Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | ELONGINA_KO_UP |
| Enrichment Score (ES) | -0.48631048 |
| Normalized Enrichment Score (NES) | -1.7553701 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.048763607 |
| FWER p-Value | 0.997 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SLC16A1 | SLC16A1 Entrez, Source | solute carrier family 16, member 1 (monocarboxylic acid transporter 1) | 376 | 0.138 | -0.0123 | No |
| 2 | IGFBP4 | IGFBP4 Entrez, Source | insulin-like growth factor binding protein 4 | 406 | 0.135 | 0.0011 | No |
| 3 | TST | TST Entrez, Source | thiosulfate sulfurtransferase (rhodanese) | 446 | 0.130 | 0.0133 | No |
| 4 | HSPA5 | HSPA5 Entrez, Source | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 567 | 0.120 | 0.0182 | No |
| 5 | HS3ST1 | HS3ST1 Entrez, Source | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | 640 | 0.116 | 0.0263 | No |
| 6 | HERPUD1 | HERPUD1 Entrez, Source | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 716 | 0.111 | 0.0335 | No |
| 7 | AQP8 | AQP8 Entrez, Source | aquaporin 8 | 728 | 0.110 | 0.0454 | No |
| 8 | PSPH | PSPH Entrez, Source | phosphoserine phosphatase | 746 | 0.109 | 0.0568 | No |
| 9 | PGA5 | PGA5 Entrez, Source | pepsinogen 5, group I (pepsinogen A) | 1055 | 0.095 | 0.0446 | No |
| 10 | GHR | GHR Entrez, Source | growth hormone receptor | 1215 | 0.089 | 0.0430 | No |
| 11 | STRA6 | STRA6 Entrez, Source | stimulated by retinoic acid gene 6 homolog (mouse) | 1299 | 0.086 | 0.0467 | No |
| 12 | SNAI1 | SNAI1 Entrez, Source | snail homolog 1 (Drosophila) | 1586 | 0.077 | 0.0341 | No |
| 13 | SPINK1 | SPINK1 Entrez, Source | serine peptidase inhibitor, Kazal type 1 | 1631 | 0.076 | 0.0396 | No |
| 14 | SPOCK1 | SPOCK1 Entrez, Source | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 1707 | 0.074 | 0.0425 | No |
| 15 | THBD | THBD Entrez, Source | thrombomodulin | 1858 | 0.071 | 0.0395 | No |
| 16 | VEGF | VEGF Entrez, Source | vascular endothelial growth factor | 1883 | 0.070 | 0.0458 | No |
| 17 | NR2F2 | NR2F2 Entrez, Source | nuclear receptor subfamily 2, group F, member 2 | 1957 | 0.069 | 0.0483 | No |
| 18 | MID1 | MID1 Entrez, Source | midline 1 (Opitz/BBB syndrome) | 2046 | 0.067 | 0.0495 | No |
| 19 | STARD10 | STARD10 Entrez, Source | START domain containing 10 | 2192 | 0.064 | 0.0460 | No |
| 20 | FBLN2 | FBLN2 Entrez, Source | fibulin 2 | 2463 | 0.059 | 0.0325 | No |
| 21 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 2588 | 0.057 | 0.0297 | No |
| 22 | EPAS1 | EPAS1 Entrez, Source | endothelial PAS domain protein 1 | 2672 | 0.056 | 0.0299 | No |
| 23 | SURF4 | SURF4 Entrez, Source | surfeit 4 | 3050 | 0.049 | 0.0072 | No |
| 24 | SERPING1 | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 3232 | 0.047 | -0.0010 | No |
| 25 | PRG1 | PRG1 Entrez, Source | proteoglycan 1, secretory granule | 3518 | 0.043 | -0.0176 | No |
| 26 | PDE1B | PDE1B Entrez, Source | phosphodiesterase 1B, calmodulin-dependent | 3769 | 0.040 | -0.0319 | No |
| 27 | KDELR2 | KDELR2 Entrez, Source | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 4041 | 0.036 | -0.0482 | No |
| 28 | TMED2 | TMED2 Entrez, Source | transmembrane emp24 domain trafficking protein 2 | 4183 | 0.034 | -0.0549 | No |
| 29 | COL4A1 | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 4425 | 0.031 | -0.0695 | No |
| 30 | TTR | TTR Entrez, Source | transthyretin (prealbumin, amyloidosis type I) | 4445 | 0.031 | -0.0674 | No |
| 31 | P4HB | P4HB Entrez, Source | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide | 4586 | 0.029 | -0.0746 | No |
| 32 | CYP26A1 | CYP26A1 Entrez, Source | cytochrome P450, family 26, subfamily A, polypeptide 1 | 4758 | 0.027 | -0.0844 | No |
| 33 | PTHR1 | PTHR1 Entrez, Source | parathyroid hormone receptor 1 | 4833 | 0.026 | -0.0870 | No |
