Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | AGEING_KIDNEY_SPECIFIC_UP |
| Enrichment Score (ES) | -0.4736311 |
| Normalized Enrichment Score (NES) | -1.7555648 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.04900333 |
| FWER p-Value | 0.997 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CDO1 | CDO1 Entrez, Source | cysteine dioxygenase, type I | 54 | 0.279 | 0.0226 | No |
| 2 | CRELD2 | CRELD2 Entrez, Source | cysteine-rich with EGF-like domains 2 | 128 | 0.201 | 0.0364 | No |
| 3 | CFB | CFB Entrez, Source | complement factor B | 140 | 0.196 | 0.0544 | No |
| 4 | PDIA4 | PDIA4 Entrez, Source | protein disulfide isomerase family A, member 4 | 151 | 0.192 | 0.0720 | No |
| 5 | SPON1 | SPON1 Entrez, Source | spondin 1, extracellular matrix protein | 176 | 0.182 | 0.0876 | No |
| 6 | VCAM1 | VCAM1 Entrez, Source | vascular cell adhesion molecule 1 | 213 | 0.170 | 0.1012 | No |
| 7 | FBN1 | FBN1 Entrez, Source | fibrillin 1 | 423 | 0.133 | 0.0981 | No |
| 8 | C1QB | C1QB Entrez, Source | complement component 1, q subcomponent, B chain | 465 | 0.129 | 0.1073 | No |
| 9 | GPR56 | GPR56 Entrez, Source | G protein-coupled receptor 56 | 553 | 0.122 | 0.1124 | No |
| 10 | SCN5A | SCN5A Entrez, Source | sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) | 980 | 0.098 | 0.0896 | No |
| 11 | UBD | UBD Entrez, Source | ubiquitin D | 1268 | 0.087 | 0.0762 | No |
| 12 | ADRA2A | ADRA2A Entrez, Source | adrenergic, alpha-2A-, receptor | 1280 | 0.087 | 0.0837 | No |
| 13 | FGG | FGG Entrez, Source | fibrinogen gamma chain | 1572 | 0.078 | 0.0692 | No |
| 14 | C3 | C3 Entrez, Source | complement component 3 | 1731 | 0.074 | 0.0643 | No |
| 15 | CDH11 | CDH11 Entrez, Source | cadherin 11, type 2, OB-cadherin (osteoblast) | 1759 | 0.073 | 0.0692 | No |
| 16 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 2001 | 0.068 | 0.0575 | No |
| 17 | ABCC3 | ABCC3 Entrez, Source | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 2034 | 0.067 | 0.0615 | No |
| 18 | CTHRC1 | CTHRC1 Entrez, Source | collagen triple helix repeat containing 1 | 2305 | 0.062 | 0.0471 | No |
| 19 | SOCS3 | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 2355 | 0.061 | 0.0492 | No |
| 20 | TNFRSF11B | TNFRSF11B Entrez, Source | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) | 2394 | 0.060 | 0.0521 | No |
| 21 | C1QC | C1QC Entrez, Source | complement component 1, q subcomponent, C chain | 2432 | 0.060 | 0.0550 | No |
| 22 | LOXL1 | LOXL1 Entrez, Source | lysyl oxidase-like 1 | 2447 | 0.060 | 0.0597 | No |
| 23 | RARRES1 | RARRES1 Entrez, Source | retinoic acid receptor responder (tazarotene induced) 1 | 2539 | 0.058 | 0.0583 | No |
| 24 | CLDN3 | CLDN3 Entrez, Source | claudin 3 | 3133 | 0.048 | 0.0181 | No |
| 25 | FHL1 | FHL1 Entrez, Source | four and a half LIM domains 1 | 3226 | 0.047 | 0.0157 | No |
| 26 | SERPING1 | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 3232 | 0.047 | 0.0198 | No |
