Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | single_gel_24h |
| GeneSet | NETPATH_IL_1_PATHWAY |
| Enrichment Score (ES) | -0.51490587 |
| Normalized Enrichment Score (NES) | -1.5839298 |
| Nominal p-value | 0.045081966 |
| FDR q-value | 0.2534475 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CASP1 | CASP1 Entrez, Source | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 1348 | 0.079 | -0.0402 | No |
| 2 | SQSTM1 | SQSTM1 Entrez, Source | sequestosome 1 | 2801 | 0.046 | -0.1136 | No |
| 3 | IL1RN | IL1RN Entrez, Source | interleukin 1 receptor antagonist | 3400 | 0.037 | -0.1301 | No |
| 4 | PELI1 | PELI1 Entrez, Source | pellino homolog 1 (Drosophila) | 4464 | 0.022 | -0.1926 | No |
| 5 | IL1R1 | IL1R1 Entrez, Source | interleukin 1 receptor, type I | 5860 | 0.006 | -0.2928 | No |
| 6 | PTPN11 | PTPN11 Entrez, Source | protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | 6041 | 0.004 | -0.3030 | No |
| 7 | MAP3K7IP2 | MAP3K7IP2 Entrez, Source | mitogen-activated protein kinase kinase kinase 7 interacting protein 2 | 6244 | 0.002 | -0.3167 | No |
| 8 | MAPK1 | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 6842 | -0.004 | -0.3583 | No |
| 9 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 7260 | -0.008 | -0.3833 | No |
| 10 | PRKCZ | PRKCZ Entrez, Source | protein kinase C, zeta | 8458 | -0.020 | -0.4575 | No |
| 11 | MYD88 | MYD88 Entrez, Source | myeloid differentiation primary response gene (88) | 8694 | -0.023 | -0.4575 | No |
| 12 | NFKBIB | NFKBIB Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 8711 | -0.023 | -0.4409 | No |
| 13 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 9174 | -0.028 | -0.4541 | No |
| 14 | PLCG1 | PLCG1 Entrez, Source | phospholipase C, gamma 1 | 9447 | -0.031 | -0.4507 | No |
| 15 | CAPN1 | CAPN1 Entrez, Source | calpain 1, (mu/I) large subunit | 10030 | -0.037 | -0.4654 | No |
| 16 | CAPNS1 | CAPNS1 Entrez, Source | calpain, small subunit 1 | 10327 | -0.041 | -0.4560 | No |
| 17 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 10753 | -0.047 | -0.4514 | No |
| 18 | IKBKAP | IKBKAP Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein | 11600 | -0.062 | -0.4666 | Yes |
| 19 | IL1RAP | IL1RAP Entrez, Source | interleukin 1 receptor accessory protein | 12123 | -0.077 | -0.4464 | Yes |
| 20 | IL1B | IL1B Entrez, Source | interleukin 1, beta | 12206 | -0.080 | -0.3910 | Yes |
| 21 | IRAK2 | IRAK2 Entrez, Source | interleukin-1 receptor-associated kinase 2 | 12849 | -0.115 | -0.3504 | Yes |
| 22 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 12964 | -0.127 | -0.2605 | Yes |
| 23 | IL1R2 | IL1R2 Entrez, Source | interleukin 1 receptor, type II | 13127 | -0.155 | -0.1524 | Yes |
| 24 | IL1A | IL1A Entrez, Source | interleukin 1, alpha | 13241 | -0.218 | 0.0076 | Yes |
