Details for gene set SUBSTRATE_SPECIFIC_CHANNEL

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos
Phenotype	class.cls#double_gel_24h_versus_single_gel_24h_repos
Upregulated in class	double_gel_24h
GeneSet	SUBSTRATE_SPECIFIC_CHANNEL_ACTIVITY
Enrichment Score (ES)	0.46005985
Normalized Enrichment Score (NES)	1.9747287
Nominal p-value	0.0
FDR q-value	0.032626554
FWER p-Value	0.427

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	CHRNA7	CHRNA7 Entrez, Source	cholinergic receptor, nicotinic, alpha 7	107	0.175	0.0258	Yes
2	AQP9	AQP9 Entrez, Source	aquaporin 9	232	0.144	0.0443	Yes
3	KCNB2	KCNB2 Entrez, Source	potassium voltage-gated channel, Shab-related subfamily, member 2	483	0.119	0.0484	Yes
4	KCNJ4	KCNJ4 Entrez, Source	potassium inwardly-rectifying channel, subfamily J, member 4	546	0.114	0.0658	Yes
5	NOX1	NOX1 Entrez, Source	NADPH oxidase 1	560	0.113	0.0867	Yes
6	SCN2B	SCN2B Entrez, Source	sodium channel, voltage-gated, type II, beta	689	0.105	0.0973	Yes
7	CACNG2	CACNG2 Entrez, Source	calcium channel, voltage-dependent, gamma subunit 2	693	0.104	0.1173	Yes
8	CLCNKB	CLCNKB Entrez, Source	chloride channel Kb	710	0.104	0.1362	Yes
9	CLCN1	CLCN1 Entrez, Source	chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant)	715	0.103	0.1559	Yes
10	TRPV5	TRPV5 Entrez, Source	transient receptor potential cation channel, subfamily V, member 5	903	0.095	0.1603	Yes
11	RYR2	RYR2 Entrez, Source	ryanodine receptor 2 (cardiac)	917	0.095	0.1777	Yes
12	KCNJ14	KCNJ14 Entrez, Source	potassium inwardly-rectifying channel, subfamily J, member 14	936	0.094	0.1945	Yes
13	CHRNA3	CHRNA3 Entrez, Source	cholinergic receptor, nicotinic, alpha 3	992	0.092	0.2081	Yes
14	KCNN3	KCNN3 Entrez, Source	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	1040	0.090	0.2220	Yes
15	CACNA2D1	CACNA2D1 Entrez, Source	calcium channel, voltage-dependent, alpha 2/delta subunit 1	1054	0.089	0.2384	Yes
16	KCNJ6	KCNJ6 Entrez, Source	potassium inwardly-rectifying channel, subfamily J, member 6	1102	0.087	0.2517	Yes
17	P2RX1	P2RX1 Entrez, Source	purinergic receptor P2X, ligand-gated ion channel, 1	1200	0.084	0.2605	Yes
18	ACCN1	ACCN1 Entrez, Source	amiloride-sensitive cation channel 1, neuronal (degenerin)	1306	0.080	0.2681	Yes
19	TRPC3	TRPC3 Entrez, Source	transient receptor potential cation channel, subfamily C, member 3	1352	0.079	0.2800	Yes
20	P2RX7	P2RX7 Entrez, Source	purinergic receptor P2X, ligand-gated ion channel, 7	1500	0.075	0.2833	Yes
21	TRPV2	TRPV2 Entrez, Source	transient receptor potential cation channel, subfamily V, member 2	1634	0.072	0.2872	Yes
22	CACNA1H	CACNA1H Entrez, Source	calcium channel, voltage-dependent, alpha 1H subunit	1737	0.069	0.2928	Yes
23	SCNN1G	SCNN1G Entrez, Source	sodium channel, nonvoltage-gated 1, gamma	1742	0.069	0.3058	Yes
24	CACNA1C	CACNA1C Entrez, Source	calcium channel, voltage-dependent, L type, alpha 1C subunit	1939	0.064	0.3034	Yes
25	CFTR	CFTR Entrez, Source	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	1946	0.064	0.3152	Yes
26	SCN4B	SCN4B Entrez, Source	sodium channel, voltage-gated, type IV, beta	1965	0.063	0.3262	Yes
27	CHRNB2	CHRNB2 Entrez, Source	cholinergic receptor, nicotinic, beta 2 (neuronal)	2101	0.060	0.3276	Yes
28	KCNK3	KCNK3 Entrez, Source	potassium channel, subfamily K, member 3	2132	0.059	0.3368	Yes
29	SCNN1B	SCNN1B Entrez, Source	sodium channel, nonvoltage-gated 1, beta (Liddle syndrome)	2267	0.056	0.3375	Yes
