Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | BRCA1_OVEREXP_UP |
| Enrichment Score (ES) | -0.45929006 |
| Normalized Enrichment Score (NES) | -1.7321186 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.05389788 |
| FWER p-Value | 0.999 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SEPHS2 | SEPHS2 Entrez, Source | selenophosphate synthetase 2 | 356 | 0.141 | -0.0090 | No |
| 2 | ENPP2 | ENPP2 Entrez, Source | ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) | 511 | 0.124 | -0.0048 | No |
| 3 | ID4 | ID4 Entrez, Source | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 547 | 0.122 | 0.0081 | No |
| 4 | HIST2H2AA3 | HIST2H2AA3 Entrez, Source | histone cluster 2, H2aa3 | 699 | 0.112 | 0.0109 | No |
| 5 | ADCYAP1 | ADCYAP1 Entrez, Source | adenylate cyclase activating polypeptide 1 (pituitary) | 918 | 0.101 | 0.0073 | No |
| 6 | ATP6V0A1 | ATP6V0A1 Entrez, Source | ATPase, H+ transporting, lysosomal V0 subunit a1 | 974 | 0.099 | 0.0157 | No |
| 7 | TUBB3 | TUBB3 Entrez, Source | tubulin, beta 3 | 1042 | 0.096 | 0.0228 | No |
| 8 | SSR1 | SSR1 Entrez, Source | signal sequence receptor, alpha (translocon-associated protein alpha) | 1133 | 0.092 | 0.0277 | No |
| 9 | PPP1R1A | PPP1R1A Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 1A | 1155 | 0.091 | 0.0378 | No |
| 10 | TITF1 | TITF1 Entrez, Source | thyroid transcription factor 1 | 1498 | 0.079 | 0.0220 | No |
| 11 | TSNAX | TSNAX Entrez, Source | translin-associated factor X | 2010 | 0.068 | -0.0080 | No |
| 12 | CD9 | CD9 Entrez, Source | CD9 molecule | 2527 | 0.058 | -0.0396 | No |
| 13 | HAGH | HAGH Entrez, Source | hydroxyacylglutathione hydrolase | 2676 | 0.056 | -0.0437 | No |
| 14 | EXOC5 | EXOC5 Entrez, Source | exocyst complex component 5 | 2804 | 0.053 | -0.0465 | No |
| 15 | PPP6C | PPP6C Entrez, Source | protein phosphatase 6, catalytic subunit | 3145 | 0.048 | -0.0662 | No |
| 16 | GUCY1B3 | GUCY1B3 Entrez, Source | guanylate cyclase 1, soluble, beta 3 | 3272 | 0.046 | -0.0698 | No |
| 17 | FGF9 | FGF9 Entrez, Source | fibroblast growth factor 9 (glia-activating factor) | 3315 | 0.046 | -0.0672 | No |
| 18 | LAMA3 | LAMA3 Entrez, Source | laminin, alpha 3 | 3419 | 0.044 | -0.0694 | No |
| 19 | SEPP1 | SEPP1 Entrez, Source | selenoprotein P, plasma, 1 | 3423 | 0.044 | -0.0640 | No |
| 20 | WWP1 | WWP1 Entrez, Source | WW domain containing E3 ubiquitin protein ligase 1 | 3459 | 0.044 | -0.0611 | No |
| 21 | CSDA | CSDA Entrez, Source | cold shock domain protein A | 3880 | 0.038 | -0.0880 | No |
| 22 | FRAP1 | FRAP1 Entrez, Source | FK506 binding protein 12-rapamycin associated protein 1 | 3947 | 0.037 | -0.0882 | No |
| 23 | IDH1 | IDH1 Entrez, Source | isocitrate dehydrogenase 1 (NADP+), soluble | 3953 | 0.037 | -0.0839 | No |
| 24 | KDELR2 | KDELR2 Entrez, Source | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 4041 | 0.036 | -0.0859 | No |
| 25 | FSTL1 | FSTL1 Entrez, Source | follistatin-like 1 | 4179 | 0.034 | -0.0919 | No |
| 26 | TMED2 | TMED2 Entrez, Source | transmembrane emp24 domain trafficking protein 2 | 4183 | 0.034 | -0.0878 | No |
| 27 | DDX3X | DDX3X Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked | 4329 | 0.032 | -0.0947 | No |
| 28 | RABGGTB | RABGGTB Entrez, Source | Rab geranylgeranyltransferase, beta subunit | 4373 | 0.032 | -0.0939 | No |
