Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | double_gel_24h |
| GeneSet | LIGAND_GATED_CHANNEL_ACTIVITY |
| Enrichment Score (ES) | 0.5045887 |
| Normalized Enrichment Score (NES) | 1.6720693 |
| Nominal p-value | 0.009505703 |
| FDR q-value | 0.14416368 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CHRNA7 | CHRNA7 Entrez, Source | cholinergic receptor, nicotinic, alpha 7 | 107 | 0.175 | 0.1190 | Yes |
| 2 | RYR2 | RYR2 Entrez, Source | ryanodine receptor 2 (cardiac) | 917 | 0.095 | 0.1272 | Yes |
| 3 | CHRNA3 | CHRNA3 Entrez, Source | cholinergic receptor, nicotinic, alpha 3 | 992 | 0.092 | 0.1884 | Yes |
| 4 | P2RX1 | P2RX1 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 1 | 1200 | 0.084 | 0.2336 | Yes |
| 5 | ACCN1 | ACCN1 Entrez, Source | amiloride-sensitive cation channel 1, neuronal (degenerin) | 1306 | 0.080 | 0.2840 | Yes |
| 6 | TRPC3 | TRPC3 Entrez, Source | transient receptor potential cation channel, subfamily C, member 3 | 1352 | 0.079 | 0.3379 | Yes |
| 7 | P2RX7 | P2RX7 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 7 | 1500 | 0.075 | 0.3812 | Yes |
| 8 | SCNN1G | SCNN1G Entrez, Source | sodium channel, nonvoltage-gated 1, gamma | 1742 | 0.069 | 0.4131 | Yes |
| 9 | CFTR | CFTR Entrez, Source | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) | 1946 | 0.064 | 0.4442 | Yes |
| 10 | CHRNB2 | CHRNB2 Entrez, Source | cholinergic receptor, nicotinic, beta 2 (neuronal) | 2101 | 0.060 | 0.4763 | Yes |
| 11 | SCNN1B | SCNN1B Entrez, Source | sodium channel, nonvoltage-gated 1, beta (Liddle syndrome) | 2267 | 0.056 | 0.5046 | Yes |
| 12 | CNGA3 | CNGA3 Entrez, Source | cyclic nucleotide gated channel alpha 3 | 3305 | 0.038 | 0.4545 | No |
| 13 | CHRNA6 | CHRNA6 Entrez, Source | cholinergic receptor, nicotinic, alpha 6 | 4014 | 0.028 | 0.4217 | No |
| 14 | TRPC5 | TRPC5 Entrez, Source | transient receptor potential cation channel, subfamily C, member 5 | 4328 | 0.024 | 0.4158 | No |
| 15 | GLRA1 | GLRA1 Entrez, Source | glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome) | 4330 | 0.024 | 0.4334 | No |
| 16 | CHRNA2 | CHRNA2 Entrez, Source | cholinergic receptor, nicotinic, alpha 2 (neuronal) | 4515 | 0.022 | 0.4353 | No |
| 17 | P2RX3 | P2RX3 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 3 | 4544 | 0.021 | 0.4487 | No |
| 18 | TRPC4 | TRPC4 Entrez, Source | transient receptor potential cation channel, subfamily C, member 4 | 4722 | 0.019 | 0.4494 | No |
| 19 | HTR3A | HTR3A Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 3A | 4785 | 0.019 | 0.4584 | No |
| 20 | GLRA2 | GLRA2 Entrez, Source | glycine receptor, alpha 2 | 4835 | 0.018 | 0.4679 | No |
| 21 | RYR1 | RYR1 Entrez, Source | ryanodine receptor 1 (skeletal) | 5589 | 0.009 | 0.4180 | No |
| 22 | CHRNA4 | CHRNA4 Entrez, Source | cholinergic receptor, nicotinic, alpha 4 | 5906 | 0.005 | 0.3982 | No |
| 23 | P2RX2 | P2RX2 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 2 | 6139 | 0.003 | 0.3831 | No |
| 24 | CHRNE | CHRNE Entrez, Source | cholinergic receptor, nicotinic, epsilon | 6825 | -0.004 | 0.3345 | No |
| 25 | CHRNB4 | CHRNB4 Entrez, Source | cholinergic receptor, nicotinic, beta 4 | 7214 | -0.008 | 0.3111 | No |
| 26 | CHRND | CHRND Entrez, Source | cholinergic receptor, nicotinic, delta | 7510 | -0.011 | 0.2966 | No |
| 27 | CHRNA1 | CHRNA1 Entrez, Source | cholinergic receptor, nicotinic, alpha 1 (muscle) | 7580 | -0.011 | 0.2996 | No |
| 28 | CNGB1 | CNGB1 Entrez, Source | cyclic nucleotide gated channel beta 1 | 7881 | -0.014 | 0.2875 | No |
| 29 | CHRNB3 | CHRNB3 Entrez, Source | cholinergic receptor, nicotinic, beta 3 | 8039 | -0.016 | 0.2874 | No |
| 30 | GLRB | GLRB Entrez, Source | glycine receptor, beta | 8597 | -0.022 | 0.2614 | No |
| 31 | P2RX4 | P2RX4 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 4 | 9274 | -0.029 | 0.2315 | No |
| 32 | HTR3B | HTR3B Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 3B | 10347 | -0.041 | 0.1809 | No |
| 33 | TRPC1 | TRPC1 Entrez, Source | transient receptor potential cation channel, subfamily C, member 1 | 11504 | -0.060 | 0.1381 | No |