30	CACNA1S	CACNA1S Entrez, Source	calcium channel, voltage-dependent, L type, alpha 1S subunit	2440	0.053	0.3348	Yes
31	TRPV1	TRPV1 Entrez, Source	transient receptor potential cation channel, subfamily V, member 1	2478	0.052	0.3421	Yes
32	CACNB3	CACNB3 Entrez, Source	calcium channel, voltage-dependent, beta 3 subunit	2538	0.051	0.3475	Yes
33	CACNA1E	CACNA1E Entrez, Source	calcium channel, voltage-dependent, alpha 1E subunit	2545	0.051	0.3568	Yes
34	KCNH3	KCNH3 Entrez, Source	potassium voltage-gated channel, subfamily H (eag-related), member 3	2561	0.050	0.3655	Yes
35	BSND	BSND Entrez, Source	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	2593	0.050	0.3728	Yes
36	MS4A2	MS4A2 Entrez, Source	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	2608	0.050	0.3814	Yes
37	KCNH4	KCNH4 Entrez, Source	potassium voltage-gated channel, subfamily H (eag-related), member 4	2628	0.049	0.3895	Yes
38	KCNMB1	KCNMB1 Entrez, Source	potassium large conductance calcium-activated channel, subfamily M, beta member 1	2672	0.049	0.3957	Yes
39	KCNK15	KCNK15 Entrez, Source	potassium channel, subfamily K, member 15	2726	0.048	0.4009	Yes
40	AQP5	AQP5 Entrez, Source	aquaporin 5	3113	0.041	0.3797	Yes
41	CACNA1D	CACNA1D Entrez, Source	calcium channel, voltage-dependent, L type, alpha 1D subunit	3122	0.041	0.3871	Yes
42	CACNG5	CACNG5 Entrez, Source	calcium channel, voltage-dependent, gamma subunit 5	3203	0.040	0.3888	Yes
43	KCNK10	KCNK10 Entrez, Source	potassium channel, subfamily K, member 10	3239	0.040	0.3938	Yes
44	KCNA2	KCNA2 Entrez, Source	potassium voltage-gated channel, shaker-related subfamily, member 2	3251	0.039	0.4006	Yes
45	KCNH2	KCNH2 Entrez, Source	potassium voltage-gated channel, subfamily H (eag-related), member 2	3257	0.039	0.4078	Yes
46	CNGA3	CNGA3 Entrez, Source	cyclic nucleotide gated channel alpha 3	3305	0.038	0.4116	Yes
47	KCNS1	KCNS1 Entrez, Source	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1	3324	0.038	0.4176	Yes
48	KCNK1	KCNK1 Entrez, Source	potassium channel, subfamily K, member 1	3345	0.037	0.4234	Yes
49	KCNN4	KCNN4 Entrez, Source	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	3482	0.035	0.4200	Yes
50	CACNA1A	CACNA1A Entrez, Source	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	3570	0.034	0.4200	Yes
51	KCNE2	KCNE2 Entrez, Source	potassium voltage-gated channel, Isk-related family, member 2	3669	0.033	0.4190	Yes
52	SCN5A	SCN5A Entrez, Source	sodium channel, voltage-gated, type V, alpha (long QT syndrome 3)	3775	0.032	0.4171	Yes
53	TRPM1	TRPM1 Entrez, Source	transient receptor potential cation channel, subfamily M, member 1	3784	0.031	0.4226	Yes
54	KCNC3	KCNC3 Entrez, Source	potassium voltage-gated channel, Shaw-related subfamily, member 3	3788	0.031	0.4285	Yes
55	KCND3	KCND3 Entrez, Source	potassium voltage-gated channel, Shal-related subfamily, member 3	3813	0.031	0.4326	Yes
56	SCN7A	SCN7A Entrez, Source	sodium channel, voltage-gated, type VII, alpha	3851	0.030	0.4357	Yes
57	KCNA1	KCNA1 Entrez, Source	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	3853	0.030	0.4415	Yes
58	KCNA6	KCNA6 Entrez, Source	potassium voltage-gated channel, shaker-related subfamily, member 6	3892	0.030	0.4444	Yes
59	KCNA5	KCNA5 Entrez, Source	potassium voltage-gated channel, shaker-related subfamily, member 5	3911	0.030	0.4488	Yes
