Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_24h_versus_single_gel_24h.class.cls #double_gel_24h_versus_single_gel_24h_repos |
| Phenotype | class.cls#double_gel_24h_versus_single_gel_24h_repos |
| Upregulated in class | single_gel_24h |
| GeneSet | UVB_NHEK1_DN |
| Enrichment Score (ES) | -0.42881882 |
| Normalized Enrichment Score (NES) | -1.7667296 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.14105457 |
| FWER p-Value | 0.992 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | DDIT4 | DDIT4 Entrez, Source | DNA-damage-inducible transcript 4 | 25 | 0.248 | 0.0387 | No |
| 2 | CREBBP | CREBBP Entrez, Source | CREB binding protein (Rubinstein-Taybi syndrome) | 179 | 0.152 | 0.0521 | No |
| 3 | IGF2BP3 | IGF2BP3 Entrez, Source | insulin-like growth factor 2 mRNA binding protein 3 | 199 | 0.149 | 0.0751 | No |
| 4 | IRS1 | IRS1 Entrez, Source | insulin receptor substrate 1 | 549 | 0.114 | 0.0673 | No |
| 5 | PPP1R3C | PPP1R3C Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 3C | 721 | 0.103 | 0.0713 | No |
| 6 | BAZ1B | BAZ1B Entrez, Source | bromodomain adjacent to zinc finger domain, 1B | 1136 | 0.086 | 0.0541 | No |
| 7 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 1411 | 0.077 | 0.0461 | No |
| 8 | SH2B3 | SH2B3 Entrez, Source | SH2B adaptor protein 3 | 2146 | 0.059 | 0.0003 | No |
| 9 | SP3 | SP3 Entrez, Source | Sp3 transcription factor | 2400 | 0.054 | -0.0100 | No |
| 10 | MTUS1 | MTUS1 Entrez, Source | mitochondrial tumor suppressor 1 | 2523 | 0.051 | -0.0108 | No |
| 11 | CTBP2 | CTBP2 Entrez, Source | C-terminal binding protein 2 | 2635 | 0.049 | -0.0112 | No |
| 12 | KLF9 | KLF9 Entrez, Source | Kruppel-like factor 9 | 2689 | 0.048 | -0.0073 | No |
| 13 | CEBPD | CEBPD Entrez, Source | CCAAT/enhancer binding protein (C/EBP), delta | 4222 | 0.026 | -0.1189 | No |
| 14 | E2F5 | E2F5 Entrez, Source | E2F transcription factor 5, p130-binding | 4371 | 0.024 | -0.1262 | No |
| 15 | ANKRD15 | ANKRD15 Entrez, Source | ankyrin repeat domain 15 | 4389 | 0.023 | -0.1237 | No |
| 16 | CBLB | CBLB Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence b | 4550 | 0.021 | -0.1323 | No |
| 17 | GNE | GNE Entrez, Source | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 4730 | 0.019 | -0.1426 | No |
| 18 | ORC2L | ORC2L Entrez, Source | origin recognition complex, subunit 2-like (yeast) | 4798 | 0.019 | -0.1447 | No |
| 19 | PRKCBP1 | PRKCBP1 Entrez, Source | protein kinase C binding protein 1 | 4831 | 0.018 | -0.1441 | No |
| 20 | CREB3L2 | CREB3L2 Entrez, Source | cAMP responsive element binding protein 3-like 2 | 4834 | 0.018 | -0.1413 | No |
| 21 | EDD1 | EDD1 Entrez, Source | E3 ubiquitin protein ligase, HECT domain containing, 1 | 4878 | 0.018 | -0.1416 | No |
| 22 | GCLC | GCLC Entrez, Source | glutamate-cysteine ligase, catalytic subunit | 5067 | 0.015 | -0.1534 | No |
| 23 | PHLPP | PHLPP Entrez, Source | PH domain and leucine rich repeat protein phosphatase | 5073 | 0.015 | -0.1513 | No |
| 24 | SLC7A1 | SLC7A1 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 5188 | 0.014 | -0.1576 | No |
| 25 | ADNP | ADNP Entrez, Source | activity-dependent neuroprotector | 5220 | 0.013 | -0.1577 | No |