| 27 | COL15A1 | COL15A1 Entrez, Source | collagen, type XV, alpha 1 | 3242 | 0.047 | 0.0236 | No |
| 28 | RPN1 | RPN1 Entrez, Source | ribophorin I | 3301 | 0.046 | 0.0236 | No |
| 29 | HGF | HGF Entrez, Source | hepatocyte growth factor (hepapoietin A; scatter factor) | 3627 | 0.041 | 0.0030 | No |
| 30 | SERPINE2 | SERPINE2 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 3843 | 0.039 | -0.0096 | No |
| 31 | VSNL1 | VSNL1 Entrez, Source | visinin-like 1 | 3879 | 0.038 | -0.0085 | No |
| 32 | CHRNA3 | CHRNA3 Entrez, Source | cholinergic receptor, nicotinic, alpha 3 | 4005 | 0.036 | -0.0145 | No |
| 33 | SPARCL1 | SPARCL1 Entrez, Source | SPARC-like 1 (mast9, hevin) | 4113 | 0.035 | -0.0192 | No |
| 34 | SYMPK | SYMPK Entrez, Source | symplekin | 4123 | 0.035 | -0.0166 | No |
| 35 | COL5A1 | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 4268 | 0.033 | -0.0243 | No |
| 36 | AATF | AATF Entrez, Source | apoptosis antagonizing transcription factor | 4295 | 0.033 | -0.0232 | No |
| 37 | COL1A1 | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 4462 | 0.030 | -0.0328 | No |
| 38 | NR2F1 | NR2F1 Entrez, Source | nuclear receptor subfamily 2, group F, member 1 | 4499 | 0.030 | -0.0326 | No |
| 39 | RBP1 | RBP1 Entrez, Source | retinol binding protein 1, cellular | 4518 | 0.030 | -0.0311 | No |
| 40 | P4HB | P4HB Entrez, Source | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide | 4586 | 0.029 | -0.0334 | No |
| 41 | AMBP | AMBP Entrez, Source | alpha-1-microglobulin/bikunin precursor | 4725 | 0.027 | -0.0412 | No |
| 42 | SLC1A3 | SLC1A3 Entrez, Source | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 4742 | 0.027 | -0.0399 | No |
| 43 | NOV | NOV Entrez, Source | nephroblastoma overexpressed gene | 4769 | 0.027 | -0.0393 | No |
| 44 | MGLL | MGLL Entrez, Source | monoglyceride lipase | 5400 | 0.019 | -0.0850 | No |
| 45 | RPN2 | RPN2 Entrez, Source | ribophorin II | 5686 | 0.016 | -0.1050 | No |
| 46 | TSPAN1 | TSPAN1 Entrez, Source | tetraspanin 1 | 5814 | 0.015 | -0.1132 | No |
| 47 | RPL35A | RPL35A Entrez, Source | ribosomal protein L35a | 6180 | 0.011 | -0.1397 | No |
| 48 | PLK2 | PLK2 Entrez, Source | polo-like kinase 2 (Drosophila) | 6290 | 0.010 | -0.1470 | No |
| 49 | GGTA1 | GGTA1 Entrez, Source | glycoprotein, alpha-galactosyltransferase 1 | 6325 | 0.009 | -0.1487 | No |
| 50 | GGTLA1 | GGTLA1 Entrez, Source | gamma-glutamyltransferase-like activity 1 | 6376 | 0.009 | -0.1516 | No |
| 51 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 6389 | 0.009 | -0.1517 | No |
| 52 | RPL35 | RPL35 Entrez, Source | ribosomal protein L35 | 6491 | 0.008 | -0.1586 | No |
| 53 | RPS25 | RPS25 Entrez, Source | ribosomal protein S25 | 6664 | 0.006 | -0.1710 | No |
| 54 | SSR4 | SSR4 Entrez, Source | signal sequence receptor, delta (translocon-associated protein delta) | 6776 | 0.004 | -0.1790 | No |
| 55 | FN1 | FN1 Entrez, Source | fibronectin 1 | 7215 | -0.000 | -0.2121 | No |