60	CACNG1	CACNG1 Entrez, Source	calcium channel, voltage-dependent, gamma subunit 1	3925	0.029	0.4535	Yes
61	CACNA1G	CACNA1G Entrez, Source	calcium channel, voltage-dependent, alpha 1G subunit	3937	0.029	0.4583	Yes
62	CHRNA6	CHRNA6 Entrez, Source	cholinergic receptor, nicotinic, alpha 6	4014	0.028	0.4580	Yes
63	KCNMB4	KCNMB4 Entrez, Source	potassium large conductance calcium-activated channel, subfamily M, beta member 4	4059	0.028	0.4601	Yes
64	KCNQ2	KCNQ2 Entrez, Source	potassium voltage-gated channel, KQT-like subfamily, member 2	4151	0.026	0.4583	No
65	TRPC5	TRPC5 Entrez, Source	transient receptor potential cation channel, subfamily C, member 5	4328	0.024	0.4497	No
66	GLRA1	GLRA1 Entrez, Source	glycine receptor, alpha 1 (startle disease/hyperekplexia, stiff man syndrome)	4330	0.024	0.4543	No
67	FXYD3	FXYD3 Entrez, Source	FXYD domain containing ion transport regulator 3	4367	0.024	0.4561	No
68	FXYD1	FXYD1 Entrez, Source	FXYD domain containing ion transport regulator 1 (phospholemman)	4502	0.022	0.4502	No
69	CHRNA2	CHRNA2 Entrez, Source	cholinergic receptor, nicotinic, alpha 2 (neuronal)	4515	0.022	0.4535	No
70	P2RX3	P2RX3 Entrez, Source	purinergic receptor P2X, ligand-gated ion channel, 3	4544	0.021	0.4555	No
71	ACCN4	ACCN4 Entrez, Source	amiloride-sensitive cation channel 4, pituitary	4630	0.020	0.4530	No
72	TRPC4	TRPC4 Entrez, Source	transient receptor potential cation channel, subfamily C, member 4	4722	0.019	0.4499	No
73	HTR3A	HTR3A Entrez, Source	5-hydroxytryptamine (serotonin) receptor 3A	4785	0.019	0.4488	No
74	KCNJ3	KCNJ3 Entrez, Source	potassium inwardly-rectifying channel, subfamily J, member 3	4792	0.019	0.4520	No
75	KCNH1	KCNH1 Entrez, Source	potassium voltage-gated channel, subfamily H (eag-related), member 1	4830	0.018	0.4527	No
76	GLRA2	GLRA2 Entrez, Source	glycine receptor, alpha 2	4835	0.018	0.4559	No
77	KCNA3	KCNA3 Entrez, Source	potassium voltage-gated channel, shaker-related subfamily, member 3	4844	0.018	0.4588	No
78	KCNQ3	KCNQ3 Entrez, Source	potassium voltage-gated channel, KQT-like subfamily, member 3	4990	0.016	0.4510	No
79	KCNS3	KCNS3 Entrez, Source	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	5174	0.014	0.4398	No
80	KCNA4	KCNA4 Entrez, Source	potassium voltage-gated channel, shaker-related subfamily, member 4	5299	0.013	0.4329	No
81	AQP8	AQP8 Entrez, Source	aquaporin 8	5336	0.012	0.4325	No
82	NMUR2	NMUR2 Entrez, Source	neuromedin U receptor 2	5367	0.012	0.4325	No
83	SCN11A	SCN11A Entrez, Source	sodium channel, voltage-gated, type XI, alpha	5399	0.011	0.4323	No
84	CACNG4	CACNG4 Entrez, Source	calcium channel, voltage-dependent, gamma subunit 4	5484	0.010	0.4280	No
85	SCN4A	SCN4A Entrez, Source	sodium channel, voltage-gated, type IV, alpha	5567	0.009	0.4236	No
86	RYR1	RYR1 Entrez, Source	ryanodine receptor 1 (skeletal)	5589	0.009	0.4238	No
87	PDPN	PDPN Entrez, Source	podoplanin	5603	0.009	0.4246	No
88	CLCN2	CLCN2 Entrez, Source	chloride channel 2	5847	0.006	0.4074	No
89	KCNIP2	KCNIP2 Entrez, Source	Kv channel interacting protein 2	5898	0.006	0.4047	No
90	CHRNA4	CHRNA4 Entrez, Source	cholinergic receptor, nicotinic, alpha 4	5906	0.005	0.4052	No
91	KCNJ15	KCNJ15 Entrez, Source	potassium inwardly-rectifying channel, subfamily J, member 15	6003	0.005	0.3988	No
92	KCNE1	KCNE1 Entrez, Source	potassium voltage-gated channel, Isk-related family, member 1	6053	0.004	0.3959	No
93	P2RX2	P2RX2 Entrez, Source	purinergic receptor P2X, ligand-gated ion channel, 2	6139	0.003	0.3901	No