| 26 | FYN | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 5269 | 0.013 | -0.1592 | No |
| 27 | BIRC2 | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 5286 | 0.013 | -0.1583 | No |
| 28 | BRD8 | BRD8 Entrez, Source | bromodomain containing 8 | 5377 | 0.012 | -0.1633 | No |
| 29 | USP1 | USP1 Entrez, Source | ubiquitin specific peptidase 1 | 5517 | 0.010 | -0.1721 | No |
| 30 | MYST3 | MYST3 Entrez, Source | MYST histone acetyltransferase (monocytic leukemia) 3 | 5716 | 0.008 | -0.1858 | No |
| 31 | SPOP | SPOP Entrez, Source | speckle-type POZ protein | 5734 | 0.008 | -0.1859 | No |
| 32 | SERTAD2 | SERTAD2 Entrez, Source | SERTA domain containing 2 | 5784 | 0.007 | -0.1884 | No |
| 33 | NFE2L2 | NFE2L2 Entrez, Source | nuclear factor (erythroid-derived 2)-like 2 | 5811 | 0.007 | -0.1893 | No |
| 34 | ATF2 | ATF2 Entrez, Source | activating transcription factor 2 | 6021 | 0.004 | -0.2044 | No |
| 35 | PUM2 | PUM2 Entrez, Source | pumilio homolog 2 (Drosophila) | 6077 | 0.004 | -0.2079 | No |
| 36 | FOXO1A | FOXO1A Entrez, Source | forkhead box O1A (rhabdomyosarcoma) | 6085 | 0.004 | -0.2078 | No |
| 37 | PAFAH1B1 | PAFAH1B1 Entrez, Source | platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa | 6305 | 0.001 | -0.2242 | No |
| 38 | DMTF1 | DMTF1 Entrez, Source | cyclin D binding myb-like transcription factor 1 | 6347 | 0.001 | -0.2271 | No |
| 39 | RCHY1 | RCHY1 Entrez, Source | ring finger and CHY zinc finger domain containing 1 | 6580 | -0.002 | -0.2444 | No |
| 40 | CTCF | CTCF Entrez, Source | CCCTC-binding factor (zinc finger protein) | 6595 | -0.002 | -0.2451 | No |
| 41 | TUBGCP3 | TUBGCP3 Entrez, Source | tubulin, gamma complex associated protein 3 | 6657 | -0.003 | -0.2493 | No |
| 42 | ZNF148 | ZNF148 Entrez, Source | zinc finger protein 148 | 6724 | -0.003 | -0.2538 | No |
| 43 | MECP2 | MECP2 Entrez, Source | methyl CpG binding protein 2 (Rett syndrome) | 6994 | -0.006 | -0.2732 | No |
| 44 | BDKRB2 | BDKRB2 Entrez, Source | bradykinin receptor B2 | 7014 | -0.006 | -0.2737 | No |
| 45 | INSIG2 | INSIG2 Entrez, Source | insulin induced gene 2 | 7082 | -0.006 | -0.2777 | No |
| 46 | CEP170 | CEP170 Entrez, Source | centrosomal protein 170kDa | 7086 | -0.006 | -0.2769 | No |
| 47 | NUP153 | NUP153 Entrez, Source | nucleoporin 153kDa | 7107 | -0.007 | -0.2773 | No |
| 48 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 7260 | -0.008 | -0.2875 | No |
| 49 | NR2F2 | NR2F2 Entrez, Source | nuclear receptor subfamily 2, group F, member 2 | 7287 | -0.009 | -0.2880 | No |
| 50 | LPHN2 | LPHN2 Entrez, Source | latrophilin 2 | 7314 | -0.009 | -0.2886 | No |
| 51 | XPO1 | XPO1 Entrez, Source | exportin 1 (CRM1 homolog, yeast) | 7439 | -0.010 | -0.2963 | No |
| 52 | SMAD5 | SMAD5 Entrez, Source | SMAD, mothers against DPP homolog 5 (Drosophila) | 7491 | -0.010 | -0.2985 | No |
| 53 | ATRX | ATRX Entrez, Source | alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae) | 7684 | -0.012 | -0.3110 | No |
| 54 | ARHGEF7 | ARHGEF7 Entrez, Source | Rho guanine nucleotide exchange factor (GEF) 7 | 7877 | -0.014 | -0.3231 | No |
