Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | double_gel_48h |
| GeneSet | HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY |
| Enrichment Score (ES) | 0.41413152 |
| Normalized Enrichment Score (NES) | 1.5451945 |
| Nominal p-value | 0.011142061 |
| FDR q-value | 0.12320277 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | G6PC | G6PC Entrez, Source | glucose-6-phosphatase, catalytic subunit | 26 | 0.337 | 0.0784 | Yes |
| 2 | PCK1 | PCK1 Entrez, Source | phosphoenolpyruvate carboxykinase 1 (soluble) | 148 | 0.193 | 0.1153 | Yes |
| 3 | PPARA | PPARA Entrez, Source | peroxisome proliferative activated receptor, alpha | 155 | 0.190 | 0.1602 | Yes |
| 4 | IRS1 | IRS1 Entrez, Source | insulin receptor substrate 1 | 233 | 0.163 | 0.1932 | Yes |
| 5 | CAMKK1 | CAMKK1 Entrez, Source | calcium/calmodulin-dependent protein kinase kinase 1, alpha | 334 | 0.144 | 0.2201 | Yes |
| 6 | LEPR | LEPR Entrez, Source | leptin receptor | 448 | 0.130 | 0.2425 | Yes |
| 7 | CPT1A | CPT1A Entrez, Source | carnitine palmitoyltransferase 1A (liver) | 469 | 0.128 | 0.2715 | Yes |
| 8 | ACSL1 | ACSL1 Entrez, Source | acyl-CoA synthetase long-chain family member 1 | 564 | 0.121 | 0.2932 | Yes |
| 9 | CPT2 | CPT2 Entrez, Source | carnitine palmitoyltransferase II | 840 | 0.105 | 0.2976 | Yes |
| 10 | AKT3 | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 871 | 0.104 | 0.3201 | Yes |
| 11 | SLC2A4 | SLC2A4 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 4 | 900 | 0.102 | 0.3424 | Yes |
| 12 | PRKCQ | PRKCQ Entrez, Source | protein kinase C, theta | 928 | 0.101 | 0.3644 | Yes |
| 13 | ACSL3 | ACSL3 Entrez, Source | acyl-CoA synthetase long-chain family member 3 | 1240 | 0.088 | 0.3620 | Yes |
| 14 | CAMKK2 | CAMKK2 Entrez, Source | calcium/calmodulin-dependent protein kinase kinase 2, beta | 1389 | 0.083 | 0.3706 | Yes |
| 15 | RXRA | RXRA Entrez, Source | retinoid X receptor, alpha | 1400 | 0.083 | 0.3896 | Yes |
| 16 | ACSL5 | ACSL5 Entrez, Source | acyl-CoA synthetase long-chain family member 5 | 1561 | 0.078 | 0.3961 | Yes |
| 17 | PRKAA1 | PRKAA1 Entrez, Source | protein kinase, AMP-activated, alpha 1 catalytic subunit | 1569 | 0.078 | 0.4141 | Yes |
| 18 | RXRG | RXRG Entrez, Source | retinoid X receptor, gamma | 2314 | 0.062 | 0.3728 | No |
| 19 | SOCS3 | SOCS3 Entrez, Source | suppressor of cytokine signaling 3 | 2355 | 0.061 | 0.3843 | No |
| 20 | PRKAA2 | PRKAA2 Entrez, Source | protein kinase, AMP-activated, alpha 2 catalytic subunit | 2659 | 0.056 | 0.3749 | No |
| 21 | CPT1C | CPT1C Entrez, Source | carnitine palmitoyltransferase 1C | 2734 | 0.055 | 0.3823 | No |
| 22 | TNFRSF1A | TNFRSF1A Entrez, Source | tumor necrosis factor receptor superfamily, member 1A | 2994 | 0.050 | 0.3747 | No |
| 23 | ACSL4 | ACSL4 Entrez, Source | acyl-CoA synthetase long-chain family member 4 | 3359 | 0.045 | 0.3580 | No |
| 24 | RXRB | RXRB Entrez, Source | retinoid X receptor, beta | 3669 | 0.041 | 0.3445 | No |
| 25 | FRAP1 | FRAP1 Entrez, Source | FK506 binding protein 12-rapamycin associated protein 1 | 3947 | 0.037 | 0.3325 | No |
| 26 | AKT2 | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 4202 | 0.034 | 0.3214 | No |
| 27 | ACSL6 | ACSL6 Entrez, Source | acyl-CoA synthetase long-chain family member 6 | 4555 | 0.029 | 0.3019 | No |