| 29 | GALNT3 | GALNT3 Entrez, Source | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) | 4949 | 0.024 | -0.1343 | No |
| 30 | NFYC | NFYC Entrez, Source | nuclear transcription factor Y, gamma | 5050 | 0.023 | -0.1389 | No |
| 31 | COPS8 | COPS8 Entrez, Source | COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) | 5364 | 0.020 | -0.1600 | No |
| 32 | NDUFS1 | NDUFS1 Entrez, Source | NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) | 5421 | 0.019 | -0.1618 | No |
| 33 | RAB6A | RAB6A Entrez, Source | RAB6A, member RAS oncogene family | 5432 | 0.019 | -0.1602 | No |
| 34 | SDHC | SDHC Entrez, Source | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa | 5522 | 0.018 | -0.1646 | No |
| 35 | PCBD1 | PCBD1 Entrez, Source | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) | 5591 | 0.017 | -0.1676 | No |
| 36 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 5802 | 0.015 | -0.1815 | No |
| 37 | NID1 | NID1 Entrez, Source | nidogen 1 | 6040 | 0.012 | -0.1979 | No |
| 38 | TEGT | TEGT Entrez, Source | testis enhanced gene transcript (BAX inhibitor 1) | 6284 | 0.010 | -0.2150 | No |
| 39 | ADD3 | ADD3 Entrez, Source | adducin 3 (gamma) | 6472 | 0.008 | -0.2281 | No |
| 40 | HTATIP | HTATIP Entrez, Source | HIV-1 Tat interacting protein, 60kDa | 6539 | 0.007 | -0.2322 | No |
| 41 | PGRMC1 | PGRMC1 Entrez, Source | progesterone receptor membrane component 1 | 6542 | 0.007 | -0.2315 | No |
| 42 | TSG101 | TSG101 Entrez, Source | tumor susceptibility gene 101 | 6620 | 0.006 | -0.2365 | No |
| 43 | ZNF148 | ZNF148 Entrez, Source | zinc finger protein 148 | 6751 | 0.005 | -0.2457 | No |
| 44 | CREB1 | CREB1 Entrez, Source | cAMP responsive element binding protein 1 | 6781 | 0.004 | -0.2474 | No |
| 45 | TAF11 | TAF11 Entrez, Source | TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa | 6844 | 0.004 | -0.2516 | No |
| 46 | ARF6 | ARF6 Entrez, Source | ADP-ribosylation factor 6 | 6899 | 0.003 | -0.2553 | No |
| 47 | LTB4DH | LTB4DH Entrez, Source | leukotriene B4 12-hydroxydehydrogenase | 6909 | 0.003 | -0.2556 | No |
| 48 | TMED10 | TMED10 Entrez, Source | transmembrane emp24-like trafficking protein 10 (yeast) | 7149 | 0.000 | -0.2736 | No |
| 49 | RAB1A | RAB1A Entrez, Source | RAB1A, member RAS oncogene family | 7222 | -0.000 | -0.2790 | No |
| 50 | P2RX4 | P2RX4 Entrez, Source | purinergic receptor P2X, ligand-gated ion channel, 4 | 7423 | -0.003 | -0.2938 | No |
| 51 | CSNK1A1 | CSNK1A1 Entrez, Source | casein kinase 1, alpha 1 | 7431 | -0.003 | -0.2939 | No |
| 52 | KCNK1 | KCNK1 Entrez, Source | potassium channel, subfamily K, member 1 | 7451 | -0.003 | -0.2949 | No |
| 53 | SFRS5 | SFRS5 Entrez, Source | splicing factor, arginine/serine-rich 5 | 7522 | -0.004 | -0.2997 | No |
| 54 | TM9SF1 | TM9SF1 Entrez, Source | transmembrane 9 superfamily member 1 | 7538 | -0.004 | -0.3003 | No |
| 55 | GATA3 | GATA3 Entrez, Source | GATA binding protein 3 | 7644 | -0.005 | -0.3076 | No |
| 56 | COPS2 | COPS2 Entrez, Source | COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) | 7649 | -0.005 | -0.3072 | No |
| 57 | PRKAR1A | PRKAR1A Entrez, Source | protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) | 7920 | -0.009 | -0.3266 | No |
| 58 | UBE2D3 | UBE2D3 Entrez, Source | ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) | 7926 | -0.009 | -0.3258 | No |
| 59 | STC1 | STC1 Entrez, Source | stanniocalcin 1 | 8140 | -0.011 | -0.3405 | No |
