Details for gene set CARBOXYLIC_ACID_METABOLIC

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos
Phenotype	class.cls#double_gel_48h_versus_single_gel_48h_repos
Upregulated in class	double_gel_48h
GeneSet	CARBOXYLIC_ACID_METABOLIC_PROCESS
Enrichment Score (ES)	0.51849633
Normalized Enrichment Score (NES)	2.2144082
Nominal p-value	0.0
FDR q-value	4.2122067E-4
FWER p-Value	0.0080

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	SLC27A5	SLC27A5 Entrez, Source	solute carrier family 27 (fatty acid transporter), member 5	12	0.395	0.0363	Yes
2	FTCD	FTCD Entrez, Source	formiminotransferase cyclodeaminase	27	0.336	0.0668	Yes
3	BBOX1	BBOX1 Entrez, Source	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1	37	0.303	0.0946	Yes
4	CDO1	CDO1 Entrez, Source	cysteine dioxygenase, type I	54	0.279	0.1196	Yes
5	SC4MOL	SC4MOL Entrez, Source	sterol-C4-methyl oxidase-like	90	0.236	0.1391	Yes
6	HACL1	HACL1 Entrez, Source	2-hydroxyacyl-CoA lyase 1	94	0.229	0.1604	Yes
7	GLYAT	GLYAT Entrez, Source	glycine-N-acyltransferase	102	0.225	0.1810	Yes
8	ARG1	ARG1 Entrez, Source	arginase, liver	117	0.209	0.1996	Yes
9	ACLY	ACLY Entrez, Source	ATP citrate lyase	127	0.202	0.2179	Yes
10	PPARA	PPARA Entrez, Source	peroxisome proliferative activated receptor, alpha	155	0.190	0.2338	Yes
11	GOT1	GOT1 Entrez, Source	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	197	0.173	0.2470	Yes
12	GCK	GCK Entrez, Source	glucokinase (hexokinase 4, maturity onset diabetes of the young 2)	218	0.170	0.2614	Yes
13	ASL	ASL Entrez, Source	argininosuccinate lyase	273	0.154	0.2718	Yes
14	ALDH6A1	ALDH6A1 Entrez, Source	aldehyde dehydrogenase 6 family, member A1	314	0.148	0.2827	Yes
15	MAT1A	MAT1A Entrez, Source	methionine adenosyltransferase I, alpha	323	0.146	0.2958	Yes
16	FADS2	FADS2 Entrez, Source	fatty acid desaturase 2	362	0.140	0.3061	Yes
17	HDC	HDC Entrez, Source	histidine decarboxylase	383	0.138	0.3176	Yes
18	NR1H4	NR1H4 Entrez, Source	nuclear receptor subfamily 1, group H, member 4	390	0.137	0.3300	Yes
19	ACOX2	ACOX2 Entrez, Source	acyl-Coenzyme A oxidase 2, branched chain	442	0.130	0.3384	Yes
20	HGD	HGD Entrez, Source	homogentisate 1,2-dioxygenase (homogentisate oxidase)	457	0.129	0.3495	Yes
21	CPT1A	CPT1A Entrez, Source	carnitine palmitoyltransferase 1A (liver)	469	0.128	0.3607	Yes
22	PFKFB1	PFKFB1 Entrez, Source	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	476	0.127	0.3722	Yes
23	AS3MT	AS3MT Entrez, Source	arsenic (+3 oxidation state) methyltransferase	480	0.127	0.3839	Yes
24	FAH	FAH Entrez, Source	fumarylacetoacetate hydrolase (fumarylacetoacetase)	489	0.126	0.3952	Yes
25	SLC7A2	SLC7A2 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	494	0.125	0.4066	Yes
26	ALDH1L1	ALDH1L1 Entrez, Source	aldehyde dehydrogenase 1 family, member L1	502	0.125	0.4178	Yes
27	ACADVL	ACADVL Entrez, Source	acyl-Coenzyme A dehydrogenase, very long chain	526	0.123	0.4277	Yes
28	AGXT	AGXT Entrez, Source	alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase)	591	0.118	0.4340	Yes
29	SLC25A10	SLC25A10 Entrez, Source	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	790	0.107	0.4291	Yes
