Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | double_gel_48h |
| GeneSet | CHOLESTEROL_BIOSYNTHESIS |
| Enrichment Score (ES) | 0.96279234 |
| Normalized Enrichment Score (NES) | 2.575718 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | IDI1 | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 13 | 0.382 | 0.1023 | Yes |
| 2 | LSS | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 20 | 0.353 | 0.1972 | Yes |
| 3 | MVD | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 21 | 0.352 | 0.2923 | Yes |
| 4 | HMGCS1 | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 36 | 0.306 | 0.3737 | Yes |
| 5 | FDFT1 | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 44 | 0.291 | 0.4518 | Yes |
| 6 | HMGCR | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 55 | 0.278 | 0.5262 | Yes |
| 7 | CYP51A1 | CYP51A1 Entrez, Source | cytochrome P450, family 51, subfamily A, polypeptide 1 | 56 | 0.277 | 0.6010 | Yes |
| 8 | PMVK | PMVK Entrez, Source | phosphomevalonate kinase | 73 | 0.247 | 0.6666 | Yes |
| 9 | SC4MOL | SC4MOL Entrez, Source | sterol-C4-methyl oxidase-like | 90 | 0.236 | 0.7292 | Yes |
| 10 | SQLE | SQLE Entrez, Source | squalene epoxidase | 112 | 0.214 | 0.7854 | Yes |
| 11 | FDPS | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 171 | 0.184 | 0.8306 | Yes |
| 12 | SC5DL | SC5DL Entrez, Source | sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like | 187 | 0.176 | 0.8770 | Yes |
| 13 | MVK | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 195 | 0.174 | 0.9234 | Yes |
| 14 | DHCR7 | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 247 | 0.160 | 0.9628 | Yes |
| 15 | NSDHL | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 1768 | 0.073 | 0.8684 | No |
