source | Niemann-Pick disease, type C2 | 5920 | 0.005 | -0.2316 | No |
| 14 | DYRK3 | DYRK3 Entrez, Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 6511 | -0.001 | -0.2756 | No |
| 15 | PDLIM3 | PDLIM3 Entrez, Source | PDZ and LIM domain 3 | 6622 | -0.002 | -0.2831 | No |
| 16 | MAPK14 | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 6688 | -0.003 | -0.2871 | No |
| 17 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 6874 | -0.004 | -0.2995 | No |
| 18 | ATP2A2 | ATP2A2 Entrez, Source | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 7144 | -0.007 | -0.3173 | No |
| 19 | ITGB5 | ITGB5 Entrez, Source | integrin, beta 5 | 7411 | -0.010 | -0.3341 | No |
| 20 | PTPRE | PTPRE Entrez, Source | protein tyrosine phosphatase, receptor type, E | 7668 | -0.012 | -0.3492 | No |
| 21 | STAT1 | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 7778 | -0.013 | -0.3529 | No |
| 22 | ACTA2 | ACTA2 Entrez, Source | actin, alpha 2, smooth muscle, aorta | 7897 | -0.014 | -0.3568 | No |
| 23 | BECN1 | BECN1 Entrez, Source | beclin 1 (coiled-coil, myosin-like BCL2 interacting protein) | 8175 | -0.017 | -0.3718 | No |
| 24 | SMARCA4 | SMARCA4 Entrez, Source | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | 8374 | -0.019 | -0.3801 | No |
| 25 | KIDINS220 | KIDINS220 Entrez, Source | - | 8659 | -0.022 | -0.3939 | No |
| 26 | PPP3R1 | PPP3R1 Entrez, Source | protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) | 8891 | -0.025 | -0.4028 | No |
| 27 | TLN1 | TLN1 Entrez, Source | talin 1 | 9094 | -0.027 | -0.4089 | No |
| 28 | CASP4 | CASP4 Entrez, Source | caspase 4, apoptosis-related cysteine peptidase | 9198 | -0.028 | -0.4072 | No |
| 29 | PTPN1 | PTPN1 Entrez, Source | protein tyrosine phosphatase, non-receptor type 1 | 10210 | -0.040 | -0.4698 | No |
| 30 | PLCL1 | PLCL1 Entrez, Source | phospholipase C-like 1 | 10415 | -0.042 | -0.4708 | No |
| 31 | MAP2K3 | MAP2K3 Entrez, Source | mitogen-activated protein kinase kinase 3 | 11810 | -0.068 | -0.5528 | Yes |
| 32 | CFLAR | CFLAR Entrez, Source | CASP8 and FADD-like apoptosis regulator | 11917 | -0.070 | -0.5370 | Yes |
| 33 | ARL6IP5 | ARL6IP5 Entrez, Source | ADP-ribosylation-like factor 6 interacting protein 5 | 11950 | -0.071 | -0.5153 | Yes |
| 34 | TYRO3 | TYRO3 Entrez, Source | TYRO3 protein tyrosine kinase | 12342 | -0.085 | -0.5160 | Yes |
| 35 | ACTG2 | ACTG2 Entrez, Source | actin, gamma 2, smooth muscle, enteric | 12642 | -0.099 | -0.5050 | Yes |
| 36 | TNFRSF11B | TNFRSF11B Entrez, Source | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) | 12718 | -0.104 | -0.4753 | Yes |
| 37 | SH3BP4 | SH3BP4 Entrez, Source | SH3-domain binding protein 4 | 12793 | -0.110 | -0.4436 | Yes |
| 38 | PAWR | PAWR Entrez, Source | PRKC, apoptosis, WT1, regulator | 12871 | -0.118 | -0.4094 | Yes |
| 39 | VIL2 | VIL2 Entrez, Source | villin 2 (ezrin) | 13021 | -0.135 | -0.3750 | Yes |
| 40 | ACTN1 | ACTN1 Entrez, Source | actinin, alpha 1 | 13295 | -0.275 | -0.3026 | Yes |
| 41 | ACTA1 | ACTA1 Entrez, Source | actin, alpha 1, skeletal muscle | 13342 | -0.905 | -0.0000 | Yes |
