Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | double_gel_48h |
| GeneSet | HSA00380_TRYPTOPHAN_METABOLISM |
| Enrichment Score (ES) | 0.659981 |
| Normalized Enrichment Score (NES) | 2.2892163 |
| Nominal p-value | 0.0 |
| FDR q-value | 7.149281E-5 |
| FWER p-Value | 0.0010 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | EHHADH | EHHADH Entrez, Source | enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | 6 | 0.447 | 0.1320 | Yes |
| 2 | ACAT2 | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 14 | 0.377 | 0.2433 | Yes |
| 3 | ABP1 | ABP1 Entrez, Source | amiloride binding protein 1 (amine oxidase (copper-containing)) | 113 | 0.213 | 0.2991 | Yes |
| 4 | TDO2 | TDO2 Entrez, Source | tryptophan 2,3-dioxygenase | 133 | 0.199 | 0.3567 | Yes |
| 5 | HAAO | HAAO Entrez, Source | 3-hydroxyanthranilate 3,4-dioxygenase | 143 | 0.195 | 0.4140 | Yes |
| 6 | KMO | KMO Entrez, Source | kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | 173 | 0.183 | 0.4662 | Yes |
| 7 | AADAT | AADAT Entrez, Source | aminoadipate aminotransferase | 283 | 0.152 | 0.5030 | Yes |
| 8 | CAT | CAT Entrez, Source | catalase | 391 | 0.137 | 0.5355 | Yes |
| 9 | CYP1B1 | CYP1B1 Entrez, Source | cytochrome P450, family 1, subfamily B, polypeptide 1 | 506 | 0.124 | 0.5638 | Yes |
| 10 | ACMSD | ACMSD Entrez, Source | aminocarboxymuconate semialdehyde decarboxylase | 514 | 0.124 | 0.6001 | Yes |
| 11 | AANAT | AANAT Entrez, Source | arylalkylamine N-acetyltransferase | 818 | 0.106 | 0.6087 | Yes |
| 12 | ACAT1 | ACAT1 Entrez, Source | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | 1295 | 0.086 | 0.5985 | Yes |
| 13 | AOX1 | AOX1 Entrez, Source | aldehyde oxidase 1 | 1365 | 0.084 | 0.6181 | Yes |
| 14 | ECHS1 | ECHS1 Entrez, Source | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | 1528 | 0.079 | 0.6292 | Yes |
| 15 | AOC3 | AOC3 Entrez, Source | amine oxidase, copper containing 3 (vascular adhesion protein 1) | 1556 | 0.078 | 0.6503 | Yes |
| 16 | CYP1A1 | CYP1A1 Entrez, Source | cytochrome P450, family 1, subfamily A, polypeptide 1 | 1719 | 0.074 | 0.6600 | Yes |
| 17 | CYP1A2 | CYP1A2 Entrez, Source | cytochrome P450, family 1, subfamily A, polypeptide 2 | 3939 | 0.037 | 0.5042 | No |
| 18 | KYNU | KYNU Entrez, Source | kynureninase (L-kynurenine hydrolase) | 4061 | 0.035 | 0.5056 | No |
| 19 | PRMT3 | PRMT3 Entrez, Source | protein arginine methyltransferase 3 | 4207 | 0.034 | 0.5047 | No |
| 20 | HSD17B4 | HSD17B4 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 4 | 4370 | 0.032 | 0.5019 | No |
| 21 | DDC | DDC Entrez, Source | dopa decarboxylase (aromatic L-amino acid decarboxylase) | 4512 | 0.030 | 0.5002 | No |
| 22 | INDO | INDO Entrez, Source | indoleamine-pyrrole 2,3 dioxygenase | 4751 | 0.027 | 0.4903 | No |
| 23 | CARM1 | CARM1 Entrez, Source | coactivator-associated arginine methyltransferase 1 | 5136 | 0.022 | 0.4680 | No |
| 24 | HADHA | HADHA Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit | 5156 | 0.022 | 0.4731 | No |
| 25 | MAOA | MAOA Entrez, Source | monoamine oxidase A | 5177 | 0.022 | 0.4780 | No |
| 26 | TPH1 | TPH1 Entrez, Source | tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) | 6930 | 0.003 | 0.3471 | No |
| 27 | ALDH3A1 | ALDH3A1 Entrez, Source | aldehyde dehydrogenase 3 family, memberA1 | 7461 | -0.003 | 0.3082 | No |
| 28 | PRMT2 | PRMT2 Entrez, Source | protein arginine methyltransferase 2 | 7736 | -0.006 | 0.2895 | No |
| 29 | HADH | HADH Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase | 7824 | -0.007 | 0.2851 | No |
| 30 | WARS | WARS Entrez, Source | tryptophanyl-tRNA synthetase | 7995 | -0.009 | 0.2751 | No |
| 31 | LCMT1 | LCMT1 Entrez, Source | leucine carboxyl methyltransferase 1 | 8072 | -0.010 | 0.2725 | No |
| 32 | NFX1 | NFX1 Entrez, Source | nuclear transcription factor, X-box binding 1 | 8306 | -0.013 | 0.2588 | No |
| 33 | ALDH2 | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 8630 | -0.017 | 0.2397 | No |
| 34 | LCMT2 | LCMT2 Entrez, Source | leucine carboxyl methyltransferase 2 | 8774 | -0.019 | 0.2345 | No |
| 35 | MAOB | MAOB Entrez, Source | monoamine oxidase B | 8794 | -0.019 | 0.2388 | No |
| 36 | ALDH9A1 | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 9309 | -0.026 | 0.2079 | No |
| 37 | METTL6 | METTL6 Entrez, Source | methyltransferase like 6 | 9390 | -0.027 | 0.2100 | No |
| 38 | ALDH3A2 | ALDH3A2 Entrez, Source | aldehyde dehydrogenase 3 family, member A2 | 9511 | -0.029 | 0.2095 | No |
| 39 | ALDH7A1 | ALDH7A1 Entrez, Source | aldehyde dehydrogenase 7 family, member A1 | 10287 | -0.041 | 0.1635 | No |
| 40 | ASMT | ASMT Entrez, Source | acetylserotonin O-methyltransferase | 12058 | -0.090 | 0.0570 | No |
| 41 | ALDH1B1 | ALDH1B1 Entrez, Source | aldehyde dehydrogenase 1 family, member B1 | 12682 | -0.133 | 0.0496 | No |
