Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | HSA04510_FOCAL_ADHESION |
| Enrichment Score (ES) | -0.46874142 |
| Normalized Enrichment Score (NES) | -1.7777197 |
| Nominal p-value | 0.0013947001 |
| FDR q-value | 0.04630609 |
| FWER p-Value | 0.988 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | COL5A3 | COL5A3 Entrez, Source | collagen, type V, alpha 3 | 285 | 0.151 | -0.0059 | No |
| 2 | EGF | EGF Entrez, Source | epidermal growth factor (beta-urogastrone) | 316 | 0.148 | 0.0071 | No |
| 3 | VTN | VTN Entrez, Source | vitronectin | 420 | 0.133 | 0.0130 | No |
| 4 | ITGA7 | ITGA7 Entrez, Source | integrin, alpha 7 | 752 | 0.109 | -0.0008 | No |
| 5 | BRAF | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 842 | 0.105 | 0.0033 | No |
| 6 | AKT3 | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 871 | 0.104 | 0.0119 | No |
| 7 | ITGB5 | ITGB5 Entrez, Source | integrin, beta 5 | 1194 | 0.090 | -0.0032 | No |
| 8 | FYN | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 1682 | 0.075 | -0.0323 | No |
| 9 | COL1A2 | COL1A2 Entrez, Source | collagen, type I, alpha 2 | 2001 | 0.068 | -0.0494 | No |
| 10 | CRKL | CRKL Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 2223 | 0.064 | -0.0595 | No |
| 11 | RAF1 | RAF1 Entrez, Source | v-raf-1 murine leukemia viral oncogene homolog 1 | 2284 | 0.062 | -0.0576 | No |
| 12 | FLNC | FLNC Entrez, Source | filamin C, gamma (actin binding protein 280) | 2361 | 0.061 | -0.0571 | No |
| 13 | SHC1 | SHC1 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 1 | 2417 | 0.060 | -0.0551 | No |
| 14 | KDR | KDR Entrez, Source | kinase insert domain receptor (a type III receptor tyrosine kinase) | 2505 | 0.058 | -0.0556 | No |
| 15 | IBSP | IBSP Entrez, Source | integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II) | 2513 | 0.058 | -0.0501 | No |
| 16 | VAV1 | VAV1 Entrez, Source | vav 1 oncogene | 2574 | 0.057 | -0.0488 | No |
| 17 | SPP1 | SPP1 Entrez, Source | secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) | 2593 | 0.057 | -0.0442 | No |
| 18 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 2668 | 0.056 | -0.0441 | No |
| 19 | EGFR | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 2688 | 0.055 | -0.0398 | No |
| 20 | MYL2 | MYL2 Entrez, Source | myosin, light chain 2, regulatory, cardiac, slow | 2705 | 0.055 | -0.0353 | No |
| 21 | THBS4 | THBS4 Entrez, Source | thrombospondin 4 | 2758 | 0.054 | -0.0337 | No |
| 22 | MYLK2 | MYLK2 Entrez, Source | myosin light chain kinase 2, skeletal muscle | 2947 | 0.051 | -0.0426 | No |
| 23 | ITGB7 | ITGB7 Entrez, Source | integrin, beta 7 | 3051 | 0.049 | -0.0453 | No |
| 24 | LAMA3 | LAMA3 Entrez, Source | laminin, alpha 3 | 3419 | 0.044 | -0.0685 | No |
| 25 | FLT1 | FLT1 Entrez, Source | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 3532 | 0.042 | -0.0726 | No |
| 26 | PDGFRA | PDGFRA Entrez, Source | platelet-derived growth factor receptor, alpha polypeptide | 3570 | 0.042 | -0.0711 | No |
| 27 | HGF | HGF Entrez, Source | hepatocyte growth factor (hepapoietin A; scatter factor) | 3627 | 0.041 | -0.0711 | No |
| 28 | COL6A2 | COL6A2 Entrez, Source | collagen, type VI, alpha 2 | 3659 | 0.041 | -0.0692 | No |
| 29 | CAV3 | CAV3 Entrez, Source | caveolin 3 | 3663 | 0.041 | -0.0652 | No |
| 30 | CHAD | CHAD Entrez, Source | chondroadherin | 3762 | 0.040 | -0.0685 | No |
