Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | double_gel_48h |
| GeneSet | HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES |
| Enrichment Score (ES) | 0.41108257 |
| Normalized Enrichment Score (NES) | 1.4747164 |
| Nominal p-value | 0.031496063 |
| FDR q-value | 0.1614051 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | C4BPB | C4BPB Entrez, Source | complement component 4 binding protein, beta | 22 | 0.342 | 0.0554 | Yes |
| 2 | KLKB1 | KLKB1 Entrez, Source | kallikrein B, plasma (Fletcher factor) 1 | 77 | 0.245 | 0.0923 | Yes |
| 3 | C4BPA | C4BPA Entrez, Source | complement component 4 binding protein, alpha | 79 | 0.243 | 0.1327 | Yes |
| 4 | SERPIND1 | SERPIND1 Entrez, Source | serpin peptidase inhibitor, clade D (heparin cofactor), member 1 | 83 | 0.240 | 0.1726 | Yes |
| 5 | PLG | PLG Entrez, Source | plasminogen | 120 | 0.206 | 0.2043 | Yes |
| 6 | CFB | CFB Entrez, Source | complement factor B | 140 | 0.196 | 0.2357 | Yes |
| 7 | F9 | F9 Entrez, Source | coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B) | 243 | 0.161 | 0.2548 | Yes |
| 8 | FGB | FGB Entrez, Source | fibrinogen beta chain | 461 | 0.129 | 0.2600 | Yes |
| 9 | C1QB | C1QB Entrez, Source | complement component 1, q subcomponent, B chain | 465 | 0.129 | 0.2812 | Yes |
| 10 | A2M | A2M Entrez, Source | alpha-2-macroglobulin | 573 | 0.120 | 0.2932 | Yes |
| 11 | C1QA | C1QA Entrez, Source | complement component 1, q subcomponent, A chain | 620 | 0.117 | 0.3093 | Yes |
| 12 | SERPINF2 | SERPINF2 Entrez, Source | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 | 621 | 0.117 | 0.3288 | Yes |
| 13 | C6 | C6 Entrez, Source | complement component 6 | 786 | 0.107 | 0.3344 | Yes |
| 14 | SERPINC1 | SERPINC1 Entrez, Source | serpin peptidase inhibitor, clade C (antithrombin), member 1 | 864 | 0.104 | 0.3460 | Yes |
| 15 | CFH | CFH Entrez, Source | complement factor H | 1213 | 0.089 | 0.3348 | Yes |
| 16 | FGA | FGA Entrez, Source | fibrinogen alpha chain | 1253 | 0.088 | 0.3464 | Yes |
| 17 | MASP2 | MASP2 Entrez, Source | mannan-binding lectin serine peptidase 2 | 1254 | 0.088 | 0.3611 | Yes |
| 18 | SERPINA5 | SERPINA5 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | 1311 | 0.086 | 0.3711 | Yes |
| 19 | F10 | F10 Entrez, Source | coagulation factor X | 1312 | 0.086 | 0.3854 | Yes |
| 20 | FGG | FGG Entrez, Source | fibrinogen gamma chain | 1572 | 0.078 | 0.3789 | Yes |
| 21 | C3 | C3 Entrez, Source | complement component 3 | 1731 | 0.074 | 0.3793 | Yes |
| 22 | THBD | THBD Entrez, Source | thrombomodulin | 1858 | 0.071 | 0.3816 | Yes |
| 23 | C9 | C9 Entrez, Source | complement component 9 | 1879 | 0.070 | 0.3919 | Yes |
| 24 | PROC | PROC Entrez, Source | protein C (inactivator of coagulation factors Va and VIIIa) | 1881 | 0.070 | 0.4035 | Yes |
| 25 | CFI | CFI Entrez, Source | complement factor I | 1936 | 0.069 | 0.4111 | Yes |
| 26 | C5AR1 | C5AR1 Entrez, Source | complement component 5a receptor 1 | 2348 | 0.061 | 0.3903 | No |
| 27 | C1QC | C1QC Entrez, Source | complement component 1, q subcomponent, C chain | 2432 | 0.060 | 0.3941 | No |
| 28 | F2 | F2 Entrez, Source | coagulation factor II (thrombin) | 2483 | 0.059 | 0.4001 | No |
| 29 | CFD | CFD Entrez, Source | complement factor D (adipsin) | 2506 | 0.058 | 0.4082 | No |
| 30 | SERPINA1 | SERPINA1 Entrez, Source | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 2824 | 0.053 | 0.3932 | No |
| 31 | SERPING1 | SERPING1 Entrez, Source | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | 3232 | 0.047 | 0.3704 | No |
| 32 | PLAU | PLAU Entrez, Source | plasminogen activator, urokinase | 3505 | 0.043 | 0.3571 | No |
| 33 | F12 | F12 Entrez, Source | coagulation factor XII (Hageman factor) | 4131 | 0.035 | 0.3158 | No |
| 34 | F13A1 | F13A1 Entrez, Source | coagulation factor XIII, A1 polypeptide | 5027 | 0.023 | 0.2524 | No |
| 35 | VWF | VWF Entrez, Source | von Willebrand factor | 5296 | 0.020 | 0.2357 | No |
| 36 | CPB2 | CPB2 Entrez, Source | carboxypeptidase B2 (plasma, carboxypeptidase U) | 5335 | 0.020 | 0.2361 | No |
| 37 | MASP1 | MASP1 Entrez, Source | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) | 5355 | 0.020 | 0.2380 | No |
| 38 | PROS1 | PROS1 Entrez, Source | protein S (alpha) | 5663 | 0.016 | 0.2176 | No |
| 39 | BDKRB2 | BDKRB2 Entrez, Source | bradykinin receptor B2 | 7148 | 0.000 | 0.1061 | No |
| 40 | C3AR1 | C3AR1 Entrez, Source | complement component 3a receptor 1 | 7802 | -0.007 | 0.0581 | No |
| 41 | MBL2 | MBL2 Entrez, Source | mannose-binding lectin (protein C) 2, soluble (opsonic defect) | 8903 | -0.021 | -0.0212 | No |
| 42 | TFPI | TFPI Entrez, Source | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 8929 | -0.021 | -0.0196 | No |
| 43 | F8 | F8 Entrez, Source | coagulation factor VIII, procoagulant component (hemophilia A) | 9088 | -0.023 | -0.0276 | No |
| 44 | BDKRB1 | BDKRB1 Entrez, Source | bradykinin receptor B1 | 10044 | -0.037 | -0.0932 | No |
| 45 | C1R | C1R Entrez, Source | complement component 1, r subcomponent | 11719 | -0.076 | -0.2065 | No |
| 46 | C2 | C2 Entrez, Source | complement component 2 | 11739 | -0.077 | -0.1951 | No |
| 47 | CD59 | CD59 Entrez, Source | CD59 molecule, complement regulatory protein | 12353 | -0.107 | -0.2233 | No |
| 48 | PLAUR | PLAUR Entrez, Source | plasminogen activator, urokinase receptor | 12561 | -0.122 | -0.2185 | No |
| 49 | F2R | F2R Entrez, Source | coagulation factor II (thrombin) receptor | 13224 | -0.321 | -0.2148 | No |
| 50 | PLAT | PLAT Entrez, Source | plasminogen activator, tissue | 13241 | -0.343 | -0.1587 | No |
| 51 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 13308 | -0.484 | -0.0828 | No |
| 52 | F3 | F3 Entrez, Source | coagulation factor III (thromboplastin, tissue factor) | 13315 | -0.511 | 0.0020 | No |
