Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | double_gel_48h |
| GeneSet | AMINO_ACID_AND_DERIVATIVE_METABOLIC_PROCESS |
| Enrichment Score (ES) | 0.4466838 |
| Normalized Enrichment Score (NES) | 1.7290919 |
| Nominal p-value | 0.005277045 |
| FDR q-value | 0.049464293 |
| FWER p-Value | 0.994 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | BBOX1 | BBOX1 Entrez, Source | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 37 | 0.303 | 0.0532 | Yes |
| 2 | CDO1 | CDO1 Entrez, Source | cysteine dioxygenase, type I | 54 | 0.279 | 0.1035 | Yes |
| 3 | ARG1 | ARG1 Entrez, Source | arginase, liver | 117 | 0.209 | 0.1374 | Yes |
| 4 | GOT1 | GOT1 Entrez, Source | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) | 197 | 0.173 | 0.1635 | Yes |
| 5 | ASL | ASL Entrez, Source | argininosuccinate lyase | 273 | 0.154 | 0.1863 | Yes |
| 6 | ALDH6A1 | ALDH6A1 Entrez, Source | aldehyde dehydrogenase 6 family, member A1 | 314 | 0.148 | 0.2107 | Yes |
| 7 | MAT1A | MAT1A Entrez, Source | methionine adenosyltransferase I, alpha | 323 | 0.146 | 0.2370 | Yes |
| 8 | HDC | HDC Entrez, Source | histidine decarboxylase | 383 | 0.138 | 0.2581 | Yes |
| 9 | HGD | HGD Entrez, Source | homogentisate 1,2-dioxygenase (homogentisate oxidase) | 457 | 0.129 | 0.2765 | Yes |
| 10 | FAH | FAH Entrez, Source | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 489 | 0.126 | 0.2974 | Yes |
| 11 | SLC7A2 | SLC7A2 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 494 | 0.125 | 0.3203 | Yes |
| 12 | BCKDK | BCKDK Entrez, Source | branched chain ketoacid dehydrogenase kinase | 866 | 0.104 | 0.3115 | Yes |
| 13 | PTS | PTS Entrez, Source | 6-pyruvoyltetrahydropterin synthase | 877 | 0.104 | 0.3300 | Yes |
| 14 | GAMT | GAMT Entrez, Source | guanidinoacetate N-methyltransferase | 910 | 0.102 | 0.3464 | Yes |
| 15 | SCLY | SCLY Entrez, Source | selenocysteine lyase | 1056 | 0.095 | 0.3530 | Yes |
| 16 | SLC25A15 | SLC25A15 Entrez, Source | solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 | 1184 | 0.090 | 0.3601 | Yes |
| 17 | GAD2 | GAD2 Entrez, Source | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) | 1212 | 0.089 | 0.3746 | Yes |
| 18 | GCLC | GCLC Entrez, Source | glutamate-cysteine ligase, catalytic subunit | 1237 | 0.088 | 0.3891 | Yes |
| 19 | MSRA | MSRA Entrez, Source | methionine sulfoxide reductase A | 1404 | 0.082 | 0.3918 | Yes |
| 20 | SULT1B1 | SULT1B1 Entrez, Source | sulfotransferase family, cytosolic, 1B, member 1 | 1416 | 0.082 | 0.4062 | Yes |
| 21 | PAH | PAH Entrez, Source | phenylalanine hydroxylase | 1513 | 0.079 | 0.4135 | Yes |
| 22 | SLC7A8 | SLC7A8 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 | 1584 | 0.077 | 0.4226 | Yes |
| 23 | BAAT | BAAT Entrez, Source | bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase) | 1625 | 0.077 | 0.4337 | Yes |
| 24 | YARS | YARS Entrez, Source | tyrosyl-tRNA synthetase | 1907 | 0.070 | 0.4255 | Yes |
| 25 | SLC5A7 | SLC5A7 Entrez, Source | solute carrier family 5 (choline transporter), member 7 | 1922 | 0.070 | 0.4373 | Yes |
| 26 | QDPR | QDPR Entrez, Source | quinoid dihydropteridine reductase | 1967 | 0.069 | 0.4467 | Yes |
| 27 | BCKDHA | BCKDHA Entrez, Source | branched chain keto acid dehydrogenase E1, alpha polypeptide | 2252 | 0.063 | 0.4369 | No |
| 28 | SLC7A5 | SLC7A5 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 | 2396 | 0.060 | 0.4373 | No |
| 29 | DIO2 | DIO2 Entrez, Source | deiodinase, iodothyronine, type II | 2436 | 0.060 | 0.4454 | No |
| 30 | ASRGL1 | ASRGL1 Entrez, Source | asparaginase like 1 | 2861 | 0.052 | 0.4231 | No |
| 31 | AARS | AARS Entrez, Source | alanyl-tRNA synthetase | 3123 | 0.048 | 0.4124 | No |
| 32 | GCSH | GCSH Entrez, Source | glycine cleavage system protein H (aminomethyl carrier) | 3126 | 0.048 | 0.4211 | No |
| 33 | AMT | AMT Entrez, Source | aminomethyltransferase | 3552 | 0.042 | 0.3969 | No |
| 34 | GLS2 | GLS2 Entrez, Source | glutaminase 2 (liver, mitochondrial) | 3555 | 0.042 | 0.4046 | No |
| 35 | ATF4 | ATF4 Entrez, Source | activating transcription factor 4 (tax-responsive enhancer element B67) | 3579 | 0.042 | 0.4106 | No |
