Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | single_gel_24h |
| GeneSet | MUSCLE_DEVELOPMENT |
| Enrichment Score (ES) | -0.4108155 |
| Normalized Enrichment Score (NES) | -1.5221605 |
| Nominal p-value | 0.013806706 |
| FDR q-value | 0.27443677 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SPEG | SPEG Entrez, Source | SPEG complex locus | 242 | 0.142 | 0.0123 | No |
| 2 | TTN | TTN Entrez, Source | titin | 262 | 0.140 | 0.0408 | No |
| 3 | IFRD1 | IFRD1 Entrez, Source | interferon-related developmental regulator 1 | 263 | 0.140 | 0.0708 | No |
| 4 | MYH11 | MYH11 Entrez, Source | myosin, heavy chain 11, smooth muscle | 500 | 0.118 | 0.0782 | No |
| 5 | TNNI3 | TNNI3 Entrez, Source | troponin I type 3 (cardiac) | 617 | 0.109 | 0.0929 | No |
| 6 | CAPN3 | CAPN3 Entrez, Source | calpain 3, (p94) | 700 | 0.104 | 0.1090 | No |
| 7 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 763 | 0.101 | 0.1260 | No |
| 8 | MYOD1 | MYOD1 Entrez, Source | myogenic differentiation 1 | 807 | 0.099 | 0.1441 | No |
| 9 | NOTCH1 | NOTCH1 Entrez, Source | Notch homolog 1, translocation-associated (Drosophila) | 1199 | 0.084 | 0.1326 | No |
| 10 | SGCG | SGCG Entrez, Source | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) | 1310 | 0.080 | 0.1414 | No |
| 11 | NF1 | NF1 Entrez, Source | neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) | 1548 | 0.073 | 0.1393 | No |
| 12 | COL4A4 | COL4A4 Entrez, Source | collagen, type IV, alpha 4 | 1561 | 0.073 | 0.1541 | No |
| 13 | MEF2D | MEF2D Entrez, Source | MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D) | 1595 | 0.073 | 0.1671 | No |
| 14 | CACNA1H | CACNA1H Entrez, Source | calcium channel, voltage-dependent, alpha 1H subunit | 1737 | 0.069 | 0.1713 | No |
| 15 | IGFBP3 | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 1964 | 0.063 | 0.1678 | No |
| 16 | MYH7 | MYH7 Entrez, Source | myosin, heavy chain 7, cardiac muscle, beta | 2024 | 0.062 | 0.1767 | No |
| 17 | CSRP3 | CSRP3 Entrez, Source | cysteine and glycine-rich protein 3 (cardiac LIM protein) | 2345 | 0.055 | 0.1643 | No |
| 18 | UBB | UBB Entrez, Source | ubiquitin B | 3356 | 0.037 | 0.0962 | No |
| 19 | SIX1 | SIX1 Entrez, Source | sine oculis homeobox homolog 1 (Drosophila) | 3519 | 0.035 | 0.0915 | No |
| 20 | EGR3 | EGR3 Entrez, Source | early growth response 3 | 3724 | 0.032 | 0.0831 | No |
| 21 | ITGA7 | ITGA7 Entrez, Source | integrin, alpha 7 | 3867 | 0.030 | 0.0788 | No |
| 22 | BMP4 | BMP4 Entrez, Source | bone morphogenetic protein 4 | 4064 | 0.027 | 0.0700 | No |
| 23 | TBX3 | TBX3 Entrez, Source | T-box 3 (ulnar mammary syndrome) | 4134 | 0.027 | 0.0705 | No |
| 24 | IGF1 | IGF1 Entrez, Source | insulin-like growth factor 1 (somatomedin C) | 4287 | 0.025 | 0.0643 | No |
| 25 | MYH6 | MYH6 Entrez, Source | myosin, heavy chain 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) | 4670 | 0.020 | 0.0398 | No |
| 26 | KCNH1 | KCNH1 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 1 | 4830 | 0.018 | 0.0318 | No |
| 27 | POU6F1 | POU6F1 Entrez, Source | POU domain, class 6, transcription factor 1 | 5518 | 0.010 | -0.0178 | No |
