Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | single_gel_24h |
| GeneSet | LVAD_HEARTFAILURE_UP |
| Enrichment Score (ES) | -0.42448694 |
| Normalized Enrichment Score (NES) | -1.5611981 |
| Nominal p-value | 0.022633744 |
| FDR q-value | 0.25295687 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | DDIT4 | DDIT4 Entrez, Source | DNA-damage-inducible transcript 4 | 25 | 0.248 | 0.0472 | No |
| 2 | PDK4 | PDK4 Entrez, Source | pyruvate dehydrogenase kinase, isozyme 4 | 44 | 0.215 | 0.0884 | No |
| 3 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 491 | 0.118 | 0.0783 | No |
| 4 | ATF3 | ATF3 Entrez, Source | activating transcription factor 3 | 502 | 0.118 | 0.1009 | No |
| 5 | SLCO4A1 | SLCO4A1 Entrez, Source | solute carrier organic anion transporter family, member 4A1 | 517 | 0.116 | 0.1227 | No |
| 6 | BTG2 | BTG2 Entrez, Source | BTG family, member 2 | 677 | 0.105 | 0.1316 | No |
| 7 | ADFP | ADFP Entrez, Source | adipose differentiation-related protein | 1046 | 0.090 | 0.1216 | No |
| 8 | AREG | AREG Entrez, Source | amphiregulin (schwannoma-derived growth factor) | 1215 | 0.083 | 0.1254 | No |
| 9 | PER1 | PER1 Entrez, Source | period homolog 1 (Drosophila) | 1312 | 0.080 | 0.1340 | No |
| 10 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 1431 | 0.077 | 0.1403 | No |
| 11 | GADD45G | GADD45G Entrez, Source | growth arrest and DNA-damage-inducible, gamma | 1628 | 0.072 | 0.1398 | No |
| 12 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 1805 | 0.067 | 0.1398 | No |
| 13 | FLNC | FLNC Entrez, Source | filamin C, gamma (actin binding protein 280) | 1809 | 0.067 | 0.1529 | No |
| 14 | AGTR1 | AGTR1 Entrez, Source | angiotensin II receptor, type 1 | 2090 | 0.060 | 0.1438 | No |
| 15 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 2228 | 0.057 | 0.1447 | No |
| 16 | FKBP5 | FKBP5 Entrez, Source | FK506 binding protein 5 | 2248 | 0.056 | 0.1544 | No |
| 17 | KLF9 | KLF9 Entrez, Source | Kruppel-like factor 9 | 2689 | 0.048 | 0.1309 | No |
| 18 | SLC38A2 | SLC38A2 Entrez, Source | solute carrier family 38, member 2 | 2830 | 0.046 | 0.1294 | No |
| 19 | FHL1 | FHL1 Entrez, Source | four and a half LIM domains 1 | 2980 | 0.043 | 0.1267 | No |
| 20 | KCNK1 | KCNK1 Entrez, Source | potassium channel, subfamily K, member 1 | 3345 | 0.037 | 0.1068 | No |
| 21 | FSTL3 | FSTL3 Entrez, Source | follistatin-like 3 (secreted glycoprotein) | 3563 | 0.034 | 0.0972 | No |
| 22 | NFIL3 | NFIL3 Entrez, Source | nuclear factor, interleukin 3 regulated | 3661 | 0.033 | 0.0964 | No |
| 23 | CHST3 | CHST3 Entrez, Source | carbohydrate (chondroitin 6) sulfotransferase 3 | 3862 | 0.030 | 0.0874 | No |
| 24 | CDC37L1 | CDC37L1 Entrez, Source | CDC37 cell division cycle 37 homolog (S. cerevisiae)-like 1 | 3922 | 0.029 | 0.0888 | No |
| 25 | CEBPD | CEBPD Entrez, Source | CCAAT/enhancer binding protein (C/EBP), delta | 4222 | 0.026 | 0.0713 | No |
| 26 | JUN | JUN Entrez, Source | jun oncogene | 4841 | 0.018 | 0.0284 | No |