94	SCN9A	SCN9A Entrez, Source	sodium channel, voltage-gated, type IX, alpha	6177	0.003	0.3878	No
95	KCNG2	KCNG2 Entrez, Source	potassium voltage-gated channel, subfamily G, member 2	6206	0.002	0.3861	No
96	KCNJ5	KCNJ5 Entrez, Source	potassium inwardly-rectifying channel, subfamily J, member 5	6426	-0.000	0.3696	No
97	SCN1B	SCN1B Entrez, Source	sodium channel, voltage-gated, type I, beta	6455	-0.000	0.3675	No
98	CACNB2	CACNB2 Entrez, Source	calcium channel, voltage-dependent, beta 2 subunit	6462	-0.000	0.3671	No
99	CACNA1B	CACNA1B Entrez, Source	calcium channel, voltage-dependent, L type, alpha 1B subunit	6647	-0.002	0.3537	No
100	CHRNE	CHRNE Entrez, Source	cholinergic receptor, nicotinic, epsilon	6825	-0.004	0.3411	No
101	KCNC1	KCNC1 Entrez, Source	potassium voltage-gated channel, Shaw-related subfamily, member 1	6848	-0.004	0.3402	No
102	KCNQ1	KCNQ1 Entrez, Source	potassium voltage-gated channel, KQT-like subfamily, member 1	6895	-0.005	0.3376	No
103	CHRNB4	CHRNB4 Entrez, Source	cholinergic receptor, nicotinic, beta 4	7214	-0.008	0.3151	No
104	CHRND	CHRND Entrez, Source	cholinergic receptor, nicotinic, delta	7510	-0.011	0.2948	No
105	CACNB4	CACNB4 Entrez, Source	calcium channel, voltage-dependent, beta 4 subunit	7521	-0.011	0.2961	No
106	CHRNA1	CHRNA1 Entrez, Source	cholinergic receptor, nicotinic, alpha 1 (muscle)	7580	-0.011	0.2939	No
107	KCNJ10	KCNJ10 Entrez, Source	potassium inwardly-rectifying channel, subfamily J, member 10	7799	-0.014	0.2801	No
108	CNGB1	CNGB1 Entrez, Source	cyclic nucleotide gated channel beta 1	7881	-0.014	0.2767	No
109	CHRNB3	CHRNB3 Entrez, Source	cholinergic receptor, nicotinic, beta 3	8039	-0.016	0.2680	No
110	CLCA2	CLCA2 Entrez, Source	chloride channel, calcium activated, family member 2	8169	-0.017	0.2615	No
111	KCNJ1	KCNJ1 Entrez, Source	potassium inwardly-rectifying channel, subfamily J, member 1	8394	-0.020	0.2484	No
112	KCNJ12	KCNJ12 Entrez, Source	potassium inwardly-rectifying channel, subfamily J, member 12	8416	-0.020	0.2507	No
113	GLRB	GLRB Entrez, Source	glycine receptor, beta	8597	-0.022	0.2413	No
114	AQP7	AQP7 Entrez, Source	aquaporin 7	8603	-0.022	0.2451	No
115	CACNB1	CACNB1 Entrez, Source	calcium channel, voltage-dependent, beta 1 subunit	8689	-0.023	0.2431	No
116	KCNN2	KCNN2 Entrez, Source	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	8839	-0.024	0.2365	No
117	P2RX4	P2RX4 Entrez, Source	purinergic receptor P2X, ligand-gated ion channel, 4	9274	-0.029	0.2093	No
118	AQP6	AQP6 Entrez, Source	aquaporin 6, kidney specific	9826	-0.035	0.1744	No
119	TRPV6	TRPV6 Entrez, Source	transient receptor potential cation channel, subfamily V, member 6	10024	-0.037	0.1668	No
120	TRPM2	TRPM2 Entrez, Source	transient receptor potential cation channel, subfamily M, member 2	10275	-0.040	0.1557	No
121	HTR3B	HTR3B Entrez, Source	5-hydroxytryptamine (serotonin) receptor 3B	10347	-0.041	0.1583	No
122	CLCN3	CLCN3 Entrez, Source	chloride channel 3	10689	-0.046	0.1414	No
123	TRPC1	TRPC1 Entrez, Source	transient receptor potential cation channel, subfamily C, member 1	11504	-0.060	0.0916	No
124	AQP2	AQP2 Entrez, Source	aquaporin 2 (collecting duct)	11513	-0.061	0.1027	No
125	CUL5	CUL5 Entrez, Source	cullin 5	11698	-0.065	0.1013	No
126	P2RX5	P2RX5 Entrez, Source	purinergic receptor P2X, ligand-gated ion channel, 5	12877	-0.118	0.0352	No