Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | ACTIN_FILAMENT_BASED_PROCESS |
| Enrichment Score (ES) | -0.5288175 |
| Normalized Enrichment Score (NES) | -1.7965899 |
| Nominal p-value | 0.0031847134 |
| FDR q-value | 0.04290791 |
| FWER p-Value | 0.977 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CXCL12 | CXCL12 Entrez, Source | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | 295 | 0.150 | 0.0069 | No |
| 2 | NF2 | NF2 Entrez, Source | neurofibromin 2 (bilateral acoustic neuroma) | 1025 | 0.096 | -0.0293 | No |
| 3 | TESK2 | TESK2 Entrez, Source | testis-specific kinase 2 | 1137 | 0.092 | -0.0199 | No |
| 4 | ADRA2A | ADRA2A Entrez, Source | adrenergic, alpha-2A-, receptor | 1280 | 0.087 | -0.0138 | No |
| 5 | CENTD2 | CENTD2 Entrez, Source | centaurin, delta 2 | 1661 | 0.075 | -0.0278 | No |
| 6 | TTN | TTN Entrez, Source | titin | 1695 | 0.074 | -0.0158 | No |
| 7 | NF1 | NF1 Entrez, Source | neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) | 1803 | 0.072 | -0.0099 | No |
| 8 | MYH6 | MYH6 Entrez, Source | myosin, heavy chain 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) | 2066 | 0.067 | -0.0167 | No |
| 9 | MYH11 | MYH11 Entrez, Source | myosin, heavy chain 11, smooth muscle | 2696 | 0.055 | -0.0534 | No |
| 10 | NUAK2 | NUAK2 Entrez, Source | NUAK family, SNF1-like kinase, 2 | 3142 | 0.048 | -0.0776 | No |
| 11 | FLNB | FLNB Entrez, Source | filamin B, beta (actin binding protein 278) | 4024 | 0.036 | -0.1369 | No |
| 12 | GHSR | GHSR Entrez, Source | growth hormone secretagogue receptor | 4226 | 0.033 | -0.1456 | No |
| 13 | MYH7 | MYH7 Entrez, Source | myosin, heavy chain 7, cardiac muscle, beta | 4454 | 0.031 | -0.1567 | No |
| 14 | SCIN | SCIN Entrez, Source | scinderin | 4841 | 0.026 | -0.1808 | No |
| 15 | TNNT2 | TNNT2 Entrez, Source | troponin T type 2 (cardiac) | 5334 | 0.020 | -0.2140 | No |
| 16 | PDPK1 | PDPK1 Entrez, Source | 3-phosphoinositide dependent protein kinase-1 | 5563 | 0.018 | -0.2277 | No |
| 17 | EVL | EVL Entrez, Source | Enah/Vasp-like | 5897 | 0.014 | -0.2501 | No |
| 18 | ARHGDIB | ARHGDIB Entrez, Source | Rho GDP dissociation inhibitor (GDI) beta | 6080 | 0.012 | -0.2615 | No |
| 19 | PACSIN2 | PACSIN2 Entrez, Source | protein kinase C and casein kinase substrate in neurons 2 | 6304 | 0.010 | -0.2764 | No |
| 20 | PLA2G1B | PLA2G1B Entrez, Source | phospholipase A2, group IB (pancreas) | 6366 | 0.009 | -0.2793 | No |
| 21 | FGD4 | FGD4 Entrez, Source | FYVE, RhoGEF and PH domain containing 4 | 6756 | 0.005 | -0.3076 | No |
| 22 | SORBS3 | SORBS3 Entrez, Source | sorbin and SH3 domain containing 3 | 6891 | 0.003 | -0.3171 | No |
| 23 | ARF6 | ARF6 Entrez, Source | ADP-ribosylation factor 6 | 6899 | 0.003 | -0.3171 | No |
| 24 | TAOK2 | TAOK2 Entrez, Source | TAO kinase 2 | 7066 | 0.001 | -0.3293 | No |
| 25 | ARFIP2 | ARFIP2 Entrez, Source | ADP-ribosylation factor interacting protein 2 (arfaptin 2) | 7165 | 0.000 | -0.3367 | No |
| 26 | RASA1 | RASA1 Entrez, Source | RAS p21 protein activator (GTPase activating protein) 1 | 7619 | -0.005 | -0.3698 | No |
| 27 | CXCL1 | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 8149 | -0.011 | -0.4075 | No |
| 28 | DLG1 | DLG1 Entrez, Source | discs, large homolog 1 (Drosophila) | 8290 | -0.013 | -0.4155 | No |
| 29 | ARHGEF2 | ARHGEF2 Entrez, Source | rho/rac guanine nucleotide exchange factor (GEF) 2 | 8556 | -0.016 | -0.4323 | No |
| 30 | MRAS | MRAS Entrez, Source | muscle RAS oncogene homolog | 8707 | -0.018 | -0.4401 | No |
