Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | double_gel_24h |
| GeneSet | METAL_ION_TRANSMEMBRANE_TRANSPORTER_ACTIVITY |
| Enrichment Score (ES) | 0.42988446 |
| Normalized Enrichment Score (NES) | 1.8172097 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.081030786 |
| FWER p-Value | 0.966 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CHRNA7 | CHRNA7 Entrez, Source | cholinergic receptor, nicotinic, alpha 7 | 107 | 0.175 | 0.0266 | Yes |
| 2 | ABCC8 | ABCC8 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 | 472 | 0.120 | 0.0229 | Yes |
| 3 | KCNB2 | KCNB2 Entrez, Source | potassium voltage-gated channel, Shab-related subfamily, member 2 | 483 | 0.119 | 0.0458 | Yes |
| 4 | KCNJ4 | KCNJ4 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 4 | 546 | 0.114 | 0.0637 | Yes |
| 5 | ATP2B4 | ATP2B4 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 4 | 620 | 0.109 | 0.0798 | Yes |
| 6 | SCN2B | SCN2B Entrez, Source | sodium channel, voltage-gated, type II, beta | 689 | 0.105 | 0.0955 | Yes |
| 7 | CACNG2 | CACNG2 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 2 | 693 | 0.104 | 0.1160 | Yes |
| 8 | TRPV5 | TRPV5 Entrez, Source | transient receptor potential cation channel, subfamily V, member 5 | 903 | 0.095 | 0.1191 | Yes |
| 9 | RYR2 | RYR2 Entrez, Source | ryanodine receptor 2 (cardiac) | 917 | 0.095 | 0.1370 | Yes |
| 10 | KCNJ14 | KCNJ14 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 14 | 936 | 0.094 | 0.1543 | Yes |
| 11 | CHRNA3 | CHRNA3 Entrez, Source | cholinergic receptor, nicotinic, alpha 3 | 992 | 0.092 | 0.1684 | Yes |
| 12 | KCNN3 | KCNN3 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 | 1040 | 0.090 | 0.1827 | Yes |
| 13 | CACNA2D1 | CACNA2D1 Entrez, Source | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 1054 | 0.089 | 0.1994 | Yes |
| 14 | ATP2A1 | ATP2A1 Entrez, Source | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | 1072 | 0.088 | 0.2157 | Yes |
| 15 | KCNJ6 | KCNJ6 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 6 | 1102 | 0.087 | 0.2308 | Yes |
| 16 | P2RX1 | P2RX1 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 1 | 1200 | 0.084 | 0.2401 | Yes |
| 17 | ACCN1 | ACCN1 Entrez, Source | amiloride-sensitive cation channel 1, neuronal (degenerin) | 1306 | 0.080 | 0.2480 | Yes |
| 18 | TRPC3 | TRPC3 Entrez, Source | transient receptor potential cation channel, subfamily C, member 3 | 1352 | 0.079 | 0.2603 | Yes |
| 19 | P2RX7 | P2RX7 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 7 | 1500 | 0.075 | 0.2640 | Yes |
| 20 | CACNA1H | CACNA1H Entrez, Source | calcium channel, voltage-dependent, alpha 1H subunit | 1737 | 0.069 | 0.2598 | Yes |
| 21 | SCNN1G | SCNN1G Entrez, Source | sodium channel, nonvoltage-gated 1, gamma | 1742 | 0.069 | 0.2732 | Yes |
| 22 | ATP2A3 | ATP2A3 Entrez, Source | ATPase, Ca++ transporting, ubiquitous | 1912 | 0.064 | 0.2732 | Yes |
| 23 | CACNA1C | CACNA1C Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1C subunit | 1939 | 0.064 | 0.2839 | Yes |
| 24 | SLC30A3 | SLC30A3 Entrez, Source | solute carrier family 30 (zinc transporter), member 3 | 1963 | 0.063 | 0.2948 | Yes |
| 25 | SCN4B | SCN4B Entrez, Source | sodium channel, voltage-gated, type IV, beta | 1965 | 0.063 | 0.3073 | Yes |
| 26 | CHRNB2 | CHRNB2 Entrez, Source | cholinergic receptor, nicotinic, beta 2 (neuronal) | 2101 | 0.060 | 0.3090 | Yes |
| 27 | KCNK3 | KCNK3 Entrez, Source | potassium channel, subfamily K, member 3 | 2132 | 0.059 | 0.3185 | Yes |
| 28 | ITPR3 | ITPR3 Entrez, Source | inositol 1,4,5-triphosphate receptor, type 3 | 2251 | 0.056 | 0.3208 | Yes |