30	BCKDK	BCKDK Entrez, Source	branched chain ketoacid dehydrogenase kinase	866	0.104	0.4332	Yes
31	PTS	PTS Entrez, Source	6-pyruvoyltetrahydropterin synthase	877	0.104	0.4422	Yes
32	GAMT	GAMT Entrez, Source	guanidinoacetate N-methyltransferase	910	0.102	0.4493	Yes
33	SCLY	SCLY Entrez, Source	selenocysteine lyase	1056	0.095	0.4473	Yes
34	CD74	CD74 Entrez, Source	CD74 molecule, major histocompatibility complex, class II invariant chain	1097	0.093	0.4531	Yes
35	SLC25A15	SLC25A15 Entrez, Source	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15	1184	0.090	0.4550	Yes
36	GAD2	GAD2 Entrez, Source	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	1212	0.089	0.4614	Yes
37	GCLC	GCLC Entrez, Source	glutamate-cysteine ligase, catalytic subunit	1237	0.088	0.4679	Yes
38	MSRA	MSRA Entrez, Source	methionine sulfoxide reductase A	1404	0.082	0.4630	Yes
39	GNE	GNE Entrez, Source	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	1441	0.081	0.4680	Yes
40	ME1	ME1 Entrez, Source	malic enzyme 1, NADP(+)-dependent, cytosolic	1493	0.080	0.4716	Yes
41	PAH	PAH Entrez, Source	phenylalanine hydroxylase	1513	0.079	0.4776	Yes
42	ECHS1	ECHS1 Entrez, Source	enoyl Coenzyme A hydratase, short chain, 1, mitochondrial	1528	0.079	0.4839	Yes
43	UGDH	UGDH Entrez, Source	UDP-glucose dehydrogenase	1562	0.078	0.4887	Yes
44	SLC7A8	SLC7A8 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 8	1584	0.077	0.4944	Yes
45	BAAT	BAAT Entrez, Source	bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)	1625	0.077	0.4986	Yes
46	NANP	NANP Entrez, Source	N-acetylneuraminic acid phosphatase	1668	0.075	0.5025	Yes
47	ACN9	ACN9 Entrez, Source	ACN9 homolog (S. cerevisiae)	1743	0.073	0.5038	Yes
48	PTGES	PTGES Entrez, Source	prostaglandin E synthase	1797	0.072	0.5065	Yes
49	YARS	YARS Entrez, Source	tyrosyl-tRNA synthetase	1907	0.070	0.5049	Yes
50	FADS1	FADS1 Entrez, Source	fatty acid desaturase 1	1932	0.070	0.5096	Yes
51	QDPR	QDPR Entrez, Source	quinoid dihydropteridine reductase	1967	0.069	0.5135	Yes
52	AKR1D1	AKR1D1 Entrez, Source	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	2098	0.066	0.5099	Yes
53	FAAH	FAAH Entrez, Source	fatty acid amide hydrolase	2116	0.066	0.5147	Yes
54	BCKDHA	BCKDHA Entrez, Source	branched chain keto acid dehydrogenase E1, alpha polypeptide	2252	0.063	0.5104	Yes
55	CYP4F2	CYP4F2 Entrez, Source	cytochrome P450, family 4, subfamily F, polypeptide 2	2291	0.062	0.5134	Yes
56	MLYCD	MLYCD Entrez, Source	malonyl-CoA decarboxylase	2302	0.062	0.5185	Yes
57	SLC7A5	SLC7A5 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	2396	0.060	0.5171	No
58	PPARD	PPARD Entrez, Source	peroxisome proliferative activated receptor, delta	2558	0.058	0.5103	No
59	ASRGL1	ASRGL1 Entrez, Source	asparaginase like 1	2861	0.052	0.4924	No
60	TNFRSF1A	TNFRSF1A Entrez, Source	tumor necrosis factor receptor superfamily, member 1A	2994	0.050	0.4871	No
61	PTGS1	PTGS1 Entrez, Source	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	3007	0.050	0.4909	No
62	AARS	AARS Entrez, Source	alanyl-tRNA synthetase	3123	0.048	0.4867	No
63	GCSH	GCSH Entrez, Source	glycine cleavage system protein H (aminomethyl carrier)	3126	0.048	0.4911	No
