Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | CYTOSKELETON_ORGANIZATION_AND_BIOGENESIS |
| Enrichment Score (ES) | -0.47176936 |
| Normalized Enrichment Score (NES) | -1.7691481 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.04665204 |
| FWER p-Value | 0.994 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CXCL12 | CXCL12 Entrez, Source | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | 295 | 0.150 | -0.0048 | No |
| 2 | KIF5A | KIF5A Entrez, Source | kinesin family member 5A | 471 | 0.128 | -0.0032 | No |
| 3 | SEPT5 | SEPT5 Entrez, Source | septin 5 | 645 | 0.116 | -0.0028 | No |
| 4 | THY1 | THY1 Entrez, Source | Thy-1 cell surface antigen | 748 | 0.109 | 0.0022 | No |
| 5 | NF2 | NF2 Entrez, Source | neurofibromin 2 (bilateral acoustic neuroma) | 1025 | 0.096 | -0.0075 | No |
| 6 | TESK2 | TESK2 Entrez, Source | testis-specific kinase 2 | 1137 | 0.092 | -0.0052 | No |
| 7 | ADRA2A | ADRA2A Entrez, Source | adrenergic, alpha-2A-, receptor | 1280 | 0.087 | -0.0059 | No |
| 8 | PCLO | PCLO Entrez, Source | piccolo (presynaptic cytomatrix protein) | 1348 | 0.084 | -0.0011 | No |
| 9 | CENTD2 | CENTD2 Entrez, Source | centaurin, delta 2 | 1661 | 0.075 | -0.0160 | No |
| 10 | TTN | TTN Entrez, Source | titin | 1695 | 0.074 | -0.0098 | No |
| 11 | LRPPRC | LRPPRC Entrez, Source | leucine-rich PPR-motif containing | 1721 | 0.074 | -0.0032 | No |
| 12 | NF1 | NF1 Entrez, Source | neurofibromin 1 (neurofibromatosis, von Recklinghausen disease, Watson disease) | 1803 | 0.072 | -0.0009 | No |
| 13 | HOOK3 | HOOK3 Entrez, Source | hook homolog 3 (Drosophila) | 1889 | 0.070 | 0.0008 | No |
| 14 | DMD | DMD Entrez, Source | dystrophin (muscular dystrophy, Duchenne and Becker types) | 1934 | 0.070 | 0.0056 | No |
| 15 | MID1 | MID1 Entrez, Source | midline 1 (Opitz/BBB syndrome) | 2046 | 0.067 | 0.0050 | No |
| 16 | MAST1 | MAST1 Entrez, Source | microtubule associated serine/threonine kinase 1 | 2057 | 0.067 | 0.0120 | No |
| 17 | MYH6 | MYH6 Entrez, Source | myosin, heavy chain 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1) | 2066 | 0.067 | 0.0191 | No |
| 18 | KIF1A | KIF1A Entrez, Source | kinesin family member 1A | 2587 | 0.057 | -0.0136 | No |
| 19 | MYH11 | MYH11 Entrez, Source | myosin, heavy chain 11, smooth muscle | 2696 | 0.055 | -0.0153 | No |
| 20 | NLGN1 | NLGN1 Entrez, Source | neuroligin 1 | 3061 | 0.049 | -0.0371 | No |
| 21 | NUAK2 | NUAK2 Entrez, Source | NUAK family, SNF1-like kinase, 2 | 3142 | 0.048 | -0.0376 | No |
| 22 | FLNB | FLNB Entrez, Source | filamin B, beta (actin binding protein 278) | 4024 | 0.036 | -0.1000 | No |
| 23 | GHSR | GHSR Entrez, Source | growth hormone secretagogue receptor | 4226 | 0.033 | -0.1114 | No |
| 24 | MYH7 | MYH7 Entrez, Source | myosin, heavy chain 7, cardiac muscle, beta | 4454 | 0.031 | -0.1250 | No |
| 25 | ANK3 | ANK3 Entrez, Source | ankyrin 3, node of Ranvier (ankyrin G) | 4640 | 0.028 | -0.1357 | No |
| 26 | CCL3 | CCL3 Entrez, Source | chemokine (C-C motif) ligand 3 | 4706 | 0.027 | -0.1374 | No |
| 27 | SCIN | SCIN Entrez, Source | scinderin | 4841 | 0.026 | -0.1445 | No |
| 28 | ARHGAP4 | ARHGAP4 Entrez, Source | Rho GTPase activating protein 4 | 4908 | 0.025 | -0.1466 | No |
| 29 | TNNT2 | TNNT2 Entrez, Source | troponin T type 2 (cardiac) | 5334 | 0.020 | -0.1764 | No |
