Details for gene set HSA04530_TIGHT

Table: GSEA Results Summary

Dataset	double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos
Phenotype	class.cls#double_gel_48h_versus_single_gel_48h_repos
Upregulated in class	single_gel_48h
GeneSet	HSA04530_TIGHT_JUNCTION
Enrichment Score (ES)	-0.49144045
Normalized Enrichment Score (NES)	-1.7367576
Nominal p-value	0.0031298904
FDR q-value	0.052327972
FWER p-Value	0.999

Table: GSEA details [plain text format]
	PROBE	GENE SYMBOL	GENE_TITLE	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	CLDN14	CLDN14 Entrez, Source	claudin 14	599	0.118	-0.0264	No
2	AKT3	AKT3 Entrez, Source	v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)	871	0.104	-0.0302	No
3	PRKCQ	PRKCQ Entrez, Source	protein kinase C, theta	928	0.101	-0.0184	No
4	MYH13	MYH13 Entrez, Source	myosin, heavy chain 13, skeletal muscle	988	0.098	-0.0072	No
5	MPDZ	MPDZ Entrez, Source	multiple PDZ domain protein	1036	0.096	0.0045	No
6	MYH2	MYH2 Entrez, Source	myosin, heavy chain 2, skeletal muscle, adult	1689	0.074	-0.0328	No
7	CLDN8	CLDN8 Entrez, Source	claudin 8	1724	0.074	-0.0236	No
8	PRKCE	PRKCE Entrez, Source	protein kinase C, epsilon	2008	0.068	-0.0341	No
9	CLDN11	CLDN11 Entrez, Source	claudin 11 (oligodendrocyte transmembrane protein)	2041	0.067	-0.0258	No
10	MYH6	MYH6 Entrez, Source	myosin, heavy chain 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1)	2066	0.067	-0.0170	No
11	PPP2R2C	PPP2R2C Entrez, Source	protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform	2277	0.063	-0.0229	No
12	MYH3	MYH3 Entrez, Source	myosin, heavy chain 3, skeletal muscle, embryonic	2301	0.062	-0.0147	No
13	JAM2	JAM2 Entrez, Source	junctional adhesion molecule 2	2351	0.061	-0.0087	No
14	MYH11	MYH11 Entrez, Source	myosin, heavy chain 11, smooth muscle	2696	0.055	-0.0258	No
15	MYL2	MYL2 Entrez, Source	myosin, light chain 2, regulatory, cardiac, slow	2705	0.055	-0.0176	No
16	CLDN16	CLDN16 Entrez, Source	claudin 16	2716	0.055	-0.0096	No
17	PPM1J	PPM1J Entrez, Source	protein phosphatase 1J (PP2C domain containing)	2769	0.054	-0.0050	No
18	MAGI2	MAGI2 Entrez, Source	membrane associated guanylate kinase, WW and PDZ domain containing 2	2940	0.051	-0.0096	No
19	CLDN3	CLDN3 Entrez, Source	claudin 3	3133	0.048	-0.0164	No
20	CSDA	CSDA Entrez, Source	cold shock domain protein A	3880	0.038	-0.0666	No
21	SRC	SRC Entrez, Source	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	3918	0.038	-0.0634	No
22	PRKCH	PRKCH Entrez, Source	protein kinase C, eta	3971	0.037	-0.0614	No
23	SYMPK	SYMPK Entrez, Source	symplekin	4123	0.035	-0.0673	No
24	MYH14	MYH14 Entrez, Source	myosin, heavy chain 14	4146	0.034	-0.0634	No
25	CLDN5	CLDN5 Entrez, Source	claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)	4162	0.034	-0.0591	No
26	AKT2	AKT2 Entrez, Source	v-akt murine thymoma viral oncogene homolog 2	4202	0.034	-0.0567	No
27	MYH7	MYH7 Entrez, Source	myosin, heavy chain 7, cardiac muscle, beta	4454	0.031	-0.0707	No
28	PTEN	PTEN Entrez, Source	phosphatase and tensin homolog (mutated in multiple advanced cancers 1)	4572	0.029	-0.0749	No
29	PRKCB1	PRKCB1 Entrez, Source	protein kinase C, beta 1	4579	0.029	-0.0708	No
30	PPP2R2B	PPP2R2B Entrez, Source	protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform	4958	0.024	-0.0954	No
31	HCLS1	HCLS1 Entrez, Source	hematopoietic cell-specific Lyn substrate 1	4986	0.024	-0.0936	No
32	MYH1	MYH1 Entrez, Source	myosin, heavy chain 1, skeletal muscle, adult	5231	0.021	-0.1086	No
33	PARD3	PARD3 Entrez, Source	par-3 partitioning defective 3 homolog (C. elegans)	5990	0.013	-0.1638	No
34	CLDN19	CLDN19 Entrez, Source	claudin 19	6126	0.012	-0.1721	No
35	PARD6A	PARD6A Entrez, Source	par-6 partitioning defective 6 homolog alpha (C.elegans)	6164	0.011	-0.1731	No
36	PRKCZ	PRKCZ Entrez, Source	protein kinase C, zeta	6220	0.011	-0.1755	No
37	MYH4	MYH4 Entrez, Source	myosin, heavy chain 4, skeletal muscle	6427	0.008	-0.1897	No
38	VAPA	VAPA Entrez, Source	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa	6477	0.008	-0.1922	No
39	CSNK2A1	CSNK2A1 Entrez, Source	casein kinase 2, alpha 1 polypeptide	6997	0.002	-0.2310	No
