Details for gene set SYNAPTIC

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos
Phenotype	class.cls#double_gel_24h_versus_single_gel_24h_repos
Upregulated in class	double_gel_24h
GeneSet	SYNAPTIC_TRANSMISSION
Enrichment Score (ES)	0.380729
Normalized Enrichment Score (NES)	1.6405169
Nominal p-value	0.0
FDR q-value	0.16966353
FWER p-Value	1.0

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	SEPT5	SEPT5 Entrez, Source	septin 5	68	0.193	0.0252	Yes
2	SLC6A5	SLC6A5 Entrez, Source	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	448	0.122	0.0156	Yes
3	CNTN4	CNTN4 Entrez, Source	contactin 4	510	0.116	0.0293	Yes
4	APBA1	APBA1 Entrez, Source	amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)	544	0.114	0.0447	Yes
5	BSN	BSN Entrez, Source	bassoon (presynaptic cytomatrix protein)	564	0.113	0.0609	Yes
6	KCND2	KCND2 Entrez, Source	potassium voltage-gated channel, Shal-related subfamily, member 2	569	0.112	0.0783	Yes
7	GAD1	GAD1 Entrez, Source	glutamate decarboxylase 1 (brain, 67kDa)	655	0.107	0.0886	Yes
8	SCN2B	SCN2B Entrez, Source	sodium channel, voltage-gated, type II, beta	689	0.105	0.1025	Yes
9	SLC6A2	SLC6A2 Entrez, Source	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	760	0.101	0.1131	Yes
10	KCNMA1	KCNMA1 Entrez, Source	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	777	0.100	0.1277	Yes
11	SYT5	SYT5 Entrez, Source	synaptotagmin V	847	0.097	0.1378	Yes
12	GABRR2	GABRR2 Entrez, Source	gamma-aminobutyric acid (GABA) receptor, rho 2	941	0.094	0.1454	Yes
13	GRIA2	GRIA2 Entrez, Source	glutamate receptor, ionotropic, AMPA 2	957	0.093	0.1590	Yes
14	SLC1A3	SLC1A3 Entrez, Source	solute carrier family 1 (glial high affinity glutamate transporter), member 3	984	0.092	0.1714	Yes
15	KCNN3	KCNN3 Entrez, Source	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	1040	0.090	0.1814	Yes
16	OPRK1	OPRK1 Entrez, Source	opioid receptor, kappa 1	1142	0.086	0.1872	Yes
17	KIF5A	KIF5A Entrez, Source	kinesin family member 5A	1145	0.086	0.2006	Yes
18	SLC5A7	SLC5A7 Entrez, Source	solute carrier family 5 (choline transporter), member 7	1183	0.084	0.2110	Yes
19	CARTPT	CARTPT Entrez, Source	CART prepropeptide	1278	0.081	0.2166	Yes
20	SYT1	SYT1 Entrez, Source	synaptotagmin I	1286	0.081	0.2288	Yes
21	KCNIP1	KCNIP1 Entrez, Source	Kv channel interacting protein 1	1295	0.080	0.2408	Yes
22	ACCN1	ACCN1 Entrez, Source	amiloride-sensitive cation channel 1, neuronal (degenerin)	1306	0.080	0.2526	Yes
23	SLC1A1	SLC1A1 Entrez, Source	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	1453	0.076	0.2535	Yes
24	NQO1	NQO1 Entrez, Source	NAD(P)H dehydrogenase, quinone 1	1457	0.076	0.2652	Yes
25	COL4A4	COL4A4 Entrez, Source	collagen, type IV, alpha 4	1561	0.073	0.2689	Yes
26	NTF5	NTF5 Entrez, Source	neurotrophin 5 (neurotrophin 4/5)	1562	0.073	0.2804	Yes
27	HTR7	HTR7 Entrez, Source	5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)	1757	0.068	0.2765	Yes
28	KLK8	KLK8 Entrez, Source	kallikrein 8 (neuropsin/ovasin)	1854	0.066	0.2796	Yes
29	AMPH	AMPH Entrez, Source	amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen)	1857	0.066	0.2898	Yes
30	DRD1	DRD1 Entrez, Source	dopamine receptor D1	2005	0.062	0.2885	Yes
