Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | APOPTOTIC_PROGRAM |
| Enrichment Score (ES) | -0.5559756 |
| Normalized Enrichment Score (NES) | -1.7448237 |
| Nominal p-value | 0.006722689 |
| FDR q-value | 0.05082742 |
| FWER p-Value | 0.999 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | BCL2L10 | BCL2L10 Entrez, Source | BCL2-like 10 (apoptosis facilitator) | 1593 | 0.077 | -0.0902 | No |
| 2 | DFFB | DFFB Entrez, Source | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) | 2159 | 0.065 | -0.1079 | No |
| 3 | F2 | F2 Entrez, Source | coagulation factor II (thrombin) | 2483 | 0.059 | -0.1097 | No |
| 4 | DNM1L | DNM1L Entrez, Source | dynamin 1-like | 3235 | 0.047 | -0.1482 | No |
| 5 | GZMB | GZMB Entrez, Source | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 4688 | 0.028 | -0.2468 | No |
| 6 | CASP9 | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 5394 | 0.019 | -0.2924 | No |
| 7 | GZMA | GZMA Entrez, Source | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 5775 | 0.015 | -0.3152 | No |
| 8 | IFNB1 | IFNB1 Entrez, Source | interferon, beta 1, fibroblast | 6079 | 0.012 | -0.3333 | No |
| 9 | CYCS | CYCS Entrez, Source | cytochrome c, somatic | 6937 | 0.003 | -0.3967 | No |
| 10 | VCP | VCP Entrez, Source | valosin-containing protein | 7832 | -0.007 | -0.4611 | No |
| 11 | VDAC1 | VDAC1 Entrez, Source | voltage-dependent anion channel 1 | 8265 | -0.013 | -0.4888 | No |
| 12 | BNIP3 | BNIP3 Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 3 | 8690 | -0.018 | -0.5138 | No |
| 13 | DIABLO | DIABLO Entrez, Source | diablo homolog (Drosophila) | 8967 | -0.021 | -0.5263 | No |
| 14 | BBC3 | BBC3 Entrez, Source | BCL2 binding component 3 | 8982 | -0.022 | -0.5191 | No |
| 15 | STAT1 | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 9067 | -0.023 | -0.5167 | No |
| 16 | MCL1 | MCL1 Entrez, Source | myeloid cell leukemia sequence 1 (BCL2-related) | 9085 | -0.023 | -0.5092 | No |
| 17 | SOD1 | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 9099 | -0.023 | -0.5013 | No |
| 18 | ACIN1 | ACIN1 Entrez, Source | apoptotic chromatin condensation inducer 1 | 9476 | -0.029 | -0.5186 | No |
| 19 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 9613 | -0.031 | -0.5171 | No |
| 20 | TOP2A | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 10131 | -0.039 | -0.5411 | Yes |
| 21 | BAX | BAX Entrez, Source | BCL2-associated X protein | 10281 | -0.041 | -0.5366 | Yes |
| 22 | DFFA | DFFA Entrez, Source | DNA fragmentation factor, 45kDa, alpha polypeptide | 10349 | -0.042 | -0.5255 | Yes |
| 23 | BCL2L1 | BCL2L1 Entrez, Source | BCL2-like 1 | 10657 | -0.048 | -0.5301 | Yes |
| 24 | GPX1 | GPX1 Entrez, Source | glutathione peroxidase 1 | 10706 | -0.050 | -0.5148 | Yes |
| 25 | BAK1 | BAK1 Entrez, Source | BCL2-antagonist/killer 1 | 10973 | -0.055 | -0.5136 | Yes |
| 26 | BIK | BIK Entrez, Source | BCL2-interacting killer (apoptosis-inducing) | 11095 | -0.058 | -0.5006 | Yes |
| 27 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 11131 | -0.059 | -0.4807 | Yes |
| 28 | HIP1 | HIP1 Entrez, Source | huntingtin interacting protein 1 | 11319 | -0.063 | -0.4708 | Yes |
| 29 | BID | BID Entrez, Source | BH3 interacting domain death agonist | 11376 | -0.064 | -0.4503 | Yes |
| 30 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 11387 | -0.065 | -0.4263 | Yes |
| 31 | BAD | BAD Entrez, Source | BCL2-antagonist of cell death | 11428 | -0.066 | -0.4041 | Yes |
| 32 | CASP7 | CASP7 Entrez, Source | caspase 7, apoptosis-related cysteine peptidase | 11446 | -0.066 | -0.3799 | Yes |
| 33 | PSEN2 | PSEN2 Entrez, Source | presenilin 2 (Alzheimer disease 4) | 11726 | -0.076 | -0.3717 | Yes |
| 34 | CASP3 | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 12003 | -0.087 | -0.3592 | Yes |
| 35 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 12064 | -0.090 | -0.3293 | Yes |
| 36 | MTCH1 | MTCH1 Entrez, Source | mitochondrial carrier homolog 1 (C. elegans) | 12580 | -0.124 | -0.3206 | Yes |
| 37 | PPT1 | PPT1 Entrez, Source | palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) | 12619 | -0.127 | -0.2749 | Yes |
| 38 | CASP2 | CASP2 Entrez, Source | caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) | 12946 | -0.175 | -0.2326 | Yes |
| 39 | F2R | F2R Entrez, Source | coagulation factor II (thrombin) receptor | 13224 | -0.321 | -0.1308 | Yes |
| 40 | APAF1 | APAF1 Entrez, Source | apoptotic peptidase activating factor | 13256 | -0.365 | 0.0065 | Yes |
