Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | HSA05212_PANCREATIC_CANCER |
| Enrichment Score (ES) | -0.50695515 |
| Normalized Enrichment Score (NES) | -1.741454 |
| Nominal p-value | 0.003164557 |
| FDR q-value | 0.05160006 |
| FWER p-Value | 0.999 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | EGF | EGF Entrez, Source | epidermal growth factor (beta-urogastrone) | 316 | 0.148 | 0.0140 | No |
| 2 | BRAF | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 842 | 0.105 | 0.0014 | No |
| 3 | AKT3 | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 871 | 0.104 | 0.0259 | No |
| 4 | RAF1 | RAF1 Entrez, Source | v-raf-1 murine leukemia viral oncogene homolog 1 | 2284 | 0.062 | -0.0644 | No |
| 5 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 2668 | 0.056 | -0.0789 | No |
| 6 | EGFR | EGFR Entrez, Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 2688 | 0.055 | -0.0661 | No |
| 7 | PIK3R3 | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 3943 | 0.037 | -0.1510 | No |
| 8 | FIGF | FIGF Entrez, Source | c-fos induced growth factor (vascular endothelial growth factor D) | 4096 | 0.035 | -0.1535 | No |
| 9 | AKT2 | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 4202 | 0.034 | -0.1528 | No |
| 10 | VEGFB | VEGFB Entrez, Source | vascular endothelial growth factor B | 4395 | 0.031 | -0.1592 | No |
| 11 | TGFA | TGFA Entrez, Source | transforming growth factor, alpha | 4483 | 0.030 | -0.1580 | No |
| 12 | TGFB2 | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 5353 | 0.020 | -0.2183 | No |
| 13 | CASP9 | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 5394 | 0.019 | -0.2164 | No |
| 14 | RAC2 | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 6150 | 0.011 | -0.2703 | No |
| 15 | TGFBR1 | TGFBR1 Entrez, Source | transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) | 6257 | 0.010 | -0.2757 | No |
| 16 | MAPK9 | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 6392 | 0.009 | -0.2836 | No |
| 17 | MAPK1 | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 6633 | 0.006 | -0.3001 | No |
| 18 | MAPK10 | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 6962 | 0.002 | -0.3242 | No |
| 19 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 7053 | 0.001 | -0.3306 | No |
| 20 | ARAF | ARAF Entrez, Source | v-raf murine sarcoma 3611 viral oncogene homolog | 7771 | -0.007 | -0.3828 | No |
| 21 | PIK3CB | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 8066 | -0.010 | -0.4024 | No |
| 22 | MAP2K1 | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 8219 | -0.012 | -0.4107 | No |
| 23 | CDK6 | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 8604 | -0.017 | -0.4353 | No |
| 24 | KRAS | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 8834 | -0.020 | -0.4475 | No |
| 25 | STAT1 | STAT1 Entrez, Source | signal transducer and activator of transcription 1, 91kDa | 9067 | -0.023 | -0.4592 | No |
| 26 | ACVR1C | ACVR1C Entrez, Source | activin A receptor, type IC | 9381 | -0.027 | -0.4758 | No |
| 27 | STAT3 | STAT3 Entrez, Source | signal transducer and activator of transcription 3 (acute-phase response factor) | 9416 | -0.028 | -0.4712 | No |
| 28 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 9613 | -0.031 | -0.4781 | No |
| 29 | BRCA2 | BRCA2 Entrez, Source | breast cancer 2, early onset | 9823 | -0.034 | -0.4853 | No |
| 30 | PGF | PGF Entrez, Source | placental growth factor, vascular endothelial growth factor-related protein | 9927 | -0.035 | -0.4840 | No |
| 31 | JAK1 | JAK1 Entrez, Source | Janus kinase 1 (a protein tyrosine kinase) | 10118 | -0.039 | -0.4884 | No |
| 32 | PLD1 | PLD1 Entrez, Source | phospholipase D1, phosphatidylcholine-specific | 10235 | -0.040 | -0.4868 | No |
| 33 | SMAD4 | SMAD4 Entrez, Source | SMAD, mothers against DPP homolog 4 (Drosophila) | 10473 | -0.045 | -0.4932 | No |
| 34 | BCL2L1 | BCL2L1 Entrez, Source | BCL2-like 1 | 10657 | -0.048 | -0.4946 | Yes |
| 35 | CDC42 | CDC42 Entrez, Source | cell division cycle 42 (GTP binding protein, 25kDa) | 10703 | -0.049 | -0.4854 | Yes |
| 36 | PIK3R2 | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 10802 | -0.052 | -0.4795 | Yes |
| 37 | RALGDS | RALGDS Entrez, Source | ral guanine nucleotide dissociation stimulator | 10901 | -0.054 | -0.4732 | Yes |
| 38 | ERBB2 | ERBB2 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 10906 | -0.054 | -0.4597 | Yes |
| 39 | RAC1 | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 10939 | -0.055 | -0.4481 | Yes |
| 40 | RALA | RALA Entrez, Source | v-ral simian leukemia viral oncogene homolog A (ras related) | 11027 | -0.056 | -0.4402 | Yes |
| 41 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 11131 | -0.059 | -0.4329 | Yes |
| 42 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 11138 | -0.059 | -0.4183 | Yes |
| 43 | RALBP1 | RALBP1 Entrez, Source | ralA binding protein 1 | 11203 | -0.060 | -0.4077 | Yes |
| 44 | SMAD2 | SMAD2 Entrez, Source | SMAD, mothers against DPP homolog 2 (Drosophila) | 11223 | -0.061 | -0.3936 | Yes |
| 45 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 11401 | -0.065 | -0.3902 | Yes |
| 46 | BAD | BAD Entrez, Source | BCL2-antagonist of cell death | 11428 | -0.066 | -0.3753 | Yes |
| 47 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 11510 | -0.069 | -0.3638 | Yes |
| 48 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 11925 | -0.084 | -0.3735 | Yes |
| 49 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 12064 | -0.090 | -0.3608 | Yes |
| 50 | TGFBR2 | TGFBR2 Entrez, Source | transforming growth factor, beta receptor II (70/80kDa) | 12175 | -0.096 | -0.3447 | Yes |
| 51 | NFKB2 | NFKB2 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 12192 | -0.096 | -0.3212 | Yes |
| 52 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 12294 | -0.103 | -0.3024 | Yes |
| 53 | IKBKB | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 12540 | -0.121 | -0.2900 | Yes |
| 54 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 12665 | -0.131 | -0.2659 | Yes |
| 55 | MAPK3 | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 12674 | -0.132 | -0.2328 | Yes |
| 56 | PIK3CA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 12788 | -0.146 | -0.2039 | Yes |
| 57 | RALB | RALB Entrez, Source | v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) | 12865 | -0.159 | -0.1690 | Yes |
| 58 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 13022 | -0.195 | -0.1308 | Yes |
| 59 | TGFB3 | TGFB3 Entrez, Source | transforming growth factor, beta 3 | 13142 | -0.253 | -0.0750 | Yes |
| 60 | CCND1 | CCND1 Entrez, Source | cyclin D1 | 13250 | -0.352 | 0.0069 | Yes |