| 29 | SCNN1B | SCNN1B Entrez, Source | sodium channel, nonvoltage-gated 1, beta (Liddle syndrome) | 2267 | 0.056 | 0.3307 | Yes |
| 30 | CACNA1S | CACNA1S Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1S subunit | 2440 | 0.053 | 0.3283 | Yes |
| 31 | TRPV1 | TRPV1 Entrez, Source | transient receptor potential cation channel, subfamily V, member 1 | 2478 | 0.052 | 0.3358 | Yes |
| 32 | CACNB3 | CACNB3 Entrez, Source | calcium channel, voltage-dependent, beta 3 subunit | 2538 | 0.051 | 0.3414 | Yes |
| 33 | CACNA1E | CACNA1E Entrez, Source | calcium channel, voltage-dependent, alpha 1E subunit | 2545 | 0.051 | 0.3511 | Yes |
| 34 | KCNH3 | KCNH3 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 3 | 2561 | 0.050 | 0.3599 | Yes |
| 35 | MS4A2 | MS4A2 Entrez, Source | membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) | 2608 | 0.050 | 0.3663 | Yes |
| 36 | KCNH4 | KCNH4 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 4 | 2628 | 0.049 | 0.3747 | Yes |
| 37 | KCNMB1 | KCNMB1 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, beta member 1 | 2672 | 0.049 | 0.3811 | Yes |
| 38 | CACNA1D | CACNA1D Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1D subunit | 3122 | 0.041 | 0.3553 | Yes |
| 39 | CACNG5 | CACNG5 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 5 | 3203 | 0.040 | 0.3572 | Yes |
| 40 | KCNK10 | KCNK10 Entrez, Source | potassium channel, subfamily K, member 10 | 3239 | 0.040 | 0.3624 | Yes |
| 41 | KCNA2 | KCNA2 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 2 | 3251 | 0.039 | 0.3694 | Yes |
| 42 | KCNH2 | KCNH2 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 2 | 3257 | 0.039 | 0.3768 | Yes |
| 43 | KCNS1 | KCNS1 Entrez, Source | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 | 3324 | 0.038 | 0.3793 | Yes |
| 44 | KCNK1 | KCNK1 Entrez, Source | potassium channel, subfamily K, member 1 | 3345 | 0.037 | 0.3853 | Yes |
| 45 | KCNN4 | KCNN4 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 | 3482 | 0.035 | 0.3820 | Yes |
| 46 | CACNA1A | CACNA1A Entrez, Source | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 3570 | 0.034 | 0.3823 | Yes |
| 47 | KCNE2 | KCNE2 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 2 | 3669 | 0.033 | 0.3814 | Yes |
| 48 | SCN5A | SCN5A Entrez, Source | sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) | 3775 | 0.032 | 0.3797 | Yes |
| 49 | TRPM1 | TRPM1 Entrez, Source | transient receptor potential cation channel, subfamily M, member 1 | 3784 | 0.031 | 0.3853 | Yes |
| 50 | KCNC3 | KCNC3 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 3 | 3788 | 0.031 | 0.3913 | Yes |
| 51 | KCND3 | KCND3 Entrez, Source | potassium voltage-gated channel, Shal-related subfamily, member 3 | 3813 | 0.031 | 0.3956 | Yes |
| 52 | SCN7A | SCN7A Entrez, Source | sodium channel, voltage-gated, type VII, alpha | 3851 | 0.030 | 0.3988 | Yes |
| 53 | KCNA1 | KCNA1 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) | 3853 | 0.030 | 0.4048 | Yes |
| 54 | KCNA6 | KCNA6 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 6 | 3892 | 0.030 | 0.4078 | Yes |
| 55 | KCNA5 | KCNA5 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 5 | 3911 | 0.030 | 0.4123 | Yes |
| 56 | CACNG1 | CACNG1 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 1 | 3925 | 0.029 | 0.4172 | Yes |
| 57 | CACNA1G | CACNA1G Entrez, Source | calcium channel, voltage-dependent, alpha 1G subunit | 3937 | 0.029 | 0.4222 | Yes |
| 58 | CLDN16 | CLDN16 Entrez, Source | claudin 16 | 4001 | 0.028 | 0.4231 | Yes |
| 59 | CHRNA6 | CHRNA6 Entrez, Source | cholinergic receptor, nicotinic, alpha 6 | 4014 | 0.028 | 0.4277 | Yes |