| 28 | SGCE | SGCE Entrez, Source | sarcoglycan, epsilon | 5608 | 0.009 | -0.0226 | No |
| 29 | UTRN | UTRN Entrez, Source | utrophin (homologous to dystrophin) | 6005 | 0.005 | -0.0514 | No |
| 30 | HBEGF | HBEGF Entrez, Source | heparin-binding EGF-like growth factor | 6200 | 0.002 | -0.0655 | No |
| 31 | CACNB2 | CACNB2 Entrez, Source | calcium channel, voltage-dependent, beta 2 subunit | 6462 | -0.000 | -0.0851 | No |
| 32 | EMD | EMD Entrez, Source | emerin (Emery-Dreifuss muscular dystrophy) | 6680 | -0.003 | -0.1008 | No |
| 33 | GYLTL1B | GYLTL1B Entrez, Source | glycosyltransferase-like 1B | 6876 | -0.004 | -0.1145 | No |
| 34 | HDAC7A | HDAC7A Entrez, Source | histone deacetylase 7A | 7004 | -0.006 | -0.1229 | No |
| 35 | SOD1 | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 7350 | -0.009 | -0.1469 | No |
| 36 | MYH3 | MYH3 Entrez, Source | myosin, heavy chain 3, skeletal muscle, embryonic | 7568 | -0.011 | -0.1609 | No |
| 37 | CHRNA1 | CHRNA1 Entrez, Source | cholinergic receptor, nicotinic, alpha 1 (muscle) | 7580 | -0.011 | -0.1593 | No |
| 38 | CTF1 | CTF1 Entrez, Source | cardiotrophin 1 | 7944 | -0.015 | -0.1834 | No |
| 39 | SIRT2 | SIRT2 Entrez, Source | sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) | 8333 | -0.019 | -0.2085 | No |
| 40 | GAA | GAA Entrez, Source | glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II) | 8598 | -0.022 | -0.2237 | No |
| 41 | VAMP5 | VAMP5 Entrez, Source | vesicle-associated membrane protein 5 (myobrevin) | 9126 | -0.027 | -0.2575 | No |
| 42 | MBNL1 | MBNL1 Entrez, Source | muscleblind-like (Drosophila) | 9251 | -0.029 | -0.2608 | No |
| 43 | MTM1 | MTM1 Entrez, Source | myotubularin 1 | 9464 | -0.031 | -0.2701 | No |
| 44 | MYF6 | MYF6 Entrez, Source | myogenic factor 6 (herculin) | 9592 | -0.033 | -0.2727 | No |
| 45 | HDAC5 | HDAC5 Entrez, Source | histone deacetylase 5 | 9996 | -0.037 | -0.2951 | No |
| 46 | NRD1 | NRD1 Entrez, Source | nardilysin (N-arginine dibasic convertase) | 10702 | -0.046 | -0.3382 | No |
| 47 | TCF12 | TCF12 Entrez, Source | transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) | 10869 | -0.049 | -0.3402 | No |
| 48 | MAPK12 | MAPK12 Entrez, Source | mitogen-activated protein kinase 12 | 11422 | -0.059 | -0.3691 | No |
| 49 | SMTN | SMTN Entrez, Source | smoothelin | 11739 | -0.066 | -0.3788 | No |
| 50 | COL5A3 | COL5A3 Entrez, Source | collagen, type V, alpha 3 | 11947 | -0.071 | -0.3791 | No |
| 51 | MYEF2 | MYEF2 Entrez, Source | myelin expression factor 2 | 12369 | -0.086 | -0.3924 | Yes |
| 52 | GATA6 | GATA6 Entrez, Source | GATA binding protein 6 | 12378 | -0.086 | -0.3746 | Yes |
| 53 | MUSK | MUSK Entrez, Source | muscle, skeletal, receptor tyrosine kinase | 12393 | -0.087 | -0.3571 | Yes |
| 54 | MRAS | MRAS Entrez, Source | muscle RAS oncogene homolog | 12754 | -0.107 | -0.3612 | Yes |
| 55 | CXCL10 | CXCL10 Entrez, Source | chemokine (C-X-C motif) ligand 10 | 13310 | -0.321 | -0.3341 | Yes |
| 56 | TAGLN | TAGLN Entrez, Source | transgelin | 13340 | -0.666 | -0.1937 | Yes |
| 57 | ACTA1 | ACTA1 Entrez, Source | actin, alpha 1, skeletal muscle | 13342 | -0.905 | -0.0000 | Yes |