| 28 | ADIPOQ | ADIPOQ Entrez, Source | adiponectin, C1Q and collagen domain containing | 5211 | 0.021 | 0.2577 | No |
| 29 | ACACB | ACACB Entrez, Source | acetyl-Coenzyme A carboxylase beta | 6337 | 0.009 | 0.1752 | No |
| 30 | MAPK9 | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 6392 | 0.009 | 0.1732 | No |
| 31 | PPARGC1A | PPARGC1A Entrez, Source | peroxisome proliferative activated receptor, gamma, coactivator 1, alpha | 6549 | 0.007 | 0.1631 | No |
| 32 | TNF | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 6778 | 0.004 | 0.1470 | No |
| 33 | MAPK10 | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 6962 | 0.002 | 0.1338 | No |
| 34 | ADIPOR2 | ADIPOR2 Entrez, Source | adiponectin receptor 2 | 7084 | 0.001 | 0.1250 | No |
| 35 | POMC | POMC Entrez, Source | proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin) | 7234 | -0.001 | 0.1139 | No |
| 36 | PTPN11 | PTPN11 Entrez, Source | protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | 7325 | -0.002 | 0.1075 | No |
| 37 | PRKAG2 | PRKAG2 Entrez, Source | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 7813 | -0.007 | 0.0726 | No |
| 38 | PRKAB2 | PRKAB2 Entrez, Source | protein kinase, AMP-activated, beta 2 non-catalytic subunit | 7852 | -0.008 | 0.0716 | No |
| 39 | JAK3 | JAK3 Entrez, Source | Janus kinase 3 (a protein tyrosine kinase, leukocyte) | 8088 | -0.010 | 0.0564 | No |
| 40 | JAK2 | JAK2 Entrez, Source | Janus kinase 2 (a protein tyrosine kinase) | 8330 | -0.013 | 0.0414 | No |
| 41 | NFKBIB | NFKBIB Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 8679 | -0.018 | 0.0194 | No |
| 42 | CPT1B | CPT1B Entrez, Source | carnitine palmitoyltransferase 1B (muscle) | 9047 | -0.023 | -0.0028 | No |
| 43 | STAT3 | STAT3 Entrez, Source | signal transducer and activator of transcription 3 (acute-phase response factor) | 9416 | -0.028 | -0.0239 | No |
| 44 | JAK1 | JAK1 Entrez, Source | Janus kinase 1 (a protein tyrosine kinase) | 10118 | -0.039 | -0.0674 | No |
| 45 | PRKAB1 | PRKAB1 Entrez, Source | protein kinase, AMP-activated, beta 1 non-catalytic subunit | 10265 | -0.041 | -0.0687 | No |
| 46 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 10388 | -0.043 | -0.0676 | No |
| 47 | ADIPOR1 | ADIPOR1 Entrez, Source | adiponectin receptor 1 | 10701 | -0.049 | -0.0793 | No |
| 48 | TRADD | TRADD Entrez, Source | TNFRSF1A-associated via death domain | 11038 | -0.057 | -0.0911 | No |
| 49 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 11138 | -0.059 | -0.0845 | No |
| 50 | LEP | LEP Entrez, Source | leptin (obesity homolog, mouse) | 11480 | -0.068 | -0.0941 | No |
| 51 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 11510 | -0.069 | -0.0799 | No |
| 52 | PRKAG1 | PRKAG1 Entrez, Source | protein kinase, AMP-activated, gamma 1 non-catalytic subunit | 11774 | -0.078 | -0.0811 | No |
| 53 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 11925 | -0.084 | -0.0724 | No |
| 54 | NFKB2 | NFKB2 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 12192 | -0.096 | -0.0694 | No |
| 55 | IKBKB | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 12540 | -0.121 | -0.0668 | No |
| 56 | NPY | NPY Entrez, Source | neuropeptide Y | 13095 | -0.230 | -0.0537 | No |
| 57 | SLC2A1 | SLC2A1 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 1 | 13210 | -0.303 | 0.0099 | No |