| 60 | KCNMB4 | KCNMB4 Entrez, Source | potassium large conductance calcium-activated channel, subfamily M, beta member 4 | 4059 | 0.028 | 0.4299 | Yes |
| 61 | KCNQ2 | KCNQ2 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 2 | 4151 | 0.026 | 0.4282 | No |
| 62 | TRPC5 | TRPC5 Entrez, Source | transient receptor potential cation channel, subfamily C, member 5 | 4328 | 0.024 | 0.4197 | No |
| 63 | CHRNA2 | CHRNA2 Entrez, Source | cholinergic receptor, nicotinic, alpha 2 (neuronal) | 4515 | 0.022 | 0.4100 | No |
| 64 | P2RX3 | P2RX3 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 3 | 4544 | 0.021 | 0.4121 | No |
| 65 | ACCN4 | ACCN4 Entrez, Source | amiloride-sensitive cation channel 4, pituitary | 4630 | 0.020 | 0.4097 | No |
| 66 | TRPC4 | TRPC4 Entrez, Source | transient receptor potential cation channel, subfamily C, member 4 | 4722 | 0.019 | 0.4066 | No |
| 67 | HTR3A | HTR3A Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 3A | 4785 | 0.019 | 0.4057 | No |
| 68 | KCNJ3 | KCNJ3 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 3 | 4792 | 0.019 | 0.4089 | No |
| 69 | KCNH1 | KCNH1 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 1 | 4830 | 0.018 | 0.4097 | No |
| 70 | KCNA3 | KCNA3 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 3 | 4844 | 0.018 | 0.4123 | No |
| 71 | KCNQ3 | KCNQ3 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 3 | 4990 | 0.016 | 0.4046 | No |
| 72 | KCNS3 | KCNS3 Entrez, Source | potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 | 5174 | 0.014 | 0.3935 | No |
| 73 | KCNA4 | KCNA4 Entrez, Source | potassium voltage-gated channel, shaker-related subfamily, member 4 | 5299 | 0.013 | 0.3866 | No |
| 74 | SCN11A | SCN11A Entrez, Source | sodium channel, voltage-gated, type XI, alpha | 5399 | 0.011 | 0.3814 | No |
| 75 | CACNG4 | CACNG4 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 4 | 5484 | 0.010 | 0.3771 | No |
| 76 | SLC11A2 | SLC11A2 Entrez, Source | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | 5523 | 0.010 | 0.3762 | No |
| 77 | ITPR2 | ITPR2 Entrez, Source | inositol 1,4,5-triphosphate receptor, type 2 | 5533 | 0.010 | 0.3775 | No |
| 78 | SCN4A | SCN4A Entrez, Source | sodium channel, voltage-gated, type IV, alpha | 5567 | 0.009 | 0.3769 | No |
| 79 | RYR1 | RYR1 Entrez, Source | ryanodine receptor 1 (skeletal) | 5589 | 0.009 | 0.3771 | No |
| 80 | KCNIP2 | KCNIP2 Entrez, Source | Kv channel interacting protein 2 | 5898 | 0.006 | 0.3549 | No |
| 81 | CHRNA4 | CHRNA4 Entrez, Source | cholinergic receptor, nicotinic, alpha 4 | 5906 | 0.005 | 0.3555 | No |
| 82 | KCNJ15 | KCNJ15 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 15 | 6003 | 0.005 | 0.3491 | No |
| 83 | KCNE1 | KCNE1 Entrez, Source | potassium voltage-gated channel, Isk-related family, member 1 | 6053 | 0.004 | 0.3462 | No |
| 84 | ABCB11 | ABCB11 Entrez, Source | ATP-binding cassette, sub-family B (MDR/TAP), member 11 | 6147 | 0.003 | 0.3398 | No |
| 85 | SCN9A | SCN9A Entrez, Source | sodium channel, voltage-gated, type IX, alpha | 6177 | 0.003 | 0.3382 | No |
| 86 | KCNG2 | KCNG2 Entrez, Source | potassium voltage-gated channel, subfamily G, member 2 | 6206 | 0.002 | 0.3365 | No |
| 87 | KCNJ5 | KCNJ5 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 5 | 6426 | -0.000 | 0.3199 | No |
| 88 | SCN1B | SCN1B Entrez, Source | sodium channel, voltage-gated, type I, beta | 6455 | -0.000 | 0.3179 | No |
| 89 | CACNB2 | CACNB2 Entrez, Source | calcium channel, voltage-dependent, beta 2 subunit | 6462 | -0.000 | 0.3175 | No |
| 90 | CACNA1B | CACNA1B Entrez, Source | calcium channel, voltage-dependent, L type, alpha 1B subunit | 6647 | -0.002 | 0.3041 | No |