31	KCNK3	KCNK3 Entrez, Source	potassium channel, subfamily K, member 3	2132	0.059	0.2882	Yes
32	TGFB2	TGFB2 Entrez, Source	transforming growth factor, beta 2	2282	0.056	0.2857	Yes
33	GABBR2	GABBR2 Entrez, Source	gamma-aminobutyric acid (GABA) B receptor, 2	2321	0.055	0.2915	Yes
34	GPR176	GPR176 Entrez, Source	G protein-coupled receptor 176	2354	0.054	0.2976	Yes
35	GHRL	GHRL Entrez, Source	ghrelin/obestatin preprohormone	2417	0.053	0.3013	Yes
36	CACNA1E	CACNA1E Entrez, Source	calcium channel, voltage-dependent, alpha 1E subunit	2545	0.051	0.2996	Yes
37	SLC1A2	SLC1A2 Entrez, Source	solute carrier family 1 (glial high affinity glutamate transporter), member 2	2558	0.051	0.3067	Yes
38	NPFF	NPFF Entrez, Source	neuropeptide FF-amide peptide precursor	2652	0.049	0.3073	Yes
39	COLQ	COLQ Entrez, Source	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	2657	0.049	0.3147	Yes
40	KCNMB1	KCNMB1 Entrez, Source	potassium large conductance calcium-activated channel, subfamily M, beta member 1	2672	0.049	0.3212	Yes
41	HTR2A	HTR2A Entrez, Source	5-hydroxytryptamine (serotonin) receptor 2A	2700	0.048	0.3267	Yes
42	HTR6	HTR6 Entrez, Source	5-hydroxytryptamine (serotonin) receptor 6	2940	0.044	0.3156	Yes
43	UTS2	UTS2 Entrez, Source	urotensin 2	2951	0.044	0.3217	Yes
44	GRM4	GRM4 Entrez, Source	glutamate receptor, metabotropic 4	3014	0.043	0.3237	Yes
45	CPLX1	CPLX1 Entrez, Source	complexin 1	3026	0.043	0.3296	Yes
46	GABRB2	GABRB2 Entrez, Source	gamma-aminobutyric acid (GABA) A receptor, beta 2	3071	0.042	0.3328	Yes
47	GALR3	GALR3 Entrez, Source	galanin receptor 3	3077	0.042	0.3390	Yes
48	SLC1A6	SLC1A6 Entrez, Source	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	3085	0.042	0.3450	Yes
49	ATXN3	ATXN3 Entrez, Source	ataxin 3	3236	0.040	0.3399	Yes
50	SLC6A4	SLC6A4 Entrez, Source	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	3343	0.038	0.3378	Yes
51	UBB	UBB Entrez, Source	ubiquitin B	3356	0.037	0.3427	Yes
52	SYN2	SYN2 Entrez, Source	synapsin II	3454	0.036	0.3410	Yes
53	CD24	CD24 Entrez, Source	CD24 molecule	3463	0.036	0.3460	Yes
54	GCH1	GCH1 Entrez, Source	GTP cyclohydrolase 1 (dopa-responsive dystonia)	3481	0.035	0.3503	Yes
55	PDE7B	PDE7B Entrez, Source	phosphodiesterase 7B	3505	0.035	0.3541	Yes
56	MPZ	MPZ Entrez, Source	myelin protein zero (Charcot-Marie-Tooth neuropathy 1B)	3523	0.035	0.3583	Yes
57	HAP1	HAP1 Entrez, Source	huntingtin-associated protein 1 (neuroan 1)	3573	0.034	0.3599	Yes
58	HCRTR1	HCRTR1 Entrez, Source	hypocretin (orexin) receptor 1	3589	0.034	0.3641	Yes
59	PXK	PXK Entrez, Source	PX domain containing serine/threonine kinase	3707	0.032	0.3604	Yes
60	SYN3	SYN3 Entrez, Source	synapsin III	3754	0.032	0.3619	Yes
61	DBH	DBH Entrez, Source	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	3789	0.031	0.3643	Yes
62	YWHAG	YWHAG Entrez, Source	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	3798	0.031	0.3685	Yes
63	KCNA1	KCNA1 Entrez, Source	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	3853	0.030	0.3692	Yes
64	GABRR1	GABRR1 Entrez, Source	gamma-aminobutyric acid (GABA) receptor, rho 1	3863	0.030	0.3733	Yes
65	VIPR1	VIPR1 Entrez, Source	vasoactive intestinal peptide receptor 1	3943	0.029	0.3719	Yes