| 60 | AGPS | AGPS Entrez, Source | alkylglycerone phosphate synthase | 8182 | -0.012 | -0.3422 | No |
| 61 | MAP2K1 | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 8219 | -0.012 | -0.3434 | No |
| 62 | SUCLG1 | SUCLG1 Entrez, Source | succinate-CoA ligase, GDP-forming, alpha subunit | 8338 | -0.013 | -0.3506 | No |
| 63 | TM9SF2 | TM9SF2 Entrez, Source | transmembrane 9 superfamily member 2 | 8603 | -0.017 | -0.3684 | No |
| 64 | BNIP3 | BNIP3 Entrez, Source | BCL2/adenovirus E1B 19kDa interacting protein 3 | 8690 | -0.018 | -0.3726 | No |
| 65 | RAB2 | RAB2 Entrez, Source | RAB2, member RAS oncogene family | 8693 | -0.018 | -0.3705 | No |
| 66 | ARPC1A | ARPC1A Entrez, Source | actin related protein 2/3 complex, subunit 1A, 41kDa | 8847 | -0.020 | -0.3795 | No |
| 67 | LUM | LUM Entrez, Source | lumican | 8862 | -0.020 | -0.3780 | No |
| 68 | STAT1 | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 9067 | -0.023 | -0.3906 | No |
| 69 | SMC1A | SMC1A Entrez, Source | structural maintenance of chromosomes 1A | 9111 | -0.023 | -0.3909 | No |
| 70 | RDX | RDX Entrez, Source | radixin | 9216 | -0.025 | -0.3956 | No |
| 71 | ID2 | ID2 Entrez, Source | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 9384 | -0.027 | -0.4048 | No |
| 72 | PPP4C | PPP4C Entrez, Source | protein phosphatase 4 (formerly X), catalytic subunit | 9891 | -0.035 | -0.4386 | No |
| 73 | FCGRT | FCGRT Entrez, Source | Fc fragment of IgG, receptor, transporter, alpha | 9933 | -0.035 | -0.4372 | No |
| 74 | ZFP36L1 | ZFP36L1 Entrez, Source | zinc finger protein 36, C3H type-like 1 | 10023 | -0.037 | -0.4392 | No |
| 75 | JAK1 | JAK1 Entrez, Source | Janus kinase 1 (a protein tyrosine kinase) | 10118 | -0.039 | -0.4414 | No |
| 76 | HMGN3 | HMGN3 Entrez, Source | high mobility group nucleosomal binding domain 3 | 10126 | -0.039 | -0.4370 | No |
| 77 | TOP2A | TOP2A Entrez, Source | topoisomerase (DNA) II alpha 170kDa | 10131 | -0.039 | -0.4324 | No |
| 78 | ALDH7A1 | ALDH7A1 Entrez, Source | aldehyde dehydrogenase 7 family, member A1 | 10287 | -0.041 | -0.4388 | No |
| 79 | MAP2K4 | MAP2K4 Entrez, Source | mitogen-activated protein kinase kinase 4 | 10315 | -0.042 | -0.4356 | No |
| 80 | TRAM1 | TRAM1 Entrez, Source | translocation associated membrane protein 1 | 10392 | -0.043 | -0.4358 | No |
| 81 | WRB | WRB Entrez, Source | tryptophan rich basic protein | 10543 | -0.046 | -0.4413 | No |
| 82 | DR1 | DR1 Entrez, Source | down-regulator of transcription 1, TBP-binding (negative cofactor 2) | 10633 | -0.048 | -0.4420 | No |
| 83 | KIF5B | KIF5B Entrez, Source | kinesin family member 5B | 10742 | -0.050 | -0.4437 | No |
| 84 | VAMP3 | VAMP3 Entrez, Source | vesicle-associated membrane protein 3 (cellubrevin) | 10788 | -0.051 | -0.4406 | No |
| 85 | ABCD3 | ABCD3 Entrez, Source | ATP-binding cassette, sub-family D (ALD), member 3 | 10872 | -0.053 | -0.4401 | No |
| 86 | EXTL2 | EXTL2 Entrez, Source | exostoses (multiple)-like 2 | 10968 | -0.055 | -0.4403 | No |
| 87 | ACTR1B | ACTR1B Entrez, Source | ARP1 actin-related protein 1 homolog B, centractin beta (yeast) | 11168 | -0.060 | -0.4477 | No |
| 88 | MFGE8 | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 11250 | -0.061 | -0.4461 | No |
| 89 | SCAMP1 | SCAMP1 Entrez, Source | secretory carrier membrane protein 1 | 11279 | -0.062 | -0.4403 | No |