| 31 | ARPC1A | ARPC1A Entrez, Source | actin related protein 2/3 complex, subunit 1A, 41kDa | 8847 | -0.020 | -0.4468 | No |
| 32 | CDC42BPB | CDC42BPB Entrez, Source | CDC42 binding protein kinase beta (DMPK-like) | 8892 | -0.020 | -0.4461 | No |
| 33 | TSC1 | TSC1 Entrez, Source | tuberous sclerosis 1 | 8983 | -0.022 | -0.4487 | No |
| 34 | RHOJ | RHOJ Entrez, Source | ras homolog gene family, member J | 9039 | -0.022 | -0.4485 | No |
| 35 | RND3 | RND3 Entrez, Source | Rho family GTPase 3 | 9751 | -0.033 | -0.4957 | No |
| 36 | CDC42BPA | CDC42BPA Entrez, Source | CDC42 binding protein kinase alpha (DMPK-like) | 9898 | -0.035 | -0.4999 | No |
| 37 | ROCK1 | ROCK1 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 1 | 9904 | -0.035 | -0.4935 | No |
| 38 | CAPG | CAPG Entrez, Source | capping protein (actin filament), gelsolin-like | 10094 | -0.038 | -0.5003 | No |
| 39 | GHRL | GHRL Entrez, Source | ghrelin/obestatin preprohormone | 10393 | -0.043 | -0.5143 | No |
| 40 | CRK | CRK Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian) | 10537 | -0.046 | -0.5162 | No |
| 41 | RHOA | RHOA Entrez, Source | ras homolog gene family, member A | 10584 | -0.047 | -0.5106 | No |
| 42 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 10703 | -0.049 | -0.5099 | No |
| 43 | LIMK1 | LIMK1 Entrez, Source | LIM domain kinase 1 | 10751 | -0.051 | -0.5036 | No |
| 44 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 10939 | -0.055 | -0.5071 | No |
| 45 | WASF2 | WASF2 Entrez, Source | WAS protein family, member 2 | 11151 | -0.059 | -0.5115 | No |
| 46 | RND1 | RND1 Entrez, Source | Rho family GTPase 1 | 11382 | -0.065 | -0.5163 | Yes |
| 47 | ATP2C1 | ATP2C1 Entrez, Source | ATPase, Ca++ transporting, type 2C, member 1 | 11421 | -0.066 | -0.5064 | Yes |
| 48 | PSCD2 | PSCD2 Entrez, Source | pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2) | 11669 | -0.074 | -0.5105 | Yes |
| 49 | WASL | WASL Entrez, Source | Wiskott-Aldrich syndrome-like | 11892 | -0.083 | -0.5112 | Yes |
| 50 | FGD1 | FGD1 Entrez, Source | FYVE, RhoGEF and PH domain containing 1 (faciogenital dysplasia) | 11895 | -0.083 | -0.4952 | Yes |
| 51 | WASF1 | WASF1 Entrez, Source | WAS protein family, member 1 | 11932 | -0.084 | -0.4815 | Yes |
| 52 | ARPC5 | ARPC5 Entrez, Source | actin related protein 2/3 complex, subunit 5, 16kDa | 12047 | -0.089 | -0.4728 | Yes |
| 53 | MYH9 | MYH9 Entrez, Source | myosin, heavy chain 9, non-muscle | 12120 | -0.093 | -0.4603 | Yes |
| 54 | CFL1 | CFL1 Entrez, Source | cofilin 1 (non-muscle) | 12205 | -0.097 | -0.4478 | Yes |
| 55 | DYNLL1 | DYNLL1 Entrez, Source | dynein, light chain, LC8-type 1 | 12221 | -0.098 | -0.4298 | Yes |
| 56 | GSN | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 12230 | -0.098 | -0.4113 | Yes |
| 57 | MYO9B | MYO9B Entrez, Source | myosin IXB | 12453 | -0.114 | -0.4059 | Yes |
| 58 | MYH10 | MYH10 Entrez, Source | myosin, heavy chain 10, non-muscle | 12486 | -0.117 | -0.3857 | Yes |
| 59 | BCAR1 | BCAR1 Entrez, Source | breast cancer anti-estrogen resistance 1 | 12497 | -0.117 | -0.3637 | Yes |
| 60 | DSTN | DSTN Entrez, Source | destrin (actin depolymerizing factor) | 12710 | -0.136 | -0.3532 | Yes |
| 61 | MYO1E | MYO1E Entrez, Source | myosin IE | 12727 | -0.138 | -0.3276 | Yes |
| 62 | CDC42EP2 | CDC42EP2 Entrez, Source | CDC42 effector protein (Rho GTPase binding) 2 | 13158 | -0.264 | -0.3088 | Yes |
| 63 | DBN1 | DBN1 Entrez, Source | drebrin 1 | 13305 | -0.475 | -0.2276 | Yes |
| 64 | ACTA1 | ACTA1 Entrez, Source | actin, alpha 1, skeletal muscle | 13342 | -1.187 | 0.0000 | Yes |