| 36 | SDS | SDS Entrez, Source | serine dehydratase | 3684 | 0.041 | 0.4102 | No |
| 37 | BCKDHB | BCKDHB Entrez, Source | branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) | 3912 | 0.038 | 0.4001 | No |
| 38 | ALDH5A1 | ALDH5A1 Entrez, Source | aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase) | 4114 | 0.035 | 0.3914 | No |
| 39 | GATM | GATM Entrez, Source | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 4229 | 0.033 | 0.3890 | No |
| 40 | P4HB | P4HB Entrez, Source | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide | 4586 | 0.029 | 0.3675 | No |
| 41 | SLC7A7 | SLC7A7 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 | 4600 | 0.029 | 0.3718 | No |
| 42 | ASPA | ASPA Entrez, Source | aspartoacylase (Canavan disease) | 4645 | 0.028 | 0.3737 | No |
| 43 | INDO | INDO Entrez, Source | indoleamine-pyrrole 2,3 dioxygenase | 4751 | 0.027 | 0.3708 | No |
| 44 | GSS | GSS Entrez, Source | glutathione synthetase | 4963 | 0.024 | 0.3594 | No |
| 45 | TGFB2 | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 5353 | 0.020 | 0.3337 | No |
| 46 | GAD1 | GAD1 Entrez, Source | glutamate decarboxylase 1 (brain, 67kDa) | 5455 | 0.019 | 0.3295 | No |
| 47 | GGT1 | GGT1 Entrez, Source | gamma-glutamyltransferase 1 | 5638 | 0.017 | 0.3189 | No |
| 48 | NFS1 | NFS1 Entrez, Source | NFS1 nitrogen fixation 1 (S. cerevisiae) | 5674 | 0.016 | 0.3193 | No |
| 49 | COLQ | COLQ Entrez, Source | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | 6022 | 0.013 | 0.2955 | No |
| 50 | GCLM | GCLM Entrez, Source | glutamate-cysteine ligase, modifier subunit | 6039 | 0.012 | 0.2966 | No |
| 51 | DARS | DARS Entrez, Source | aspartyl-tRNA synthetase | 6355 | 0.009 | 0.2745 | No |
| 52 | GGTLA1 | GGTLA1 Entrez, Source | gamma-glutamyltransferase-like activity 1 | 6376 | 0.009 | 0.2746 | No |
| 53 | ADI1 | ADI1 Entrez, Source | acireductone dioxygenase 1 | 6429 | 0.008 | 0.2722 | No |
| 54 | GOT2 | GOT2 Entrez, Source | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2) | 6812 | 0.004 | 0.2442 | No |
| 55 | KARS | KARS Entrez, Source | lysyl-tRNA synthetase | 6885 | 0.003 | 0.2393 | No |
| 56 | SLC3A1 | SLC3A1 Entrez, Source | 1 | 7608 | -0.005 | 0.1858 | No |
| 57 | WARS | WARS Entrez, Source | tryptophanyl-tRNA synthetase | 7995 | -0.009 | 0.1585 | No |
| 58 | HPD | HPD Entrez, Source | 4-hydroxyphenylpyruvate dioxygenase | 8248 | -0.012 | 0.1418 | No |
| 59 | DHPS | DHPS Entrez, Source | deoxyhypusine synthase | 8363 | -0.014 | 0.1357 | No |
| 60 | GLUD1 | GLUD1 Entrez, Source | glutamate dehydrogenase 1 | 8367 | -0.014 | 0.1381 | No |
| 61 | SCYE1 | SCYE1 Entrez, Source | small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating) | 8723 | -0.018 | 0.1147 | No |
| 62 | OAZ1 | OAZ1 Entrez, Source | ornithine decarboxylase antizyme 1 | 8815 | -0.019 | 0.1114 | No |
| 63 | BPHL | BPHL Entrez, Source | biphenyl hydrolase-like (serine hydrolase; breast epithelial mucin-associated antigen) | 9370 | -0.027 | 0.0746 | No |
| 64 | FARS2 | FARS2 Entrez, Source | phenylalanine-tRNA synthetase 2 (mitochondrial) | 9474 | -0.029 | 0.0721 | No |
| 65 | SLC7A9 | SLC7A9 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 | 9724 | -0.032 | 0.0594 | No |
| 66 | MCCC2 | MCCC2 Entrez, Source | methylcrotonoyl-Coenzyme A carboxylase 2 (beta) | 9753 | -0.033 | 0.0633 | No |
| 67 | HPRT1 | HPRT1 Entrez, Source | hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome) | 11843 | -0.081 | -0.0792 | No |
| 68 | PLOD1 | PLOD1 Entrez, Source | procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 | 12413 | -0.112 | -0.1013 | No |
| 69 | SLC6A6 | SLC6A6 Entrez, Source | solute carrier family 6 (neurotransmitter transporter, taurine), member 6 | 12793 | -0.147 | -0.1028 | No |
| 70 | DDAH1 | DDAH1 Entrez, Source | dimethylarginine dimethylaminohydrolase 1 | 12847 | -0.155 | -0.0781 | No |
| 71 | DDAH2 | DDAH2 Entrez, Source | dimethylarginine dimethylaminohydrolase 2 | 12970 | -0.181 | -0.0539 | No |
| 72 | SMS | SMS Entrez, Source | spermine synthase | 13073 | -0.219 | -0.0211 | No |
| 73 | BCAT1 | BCAT1 Entrez, Source | branched chain aminotransferase 1, cytosolic | 13084 | -0.224 | 0.0194 | No |
