Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | single_gel_24h |
| GeneSet | UVB_NHEK1_C6 |
| Enrichment Score (ES) | -0.44757935 |
| Normalized Enrichment Score (NES) | -1.6315844 |
| Nominal p-value | 0.014522822 |
| FDR q-value | 0.20789793 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | IGF2BP3 | IGF2BP3 Entrez, Source | insulin-like growth factor 2 mRNA binding protein 3 | 199 | 0.149 | 0.0393 | No |
| 2 | IRS1 | IRS1 Entrez, Source | insulin receptor substrate 1 | 549 | 0.114 | 0.0545 | No |
| 3 | SP3 | SP3 Entrez, Source | Sp3 transcription factor | 2400 | 0.054 | -0.0652 | No |
| 4 | MTUS1 | MTUS1 Entrez, Source | mitochondrial tumor suppressor 1 | 2523 | 0.051 | -0.0557 | No |
| 5 | CTBP2 | CTBP2 Entrez, Source | C-terminal binding protein 2 | 2635 | 0.049 | -0.0461 | No |
| 6 | CEBPD | CEBPD Entrez, Source | CCAAT/enhancer binding protein (C/EBP), delta | 4222 | 0.026 | -0.1561 | No |
| 7 | E2F5 | E2F5 Entrez, Source | E2F transcription factor 5, p130-binding | 4371 | 0.024 | -0.1587 | No |
| 8 | GNE | GNE Entrez, Source | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 4730 | 0.019 | -0.1786 | No |
| 9 | ORC2L | ORC2L Entrez, Source | origin recognition complex, subunit 2-like (yeast) | 4798 | 0.019 | -0.1769 | No |
| 10 | PRKCBP1 | PRKCBP1 Entrez, Source | protein kinase C binding protein 1 | 4831 | 0.018 | -0.1727 | No |
| 11 | CREB3L2 | CREB3L2 Entrez, Source | cAMP responsive element binding protein 3-like 2 | 4834 | 0.018 | -0.1662 | No |
| 12 | EDD1 | EDD1 Entrez, Source | E3 ubiquitin protein ligase, HECT domain containing, 1 | 4878 | 0.018 | -0.1630 | No |
| 13 | PHLPP | PHLPP Entrez, Source | PH domain and leucine rich repeat protein phosphatase | 5073 | 0.015 | -0.1721 | No |
| 14 | SLC7A1 | SLC7A1 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 5188 | 0.014 | -0.1756 | No |
| 15 | FYN | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 5269 | 0.013 | -0.1769 | No |
| 16 | BIRC2 | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 5286 | 0.013 | -0.1735 | No |
| 17 | MYST3 | MYST3 Entrez, Source | MYST histone acetyltransferase (monocytic leukemia) 3 | 5716 | 0.008 | -0.2029 | No |
| 18 | SPOP | SPOP Entrez, Source | speckle-type POZ protein | 5734 | 0.008 | -0.2015 | No |
| 19 | ATF2 | ATF2 Entrez, Source | activating transcription factor 2 | 6021 | 0.004 | -0.2214 | No |
| 20 | FOXO1A | FOXO1A Entrez, Source | forkhead box O1A (rhabdomyosarcoma) | 6085 | 0.004 | -0.2248 | No |
| 21 | PAFAH1B1 | PAFAH1B1 Entrez, Source | platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa | 6305 | 0.001 | -0.2408 | No |
| 22 | TUBGCP3 | TUBGCP3 Entrez, Source | tubulin, gamma complex associated protein 3 | 6657 | -0.003 | -0.2663 | No |
| 23 | MECP2 | MECP2 Entrez, Source | methyl CpG binding protein 2 (Rett syndrome) | 6994 | -0.006 | -0.2896 | No |
| 24 | INSIG2 | INSIG2 Entrez, Source | insulin induced gene 2 | 7082 | -0.006 | -0.2938 | No |
| 25 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 7260 | -0.008 | -0.3041 | No |
| 26 | LPHN2 | LPHN2 Entrez, Source | latrophilin 2 | 7314 | -0.009 | -0.3049 | No |
| 27 | XPO1 | XPO1 Entrez, Source | exportin 1 (CRM1 homolog, yeast) | 7439 | -0.010 | -0.3106 | No |
