Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | double_gel_24h |
| GeneSet | SKELETAL_DEVELOPMENT |
| Enrichment Score (ES) | 0.42811316 |
| Normalized Enrichment Score (NES) | 1.6138747 |
| Nominal p-value | 0.009727626 |
| FDR q-value | 0.19459085 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | COL2A1 | COL2A1 Entrez, Source | collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) | 231 | 0.144 | 0.0258 | Yes |
| 2 | GDF10 | GDF10 Entrez, Source | growth differentiation factor 10 | 382 | 0.127 | 0.0526 | Yes |
| 3 | IL17F | IL17F Entrez, Source | interleukin 17F | 522 | 0.115 | 0.0767 | Yes |
| 4 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 763 | 0.101 | 0.0890 | Yes |
| 5 | IGFBP4 | IGFBP4 Entrez, Source | insulin-like growth factor binding protein 4 | 859 | 0.097 | 0.1109 | Yes |
| 6 | COL10A1 | COL10A1 Entrez, Source | collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia) | 908 | 0.095 | 0.1358 | Yes |
| 7 | DLX5 | DLX5 Entrez, Source | distal-less homeobox 5 | 909 | 0.095 | 0.1643 | Yes |
| 8 | DLL3 | DLL3 Entrez, Source | delta-like 3 (Drosophila) | 924 | 0.095 | 0.1916 | Yes |
| 9 | MSX2 | MSX2 Entrez, Source | msh homeobox homolog 2 (Drosophila) | 981 | 0.092 | 0.2150 | Yes |
| 10 | PTHR1 | PTHR1 Entrez, Source | parathyroid hormone receptor 1 | 1095 | 0.087 | 0.2326 | Yes |
| 11 | PRELP | PRELP Entrez, Source | proline/arginine-rich end leucine-rich repeat protein | 1096 | 0.087 | 0.2588 | Yes |
| 12 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 1122 | 0.086 | 0.2828 | Yes |
| 13 | INHBA | INHBA Entrez, Source | inhibin, beta A (activin A, activin AB alpha polypeptide) | 1174 | 0.085 | 0.3044 | Yes |
| 14 | DMP1 | DMP1 Entrez, Source | dentin matrix acidic phosphoprotein | 1296 | 0.080 | 0.3193 | Yes |
| 15 | MGP | MGP Entrez, Source | matrix Gla protein | 1341 | 0.079 | 0.3397 | Yes |
| 16 | CASR | CASR Entrez, Source | calcium-sensing receptor (hypocalciuric hypercalcemia 1, severe neonatal hyperparathyroidism) | 1543 | 0.074 | 0.3466 | Yes |
| 17 | NF1 | NF1 Entrez, Source | neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) | 1548 | 0.073 | 0.3684 | Yes |
| 18 | CMKLR1 | CMKLR1 Entrez, Source | chemokine-like receptor 1 | 1681 | 0.070 | 0.3795 | Yes |
| 19 | RUNX2 | RUNX2 Entrez, Source | runt-related transcription factor 2 | 1784 | 0.068 | 0.3922 | Yes |
| 20 | KLF10 | KLF10 Entrez, Source | Kruppel-like factor 10 | 1837 | 0.067 | 0.4082 | Yes |
| 21 | FRZB | FRZB Entrez, Source | frizzled-related protein | 1839 | 0.067 | 0.4281 | Yes |
| 22 | TWIST1 | TWIST1 Entrez, Source | twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila) | 2728 | 0.047 | 0.3755 | No |
| 23 | DSPP | DSPP Entrez, Source | dentin sialophosphoprotein | 2804 | 0.046 | 0.3837 | No |
| 24 | IGF2 | IGF2 Entrez, Source | insulin-like growth factor 2 (somatomedin A) | 2858 | 0.045 | 0.3932 | No |
| 25 | PTH | PTH Entrez, Source | parathyroid hormone | 3299 | 0.038 | 0.3716 | No |
| 26 | SUFU | SUFU Entrez, Source | suppressor of fused homolog (Drosophila) | 3424 | 0.036 | 0.3731 | No |
| 27 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 3495 | 0.035 | 0.3785 | No |
| 28 | SHOX2 | SHOX2 Entrez, Source | short stature homeobox 2 | 3550 | 0.035 | 0.3848 | No |