| 56 | CXCL14 | CXCL14 Entrez, Source | chemokine (C-X-C motif) ligand 14 | 7432 | -0.003 | -0.2281 | No |
| 57 | SLC40A1 | SLC40A1 Entrez, Source | solute carrier family 40 (iron-regulated transporter), member 1 | 7487 | -0.004 | -0.2319 | No |
| 58 | ASNS | ASNS Entrez, Source | asparagine synthetase | 7614 | -0.005 | -0.2409 | No |
| 59 | GABRP | GABRP Entrez, Source | gamma-aminobutyric acid (GABA) A receptor, pi | 7726 | -0.006 | -0.2487 | No |
| 60 | VARS | VARS Entrez, Source | valyl-tRNA synthetase | 7781 | -0.007 | -0.2521 | No |
| 61 | ANTXR1 | ANTXR1 Entrez, Source | anthrax toxin receptor 1 | 7988 | -0.009 | -0.2668 | No |
| 62 | RGS1 | RGS1 Entrez, Source | regulator of G-protein signalling 1 | 8082 | -0.010 | -0.2728 | No |
| 63 | TMED3 | TMED3 Entrez, Source | transmembrane emp24 protein transport domain containing 3 | 8135 | -0.011 | -0.2757 | No |
| 64 | VTCN1 | VTCN1 Entrez, Source | V-set domain containing T cell activation inhibitor 1 | 8152 | -0.011 | -0.2759 | No |
| 65 | NFIX | NFIX Entrez, Source | nuclear factor I/X (CCAAT-binding transcription factor) | 8634 | -0.017 | -0.3105 | No |
| 66 | EBF1 | EBF1 Entrez, Source | early B-cell factor 1 | 8691 | -0.018 | -0.3131 | No |
| 67 | MRAS | MRAS Entrez, Source | muscle RAS oncogene homolog | 8707 | -0.018 | -0.3125 | No |
| 68 | LUM | LUM Entrez, Source | lumican | 8862 | -0.020 | -0.3222 | No |
| 69 | TFPI | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 8929 | -0.021 | -0.3252 | No |
| 70 | NRP1 | NRP1 Entrez, Source | neuropilin 1 | 9147 | -0.024 | -0.3393 | No |
| 71 | PLOD3 | PLOD3 Entrez, Source | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 | 9156 | -0.024 | -0.3376 | No |
| 72 | STS | STS Entrez, Source | steroid sulfatase (microsomal), arylsulfatase C, isozyme S | 9956 | -0.036 | -0.3946 | No |
| 73 | ITPR3 | ITPR3 Entrez, Source | inositol 1,4,5-triphosphate receptor, type 3 | 10318 | -0.042 | -0.4179 | No |
| 74 | FEZ2 | FEZ2 Entrez, Source | fasciculation and elongation protein zeta 2 (zygin II) | 10541 | -0.046 | -0.4302 | No |
| 75 | MMP7 | MMP7 Entrez, Source | matrix metallopeptidase 7 (matrilysin, uterine) | 10562 | -0.046 | -0.4273 | No |
| 76 | PHLDA3 | PHLDA3 Entrez, Source | pleckstrin homology-like domain, family A, member 3 | 10816 | -0.052 | -0.4415 | No |
| 77 | MOXD1 | MOXD1 Entrez, Source | monooxygenase, DBH-like 1 | 10970 | -0.055 | -0.4477 | No |
| 78 | UBE2Z | UBE2Z Entrez, Source | ubiquitin-conjugating enzyme E2Z (putative) | 11150 | -0.059 | -0.4556 | No |
| 79 | MFGE8 | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 11250 | -0.061 | -0.4572 | No |
| 80 | SMPD2 | SMPD2 Entrez, Source | sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) | 11305 | -0.063 | -0.4553 | No |
| 81 | AXL | AXL Entrez, Source | AXL receptor tyrosine kinase | 11348 | -0.064 | -0.4524 | No |
| 82 | DEGS1 | DEGS1 Entrez, Source | degenerative spermatocyte homolog 1, lipid desaturase (Drosophila) | 11526 | -0.069 | -0.4591 | No |
