Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | HSA05220_CHRONIC_MYELOID_LEUKEMIA |
| Enrichment Score (ES) | -0.5313732 |
| Normalized Enrichment Score (NES) | -1.7794238 |
| Nominal p-value | 0.003407155 |
| FDR q-value | 0.04627075 |
| FWER p-Value | 0.988 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | BRAF | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 842 | 0.105 | -0.0362 | No |
| 2 | AKT3 | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 871 | 0.104 | -0.0115 | No |
| 3 | STAT5A | STAT5A Entrez, Source | signal transducer and activator of transcription 5A | 1674 | 0.075 | -0.0526 | No |
| 4 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 1896 | 0.070 | -0.0511 | No |
| 5 | CRKL | CRKL Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 2223 | 0.064 | -0.0593 | No |
| 6 | RAF1 | RAF1 Entrez, Source | v-raf-1 murine leukemia viral oncogene homolog 1 | 2284 | 0.062 | -0.0477 | No |
| 7 | SHC1 | SHC1 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 1 | 2417 | 0.060 | -0.0421 | No |
| 8 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 2668 | 0.056 | -0.0465 | No |
| 9 | PIK3R3 | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 3943 | 0.037 | -0.1328 | No |
| 10 | AKT2 | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 4202 | 0.034 | -0.1436 | No |
| 11 | CBLC | CBLC Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence c | 4341 | 0.032 | -0.1457 | No |
| 12 | TGFB2 | TGFB2 Entrez, Source | transforming growth factor, beta 2 | 5353 | 0.020 | -0.2167 | No |
| 13 | GAB2 | GAB2 Entrez, Source | GRB2-associated binding protein 2 | 5597 | 0.017 | -0.2306 | No |
| 14 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 5802 | 0.015 | -0.2421 | No |
| 15 | TGFBR1 | TGFBR1 Entrez, Source | transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) | 6257 | 0.010 | -0.2736 | No |
| 16 | MAPK1 | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 6633 | 0.006 | -0.3002 | No |
| 17 | STAT5B | STAT5B Entrez, Source | signal transducer and activator of transcription 5B | 7024 | 0.002 | -0.3292 | No |
| 18 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 7053 | 0.001 | -0.3309 | No |
| 19 | GRB2 | GRB2 Entrez, Source | growth factor receptor-bound protein 2 | 7179 | 0.000 | -0.3403 | No |
| 20 | PTPN11 | PTPN11 Entrez, Source | protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | 7325 | -0.002 | -0.3508 | No |
| 21 | ARAF | ARAF Entrez, Source | v-raf murine sarcoma 3611 viral oncogene homolog | 7771 | -0.007 | -0.3826 | No |
| 22 | HDAC2 | HDAC2 Entrez, Source | histone deacetylase 2 | 8020 | -0.010 | -0.3987 | No |
| 23 | PIK3CB | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 8066 | -0.010 | -0.3995 | No |
| 24 | MAP2K1 | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 8219 | -0.012 | -0.4078 | No |
| 25 | CDK6 | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 8604 | -0.017 | -0.4323 | No |
| 26 | KRAS | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 8834 | -0.020 | -0.4445 | No |
| 27 | HRAS | HRAS Entrez, Source | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 9267 | -0.025 | -0.4705 | No |
| 28 | ACVR1C | ACVR1C Entrez, Source | activin A receptor, type IC | 9381 | -0.027 | -0.4720 | No |
| 29 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 9613 | -0.031 | -0.4814 | No |
| 30 | SOS2 | SOS2 Entrez, Source | son of sevenless homolog 2 (Drosophila) | 9696 | -0.032 | -0.4794 | No |
| 31 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 10388 | -0.043 | -0.5202 | Yes |
| 32 | SMAD4 | SMAD4 Entrez, Source | SMAD, mothers against DPP homolog 4 (Drosophila) | 10473 | -0.045 | -0.5150 | Yes |
| 33 | CRK | CRK Entrez, Source | v-crk sarcoma virus CT10 oncogene homolog (avian) | 10537 | -0.046 | -0.5079 | Yes |
| 34 | CBLB | CBLB Entrez, Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence b | 10642 | -0.048 | -0.5034 | Yes |
| 35 | BCL2L1 | BCL2L1 Entrez, Source | BCL2-like 1 | 10657 | -0.048 | -0.4921 | Yes |
| 36 | PIK3R2 | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 10802 | -0.052 | -0.4896 | Yes |
| 37 | MAP2K2 | MAP2K2 Entrez, Source | mitogen-activated protein kinase kinase 2 | 10890 | -0.053 | -0.4824 | Yes |
| 38 | SMAD3 | SMAD3 Entrez, Source | SMAD, mothers against DPP homolog 3 (Drosophila) | 11131 | -0.059 | -0.4853 | Yes |
| 39 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 11138 | -0.059 | -0.4705 | Yes |
| 40 | CTBP1 | CTBP1 Entrez, Source | C-terminal binding protein 1 | 11368 | -0.064 | -0.4712 | Yes |
| 41 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 11401 | -0.065 | -0.4568 | Yes |
| 42 | BAD | BAD Entrez, Source | BCL2-antagonist of cell death | 11428 | -0.066 | -0.4417 | Yes |
| 43 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 11510 | -0.069 | -0.4301 | Yes |
| 44 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 11651 | -0.074 | -0.4216 | Yes |
| 45 | CTBP2 | CTBP2 Entrez, Source | C-terminal binding protein 2 | 11872 | -0.082 | -0.4170 | Yes |
| 46 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 11925 | -0.084 | -0.3992 | Yes |
| 47 | CDKN2A | CDKN2A Entrez, Source | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 12064 | -0.090 | -0.3864 | Yes |
| 48 | NRAS | NRAS Entrez, Source | neuroblastoma RAS viral (v-ras) oncogene homolog | 12153 | -0.094 | -0.3687 | Yes |
| 49 | TGFBR2 | TGFBR2 Entrez, Source | transforming growth factor, beta receptor II (70/80kDa) | 12175 | -0.096 | -0.3457 | Yes |
| 50 | NFKB2 | NFKB2 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 12192 | -0.096 | -0.3220 | Yes |
| 51 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 12294 | -0.103 | -0.3030 | Yes |
| 52 | IKBKB | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 12540 | -0.121 | -0.2904 | Yes |
| 53 | MAPK3 | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 12674 | -0.132 | -0.2664 | Yes |
| 54 | PIK3CA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 12788 | -0.146 | -0.2373 | Yes |
| 55 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 13022 | -0.195 | -0.2044 | Yes |
| 56 | TGFB3 | TGFB3 Entrez, Source | transforming growth factor, beta 3 | 13142 | -0.253 | -0.1482 | Yes |
| 57 | RUNX1 | RUNX1 Entrez, Source | runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) | 13180 | -0.281 | -0.0786 | Yes |
| 58 | CCND1 | CCND1 Entrez, Source | cyclin D1 | 13250 | -0.352 | 0.0069 | Yes |
