Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | HIVNEFPATHWAY |
| Enrichment Score (ES) | -0.6665501 |
| Normalized Enrichment Score (NES) | -2.080519 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.004112544 |
| FWER p-Value | 0.059 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | DFFB | DFFB Entrez, Source | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) | 2159 | 0.065 | -0.1382 | No |
| 2 | TNFRSF1A | TNFRSF1A Entrez, Source | tumor necrosis factor receptor superfamily, member 1A | 2994 | 0.050 | -0.1823 | No |
| 3 | CDC2L1 | CDC2L1 Entrez, Source | cell division cycle 2-like 1 (PITSLRE proteins) | 4002 | 0.036 | -0.2445 | No |
| 4 | BCL2 | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 4328 | 0.032 | -0.2569 | No |
| 5 | CASP9 | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 5394 | 0.019 | -0.3298 | No |
| 6 | ARHGDIB | ARHGDIB Entrez, Source | Rho GDP dissociation inhibitor (GDI) beta | 6080 | 0.012 | -0.3768 | No |
| 7 | TNF | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 6778 | 0.004 | -0.4275 | No |
| 8 | CYCS | CYCS Entrez, Source | cytochrome c, somatic | 6937 | 0.003 | -0.4384 | No |
| 9 | NUMA1 | NUMA1 Entrez, Source | nuclear mitotic apparatus protein 1 | 7275 | -0.001 | -0.4633 | No |
| 10 | RASA1 | RASA1 Entrez, Source | RAS p21 protein activator (GTPase activating protein) 1 | 7619 | -0.005 | -0.4873 | No |
| 11 | CFLAR | CFLAR Entrez, Source | CASP8 and FADD-like apoptosis regulator | 8465 | -0.015 | -0.5451 | No |
| 12 | DAXX | DAXX Entrez, Source | death-associated protein 6 | 8710 | -0.018 | -0.5568 | No |
| 13 | BIRC2 | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 9946 | -0.036 | -0.6363 | No |
| 14 | DFFA | DFFA Entrez, Source | DNA fragmentation factor, 45kDa, alpha polypeptide | 10349 | -0.042 | -0.6508 | Yes |
| 15 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 10388 | -0.043 | -0.6375 | Yes |
| 16 | FADD | FADD Entrez, Source | Fas (TNFRSF6)-associated via death domain | 10437 | -0.044 | -0.6248 | Yes |
| 17 | PSEN1 | PSEN1 Entrez, Source | presenilin 1 (Alzheimer disease 3) | 10571 | -0.046 | -0.6175 | Yes |
| 18 | MAP3K1 | MAP3K1 Entrez, Source | mitogen-activated protein kinase kinase kinase 1 | 10643 | -0.048 | -0.6051 | Yes |
| 19 | BAG4 | BAG4 Entrez, Source | BCL2-associated athanogene 4 | 10691 | -0.049 | -0.5904 | Yes |
| 20 | CASP6 | CASP6 Entrez, Source | caspase 6, apoptosis-related cysteine peptidase | 10778 | -0.051 | -0.5778 | Yes |
| 21 | PTK2 | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 10930 | -0.054 | -0.5689 | Yes |
| 22 | TRADD | TRADD Entrez, Source | TNFRSF1A-associated via death domain | 11038 | -0.057 | -0.5559 | Yes |
| 23 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 11138 | -0.059 | -0.5414 | Yes |
| 24 | BIRC4 | BIRC4 Entrez, Source | baculoviral IAP repeat-containing 4 | 11256 | -0.061 | -0.5274 | Yes |
| 25 | BID | BID Entrez, Source | BH3 interacting domain death agonist | 11376 | -0.064 | -0.5123 | Yes |
| 26 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 11387 | -0.065 | -0.4890 | Yes |
| 27 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 11401 | -0.065 | -0.4657 | Yes |
| 28 | CASP7 | CASP7 Entrez, Source | caspase 7, apoptosis-related cysteine peptidase | 11446 | -0.066 | -0.4443 | Yes |
| 29 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 11510 | -0.069 | -0.4236 | Yes |
| 30 | PSEN2 | PSEN2 Entrez, Source | presenilin 2 (Alzheimer disease 4) | 11726 | -0.076 | -0.4113 | Yes |
| 31 | CASP3 | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 12003 | -0.087 | -0.3997 | Yes |
| 32 | PAK2 | PAK2 Entrez, Source | p21 (CDKN1A)-activated kinase 2 | 12118 | -0.092 | -0.3740 | Yes |
| 33 | GSN | GSN Entrez, Source | gelsolin (amyloidosis, Finnish type) | 12230 | -0.098 | -0.3457 | Yes |
| 34 | PRKCD | PRKCD Entrez, Source | protein kinase C, delta | 12535 | -0.120 | -0.3238 | Yes |
| 35 | LMNA | LMNA Entrez, Source | lamin A/C | 12554 | -0.122 | -0.2799 | Yes |
| 36 | BIRC3 | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 12722 | -0.137 | -0.2414 | Yes |
| 37 | CASP2 | CASP2 Entrez, Source | caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2) | 12946 | -0.175 | -0.1932 | Yes |
| 38 | LMNB1 | LMNB1 Entrez, Source | lamin B1 | 13104 | -0.234 | -0.1179 | Yes |
| 39 | APAF1 | APAF1 Entrez, Source | apoptotic peptidase activating factor | 13256 | -0.365 | 0.0065 | Yes |