| 30 | PDPK1 | PDPK1 Entrez, Source | 3-phosphoinositide dependent protein kinase-1 | 5563 | 0.018 | -0.1917 | No |
| 31 | APBA1 | APBA1 Entrez, Source | amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) | 5578 | 0.017 | -0.1907 | No |
| 32 | MID1IP1 | MID1IP1 Entrez, Source | MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish)) | 5842 | 0.014 | -0.2089 | No |
| 33 | SNAP29 | SNAP29 Entrez, Source | synaptosomal-associated protein, 29kDa | 5854 | 0.014 | -0.2081 | No |
| 34 | STX5 | STX5 Entrez, Source | syntaxin 5 | 5893 | 0.014 | -0.2093 | No |
| 35 | EVL | EVL Entrez, Source | Enah/Vasp-like | 5897 | 0.014 | -0.2079 | No |
| 36 | NUBP1 | NUBP1 Entrez, Source | nucleotide binding protein 1 (MinD homolog, E. coli) | 6021 | 0.013 | -0.2157 | No |
| 37 | ARHGDIB | ARHGDIB Entrez, Source | Rho GDP dissociation inhibitor (GDI) beta | 6080 | 0.012 | -0.2187 | No |
| 38 | KIF1B | KIF1B Entrez, Source | kinesin family member 1B | 6130 | 0.012 | -0.2211 | No |
| 39 | PACSIN2 | PACSIN2 Entrez, Source | protein kinase C and casein kinase substrate in neurons 2 | 6304 | 0.010 | -0.2330 | No |
| 40 | PLA2G1B | PLA2G1B Entrez, Source | phospholipase A2, group IB (pancreas) | 6366 | 0.009 | -0.2366 | No |
| 41 | RAN | RAN Entrez, Source | RAN, member RAS oncogene family | 6446 | 0.008 | -0.2417 | No |
| 42 | MARK1 | MARK1 Entrez, Source | MAP/microtubule affinity-regulating kinase 1 | 6468 | 0.008 | -0.2423 | No |
| 43 | DNAJB6 | DNAJB6 Entrez, Source | DnaJ (Hsp40) homolog, subfamily B, member 6 | 6710 | 0.005 | -0.2599 | No |
| 44 | FGD4 | FGD4 Entrez, Source | FYVE, RhoGEF and PH domain containing 4 | 6756 | 0.005 | -0.2628 | No |
| 45 | SORBS3 | SORBS3 Entrez, Source | sorbin and SH3 domain containing 3 | 6891 | 0.003 | -0.2726 | No |
| 46 | ARF6 | ARF6 Entrez, Source | ADP-ribosylation factor 6 | 6899 | 0.003 | -0.2728 | No |
| 47 | APC | APC Entrez, Source | adenomatosis polyposis coli | 7029 | 0.002 | -0.2823 | No |
| 48 | KPNA2 | KPNA2 Entrez, Source | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 7056 | 0.001 | -0.2841 | No |
| 49 | TAOK2 | TAOK2 Entrez, Source | TAO kinase 2 | 7066 | 0.001 | -0.2847 | No |
| 50 | TMED10 | TMED10 Entrez, Source | transmembrane emp24-like trafficking protein 10 (yeast) | 7149 | 0.000 | -0.2908 | No |
| 51 | ARFIP2 | ARFIP2 Entrez, Source | ADP-ribosylation factor interacting protein 2 (arfaptin 2) | 7165 | 0.000 | -0.2919 | No |
| 52 | APOE | APOE Entrez, Source | apolipoprotein E | 7411 | -0.003 | -0.3101 | No |
| 53 | RASA1 | RASA1 Entrez, Source | RAS p21 protein activator (GTPase activating protein) 1 | 7619 | -0.005 | -0.3252 | No |
| 54 | DYNC1I1 | DYNC1I1 Entrez, Source | dynein, cytoplasmic 1, intermediate chain 1 | 7683 | -0.006 | -0.3293 | No |
| 55 | OPA1 | OPA1 Entrez, Source | optic atrophy 1 (autosomal dominant) | 8024 | -0.010 | -0.3539 | No |
| 56 | CXCL1 | CXCL1 Entrez, Source | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 8149 | -0.011 | -0.3620 | No |
| 57 | PAFAH1B1 | PAFAH1B1 Entrez, Source | platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit 45kDa | 8159 | -0.011 | -0.3614 | No |
| 58 | DLG1 | DLG1 Entrez, Source | discs, large homolog 1 (Drosophila) | 8290 | -0.013 | -0.3697 | No |
| 59 | CENPJ | CENPJ Entrez, Source | centromere protein J | 8301 | -0.013 | -0.3689 | No |