| 91 | CHRNE | CHRNE Entrez, Source | cholinergic receptor, nicotinic, epsilon | 6825 | -0.004 | 0.2915 | No |
| 92 | KCNC1 | KCNC1 Entrez, Source | potassium voltage-gated channel, Shaw-related subfamily, member 1 | 6848 | -0.004 | 0.2906 | No |
| 93 | KCNQ1 | KCNQ1 Entrez, Source | potassium voltage-gated channel, KQT-like subfamily, member 1 | 6895 | -0.005 | 0.2881 | No |
| 94 | ATP2A2 | ATP2A2 Entrez, Source | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 7144 | -0.007 | 0.2707 | No |
| 95 | CCS | CCS Entrez, Source | copper chaperone for superoxide dismutase | 7212 | -0.008 | 0.2672 | No |
| 96 | CHRNB4 | CHRNB4 Entrez, Source | cholinergic receptor, nicotinic, beta 4 | 7214 | -0.008 | 0.2687 | No |
| 97 | SLC30A4 | SLC30A4 Entrez, Source | solute carrier family 30 (zinc transporter), member 4 | 7417 | -0.010 | 0.2553 | No |
| 98 | CHRND | CHRND Entrez, Source | cholinergic receptor, nicotinic, delta | 7510 | -0.011 | 0.2505 | No |
| 99 | CACNB4 | CACNB4 Entrez, Source | calcium channel, voltage-dependent, beta 4 subunit | 7521 | -0.011 | 0.2518 | No |
| 100 | CHRNA1 | CHRNA1 Entrez, Source | cholinergic receptor, nicotinic, alpha 1 (muscle) | 7580 | -0.011 | 0.2497 | No |
| 101 | KCNJ10 | KCNJ10 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 10 | 7799 | -0.014 | 0.2359 | No |
| 102 | ATP2B3 | ATP2B3 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 3 | 7917 | -0.015 | 0.2300 | No |
| 103 | CHRNB3 | CHRNB3 Entrez, Source | cholinergic receptor, nicotinic, beta 3 | 8039 | -0.016 | 0.2240 | No |
| 104 | KCNJ1 | KCNJ1 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 1 | 8394 | -0.020 | 0.2011 | No |
| 105 | KCNJ12 | KCNJ12 Entrez, Source | potassium inwardly-rectifying channel, subfamily J, member 12 | 8416 | -0.020 | 0.2035 | No |
| 106 | CACNB1 | CACNB1 Entrez, Source | calcium channel, voltage-dependent, beta 1 subunit | 8689 | -0.023 | 0.1874 | No |
| 107 | KCNN2 | KCNN2 Entrez, Source | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 | 8839 | -0.024 | 0.1810 | No |
| 108 | SLC31A1 | SLC31A1 Entrez, Source | solute carrier family 31 (copper transporters), member 1 | 8908 | -0.025 | 0.1808 | No |
| 109 | ATP2B1 | ATP2B1 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 1 | 8980 | -0.026 | 0.1806 | No |
| 110 | P2RX4 | P2RX4 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 4 | 9274 | -0.029 | 0.1642 | No |
| 111 | TRPV6 | TRPV6 Entrez, Source | transient receptor potential cation channel, subfamily V, member 6 | 10024 | -0.037 | 0.1150 | No |
| 112 | SLC40A1 | SLC40A1 Entrez, Source | solute carrier family 40 (iron-regulated transporter), member 1 | 10093 | -0.038 | 0.1174 | No |
| 113 | TRPM2 | TRPM2 Entrez, Source | transient receptor potential cation channel, subfamily M, member 2 | 10275 | -0.040 | 0.1117 | No |
| 114 | HTR3B | HTR3B Entrez, Source | 5-hydroxytryptamine (serotonin) receptor 3B | 10347 | -0.041 | 0.1146 | No |
| 115 | ITPR1 | ITPR1 Entrez, Source | inositol 1,4,5-triphosphate receptor, type 1 | 10751 | -0.047 | 0.0934 | No |
| 116 | TRPC1 | TRPC1 Entrez, Source | transient receptor potential cation channel, subfamily C, member 1 | 11504 | -0.060 | 0.0486 | No |
| 117 | CUL5 | CUL5 Entrez, Source | cullin 5 | 11698 | -0.065 | 0.0468 | No |
| 118 | SLC8A1 | SLC8A1 Entrez, Source | solute carrier family 8 (sodium/calcium exchanger), member 1 | 12331 | -0.084 | 0.0158 | No |
| 119 | ATP2C1 | ATP2C1 Entrez, Source | ATPase, Ca++ transporting, type 2C, member 1 | 12741 | -0.106 | 0.0059 | No |
| 120 | SLC31A2 | SLC31A2 Entrez, Source | solute carrier family 31 (copper transporters), member 2 | 13212 | -0.199 | 0.0098 | No |