| 90 | DEK | DEK Entrez, Source | DEK oncogene (DNA binding) | 11531 | -0.070 | -0.4504 | Yes |
| 91 | NEU1 | NEU1 Entrez, Source | sialidase 1 (lysosomal sialidase) | 11548 | -0.070 | -0.4427 | Yes |
| 92 | CIRBP | CIRBP Entrez, Source | cold inducible RNA binding protein | 11768 | -0.078 | -0.4494 | Yes |
| 93 | HMMR | HMMR Entrez, Source | hyaluronan-mediated motility receptor (RHAMM) | 11850 | -0.081 | -0.4452 | Yes |
| 94 | NPC2 | NPC2 Entrez, Source | Niemann-Pick disease, type C2 | 11858 | -0.081 | -0.4353 | Yes |
| 95 | CXADR | CXADR Entrez, Source | coxsackie virus and adenovirus receptor | 11909 | -0.084 | -0.4285 | Yes |
| 96 | SERINC3 | SERINC3 Entrez, Source | serine incorporator 3 | 11933 | -0.084 | -0.4195 | Yes |
| 97 | CALM2 | CALM2 Entrez, Source | calmodulin 2 (phosphorylase kinase, delta) | 12036 | -0.089 | -0.4159 | Yes |
| 98 | ACTA2 | ACTA2 Entrez, Source | actin, alpha 2, smooth muscle, aorta | 12081 | -0.091 | -0.4076 | Yes |
| 99 | MAT2A | MAT2A Entrez, Source | methionine adenosyltransferase II, alpha | 12127 | -0.093 | -0.3992 | Yes |
| 100 | ITGB3BP | ITGB3BP Entrez, Source | integrin beta 3 binding protein (beta3-endonexin) | 12281 | -0.102 | -0.3978 | Yes |
| 101 | PICALM | PICALM Entrez, Source | phosphatidylinositol binding clathrin assembly protein | 12285 | -0.102 | -0.3850 | Yes |
| 102 | TIMM17A | TIMM17A Entrez, Source | translocase of inner mitochondrial membrane 17 homolog A (yeast) | 12312 | -0.104 | -0.3736 | Yes |
| 103 | ADD1 | ADD1 Entrez, Source | adducin 1 (alpha) | 12346 | -0.107 | -0.3625 | Yes |
| 104 | IGF2R | IGF2R Entrez, Source | insulin-like growth factor 2 receptor | 12385 | -0.110 | -0.3514 | Yes |
| 105 | PPIC | PPIC Entrez, Source | peptidylprolyl isomerase C (cyclophilin C) | 12389 | -0.110 | -0.3376 | Yes |
| 106 | TFPI2 | TFPI2 Entrez, Source | tissue factor pathway inhibitor 2 | 12427 | -0.112 | -0.3261 | Yes |
| 107 | ANXA4 | ANXA4 Entrez, Source | annexin A4 | 12446 | -0.114 | -0.3129 | Yes |
| 108 | PLD3 | PLD3 Entrez, Source | phospholipase D family, member 3 | 12657 | -0.130 | -0.3122 | Yes |
| 109 | PTPN1 | PTPN1 Entrez, Source | protein tyrosine phosphatase, non-receptor type 1 | 12685 | -0.133 | -0.2973 | Yes |
| 110 | ANXA2 | ANXA2 Entrez, Source | annexin A2 | 12686 | -0.133 | -0.2803 | Yes |
| 111 | KIF2A | KIF2A Entrez, Source | kinesin heavy chain member 2A | 12733 | -0.139 | -0.2661 | Yes |
| 112 | KIF2C | KIF2C Entrez, Source | kinesin family member 2C | 12895 | -0.164 | -0.2575 | Yes |
| 113 | CYBA | CYBA Entrez, Source | cytochrome b-245, alpha polypeptide | 12938 | -0.173 | -0.2386 | Yes |
| 114 | CD47 | CD47 Entrez, Source | CD47 molecule | 12956 | -0.177 | -0.2173 | Yes |
| 115 | ALCAM | ALCAM Entrez, Source | activated leukocyte cell adhesion molecule | 12991 | -0.186 | -0.1962 | Yes |
| 116 | TCEAL1 | TCEAL1 Entrez, Source | transcription elongation factor A (SII)-like 1 | 13184 | -0.284 | -0.1745 | Yes |
| 117 | PAM | PAM Entrez, Source | peptidylglycine alpha-amidating monooxygenase | 13213 | -0.306 | -0.1376 | Yes |
| 118 | CITED2 | CITED2 Entrez, Source | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 13226 | -0.322 | -0.0975 | Yes |
| 119 | GNAI1 | GNAI1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 13239 | -0.335 | -0.0557 | Yes |
| 120 | ANXA1 | ANXA1 Entrez, Source | annexin A1 | 13312 | -0.498 | 0.0023 | Yes |