| 60 | ARHGEF2 | ARHGEF2 Entrez, Source | rho/rac guanine nucleotide exchange factor (GEF) 2 | 8556 | -0.016 | -0.3863 | No |
| 61 | DES | DES Entrez, Source | desmin | 8619 | -0.017 | -0.3890 | No |
| 62 | MRAS | MRAS Entrez, Source | muscle RAS oncogene homolog | 8707 | -0.018 | -0.3934 | No |
| 63 | ARPC1A | ARPC1A Entrez, Source | actin related protein 2/3 complex, subunit 1A, 41kDa | 8847 | -0.020 | -0.4016 | No |
| 64 | CDC42BPB | CDC42BPB Entrez, Source | CDC42 binding protein kinase beta (DMPK-like) | 8892 | -0.020 | -0.4026 | No |
| 65 | PLD2 | PLD2 Entrez, Source | phospholipase D2 | 8951 | -0.021 | -0.4045 | No |
| 66 | TSC1 | TSC1 Entrez, Source | tuberous sclerosis 1 | 8983 | -0.022 | -0.4043 | No |
| 67 | RHOJ | RHOJ Entrez, Source | ras homolog gene family, member J | 9039 | -0.022 | -0.4059 | No |
| 68 | SOD1 | SOD1 Entrez, Source | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | 9099 | -0.023 | -0.4077 | No |
| 69 | SMC1A | SMC1A Entrez, Source | structural maintenance of chromosomes 1A | 9111 | -0.023 | -0.4058 | No |
| 70 | CLASP2 | CLASP2 Entrez, Source | cytoplasmic linker associated protein 2 | 9145 | -0.024 | -0.4055 | No |
| 71 | SMC3 | SMC3 Entrez, Source | structural maintenance of chromosomes 3 | 9481 | -0.029 | -0.4275 | No |
| 72 | RND3 | RND3 Entrez, Source | Rho family GTPase 3 | 9751 | -0.033 | -0.4441 | No |
| 73 | CDC42BPA | CDC42BPA Entrez, Source | CDC42 binding protein kinase alpha (DMPK-like) | 9898 | -0.035 | -0.4511 | No |
| 74 | ROCK1 | ROCK1 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 1 | 9904 | -0.035 | -0.4474 | No |
| 75 | YKT6 | YKT6 Entrez, Source | YKT6 v-SNARE homolog (S. cerevisiae) | 10045 | -0.038 | -0.4536 | No |
| 76 | CAPG | CAPG Entrez, Source | capping protein (actin filament), gelsolin-like | 10094 | -0.038 | -0.4528 | No |
| 77 | UXT | UXT Entrez, Source | ubiquitously-expressed transcript | 10188 | -0.040 | -0.4552 | No |
| 78 | GHRL | GHRL Entrez, Source | ghrelin/obestatin preprohormone | 10393 | -0.043 | -0.4656 | No |
| 79 | KATNB1 | KATNB1 Entrez, Source | katanin p80 (WD repeat containing) subunit B 1 | 10476 | -0.045 | -0.4666 | Yes |
| 80 | TUBG1 | TUBG1 Entrez, Source | tubulin, gamma 1 | 10526 | -0.046 | -0.4650 | Yes |
| 81 | CRK | CRK Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian) | 10537 | -0.046 | -0.4604 | Yes |
| 82 | RHOA | RHOA Entrez, Source | ras homolog gene family, member A | 10584 | -0.047 | -0.4584 | Yes |
| 83 | MAP3K11 | MAP3K11 Entrez, Source | mitogen-activated protein kinase kinase kinase 11 | 10674 | -0.049 | -0.4595 | Yes |
| 84 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 10703 | -0.049 | -0.4559 | Yes |
| 85 | KIF5B | KIF5B Entrez, Source | kinesin family member 5B | 10742 | -0.050 | -0.4529 | Yes |
| 86 | LIMK1 | LIMK1 Entrez, Source | LIM domain kinase 1 | 10751 | -0.051 | -0.4476 | Yes |
| 87 | CKAP5 | CKAP5 Entrez, Source | cytoskeleton associated protein 5 | 10855 | -0.053 | -0.4493 | Yes |
| 88 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 10939 | -0.055 | -0.4492 | Yes |
| 89 | KIF4A | KIF4A Entrez, Source | kinesin family member 4A | 11030 | -0.056 | -0.4494 | Yes |
| 90 | PAK1 | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 11055 | -0.057 | -0.4446 | Yes |
| 91 | WASF2 | WASF2 Entrez, Source | WAS protein family, member 2 | 11151 | -0.059 | -0.4449 | Yes |