66	CHRNA6	CHRNA6 Entrez, Source	cholinergic receptor, nicotinic, alpha 6	4014	0.028	0.3710	Yes
67	KCNMB4	KCNMB4 Entrez, Source	potassium large conductance calcium-activated channel, subfamily M, beta member 4	4059	0.028	0.3720	Yes
68	DRD2	DRD2 Entrez, Source	dopamine receptor D2	4082	0.027	0.3746	Yes
69	KCNQ2	KCNQ2 Entrez, Source	potassium voltage-gated channel, KQT-like subfamily, member 2	4151	0.026	0.3736	Yes
70	GRIK1	GRIK1 Entrez, Source	glutamate receptor, ionotropic, kainate 1	4170	0.026	0.3763	Yes
71	GRIN2B	GRIN2B Entrez, Source	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	4206	0.026	0.3777	Yes
72	DRD4	DRD4 Entrez, Source	dopamine receptor D4	4220	0.026	0.3807	Yes
73	CHRNA10	CHRNA10 Entrez, Source	cholinergic receptor, nicotinic, alpha 10	4492	0.022	0.3637	No
74	GRM2	GRM2 Entrez, Source	glutamate receptor, metabotropic 2	4499	0.022	0.3666	No
75	GRM5	GRM5 Entrez, Source	glutamate receptor, metabotropic 5	4509	0.022	0.3694	No
76	AKAP5	AKAP5 Entrez, Source	A kinase (PRKA) anchor protein 5	4513	0.022	0.3725	No
77	GRM1	GRM1 Entrez, Source	glutamate receptor, metabotropic 1	4558	0.021	0.3725	No
78	GABARAP	GABARAP Entrez, Source	GABA(A) receptor-associated protein	4565	0.021	0.3754	No
79	CRH	CRH Entrez, Source	corticotropin releasing hormone	4615	0.021	0.3749	No
80	GAD2	GAD2 Entrez, Source	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	4673	0.020	0.3737	No
81	HTR1B	HTR1B Entrez, Source	5-hydroxytryptamine (serotonin) receptor 1B	4767	0.019	0.3696	No
82	HTR3A	HTR3A Entrez, Source	5-hydroxytryptamine (serotonin) receptor 3A	4785	0.019	0.3713	No
83	GDNF	GDNF Entrez, Source	glial cell derived neurotrophic factor	4828	0.018	0.3710	No
84	KCNQ3	KCNQ3 Entrez, Source	potassium voltage-gated channel, KQT-like subfamily, member 3	4990	0.016	0.3613	No
85	GRIA1	GRIA1 Entrez, Source	glutamate receptor, ionotropic, AMPA 1	4994	0.016	0.3636	No
86	CORT	CORT Entrez, Source	cortistatin	5114	0.015	0.3569	No
87	HCRT	HCRT Entrez, Source	hypocretin (orexin) neuropeptide precursor	5200	0.014	0.3526	No
88	GCHFR	GCHFR Entrez, Source	GTP cyclohydrolase I feedback regulator	5363	0.012	0.3422	No
89	KCNN1	KCNN1 Entrez, Source	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1	5531	0.010	0.3311	No
90	HOMER1	HOMER1 Entrez, Source	homer homolog 1 (Drosophila)	5598	0.009	0.3276	No
91	HRH3	HRH3 Entrez, Source	histamine receptor H3	5851	0.006	0.3094	No
92	RAB3A	RAB3A Entrez, Source	RAB3A, member RAS oncogene family	5896	0.006	0.3070	No
93	CHRNA4	CHRNA4 Entrez, Source	cholinergic receptor, nicotinic, alpha 4	5906	0.005	0.3072	No
94	SST	SST Entrez, Source	somatostatin	5930	0.005	0.3062	No
95	OMP	OMP Entrez, Source	olfactory marker protein	5978	0.005	0.3034	No
96	SYN1	SYN1 Entrez, Source	synapsin I	6153	0.003	0.2907	No
97	SCN1B	SCN1B Entrez, Source	sodium channel, voltage-gated, type I, beta	6455	-0.000	0.2680	No
98	CACNA1B	CACNA1B Entrez, Source	calcium channel, voltage-dependent, L type, alpha 1B subunit	6647	-0.002	0.2539	No
99	HPRT1	HPRT1 Entrez, Source	hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome)	6770	-0.004	0.2452	No
100	CHRNE	CHRNE Entrez, Source	cholinergic receptor, nicotinic, epsilon	6825	-0.004	0.2418	No