| 27 | RND3 | RND3 Entrez, Source | Rho family GTPase 3 | 5357 | 0.012 | -0.0080 | No |
| 28 | TSC22D3 | TSC22D3 Entrez, Source | TSC22 domain family, member 3 | 5572 | 0.009 | -0.0223 | No |
| 29 | RGC32 | RGC32 Entrez, Source | - | 5929 | 0.005 | -0.0480 | No |
| 30 | IER5 | IER5 Entrez, Source | immediate early response 5 | 6813 | -0.004 | -0.1137 | No |
| 31 | NID1 | NID1 Entrez, Source | nidogen 1 | 7136 | -0.007 | -0.1366 | No |
| 32 | CSDC2 | CSDC2 Entrez, Source | cold shock domain containing C2, RNA binding | 7375 | -0.009 | -0.1527 | No |
| 33 | ZBTB16 | ZBTB16 Entrez, Source | zinc finger and BTB domain containing 16 | 7722 | -0.013 | -0.1762 | No |
| 34 | CNN1 | CNN1 Entrez, Source | calponin 1, basic, smooth muscle | 7985 | -0.015 | -0.1928 | No |
| 35 | RERE | RERE Entrez, Source | arginine-glutamic acid dipeptide (RE) repeats | 8291 | -0.019 | -0.2121 | No |
| 36 | INSR | INSR Entrez, Source | insulin receptor | 8403 | -0.020 | -0.2166 | No |
| 37 | HYAL2 | HYAL2 Entrez, Source | hyaluronoglucosaminidase 2 | 9789 | -0.035 | -0.3139 | No |
| 38 | DOCK9 | DOCK9 Entrez, Source | dedicator of cytokinesis 9 | 10296 | -0.041 | -0.3439 | No |
| 39 | CYR61 | CYR61 Entrez, Source | cysteine-rich, angiogenic inducer, 61 | 10367 | -0.041 | -0.3410 | No |
| 40 | CLU | CLU Entrez, Source | clusterin | 10667 | -0.046 | -0.3544 | No |
| 41 | GLUL | GLUL Entrez, Source | glutamate-ammonia ligase (glutamine synthetase) | 11146 | -0.054 | -0.3798 | No |
| 42 | MFAP4 | MFAP4 Entrez, Source | microfibrillar-associated protein 4 | 11347 | -0.058 | -0.3834 | No |
| 43 | MYOM1 | MYOM1 Entrez, Source | myomesin 1 (skelemin) 185kDa | 11511 | -0.061 | -0.3837 | No |
| 44 | PPAP2A | PPAP2A Entrez, Source | phosphatidic acid phosphatase type 2A | 11707 | -0.065 | -0.3855 | No |
| 45 | AMD1 | AMD1 Entrez, Source | adenosylmethionine decarboxylase 1 | 12226 | -0.080 | -0.4086 | Yes |
| 46 | ELF1 | ELF1 Entrez, Source | E74-like factor 1 (ets domain transcription factor) | 12250 | -0.081 | -0.3943 | Yes |
| 47 | TIMP3 | TIMP3 Entrez, Source | TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 12540 | -0.094 | -0.3975 | Yes |
| 48 | CALD1 | CALD1 Entrez, Source | caldesmon 1 | 12565 | -0.095 | -0.3806 | Yes |
| 49 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 12964 | -0.127 | -0.3853 | Yes |
| 50 | DIXDC1 | DIXDC1 Entrez, Source | DIX domain containing 1 | 13065 | -0.142 | -0.3647 | Yes |
| 51 | RRAS2 | RRAS2 Entrez, Source | related RAS viral (r-ras) oncogene homolog 2 | 13088 | -0.147 | -0.3372 | Yes |
| 52 | CYP4B1 | CYP4B1 Entrez, Source | cytochrome P450, family 4, subfamily B, polypeptide 1 | 13244 | -0.218 | -0.3057 | Yes |
| 53 | CTGF | CTGF Entrez, Source | connective tissue growth factor | 13284 | -0.263 | -0.2566 | Yes |
| 54 | ANKRD1 | ANKRD1 Entrez, Source | ankyrin repeat domain 1 (cardiac muscle) | 13328 | -0.413 | -0.1781 | Yes |
| 55 | ACTA1 | ACTA1 Entrez, Source | actin, alpha 1, skeletal muscle | 13342 | -0.905 | 0.0000 | Yes |