64	ACOT2	ACOT2 Entrez, Source	acyl-CoA thioesterase 2	3435	0.044	0.4719	No
65	ACADSB	ACADSB Entrez, Source	acyl-Coenzyme A dehydrogenase, short/branched chain	3526	0.043	0.4691	No
66	AMT	AMT Entrez, Source	aminomethyltransferase	3552	0.042	0.4712	No
67	GLS2	GLS2 Entrez, Source	glutaminase 2 (liver, mitochondrial)	3555	0.042	0.4750	No
68	ATF4	ATF4 Entrez, Source	activating transcription factor 4 (tax-responsive enhancer element B67)	3579	0.042	0.4772	No
69	GBA2	GBA2 Entrez, Source	glucosidase, beta (bile acid) 2	3630	0.041	0.4773	No
70	SDS	SDS Entrez, Source	serine dehydratase	3684	0.041	0.4771	No
71	GNPAT	GNPAT Entrez, Source	glyceronephosphate O-acyltransferase	3783	0.039	0.4734	No
72	ACO2	ACO2 Entrez, Source	aconitase 2, mitochondrial	3799	0.039	0.4760	No
73	BCKDHB	BCKDHB Entrez, Source	branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease)	3912	0.038	0.4711	No
74	HPGD	HPGD Entrez, Source	hydroxyprostaglandin dehydrogenase 15-(NAD)	3915	0.038	0.4745	No
75	IDH1	IDH1 Entrez, Source	isocitrate dehydrogenase 1 (NADP+), soluble	3953	0.037	0.4751	No
76	ALDH5A1	ALDH5A1 Entrez, Source	aldehyde dehydrogenase 5 family, member A1 (succinate-semialdehyde dehydrogenase)	4114	0.035	0.4663	No
77	GATM	GATM Entrez, Source	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	4229	0.033	0.4608	No
78	PECI	PECI Entrez, Source	peroxisomal D3,D2-enoyl-CoA isomerase	4265	0.033	0.4613	No
79	HADHB	HADHB Entrez, Source	hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit	4313	0.032	0.4608	No
80	IGF1	IGF1 Entrez, Source	insulin-like growth factor 1 (somatomedin C)	4345	0.032	0.4614	No
81	SLC7A7	SLC7A7 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7	4600	0.029	0.4449	No
82	ASPA	ASPA Entrez, Source	aspartoacylase (Canavan disease)	4645	0.028	0.4442	No
83	ACO1	ACO1 Entrez, Source	aconitase 1, soluble	4655	0.028	0.4462	No
84	ACOX3	ACOX3 Entrez, Source	acyl-Coenzyme A oxidase 3, pristanoyl	4732	0.027	0.4430	No
85	INDO	INDO Entrez, Source	indoleamine-pyrrole 2,3 dioxygenase	4751	0.027	0.4441	No
86	GSS	GSS Entrez, Source	glutathione synthetase	4963	0.024	0.4305	No
87	HAO2	HAO2 Entrez, Source	hydroxyacid oxidase 2 (long chain)	4991	0.024	0.4307	No
88	GAD1	GAD1 Entrez, Source	glutamate decarboxylase 1 (brain, 67kDa)	5455	0.019	0.3974	No
89	GGT1	GGT1 Entrez, Source	gamma-glutamyltransferase 1	5638	0.017	0.3852	No
90	NFS1	NFS1 Entrez, Source	NFS1 nitrogen fixation 1 (S. cerevisiae)	5674	0.016	0.3841	No
91	ACADM	ACADM Entrez, Source	acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain	5845	0.014	0.3726	No
92	GCLM	GCLM Entrez, Source	glutamate-cysteine ligase, modifier subunit	6039	0.012	0.3591	No
93	IDH3B	IDH3B Entrez, Source	isocitrate dehydrogenase 3 (NAD+) beta	6092	0.012	0.3563	No
94	DARS	DARS Entrez, Source	aspartyl-tRNA synthetase	6355	0.009	0.3373	No
95	GGTLA1	GGTLA1 Entrez, Source	gamma-glutamyltransferase-like activity 1	6376	0.009	0.3366	No
96	ADI1	ADI1 Entrez, Source	acireductone dioxygenase 1	6429	0.008	0.3335	No
97	PPARGC1A	PPARGC1A Entrez, Source	peroxisome proliferative activated receptor, gamma, coactivator 1, alpha	6549	0.007	0.3251	No
98	GOT2	GOT2 Entrez, Source	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	6812	0.004	0.3057	No