| 31 | ARHGAP5 | ARHGAP5 Entrez, Source | Rho GTPase activating protein 5 | 3833 | 0.039 | -0.0698 | No |
| 32 | SRC | SRC Entrez, Source | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 3918 | 0.038 | -0.0723 | No |
| 33 | PIK3R3 | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 3943 | 0.037 | -0.0702 | No |
| 34 | FLNB | FLNB Entrez, Source | filamin B, beta (actin binding protein 278) | 4024 | 0.036 | -0.0726 | No |
| 35 | FIGF | FIGF Entrez, Source | c-fos induced growth factor (vascular endothelial growth factor D) | 4096 | 0.035 | -0.0743 | No |
| 36 | AKT2 | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 4202 | 0.034 | -0.0788 | No |
| 37 | COL5A1 | COL5A1 Entrez, Source | collagen, type V, alpha 1 | 4268 | 0.033 | -0.0803 | No |
| 38 | BCL2 | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 4328 | 0.032 | -0.0814 | No |
| 39 | IGF1 | IGF1 Entrez, Source | insulin-like growth factor 1 (somatomedin C) | 4345 | 0.032 | -0.0793 | No |
| 40 | VEGFB | VEGFB Entrez, Source | vascular endothelial growth factor B | 4395 | 0.031 | -0.0798 | No |
| 41 | COL4A1 | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 4425 | 0.031 | -0.0788 | No |
| 42 | COL1A1 | COL1A1 Entrez, Source | collagen, type I, alpha 1 | 4462 | 0.030 | -0.0784 | No |
| 43 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 4572 | 0.029 | -0.0836 | No |
| 44 | PRKCB1 | PRKCB1 Entrez, Source | protein kinase C, beta 1 | 4579 | 0.029 | -0.0811 | No |
| 45 | THBS2 | THBS2 Entrez, Source | thrombospondin 2 | 4709 | 0.027 | -0.0880 | No |
| 46 | IGF1R | IGF1R Entrez, Source | insulin-like growth factor 1 receptor | 4743 | 0.027 | -0.0877 | No |
| 47 | PPP1CB | PPP1CB Entrez, Source | protein phosphatase 1, catalytic subunit, beta isoform | 5113 | 0.022 | -0.1134 | No |
| 48 | VWF | VWF Entrez, Source | von Willebrand factor | 5296 | 0.020 | -0.1250 | No |
| 49 | PDPK1 | PDPK1 Entrez, Source | 3-phosphoinositide dependent protein kinase-1 | 5563 | 0.018 | -0.1433 | No |
| 50 | CCND2 | CCND2 Entrez, Source | cyclin D2 | 5771 | 0.015 | -0.1574 | No |
| 51 | COL2A1 | COL2A1 Entrez, Source | collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) | 6063 | 0.012 | -0.1782 | No |
| 52 | RAC2 | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 6150 | 0.011 | -0.1835 | No |
| 53 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 6389 | 0.009 | -0.2007 | No |
| 54 | MAPK9 | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 6392 | 0.009 | -0.1999 | No |
| 55 | MAPK1 | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 6633 | 0.006 | -0.2174 | No |
| 56 | MAPK10 | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 6962 | 0.002 | -0.2420 | No |
| 57 | RAP1A | RAP1A Entrez, Source | RAP1A, member of RAS oncogene family | 7041 | 0.002 | -0.2478 | No |
| 58 | GRB2 | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 7179 | 0.000 | -0.2581 | No |
| 59 | FN1 | FN1 Entrez, Source | fibronectin 1 | 7215 | -0.000 | -0.2607 | No |
| 60 | COL11A1 | COL11A1 Entrez, Source | collagen, type XI, alpha 1 | 7238 | -0.001 | -0.2623 | No |
| 61 | TNR | TNR Entrez, Source | tenascin R (restrictin, janusin) | 7239 | -0.001 | -0.2623 | No |
| 62 | PRKCA | PRKCA Entrez, Source | protein kinase C, alpha | 7310 | -0.002 | -0.2674 | No |
| 63 | PAK3 | PAK3 Entrez, Source | p21 (CDKN1A)-activated kinase 3 | 7555 | -0.004 | -0.2854 | No |
| 64 | ITGA9 | ITGA9 Entrez, Source | integrin, alpha 9 | 7618 | -0.005 | -0.2896 | No |