| 29 | KL | KL Entrez, Source | klotho | 3988 | 0.029 | 0.3605 | No |
| 30 | FBN1 | FBN1 Entrez, Source | fibrillin 1 | 4008 | 0.028 | 0.3675 | No |
| 31 | AHSG | AHSG Entrez, Source | alpha-2-HS-glycoprotein | 4036 | 0.028 | 0.3738 | No |
| 32 | BMP4 | BMP4 Entrez, Source | bone morphogenetic protein 4 | 4064 | 0.027 | 0.3800 | No |
| 33 | EBP | EBP Entrez, Source | emopamil binding protein (sterol isomerase) | 4120 | 0.027 | 0.3839 | No |
| 34 | TBX3 | TBX3 Entrez, Source | T-box 3 (ulnar mammary syndrome) | 4134 | 0.027 | 0.3909 | No |
| 35 | INHA | INHA Entrez, Source | inhibin, alpha | 4234 | 0.025 | 0.3911 | No |
| 36 | IGF1 | IGF1 Entrez, Source | insulin-like growth factor 1 (somatomedin C) | 4287 | 0.025 | 0.3946 | No |
| 37 | BMP1 | BMP1 Entrez, Source | bone morphogenetic protein 1 | 4312 | 0.024 | 0.4001 | No |
| 38 | FGFR1 | FGFR1 Entrez, Source | fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) | 4922 | 0.017 | 0.3594 | No |
| 39 | MEPE | MEPE Entrez, Source | matrix, extracellular phosphoglycoprotein with ASARM motif (bone) | 5482 | 0.010 | 0.3204 | No |
| 40 | COL12A1 | COL12A1 Entrez, Source | collagen, type XII, alpha 1 | 6129 | 0.003 | 0.2728 | No |
| 41 | UFD1L | UFD1L Entrez, Source | ubiquitin fusion degradation 1 like (yeast) | 6141 | 0.003 | 0.2729 | No |
| 42 | GHRHR | GHRHR Entrez, Source | growth hormone releasing hormone receptor | 6330 | 0.001 | 0.2590 | No |
| 43 | COL11A1 | COL11A1 Entrez, Source | collagen, type XI, alpha 1 | 6865 | -0.004 | 0.2201 | No |
| 44 | SPP2 | SPP2 Entrez, Source | secreted phosphoprotein 2, 24kDa | 7334 | -0.009 | 0.1875 | No |
| 45 | ACVR1 | ACVR1 Entrez, Source | activin A receptor, type I | 7360 | -0.009 | 0.1884 | No |
| 46 | PRDX1 | PRDX1 Entrez, Source | peroxiredoxin 1 | 7611 | -0.012 | 0.1731 | No |
| 47 | CHRD | CHRD Entrez, Source | chordin | 7727 | -0.013 | 0.1683 | No |
| 48 | GDF11 | GDF11 Entrez, Source | growth differentiation factor 11 | 8265 | -0.018 | 0.1333 | No |
| 49 | OSTF1 | OSTF1 Entrez, Source | osteoclast stimulating factor 1 | 9146 | -0.027 | 0.0753 | No |
| 50 | CDK6 | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 9381 | -0.030 | 0.0667 | No |
| 51 | GLI1 | GLI1 Entrez, Source | glioma-associated oncogene homolog 1 (zinc finger protein) | 9643 | -0.033 | 0.0570 | No |
| 52 | NPR3 | NPR3 Entrez, Source | natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) | 9749 | -0.034 | 0.0594 | No |
| 53 | GHR | GHR Entrez, Source | growth hormone receptor | 10389 | -0.042 | 0.0238 | No |
| 54 | ANXA2 | ANXA2 Entrez, Source | annexin A2 | 10835 | -0.049 | 0.0049 | No |
| 55 | TWIST2 | TWIST2 Entrez, Source | twist homolog 2 (Drosophila) | 11100 | -0.053 | 0.0009 | No |
| 56 | COMP | COMP Entrez, Source | cartilage oligomeric matrix protein | 12469 | -0.090 | -0.0752 | No |
| 57 | TNFRSF11B | TNFRSF11B Entrez, Source | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) | 12718 | -0.104 | -0.0625 | No |
| 58 | ARSE | ARSE Entrez, Source | arylsulfatase E (chondrodysplasia punctata 1) | 12894 | -0.120 | -0.0396 | No |
| 59 | FGFR3 | FGFR3 Entrez, Source | fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) | 13275 | -0.244 | 0.0050 | No |
