Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | HSA04115_P53_SIGNALING_PATHWAY |
| Enrichment Score (ES) | -0.570752 |
| Normalized Enrichment Score (NES) | -1.7876377 |
| Nominal p-value | 0.0017182131 |
| FDR q-value | 0.04416714 |
| FWER p-Value | 0.984 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | GADD45G | GADD45G Entrez, Source | growth arrest and DNA-damage-inducible, gamma | 160 | 0.189 | 0.0452 | No |
| 2 | MDM4 | MDM4 Entrez, Source | Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) | 683 | 0.113 | 0.0401 | No |
| 3 | IGFBP3 | IGFBP3 Entrez, Source | insulin-like growth factor binding protein 3 | 2407 | 0.060 | -0.0713 | No |
| 4 | IGF1 | IGF1 Entrez, Source | insulin-like growth factor 1 (somatomedin C) | 4345 | 0.032 | -0.2072 | No |
| 5 | RCHY1 | RCHY1 Entrez, Source | ring finger and CHY zinc finger domain containing 1 | 4408 | 0.031 | -0.2024 | No |
| 6 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 4572 | 0.029 | -0.2059 | No |
| 7 | FAS | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 4836 | 0.026 | -0.2179 | No |
| 8 | GADD45A | GADD45A Entrez, Source | growth arrest and DNA-damage-inducible, alpha | 5178 | 0.022 | -0.2369 | No |
| 9 | CASP9 | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 5394 | 0.019 | -0.2472 | No |
| 10 | CCNE1 | CCNE1 Entrez, Source | cyclin E1 | 5568 | 0.017 | -0.2550 | No |
| 11 | CCND2 | CCND2 Entrez, Source | cyclin D2 | 5771 | 0.015 | -0.2655 | No |
| 12 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 5802 | 0.015 | -0.2633 | No |
| 13 | CYCS | CYCS Entrez, Source | cytochrome c, somatic | 6937 | 0.003 | -0.3477 | No |
| 14 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 7469 | -0.003 | -0.3866 | No |
| 15 | SERPINB5 | SERPINB5 Entrez, Source | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 8500 | -0.016 | -0.4594 | No |
| 16 | CDK6 | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 8604 | -0.017 | -0.4620 | No |
| 17 | BBC3 | BBC3 Entrez, Source | BCL2 binding component 3 | 8982 | -0.022 | -0.4838 | No |
| 18 | ZMAT3 | ZMAT3 Entrez, Source | zinc finger, matrin type 3 | 9110 | -0.023 | -0.4863 | No |
| 19 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 9613 | -0.031 | -0.5147 | No |
| 20 | CHEK2 | CHEK2 Entrez, Source | CHK2 checkpoint homolog (S. pombe) | 10020 | -0.037 | -0.5341 | No |
| 21 | EI24 | EI24 Entrez, Source | etoposide induced 2.4 mRNA | 10107 | -0.038 | -0.5289 | No |
| 22 | CCNG1 | CCNG1 Entrez, Source | cyclin G1 | 10280 | -0.041 | -0.5295 | No |
| 23 | BAX | BAX Entrez, Source | BCL2-associated X protein | 10281 | -0.041 | -0.5171 | No |
| 24 | TSC2 | TSC2 Entrez, Source | tuberous sclerosis 2 | 10588 | -0.047 | -0.5259 | No |
| 25 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 10614 | -0.047 | -0.5136 | No |
| 26 | BID | BID Entrez, Source | BH3 interacting domain death agonist | 11376 | -0.064 | -0.5513 | Yes |
| 27 | CASP8 | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 11387 | -0.065 | -0.5325 | Yes |
| 28 | CCND3 | CCND3 Entrez, Source | cyclin D3 | 11760 | -0.077 | -0.5371 | Yes |
| 29 | STEAP3 | STEAP3 Entrez, Source | STEAP family member 3 | 11866 | -0.082 | -0.5203 | Yes |
| 30 | CD82 | CD82 Entrez, Source | CD82 molecule | 11868 | -0.082 | -0.4957 | Yes |
| 31 | CASP3 | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 12003 | -0.087 | -0.4795 | Yes |
| 32 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 12064 | -0.090 | -0.4568 | Yes |
| 33 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 12294 | -0.103 | -0.4429 | Yes |
| 34 | CCNB2 | CCNB2 Entrez, Source | cyclin B2 | 12396 | -0.111 | -0.4170 | Yes |
| 35 | CHEK1 | CHEK1 Entrez, Source | CHK1 checkpoint homolog (S. pombe) | 12915 | -0.168 | -0.4051 | Yes |
| 36 | CCNB1 | CCNB1 Entrez, Source | cyclin B1 | 13126 | -0.245 | -0.3469 | Yes |
| 37 | CCND1 | CCND1 Entrez, Source | cyclin D1 | 13250 | -0.352 | -0.2498 | Yes |
| 38 | APAF1 | APAF1 Entrez, Source | apoptotic peptidase activating factor | 13256 | -0.365 | -0.1400 | Yes |
| 39 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 13308 | -0.484 | 0.0026 | Yes |