| 65 | ITGA1 | ITGA1 Entrez, Source | integrin, alpha 1 | 7816 | -0.007 | -0.3038 | No |
| 66 | COL5A2 | COL5A2 Entrez, Source | collagen, type V, alpha 2 | 7962 | -0.009 | -0.3138 | No |
| 67 | PIK3CB | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 8066 | -0.010 | -0.3205 | No |
| 68 | JUN | JUN Entrez, Source | jun oncogene | 8081 | -0.010 | -0.3205 | No |
| 69 | MAP2K1 | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 8219 | -0.012 | -0.3297 | No |
| 70 | LAMA5 | LAMA5 Entrez, Source | laminin, alpha 5 | 8549 | -0.016 | -0.3529 | No |
| 71 | PDGFRB | PDGFRB Entrez, Source | platelet-derived growth factor receptor, beta polypeptide | 8636 | -0.017 | -0.3576 | No |
| 72 | PPP1CC | PPP1CC Entrez, Source | protein phosphatase 1, catalytic subunit, gamma isoform | 8913 | -0.021 | -0.3764 | No |
| 73 | CTNNB1 | CTNNB1 Entrez, Source | catenin (cadherin-associated protein), beta 1, 88kDa | 8921 | -0.021 | -0.3748 | No |
| 74 | HRAS | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 9267 | -0.025 | -0.3982 | No |
| 75 | RAPGEF1 | RAPGEF1 Entrez, Source | Rap guanine nucleotide exchange factor (GEF) 1 | 9443 | -0.028 | -0.4086 | No |
| 76 | PARVA | PARVA Entrez, Source | parvin, alpha | 9522 | -0.029 | -0.4115 | No |
| 77 | SOS2 | SOS2 Entrez, Source | son of sevenless homolog 2 (Drosophila) | 9696 | -0.032 | -0.4213 | No |
| 78 | ROCK1 | ROCK1 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 1 | 9904 | -0.035 | -0.4333 | No |
| 79 | PGF | PGF Entrez, Source | placental growth factor, vascular endothelial growth factor-related protein | 9927 | -0.035 | -0.4313 | No |
| 80 | ITGB4 | ITGB4 Entrez, Source | integrin, beta 4 | 9935 | -0.035 | -0.4282 | No |
| 81 | BIRC2 | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 9946 | -0.036 | -0.4253 | No |
| 82 | ITGB1 | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 10521 | -0.046 | -0.4640 | Yes |
| 83 | CRK | CRK Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian) | 10537 | -0.046 | -0.4604 | Yes |
| 84 | RHOA | RHOA Entrez, Source | ras homolog gene family, member A | 10584 | -0.047 | -0.4591 | Yes |
| 85 | PDGFD | PDGFD Entrez, Source | platelet derived growth factor D | 10631 | -0.048 | -0.4577 | Yes |
| 86 | PPP1CA | PPP1CA Entrez, Source | protein phosphatase 1, catalytic subunit, alpha isoform | 10652 | -0.048 | -0.4542 | Yes |
| 87 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 10703 | -0.049 | -0.4529 | Yes |
| 88 | PPP1R12A | PPP1R12A Entrez, Source | protein phosphatase 1, regulatory (inhibitor) subunit 12A | 10736 | -0.050 | -0.4502 | Yes |
| 89 | PIK3R2 | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 10802 | -0.052 | -0.4497 | Yes |
| 90 | TLN1 | TLN1 Entrez, Source | talin 1 | 10840 | -0.052 | -0.4471 | Yes |
| 91 | COL4A4 | COL4A4 Entrez, Source | collagen, type IV, alpha 4 | 10867 | -0.053 | -0.4436 | Yes |
| 92 | ERBB2 | ERBB2 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 10906 | -0.054 | -0.4409 | Yes |
| 93 | PTK2 | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 10930 | -0.054 | -0.4371 | Yes |
| 94 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 10939 | -0.055 | -0.4320 | Yes |
| 95 | PAK1 | PAK1 Entrez, Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 11055 | -0.057 | -0.4348 | Yes |
| 96 | COMP | COMP Entrez, Source | cartilage oligomeric matrix protein | 11234 | -0.061 | -0.4420 | Yes |