| 55 | MTIF2 | MTIF2 Entrez, Source | mitochondrial translational initiation factor 2 | 8372 | -0.019 | -0.3573 | No |
| 56 | UBE2G1 | UBE2G1 Entrez, Source | ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) | 8739 | -0.023 | -0.3811 | No |
| 57 | TAF5L | TAF5L Entrez, Source | TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa | 8746 | -0.023 | -0.3778 | No |
| 58 | CCNB2 | CCNB2 Entrez, Source | cyclin B2 | 8905 | -0.025 | -0.3856 | No |
| 59 | ATP2B1 | ATP2B1 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 1 | 8980 | -0.026 | -0.3870 | No |
| 60 | DYRK1A | DYRK1A Entrez, Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 9041 | -0.026 | -0.3872 | No |
| 61 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 9056 | -0.027 | -0.3838 | No |
| 62 | FGFR2 | FGFR2 Entrez, Source | ffer syndrome, Jackson-Weiss syndrome) | 9074 | -0.027 | -0.3807 | No |
| 63 | TOP2A | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 9337 | -0.029 | -0.3957 | No |
| 64 | CEP350 | CEP350 Entrez, Source | centrosomal protein 350kDa | 9340 | -0.029 | -0.3910 | No |
| 65 | CCNE1 | CCNE1 Entrez, Source | cyclin E1 | 9404 | -0.030 | -0.3908 | No |
| 66 | MTM1 | MTM1 Entrez, Source | myotubularin 1 | 9464 | -0.031 | -0.3902 | No |
| 67 | HMGA2 | HMGA2 Entrez, Source | high mobility group AT-hook 2 | 9527 | -0.032 | -0.3897 | No |
| 68 | NIPBL | NIPBL Entrez, Source | Nipped-B homolog (Drosophila) | 9627 | -0.033 | -0.3918 | No |
| 69 | AURKA | AURKA Entrez, Source | aurora kinase A | 9667 | -0.034 | -0.3892 | No |
| 70 | SHOC2 | SHOC2 Entrez, Source | soc-2 suppressor of clear homolog (C. elegans) | 9844 | -0.036 | -0.3967 | No |
| 71 | RAPGEF5 | RAPGEF5 Entrez, Source | Rap guanine nucleotide exchange factor (GEF) 5 | 9858 | -0.036 | -0.3918 | No |
| 72 | NCOA3 | NCOA3 Entrez, Source | nuclear receptor coactivator 3 | 9861 | -0.036 | -0.3861 | No |
| 73 | APPBP2 | APPBP2 Entrez, Source | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | 9965 | -0.037 | -0.3879 | No |
| 74 | SKAP2 | SKAP2 Entrez, Source | src kinase associated phosphoprotein 2 | 10200 | -0.039 | -0.3991 | No |
| 75 | DOCK9 | DOCK9 Entrez, Source | dedicator of cytokinesis 9 | 10296 | -0.041 | -0.3996 | No |
| 76 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 10368 | -0.041 | -0.3982 | No |
| 77 | EIF2C2 | EIF2C2 Entrez, Source | eukaryotic translation initiation factor 2C, 2 | 10536 | -0.044 | -0.4036 | No |
| 78 | KEAP1 | KEAP1 Entrez, Source | kelch-like ECH-associated protein 1 | 10734 | -0.047 | -0.4108 | No |
| 79 | PLEKHC1 | PLEKHC1 Entrez, Source | pleckstrin homology domain containing, family C (with FERM domain) member 1 | 10973 | -0.051 | -0.4205 | Yes |
| 80 | PPP1R12A | PPP1R12A Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 12A | 11026 | -0.051 | -0.4160 | Yes |
| 81 | NAGK | NAGK Entrez, Source | N-acetylglucosamine kinase | 11055 | -0.052 | -0.4096 | Yes |
| 82 | STRN | STRN Entrez, Source | striatin, calmodulin binding protein | 11173 | -0.054 | -0.4096 | Yes |
| 83 | CNOT2 | CNOT2 Entrez, Source | CCR4-NOT transcription complex, subunit 2 | 11214 | -0.055 | -0.4036 | Yes |