| 83 | C1R | C1R Entrez, Source | complement component 1, r subcomponent | 11719 | -0.076 | -0.4664 | Yes |
| 84 | GGA2 | GGA2 Entrez, Source | golgi associated, gamma adaptin ear containing, ARF binding protein 2 | 11752 | -0.077 | -0.4614 | Yes |
| 85 | COL27A1 | COL27A1 Entrez, Source | collagen, type XXVII, alpha 1 | 11812 | -0.080 | -0.4582 | Yes |
| 86 | ITGB6 | ITGB6 Entrez, Source | integrin, beta 6 | 11921 | -0.084 | -0.4583 | Yes |
| 87 | CLDN1 | CLDN1 Entrez, Source | claudin 1 | 12033 | -0.089 | -0.4582 | Yes |
| 88 | PROM1 | PROM1 Entrez, Source | prominin 1 | 12141 | -0.094 | -0.4573 | Yes |
| 89 | DPP3 | DPP3 Entrez, Source | dipeptidyl-peptidase 3 | 12168 | -0.095 | -0.4502 | Yes |
| 90 | PRICKLE1 | PRICKLE1 Entrez, Source | prickle homolog 1 (Drosophila) | 12357 | -0.107 | -0.4541 | Yes |
| 91 | TGIF | TGIF Entrez, Source | TGFB-induced factor (TALE family homeobox) | 12388 | -0.110 | -0.4458 | Yes |
| 92 | HOMER3 | HOMER3 Entrez, Source | homer homolog 3 (Drosophila) | 12616 | -0.127 | -0.4509 | Yes |
| 93 | RAB34 | RAB34 Entrez, Source | RAB34, member RAS oncogene family | 12627 | -0.128 | -0.4394 | Yes |
| 94 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 12665 | -0.131 | -0.4297 | Yes |
| 95 | HEXB | HEXB Entrez, Source | hexosaminidase B (beta polypeptide) | 12669 | -0.131 | -0.4173 | Yes |
| 96 | ANXA2 | ANXA2 Entrez, Source | annexin A2 | 12686 | -0.133 | -0.4058 | Yes |
| 97 | WFDC2 | WFDC2 Entrez, Source | WAP four-disulfide core domain 2 | 12814 | -0.150 | -0.4010 | Yes |
| 98 | ITM2C | ITM2C Entrez, Source | integral membrane protein 2C | 12821 | -0.151 | -0.3870 | Yes |
| 99 | TPM1 | TPM1 Entrez, Source | tropomyosin 1 (alpha) | 12980 | -0.185 | -0.3813 | Yes |
| 100 | PKIB | PKIB Entrez, Source | protein kinase (cAMP-dependent, catalytic) inhibitor beta | 13027 | -0.198 | -0.3658 | Yes |
| 101 | GPNMB | GPNMB Entrez, Source | glycoprotein (transmembrane) nmb | 13168 | -0.269 | -0.3506 | Yes |
| 102 | TIMP1 | TIMP1 Entrez, Source | TIMP metallopeptidase inhibitor 1 | 13187 | -0.286 | -0.3246 | Yes |
| 103 | PAM | PAM Entrez, Source | peptidylglycine alpha-amidating monooxygenase | 13213 | -0.306 | -0.2972 | Yes |
| 104 | CXCL2 | CXCL2 Entrez, Source | chemokine (C-X-C motif) ligand 2 | 13254 | -0.355 | -0.2663 | Yes |
| 105 | PDGFC | PDGFC Entrez, Source | platelet derived growth factor C | 13269 | -0.383 | -0.2306 | Yes |
| 106 | MMP11 | MMP11 Entrez, Source | matrix metallopeptidase 11 (stromelysin 3) | 13286 | -0.422 | -0.1914 | Yes |
| 107 | TPBG | TPBG Entrez, Source | trophoblast glycoprotein | 13288 | -0.427 | -0.1506 | Yes |
| 108 | BHLHB3 | BHLHB3 Entrez, Source | basic helix-loop-helix domain containing, class B, 3 | 13309 | -0.487 | -0.1055 | Yes |
| 109 | ANXA1 | ANXA1 Entrez, Source | annexin A1 | 13312 | -0.498 | -0.0579 | Yes |
| 110 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 13326 | -0.627 | 0.0012 | Yes |