| 97 | BIRC4 | BIRC4 Entrez, Source | baculoviral IAP repeat-containing 4 | 11256 | -0.061 | -0.4373 | Yes |
| 98 | ACTB | ACTB Entrez, Source | actin, beta | 11264 | -0.061 | -0.4315 | Yes |
| 99 | BAD | BAD Entrez, Source | BCL2-antagonist of cell death | 11428 | -0.066 | -0.4370 | Yes |
| 100 | GSK3B | GSK3B Entrez, Source | glycogen synthase kinase 3 beta | 11670 | -0.074 | -0.4475 | Yes |
| 101 | RAP1B | RAP1B Entrez, Source | RAP1B, member of RAS oncogene family | 11692 | -0.075 | -0.4414 | Yes |
| 102 | CCND3 | CCND3 Entrez, Source | cyclin D3 | 11760 | -0.077 | -0.4385 | Yes |
| 103 | CAPN2 | CAPN2 Entrez, Source | calpain 2, (m/II) large subunit | 11891 | -0.083 | -0.4398 | Yes |
| 104 | ITGB6 | ITGB6 Entrez, Source | integrin, beta 6 | 11921 | -0.084 | -0.4333 | Yes |
| 105 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 11925 | -0.084 | -0.4248 | Yes |
| 106 | RELN | RELN Entrez, Source | reelin | 12016 | -0.088 | -0.4226 | Yes |
| 107 | PAK2 | PAK2 Entrez, Source | p21 (CDKN1A)-activated kinase 2 | 12118 | -0.092 | -0.4207 | Yes |
| 108 | ELK1 | ELK1 Entrez, Source | ELK1, member of ETS oncogene family | 12262 | -0.100 | -0.4211 | Yes |
| 109 | BCAR1 | BCAR1 Entrez, Source | breast cancer anti-estrogen resistance 1 | 12497 | -0.117 | -0.4267 | Yes |
| 110 | LAMB2 | LAMB2 Entrez, Source | laminin, beta 2 (laminin S) | 12523 | -0.119 | -0.4163 | Yes |
| 111 | ROCK2 | ROCK2 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 2 | 12599 | -0.125 | -0.4091 | Yes |
| 112 | ILK | ILK Entrez, Source | integrin-linked kinase | 12613 | -0.126 | -0.3970 | Yes |
| 113 | MET | MET Entrez, Source | met proto-oncogene (hepatocyte growth factor receptor) | 12631 | -0.128 | -0.3851 | Yes |
| 114 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 12665 | -0.131 | -0.3741 | Yes |
| 115 | MAPK3 | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 12674 | -0.132 | -0.3611 | Yes |
| 116 | ITGA6 | ITGA6 Entrez, Source | integrin, alpha 6 | 12716 | -0.137 | -0.3501 | Yes |
| 117 | BIRC3 | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 12722 | -0.137 | -0.3363 | Yes |
| 118 | PIK3CA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 12788 | -0.146 | -0.3261 | Yes |
| 119 | PIP5K1C | PIP5K1C Entrez, Source | phosphatidylinositol-4-phosphate 5-kinase, type I, gamma | 12836 | -0.153 | -0.3138 | Yes |
| 120 | ACTN4 | ACTN4 Entrez, Source | actinin, alpha 4 | 12842 | -0.155 | -0.2982 | Yes |
| 121 | PXN | PXN Entrez, Source | paxillin | 12950 | -0.176 | -0.2882 | Yes |
| 122 | LAMC1 | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 13024 | -0.196 | -0.2735 | Yes |
| 123 | ACTN3 | ACTN3 Entrez, Source | actinin, alpha 3 | 13042 | -0.204 | -0.2537 | Yes |
| 124 | ZYX | ZYX Entrez, Source | zyxin | 13115 | -0.238 | -0.2345 | Yes |
| 125 | CAV2 | CAV2 Entrez, Source | caveolin 2 | 13140 | -0.252 | -0.2103 | Yes |
| 126 | PDGFA | PDGFA Entrez, Source | platelet-derived growth factor alpha polypeptide | 13145 | -0.254 | -0.1843 | Yes |
| 127 | LAMB3 | LAMB3 Entrez, Source | laminin, beta 3 | 13233 | -0.329 | -0.1570 | Yes |
| 128 | CCND1 | CCND1 Entrez, Source | cyclin D1 | 13250 | -0.352 | -0.1219 | Yes |
| 129 | PDGFC | PDGFC Entrez, Source | platelet derived growth factor C | 13269 | -0.383 | -0.0837 | Yes |
| 130 | LAMC2 | LAMC2 Entrez, Source | laminin, gamma 2 | 13270 | -0.390 | -0.0434 | Yes |
| 131 | ACTN1 | ACTN1 Entrez, Source | actinin, alpha 1 | 13303 | -0.473 | 0.0030 | Yes |