99	KARS	KARS Entrez, Source	lysyl-tRNA synthetase	6885	0.003	0.3005	No
100	PTGDS	PTGDS Entrez, Source	prostaglandin D2 synthase 21kDa (brain)	6985	0.002	0.2932	No
101	ADIPOR2	ADIPOR2 Entrez, Source	adiponectin receptor 2	7084	0.001	0.2859	No
102	SLC3A1	SLC3A1 Entrez, Source	1	7608	-0.005	0.2468	No
103	ACOT12	ACOT12 Entrez, Source	acyl-CoA thioesterase 12	7714	-0.006	0.2394	No
104	AGPAT1	AGPAT1 Entrez, Source	1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)	7919	-0.009	0.2248	No
105	ACADS	ACADS Entrez, Source	acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain	7949	-0.009	0.2234	No
106	WARS	WARS Entrez, Source	tryptophanyl-tRNA synthetase	7995	-0.009	0.2209	No
107	ECH1	ECH1 Entrez, Source	enoyl Coenzyme A hydratase 1, peroxisomal	8150	-0.011	0.2103	No
108	HPD	HPD Entrez, Source	4-hydroxyphenylpyruvate dioxygenase	8248	-0.012	0.2041	No
109	GLUD1	GLUD1 Entrez, Source	glutamate dehydrogenase 1	8367	-0.014	0.1965	No
110	HSD3B7	HSD3B7 Entrez, Source	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	8545	-0.016	0.1846	No
111	SCYE1	SCYE1 Entrez, Source	small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)	8723	-0.018	0.1729	No
112	ARPP-19	ARPP-19 Entrez, Source	-	8985	-0.022	0.1552	No
113	CPT1B	CPT1B Entrez, Source	carnitine palmitoyltransferase 1B (muscle)	9047	-0.023	0.1527	No
114	FARS2	FARS2 Entrez, Source	phenylalanine-tRNA synthetase 2 (mitochondrial)	9474	-0.029	0.1231	No
115	SLC7A9	SLC7A9 Entrez, Source	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	9724	-0.032	0.1073	No
116	MCCC2	MCCC2 Entrez, Source	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	9753	-0.033	0.1083	No
117	CYP7B1	CYP7B1 Entrez, Source	cytochrome P450, family 7, subfamily B, polypeptide 1	9803	-0.033	0.1077	No
118	LTA4H	LTA4H Entrez, Source	leukotriene A4 hydrolase	9958	-0.036	0.0994	No
119	ABCD2	ABCD2 Entrez, Source	ATP-binding cassette, sub-family D (ALD), member 2	10245	-0.041	0.0816	No
120	ADIPOR1	ADIPOR1 Entrez, Source	adiponectin receptor 1	10701	-0.049	0.0518	No
121	MIF	MIF Entrez, Source	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11278	-0.062	0.0140	No
122	DEGS1	DEGS1 Entrez, Source	degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)	11526	-0.069	0.0018	No
123	PLOD1	PLOD1 Entrez, Source	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1	12413	-0.112	-0.0547	No
124	LYPLA3	LYPLA3 Entrez, Source	lysophospholipase 3 (lysosomal phospholipase A2)	12539	-0.121	-0.0528	No
125	CROT	CROT Entrez, Source	carnitine O-octanoyltransferase	12676	-0.132	-0.0507	No
126	BRCA1	BRCA1 Entrez, Source	breast cancer 1, early onset	12787	-0.146	-0.0454	No
127	SLC6A6	SLC6A6 Entrez, Source	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	12793	-0.147	-0.0319	No
128	DDAH1	DDAH1 Entrez, Source	dimethylarginine dimethylaminohydrolase 1	12847	-0.155	-0.0214	No
129	DDAH2	DDAH2 Entrez, Source	dimethylarginine dimethylaminohydrolase 2	12970	-0.181	-0.0136	No
130	SMS	SMS Entrez, Source	spermine synthase	13073	-0.219	-0.0007	No
131	BCAT1	BCAT1 Entrez, Source	branched chain aminotransferase 1, cytosolic	13084	-0.224	0.0195	No