40	CSNK2B	CSNK2B Entrez, Source	casein kinase 2, beta polypeptide	7077	0.001	-0.2368	No
41	PRKCA	PRKCA Entrez, Source	protein kinase C, alpha	7310	-0.002	-0.2540	No
42	PPP2R2A	PPP2R2A Entrez, Source	protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform	7540	-0.004	-0.2706	No
43	PPP2CA	PPP2CA Entrez, Source	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	7638	-0.005	-0.2771	No
44	GNAI3	GNAI3 Entrez, Source	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3	7783	-0.007	-0.2869	No
45	PPP2R1A	PPP2R1A Entrez, Source	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	8667	-0.018	-0.3507	No
46	MRAS	MRAS Entrez, Source	muscle RAS oncogene homolog	8707	-0.018	-0.3507	No
47	KRAS	KRAS Entrez, Source	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	8834	-0.020	-0.3571	No
48	CTNNB1	CTNNB1 Entrez, Source	catenin (cadherin-associated protein), beta 1, 88kDa	8921	-0.021	-0.3603	No
49	MYH8	MYH8 Entrez, Source	myosin, heavy chain 8, skeletal muscle, perinatal	8972	-0.022	-0.3606	No
50	HRAS	HRAS Entrez, Source	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	9267	-0.025	-0.3787	No
51	EXOC3	EXOC3 Entrez, Source	exocyst complex component 3	9500	-0.029	-0.3916	No
52	RAB3B	RAB3B Entrez, Source	RAB3B, member RAS oncogene family	9706	-0.032	-0.4020	No
53	PPP2R1B	PPP2R1B Entrez, Source	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform	9775	-0.033	-0.4018	No
54	MLLT4	MLLT4 Entrez, Source	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	10164	-0.039	-0.4248	No
55	PPP2CB	PPP2CB Entrez, Source	protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform	10348	-0.042	-0.4319	No
56	RHOA	RHOA Entrez, Source	ras homolog gene family, member A	10584	-0.047	-0.4421	No
57	CDC42	CDC42 Entrez, Source	cell division cycle 42 (GTP binding protein, 25kDa)	10703	-0.049	-0.4431	No
58	CRB3	CRB3 Entrez, Source	crumbs homolog 3 (Drosophila)	11057	-0.057	-0.4607	No
59	ACTB	ACTB Entrez, Source	actin, beta	11264	-0.061	-0.4664	No
60	CTTN	CTTN Entrez, Source	cortactin	11597	-0.072	-0.4800	Yes
61	F11R	F11R Entrez, Source	F11 receptor	11615	-0.073	-0.4697	Yes
62	CASK	CASK Entrez, Source	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	11862	-0.081	-0.4753	Yes
63	EXOC4	EXOC4 Entrez, Source	exocyst complex component 4	11873	-0.082	-0.4630	Yes
64	AKT1	AKT1 Entrez, Source	v-akt murine thymoma viral oncogene homolog 1	11925	-0.084	-0.4534	Yes
65	CLDN1	CLDN1 Entrez, Source	claudin 1	12033	-0.089	-0.4473	Yes
66	MYH9	MYH9 Entrez, Source	myosin, heavy chain 9, non-muscle	12120	-0.093	-0.4390	Yes
67	NRAS	NRAS Entrez, Source	neuroblastoma RAS viral (v-ras) oncogene homolog	12153	-0.094	-0.4264	Yes
68	RAB13	RAB13 Entrez, Source	RAB13, member RAS oncogene family	12213	-0.098	-0.4153	Yes
69	PRKCI	PRKCI Entrez, Source	protein kinase C, iota	12255	-0.100	-0.4025	Yes
70	CDK4	CDK4 Entrez, Source	cyclin-dependent kinase 4	12294	-0.103	-0.3889	Yes
71	TJP2	TJP2 Entrez, Source	tight junction protein 2 (zona occludens 2)	12313	-0.104	-0.3736	Yes
72	CLDN7	CLDN7 Entrez, Source	claudin 7	12374	-0.109	-0.3607	Yes
73	MAGI3	MAGI3 Entrez, Source	membrane associated guanylate kinase, WW and PDZ domain containing 3	12479	-0.116	-0.3501	Yes
74	MYH10	MYH10 Entrez, Source	myosin, heavy chain 10, non-muscle	12486	-0.117	-0.3319	Yes
75	PRKCD	PRKCD Entrez, Source	protein kinase C, delta	12535	-0.120	-0.3164	Yes
76	GNAI2	GNAI2 Entrez, Source	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	12765	-0.143	-0.3108	Yes
77	ACTN4	ACTN4 Entrez, Source	actinin, alpha 4	12842	-0.155	-0.2918	Yes
78	JAM3	JAM3 Entrez, Source	junctional adhesion molecule 3	12897	-0.164	-0.2697	Yes
79	CLDN4	CLDN4 Entrez, Source	claudin 4	12969	-0.181	-0.2462	Yes
80	ACTN3	ACTN3 Entrez, Source	actinin, alpha 3	13042	-0.204	-0.2191	Yes
81	RRAS2	RRAS2 Entrez, Source	related RAS viral (r-ras) oncogene homolog 2	13125	-0.244	-0.1863	Yes
82	GNAI1	GNAI1 Entrez, Source	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	13239	-0.335	-0.1413	Yes
83	PPP2R3A	PPP2R3A Entrez, Source	protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha	13298	-0.461	-0.0721	Yes
84	ACTN1	ACTN1 Entrez, Source	actinin, alpha 1	13303	-0.473	0.0029	Yes