101	MAPK1	MAPK1 Entrez, Source	mitogen-activated protein kinase 1	6842	-0.004	0.2412	No
102	GRIK4	GRIK4 Entrez, Source	glutamate receptor, ionotropic, kainate 4	6854	-0.004	0.2410	No
103	RIMS1	RIMS1 Entrez, Source	regulating synaptic membrane exocytosis 1	7006	-0.006	0.2305	No
104	GRIN2A	GRIN2A Entrez, Source	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	7043	-0.006	0.2287	No
105	CHRNB4	CHRNB4 Entrez, Source	cholinergic receptor, nicotinic, beta 4	7214	-0.008	0.2171	No
106	APOE	APOE Entrez, Source	apolipoprotein E	7282	-0.008	0.2133	No
107	PMP22	PMP22 Entrez, Source	peripheral myelin protein 22	7414	-0.010	0.2049	No
108	CHRNA1	CHRNA1 Entrez, Source	cholinergic receptor, nicotinic, alpha 1 (muscle)	7580	-0.011	0.1942	No
109	RIT2	RIT2 Entrez, Source	Ras-like without CAAX 2	7690	-0.012	0.1879	No
110	NOVA1	NOVA1 Entrez, Source	neuro-oncological ventral antigen 1	7743	-0.013	0.1860	No
111	UNC119	UNC119 Entrez, Source	unc-119 homolog (C. elegans)	7837	-0.014	0.1811	No
112	SLC6A1	SLC6A1 Entrez, Source	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	8025	-0.016	0.1695	No
113	CHRNB3	CHRNB3 Entrez, Source	cholinergic receptor, nicotinic, beta 3	8039	-0.016	0.1710	No
114	GRIK2	GRIK2 Entrez, Source	glutamate receptor, ionotropic, kainate 2	8233	-0.018	0.1592	No
115	HCRTR2	HCRTR2 Entrez, Source	hypocretin (orexin) receptor 2	8532	-0.021	0.1400	No
116	GLRB	GLRB Entrez, Source	glycine receptor, beta	8597	-0.022	0.1386	No
117	HTR1F	HTR1F Entrez, Source	5-hydroxytryptamine (serotonin) receptor 1F	8917	-0.025	0.1184	No
118	GALR2	GALR2 Entrez, Source	galanin receptor 2	9407	-0.030	0.0861	No
119	NLGN1	NLGN1 Entrez, Source	neuroligin 1	9581	-0.032	0.0781	No
120	HTR2C	HTR2C Entrez, Source	5-hydroxytryptamine (serotonin) receptor 2C	9776	-0.035	0.0688	No
121	HTR3B	HTR3B Entrez, Source	5-hydroxytryptamine (serotonin) receptor 3B	10347	-0.041	0.0321	No
122	YWHAH	YWHAH Entrez, Source	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	10384	-0.042	0.0360	No
123	MBP	MBP Entrez, Source	myelin basic protein	10406	-0.042	0.0409	No
124	GRM7	GRM7 Entrez, Source	glutamate receptor, metabotropic 7	10566	-0.044	0.0359	No
125	NPTN	NPTN Entrez, Source	neuroplastin	10756	-0.047	0.0290	No
126	NPY	NPY Entrez, Source	neuropeptide Y	10886	-0.049	0.0270	No
127	KIF1B	KIF1B Entrez, Source	kinesin family member 1B	11447	-0.059	-0.0061	No
128	QPRT	QPRT Entrez, Source	quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating))	11690	-0.064	-0.0143	No
129	ALDH9A1	ALDH9A1 Entrez, Source	aldehyde dehydrogenase 9 family, member A1	12333	-0.084	-0.0497	No
130	CNP	CNP Entrez, Source	2',3'-cyclic nucleotide 3' phosphodiesterase	12483	-0.090	-0.0468	No
131	CHRNA5	CHRNA5 Entrez, Source	cholinergic receptor, nicotinic, alpha 5	12619	-0.098	-0.0416	No
132	AKAP9	AKAP9 Entrez, Source	A kinase (PRKA) anchor protein (yotiao) 9	12906	-0.122	-0.0442	No
133	CHRNB1	CHRNB1 Entrez, Source	cholinergic receptor, nicotinic, beta 1 (muscle)	12969	-0.128	-0.0288	No
134	GRM3	GRM3 Entrez, Source	glutamate receptor, metabotropic 3	13128	-0.156	-0.0163	No
135	EDG7	EDG7 Entrez, Source	endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7	13222	-0.206	0.0091	No