| 34 | JUND | JUND Entrez, Source | jun D proto-oncogene | 4884 | 0.025 | -0.0878 | No |
| 35 | CREB3L1 | CREB3L1 Entrez, Source | cAMP responsive element binding protein 3-like 1 | 4976 | 0.024 | -0.0919 | No |
| 36 | PDIA3 | PDIA3 Entrez, Source | protein disulfide isomerase family A, member 3 | 5084 | 0.023 | -0.0973 | No |
| 37 | CITED1 | CITED1 Entrez, Source | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 | 5242 | 0.021 | -0.1067 | No |
| 38 | MYL3 | MYL3 Entrez, Source | myosin, light chain 3, alkali; ventricular, skeletal, slow | 5248 | 0.021 | -0.1047 | No |
| 39 | SLC38A1 | SLC38A1 Entrez, Source | solute carrier family 38, member 1 | 5607 | 0.017 | -0.1297 | No |
| 40 | CCND2 | CCND2 Entrez, Source | cyclin D2 | 5771 | 0.015 | -0.1403 | No |
| 41 | NID1 | NID1 Entrez, Source | nidogen 1 | 6040 | 0.012 | -0.1591 | No |
| 42 | NID2 | NID2 Entrez, Source | nidogen 2 (osteonidogen) | 6282 | 0.010 | -0.1761 | No |
| 43 | GGTA1 | GGTA1 Entrez, Source | glycoprotein, alpha-galactosyltransferase 1 | 6325 | 0.009 | -0.1782 | No |
| 44 | CD38 | CD38 Entrez, Source | CD38 molecule | 6335 | 0.009 | -0.1778 | No |
| 45 | CCNC | CCNC Entrez, Source | cyclin C | 6339 | 0.009 | -0.1770 | No |
| 46 | RAMP2 | RAMP2 Entrez, Source | receptor (calcitonin) activity modifying protein 2 | 6398 | 0.009 | -0.1804 | No |
| 47 | HSDL1 | HSDL1 Entrez, Source | hydroxysteroid dehydrogenase like 1 | 6614 | 0.006 | -0.1959 | No |
| 48 | SLC7A1 | SLC7A1 Entrez, Source | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 6719 | 0.005 | -0.2031 | No |
| 49 | NR4A1 | NR4A1 Entrez, Source | nuclear receptor subfamily 4, group A, member 1 | 6992 | 0.002 | -0.2234 | No |
| 50 | ATP1B1 | ATP1B1 Entrez, Source | ATPase, Na+/K+ transporting, beta 1 polypeptide | 7708 | -0.006 | -0.2767 | No |
| 51 | FUT8 | FUT8 Entrez, Source | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 7725 | -0.006 | -0.2772 | No |
| 52 | SRPRB | SRPRB Entrez, Source | signal recognition particle receptor, B subunit | 7795 | -0.007 | -0.2816 | No |
| 53 | WARS | WARS Entrez, Source | tryptophanyl-tRNA synthetase | 7995 | -0.009 | -0.2956 | No |
| 54 | CTSZ | CTSZ Entrez, Source | cathepsin Z | 8280 | -0.013 | -0.3155 | No |
| 55 | PTPRM | PTPRM Entrez, Source | protein tyrosine phosphatase, receptor type, M | 8923 | -0.021 | -0.3616 | No |
| 56 | TFPI | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 8929 | -0.021 | -0.3595 | No |
| 57 | LMBRD1 | LMBRD1 Entrez, Source | LMBR1 domain containing 1 | 9121 | -0.023 | -0.3712 | No |
| 58 | ATP6AP1 | ATP6AP1 Entrez, Source | ATPase, H+ transporting, lysosomal accessory protein 1 | 9190 | -0.024 | -0.3735 | No |
| 59 | TXNDC4 | TXNDC4 Entrez, Source | thioredoxin domain containing 4 (endoplasmic reticulum) | 9203 | -0.024 | -0.3716 | No |
| 60 | B2M | B2M Entrez, Source | beta-2-microglobulin | 9260 | -0.025 | -0.3729 | No |
| 61 | ID2 | ID2 Entrez, Source | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 9384 | -0.027 | -0.3790 | No |
| 62 | ARF4 | ARF4 Entrez, Source | ADP-ribosylation factor 4 | 9461 | -0.028 | -0.3815 | No |
| 63 | VAMP8 | VAMP8 Entrez, Source | vesicle-associated membrane protein 8 (endobrevin) | 9693 | -0.032 | -0.3952 | No |
| 64 | PSAP | PSAP Entrez, Source | prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) | 9699 | -0.032 | -0.3918 | No |
| 65 | GLUL | GLUL Entrez, Source | glutamate-ammonia ligase (glutamine synthetase) | 9734 | -0.033 | -0.3906 | No |
| 66 | KIT | KIT Entrez, Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 9974 | -0.036 | -0.4045 | No |
| 67 | CALM1 | CALM1 Entrez, Source | calmodulin 1 (phosphorylase kinase, delta) | 10481 | -0.045 | -0.4375 | No |