| 84 | TAF11 | TAF11 Entrez, Source | TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa | 11247 | -0.056 | -0.3968 | Yes |
| 85 | OTUD4 | OTUD4 Entrez, Source | OTU domain containing 4 | 11407 | -0.059 | -0.3992 | Yes |
| 86 | PRKCD | PRKCD Entrez, Source | protein kinase C, delta | 11467 | -0.060 | -0.3938 | Yes |
| 87 | REV3L | REV3L Entrez, Source | REV3-like, catalytic subunit of DNA polymerase zeta (yeast) | 11512 | -0.061 | -0.3872 | Yes |
| 88 | CNOT4 | CNOT4 Entrez, Source | CCR4-NOT transcription complex, subunit 4 | 11569 | -0.062 | -0.3813 | Yes |
| 89 | ID1 | ID1 Entrez, Source | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 11598 | -0.062 | -0.3732 | Yes |
| 90 | PTK2 | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 11607 | -0.063 | -0.3635 | Yes |
| 91 | UBL3 | UBL3 Entrez, Source | ubiquitin-like 3 | 11808 | -0.068 | -0.3676 | Yes |
| 92 | PTPN3 | PTPN3 Entrez, Source | protein tyrosine phosphatase, non-receptor type 3 | 11812 | -0.068 | -0.3567 | Yes |
| 93 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 11928 | -0.071 | -0.3538 | Yes |
| 94 | CCDC131 | CCDC131 Entrez, Source | coiled-coil domain containing 131 | 12162 | -0.078 | -0.3586 | Yes |
| 95 | ELF1 | ELF1 Entrez, Source | E74-like factor 1 (ets domain transcription factor) | 12250 | -0.081 | -0.3519 | Yes |
| 96 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 12416 | -0.088 | -0.3501 | Yes |
| 97 | PHC2 | PHC2 Entrez, Source | polyhomeotic homolog 2 (Drosophila) | 12525 | -0.093 | -0.3430 | Yes |
| 98 | POLD3 | POLD3 Entrez, Source | polymerase (DNA-directed), delta 3, accessory subunit | 12692 | -0.103 | -0.3387 | Yes |
| 99 | PER2 | PER2 Entrez, Source | period homolog 2 (Drosophila) | 12697 | -0.103 | -0.3222 | Yes |
| 100 | PIK3C3 | PIK3C3 Entrez, Source | phosphoinositide-3-kinase, class 3 | 12766 | -0.108 | -0.3096 | Yes |
| 101 | WEE1 | WEE1 Entrez, Source | WEE1 homolog (S. pombe) | 12787 | -0.110 | -0.2931 | Yes |
| 102 | PSCD1 | PSCD1 Entrez, Source | pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1) | 12896 | -0.121 | -0.2814 | Yes |
| 103 | AKAP9 | AKAP9 Entrez, Source | A kinase (PRKA) anchor protein (yotiao) 9 | 12906 | -0.122 | -0.2622 | Yes |
| 104 | KIF2A | KIF2A Entrez, Source | kinesin heavy chain member 2A | 12962 | -0.127 | -0.2455 | Yes |
| 105 | DTX2 | DTX2 Entrez, Source | deltex homolog 2 (Drosophila) | 13002 | -0.132 | -0.2267 | Yes |
| 106 | PIP5K2B | PIP5K2B Entrez, Source | phosphatidylinositol-4-phosphate 5-kinase, type II, beta | 13070 | -0.143 | -0.2083 | Yes |
| 107 | TLE4 | TLE4 Entrez, Source | transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) | 13153 | -0.163 | -0.1878 | Yes |
| 108 | CLASP1 | CLASP1 Entrez, Source | cytoplasmic linker associated protein 1 | 13168 | -0.170 | -0.1611 | Yes |
| 109 | AHR | AHR Entrez, Source | aryl hydrocarbon receptor | 13211 | -0.198 | -0.1317 | Yes |
| 110 | SMC4 | SMC4 Entrez, Source | structural maintenance of chromosomes 4 | 13248 | -0.219 | -0.0986 | Yes |
| 111 | ADRB2 | ADRB2 Entrez, Source | adrenergic, beta-2-, receptor, surface | 13304 | -0.298 | -0.0539 | Yes |
| 112 | ADORA2B | ADORA2B Entrez, Source | adenosine A2b receptor | 13316 | -0.346 | 0.0020 | Yes |
