Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | CORDERO_KRAS_KD_VS_CONTROL_UP |
| Enrichment Score (ES) | -0.65476465 |
| Normalized Enrichment Score (NES) | -2.0697563 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.004254231 |
| FWER p-Value | 0.072 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | HGD | HGD Entrez, Source | homogentisate 1,2-dioxygenase (homogentisate oxidase) | 457 | 0.129 | -0.0094 | No |
| 2 | GPR56 | GPR56 Entrez, Source | G protein-coupled receptor 56 | 553 | 0.122 | 0.0069 | No |
| 3 | BHLHB2 | BHLHB2 Entrez, Source | basic helix-loop-helix domain containing, class B, 2 | 766 | 0.108 | 0.0119 | No |
| 4 | CHST3 | CHST3 Entrez, Source | carbohydrate (chondroitin 6) sulfotransferase 3 | 1564 | 0.078 | -0.0330 | No |
| 5 | SNAI1 | SNAI1 Entrez, Source | snail homolog 1 (Drosophila) | 1586 | 0.077 | -0.0196 | No |
| 6 | SLC22A5 | SLC22A5 Entrez, Source | solute carrier family 22 (organic cation transporter), member 5 | 1950 | 0.069 | -0.0335 | No |
| 7 | JUNB | JUNB Entrez, Source | jun B proto-oncogene | 2033 | 0.067 | -0.0267 | No |
| 8 | IGFBP3 | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 2407 | 0.060 | -0.0431 | No |
| 9 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 2588 | 0.057 | -0.0456 | No |
| 10 | ECE1 | ECE1 Entrez, Source | endothelin converting enzyme 1 | 2605 | 0.057 | -0.0358 | No |
| 11 | DKK3 | DKK3 Entrez, Source | dickkopf homolog 3 (Xenopus laevis) | 3472 | 0.043 | -0.0926 | No |
| 12 | SERPINE2 | SERPINE2 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 3843 | 0.039 | -0.1129 | No |
| 13 | COL5A1 | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 4268 | 0.033 | -0.1384 | No |
| 14 | COL4A1 | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 4425 | 0.031 | -0.1442 | No |
| 15 | COL1A1 | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 4462 | 0.030 | -0.1410 | No |
| 16 | TGFB2 | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 5353 | 0.020 | -0.2041 | No |
| 17 | INPP4B | INPP4B Entrez, Source | inositol polyphosphate-4-phosphatase, type II, 105kDa | 5672 | 0.016 | -0.2248 | No |
| 18 | ADAM19 | ADAM19 Entrez, Source | ADAM metallopeptidase domain 19 (meltrin beta) | 5830 | 0.015 | -0.2338 | No |
| 19 | EVL | EVL Entrez, Source | Enah/Vasp-like | 5897 | 0.014 | -0.2361 | No |
| 20 | WASPIP | WASPIP Entrez, Source | Wiskott-Aldrich syndrome protein interacting protein | 6213 | 0.011 | -0.2577 | No |
| 21 | DICER1 | DICER1 Entrez, Source | Dicer1, Dcr-1 homolog (Drosophila) | 6523 | 0.007 | -0.2795 | No |
| 22 | ATP2B4 | ATP2B4 Entrez, Source | ATPase, Ca++ transporting, plasma membrane 4 | 7434 | -0.003 | -0.3474 | No |
| 23 | HSPB1 | HSPB1 Entrez, Source | heat shock 27kDa protein 1 | 7586 | -0.005 | -0.3578 | No |
| 24 | JUN | JUN Entrez, Source | jun oncogene | 8081 | -0.010 | -0.3930 | No |
| 25 | MAP3K8 | MAP3K8 Entrez, Source | mitogen-activated protein kinase kinase kinase 8 | 8105 | -0.011 | -0.3926 | No |
| 26 | GLIPR1 | GLIPR1 Entrez, Source | GLI pathogenesis-related 1 (glioma) | 8223 | -0.012 | -0.3991 | No |
| 27 | IGSF4 | IGSF4 Entrez, Source | immunoglobulin superfamily, member 4 | 9136 | -0.024 | -0.4631 | No |
| 28 | LAMP2 | LAMP2 Entrez, Source | lysosomal-associated membrane protein 2 | 9376 | -0.027 | -0.4758 | No |
| 29 | MGEA5 | MGEA5 Entrez, Source | meningioma expressed antigen 5 (hyaluronidase) | 10016 | -0.037 | -0.5168 | No |
| 30 | JAK1 | JAK1 Entrez, Source | Janus kinase 1 (a protein tyrosine kinase) | 10118 | -0.039 | -0.5169 | No |
| 31 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 10614 | -0.047 | -0.5450 | No |
| 32 | BMP1 | BMP1 Entrez, Source | bone morphogenetic protein 1 | 10783 | -0.051 | -0.5477 | No |
| 33 | TGFBI | TGFBI Entrez, Source | transforming growth factor, beta-induced, 68kDa | 10868 | -0.053 | -0.5438 | No |
| 34 | WISP2 | WISP2 Entrez, Source | WNT1 inducible signaling pathway protein 2 | 12345 | -0.107 | -0.6341 | Yes |
| 35 | SGK | SGK Entrez, Source | serum/glucocorticoid regulated kinase | 12473 | -0.116 | -0.6213 | Yes |
| 36 | PLEKHC1 | PLEKHC1 Entrez, Source | pleckstrin homology domain containing, family C (with FERM domain) member 1 | 12603 | -0.125 | -0.6067 | Yes |
| 37 | CALD1 | CALD1 Entrez, Source | caldesmon 1 | 12735 | -0.139 | -0.5897 | Yes |
| 38 | CLDN4 | CLDN4 Entrez, Source | claudin 4 | 12969 | -0.181 | -0.5723 | Yes |
| 39 | TPM1 | TPM1 Entrez, Source | tropomyosin 1 (alpha) | 12980 | -0.185 | -0.5374 | Yes |
| 40 | TIMP3 | TIMP3 Entrez, Source | TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 13175 | -0.275 | -0.4988 | Yes |
| 41 | IGFBP7 | IGFBP7 Entrez, Source | insulin-like growth factor binding protein 7 | 13304 | -0.474 | -0.4168 | Yes |
| 42 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 13308 | -0.484 | -0.3234 | Yes |
| 43 | CCL2 | CCL2 Entrez, Source | chemokine (C-C motif) ligand 2 | 13326 | -0.627 | -0.2035 | Yes |
| 44 | TAGLN | TAGLN Entrez, Source | transgelin | 13341 | -1.059 | 0.0001 | Yes |