| 28 | ARHGEF7 | ARHGEF7 Entrez, Source | Rho guanine nucleotide exchange factor (GEF) 7 | 7877 | -0.014 | -0.3383 | No |
| 29 | CCNB2 | CCNB2 Entrez, Source | cyclin B2 | 8905 | -0.025 | -0.4065 | No |
| 30 | ATP2B1 | ATP2B1 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 1 | 8980 | -0.026 | -0.4026 | No |
| 31 | FGFR2 | FGFR2 Entrez, Source | ffer syndrome, Jackson-Weiss syndrome) | 9074 | -0.027 | -0.3998 | No |
| 32 | TOP2A | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 9337 | -0.029 | -0.4088 | No |
| 33 | HMGA2 | HMGA2 Entrez, Source | high mobility group AT-hook 2 | 9527 | -0.032 | -0.4115 | No |
| 34 | SHOC2 | SHOC2 Entrez, Source | soc-2 suppressor of clear homolog (C. elegans) | 9844 | -0.036 | -0.4223 | No |
| 35 | APPBP2 | APPBP2 Entrez, Source | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | 9965 | -0.037 | -0.4179 | No |
| 36 | DOCK9 | DOCK9 Entrez, Source | dedicator of cytokinesis 9 | 10296 | -0.041 | -0.4280 | No |
| 37 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 10368 | -0.041 | -0.4182 | No |
| 38 | EIF2C2 | EIF2C2 Entrez, Source | eukaryotic translation initiation factor 2C, 2 | 10536 | -0.044 | -0.4148 | No |
| 39 | PLEKHC1 | PLEKHC1 Entrez, Source | pleckstrin homology domain containing, family C (with FERM domain) member 1 | 10973 | -0.051 | -0.4291 | Yes |
| 40 | PPP1R12A | PPP1R12A Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 12A | 11026 | -0.051 | -0.4143 | Yes |
| 41 | STRN | STRN Entrez, Source | striatin, calmodulin binding protein | 11173 | -0.054 | -0.4055 | Yes |
| 42 | CNOT2 | CNOT2 Entrez, Source | CCR4-NOT transcription complex, subunit 2 | 11214 | -0.055 | -0.3884 | Yes |
| 43 | OTUD4 | OTUD4 Entrez, Source | OTU domain containing 4 | 11407 | -0.059 | -0.3814 | Yes |
| 44 | REV3L | REV3L Entrez, Source | REV3-like, catalytic subunit of DNA polymerase zeta (yeast) | 11512 | -0.061 | -0.3671 | Yes |
| 45 | CNOT4 | CNOT4 Entrez, Source | CCR4-NOT transcription complex, subunit 4 | 11569 | -0.062 | -0.3488 | Yes |
| 46 | PTK2 | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 11607 | -0.063 | -0.3287 | Yes |
| 47 | UBL3 | UBL3 Entrez, Source | ubiquitin-like 3 | 11808 | -0.068 | -0.3192 | Yes |
| 48 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 11928 | -0.071 | -0.3024 | Yes |
| 49 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 12416 | -0.088 | -0.3071 | Yes |
| 50 | POLD3 | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 12692 | -0.103 | -0.2905 | Yes |
| 51 | PIK3C3 | PIK3C3 Entrez, Source | phosphoinositide-3-kinase, class 3 | 12766 | -0.108 | -0.2565 | Yes |
| 52 | KIF2A | KIF2A Entrez, Source | kinesin heavy chain member 2A | 12962 | -0.127 | -0.2248 | Yes |
| 53 | PIP5K2B | PIP5K2B Entrez, Source | phosphatidylinositol-4-phosphate 5-kinase, type II, beta | 13070 | -0.143 | -0.1807 | Yes |
| 54 | TLE4 | TLE4 Entrez, Source | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 13153 | -0.163 | -0.1274 | Yes |
| 55 | CLASP1 | CLASP1 Entrez, Source | cytoplasmic linker associated protein 1 | 13168 | -0.170 | -0.0667 | Yes |
| 56 | SMC4 | SMC4 Entrez, Source | structural maintenance of chromosomes 4 | 13248 | -0.219 | 0.0071 | Yes |