| 68 | ITGB1 | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 10521 | -0.046 | -0.4351 | No |
| 69 | CYBASC3 | CYBASC3 Entrez, Source | cytochrome b, ascorbate dependent 3 | 10984 | -0.056 | -0.4636 | No |
| 70 | MFGE8 | MFGE8 Entrez, Source | milk fat globule-EGF factor 8 protein | 11250 | -0.061 | -0.4765 | No |
| 71 | GNS | GNS Entrez, Source | glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) | 11302 | -0.062 | -0.4731 | No |
| 72 | FKBP9 | FKBP9 Entrez, Source | FK506 binding protein 9, 63 kDa | 11407 | -0.065 | -0.4733 | No |
| 73 | GRINA | GRINA Entrez, Source | glutamate receptor, ionotropic, N-methyl D-asparate-associated protein 1 (glutamate binding) | 11580 | -0.071 | -0.4780 | Yes |
| 74 | GATA6 | GATA6 Entrez, Source | GATA binding protein 6 | 11618 | -0.073 | -0.4724 | Yes |
| 75 | CLU | CLU Entrez, Source | clusterin | 11686 | -0.075 | -0.4687 | Yes |
| 76 | EFEMP2 | EFEMP2 Entrez, Source | EGF-containing fibulin-like extracellular matrix protein 2 | 11825 | -0.080 | -0.4698 | Yes |
| 77 | APP | APP Entrez, Source | amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | 11831 | -0.081 | -0.4608 | Yes |
| 78 | FDX1 | FDX1 Entrez, Source | ferredoxin 1 | 11956 | -0.085 | -0.4603 | Yes |
| 79 | LRPAP1 | LRPAP1 Entrez, Source | low density lipoprotein receptor-related protein associated protein 1 | 12044 | -0.089 | -0.4565 | Yes |
| 80 | CST3 | CST3 Entrez, Source | cystatin C (amyloid angiopathy and cerebral hemorrhage) | 12273 | -0.101 | -0.4619 | Yes |
| 81 | ENPEP | ENPEP Entrez, Source | glutamyl aminopeptidase (aminopeptidase A) | 12336 | -0.106 | -0.4543 | Yes |
| 82 | SGCE | SGCE Entrez, Source | sarcoglycan, epsilon | 12384 | -0.110 | -0.4451 | Yes |
| 83 | PLOD1 | PLOD1 Entrez, Source | procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 | 12413 | -0.112 | -0.4342 | Yes |
| 84 | GNA12 | GNA12 Entrez, Source | guanine nucleotide binding protein (G protein) alpha 12 | 12436 | -0.113 | -0.4227 | Yes |
| 85 | CYR61 | CYR61 Entrez, Source | cysteine-rich, angiogenic inducer, 61 | 12557 | -0.122 | -0.4176 | Yes |
| 86 | LGMN | LGMN Entrez, Source | legumain | 12623 | -0.127 | -0.4077 | Yes |
| 87 | ANXA2 | ANXA2 Entrez, Source | annexin A2 | 12686 | -0.133 | -0.3969 | Yes |
| 88 | MESDC1 | MESDC1 Entrez, Source | mesoderm development candidate 1 | 12739 | -0.139 | -0.3846 | Yes |
| 89 | P4HA1 | P4HA1 Entrez, Source | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I | 12791 | -0.146 | -0.3715 | Yes |
| 90 | DDAH1 | DDAH1 Entrez, Source | dimethylarginine dimethylaminohydrolase 1 | 12847 | -0.155 | -0.3576 | Yes |
| 91 | TAX1BP3 | TAX1BP3 Entrez, Source | Tax1 (human T-cell leukemia virus type I) binding protein 3 | 12900 | -0.165 | -0.3423 | Yes |
| 92 | LAMC1 | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 13024 | -0.196 | -0.3289 | Yes |
| 93 | ZYX | ZYX Entrez, Source | zyxin | 13115 | -0.238 | -0.3080 | Yes |
| 94 | TIMP3 | TIMP3 Entrez, Source | TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) | 13175 | -0.275 | -0.2804 | Yes |
| 95 | CLIC1 | CLIC1 Entrez, Source | chloride intracellular channel 1 | 13181 | -0.281 | -0.2482 | Yes |
| 96 | CRYAB | CRYAB Entrez, Source | crystallin, alpha B | 13206 | -0.298 | -0.2154 | Yes |
| 97 | TYRO3 | TYRO3 Entrez, Source | TYRO3 protein tyrosine kinase | 13214 | -0.309 | -0.1801 | Yes |
| 98 | CITED2 | CITED2 Entrez, Source | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 13226 | -0.322 | -0.1435 | Yes |
| 99 | PLAT | PLAT Entrez, Source | plasminogen activator, tissue | 13241 | -0.343 | -0.1047 | Yes |
| 100 | SERPINH1 | SERPINH1 Entrez, Source | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | 13296 | -0.454 | -0.0560 | Yes |
| 101 | F3 | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 13315 | -0.511 | 0.0020 | Yes |