| 92 | SPTBN4 | SPTBN4 Entrez, Source | spectrin, beta, non-erythrocytic 4 | 11326 | -0.063 | -0.4507 | Yes |
| 93 | RND1 | RND1 Entrez, Source | Rho family GTPase 1 | 11382 | -0.065 | -0.4474 | Yes |
| 94 | ATP2C1 | ATP2C1 Entrez, Source | ATPase, Ca++ transporting, type 2C, member 1 | 11421 | -0.066 | -0.4426 | Yes |
| 95 | RHOT2 | RHOT2 Entrez, Source | ras homolog gene family, member T2 | 11427 | -0.066 | -0.4353 | Yes |
| 96 | KRT20 | KRT20 Entrez, Source | keratin 20 | 11582 | -0.071 | -0.4387 | Yes |
| 97 | PSCD2 | PSCD2 Entrez, Source | pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2) | 11669 | -0.074 | -0.4365 | Yes |
| 98 | MAPT | MAPT Entrez, Source | microtubule-associated protein tau | 11785 | -0.078 | -0.4361 | Yes |
| 99 | MAPRE1 | MAPRE1 Entrez, Source | microtubule-associated protein, RP/EB family, member 1 | 11845 | -0.081 | -0.4311 | Yes |
| 100 | WASL | WASL Entrez, Source | Wiskott-Aldrich syndrome-like | 11892 | -0.083 | -0.4250 | Yes |
| 101 | FGD1 | FGD1 Entrez, Source | FYVE, RhoGEF and PH domain containing 1 (faciogenital dysplasia) | 11895 | -0.083 | -0.4154 | Yes |
| 102 | WASF1 | WASF1 Entrez, Source | WAS protein family, member 1 | 11932 | -0.084 | -0.4084 | Yes |
| 103 | LASP1 | LASP1 Entrez, Source | LIM and SH3 protein 1 | 11935 | -0.084 | -0.3987 | Yes |
| 104 | ARPC5 | ARPC5 Entrez, Source | actin related protein 2/3 complex, subunit 5, 16kDa | 12047 | -0.089 | -0.3967 | Yes |
| 105 | MYH9 | MYH9 Entrez, Source | myosin, heavy chain 9, non-muscle | 12120 | -0.093 | -0.3914 | Yes |
| 106 | CFL1 | CFL1 Entrez, Source | cofilin 1 (non-muscle) | 12205 | -0.097 | -0.3864 | Yes |
| 107 | DYNLL1 | DYNLL1 Entrez, Source | dynein, light chain, LC8-type 1 | 12221 | -0.098 | -0.3762 | Yes |
| 108 | GSN | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 12230 | -0.098 | -0.3653 | Yes |
| 109 | MYO9B | MYO9B Entrez, Source | myosin IXB | 12453 | -0.114 | -0.3688 | Yes |
| 110 | MYH10 | MYH10 Entrez, Source | myosin, heavy chain 10, non-muscle | 12486 | -0.117 | -0.3576 | Yes |
| 111 | BCAR1 | BCAR1 Entrez, Source | breast cancer anti-estrogen resistance 1 | 12497 | -0.117 | -0.3448 | Yes |
| 112 | NEFL | NEFL Entrez, Source | neurofilament, light polypeptide 68kDa | 12514 | -0.118 | -0.3322 | Yes |
| 113 | CLASP1 | CLASP1 Entrez, Source | cytoplasmic linker associated protein 1 | 12638 | -0.129 | -0.3265 | Yes |
| 114 | DSTN | DSTN Entrez, Source | destrin (actin depolymerizing factor) | 12710 | -0.136 | -0.3161 | Yes |
| 115 | MYO1E | MYO1E Entrez, Source | myosin IE | 12727 | -0.138 | -0.3012 | Yes |
| 116 | KIF2C | KIF2C Entrez, Source | kinesin family member 2C | 12895 | -0.164 | -0.2948 | Yes |
| 117 | ABI2 | ABI2 Entrez, Source | abl interactor 2 | 13075 | -0.221 | -0.2827 | Yes |
| 118 | NEXN | NEXN Entrez, Source | nexilin (F actin binding protein) | 13091 | -0.227 | -0.2574 | Yes |
| 119 | CDC42EP2 | CDC42EP2 Entrez, Source | CDC42 effector protein (Rho GTPase binding) 2 | 13158 | -0.264 | -0.2317 | Yes |
| 120 | STMN1 | STMN1 Entrez, Source | stathmin 1/oncoprotein 18 | 13294 | -0.447 | -0.1899 | Yes |
| 121 | DBN1 | DBN1 Entrez, Source | drebrin 1 | 13305 | -0.475 | -0.1354 | Yes |
| 122 | ACTA1 | ACTA1 Entrez, Source | actin, alpha 1, skeletal muscle | 13342 | -1.187 | -0.0000 | Yes |
