Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | double_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls #double_gel_48h_versus_single_gel_48h.class.cls #double_gel_48h_versus_single_gel_48h_repos |
| Phenotype | class.cls#double_gel_48h_versus_single_gel_48h_repos |
| Upregulated in class | single_gel_48h |
| GeneSet | HSA05222_SMALL_CELL_LUNG_CANCER |
| Enrichment Score (ES) | -0.5385369 |
| Normalized Enrichment Score (NES) | -1.795704 |
| Nominal p-value | 0.0016666667 |
| FDR q-value | 0.042919848 |
| FWER p-Value | 0.977 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | RARB | RARB Entrez, Source | retinoic acid receptor, beta | 394 | 0.136 | -0.0014 | No |
| 2 | AKT3 | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 871 | 0.104 | -0.0156 | No |
| 3 | PTGS2 | PTGS2 Entrez, Source | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 886 | 0.103 | 0.0048 | No |
| 4 | RXRA | RXRA Entrez, Source | retinoid X receptor, alpha | 1400 | 0.083 | -0.0166 | No |
| 5 | MYC | MYC Entrez, Source | v-myc myelocytomatosis viral oncogene homolog (avian) | 1896 | 0.070 | -0.0393 | No |
| 6 | NOS3 | NOS3 Entrez, Source | nitric oxide synthase 3 (endothelial cell) | 2292 | 0.062 | -0.0561 | No |
| 7 | RXRG | RXRG Entrez, Source | retinoid X receptor, gamma | 2314 | 0.062 | -0.0449 | No |
| 8 | PIK3R1 | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 2668 | 0.056 | -0.0598 | No |
| 9 | NOS1 | NOS1 Entrez, Source | nitric oxide synthase 1 (neuronal) | 3225 | 0.047 | -0.0920 | No |
| 10 | LAMA3 | LAMA3 Entrez, Source | laminin, alpha 3 | 3419 | 0.044 | -0.0973 | No |
| 11 | RXRB | RXRB Entrez, Source | retinoid X receptor, beta | 3669 | 0.041 | -0.1076 | No |
| 12 | PIK3R3 | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 3943 | 0.037 | -0.1204 | No |
| 13 | AKT2 | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 4202 | 0.034 | -0.1328 | No |
| 14 | BCL2 | BCL2 Entrez, Source | B-cell CLL/lymphoma 2 | 4328 | 0.032 | -0.1355 | No |
| 15 | COL4A1 | COL4A1 Entrez, Source | collagen, type IV, alpha 1 | 4425 | 0.031 | -0.1363 | No |
| 16 | PTEN | PTEN Entrez, Source | phosphatase and tensin homolog (mutated in multiple advanced cancers 1) | 4572 | 0.029 | -0.1413 | No |
| 17 | CASP9 | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 5394 | 0.019 | -0.1990 | No |
| 18 | CCNE1 | CCNE1 Entrez, Source | cyclin E1 | 5568 | 0.017 | -0.2084 | No |
| 19 | CYCS | CYCS Entrez, Source | cytochrome c, somatic | 6937 | 0.003 | -0.3109 | No |
| 20 | FN1 | FN1 Entrez, Source | fibronectin 1 | 7215 | -0.000 | -0.3316 | No |
| 21 | CDK2 | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 7469 | -0.003 | -0.3500 | No |
| 22 | PIK3CB | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 8066 | -0.010 | -0.3927 | No |
| 23 | PIAS2 | PIAS2 Entrez, Source | protein inhibitor of activated STAT, 2 | 8403 | -0.014 | -0.4150 | No |
| 24 | LAMA5 | LAMA5 Entrez, Source | laminin, alpha 5 | 8549 | -0.016 | -0.4226 | No |
| 25 | CDK6 | CDK6 Entrez, Source | cyclin-dependent kinase 6 | 8604 | -0.017 | -0.4232 | No |
| 26 | PIAS4 | PIAS4 Entrez, Source | protein inhibitor of activated STAT, 4 | 9415 | -0.028 | -0.4784 | No |
| 27 | TP53 | TP53 Entrez, Source | tumor protein p53 (Li-Fraumeni syndrome) | 9613 | -0.031 | -0.4868 | No |
| 28 | BIRC2 | BIRC2 Entrez, Source | baculoviral IAP repeat-containing 2 | 9946 | -0.036 | -0.5044 | No |
| 29 | NFKBIA | NFKBIA Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 10388 | -0.043 | -0.5286 | No |
| 30 | ITGB1 | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 10521 | -0.046 | -0.5291 | Yes |
| 31 | MAX | MAX Entrez, Source | MYC associated factor X | 10590 | -0.047 | -0.5245 | Yes |
| 32 | FHIT | FHIT Entrez, Source | fragile histidine triad gene | 10628 | -0.047 | -0.5174 | Yes |
| 33 | BCL2L1 | BCL2L1 Entrez, Source | BCL2-like 1 | 10657 | -0.048 | -0.5095 | Yes |
| 34 | PIK3R2 | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 10802 | -0.052 | -0.5096 | Yes |
| 35 | COL4A4 | COL4A4 Entrez, Source | collagen, type IV, alpha 4 | 10867 | -0.053 | -0.5034 | Yes |
| 36 | PTK2 | PTK2 Entrez, Source | PTK2 protein tyrosine kinase 2 | 10930 | -0.054 | -0.4968 | Yes |
| 37 | CDKN2B | CDKN2B Entrez, Source | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | 11022 | -0.056 | -0.4919 | Yes |
| 38 | RELA | RELA Entrez, Source | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 11138 | -0.059 | -0.4884 | Yes |
| 39 | BIRC4 | BIRC4 Entrez, Source | baculoviral IAP repeat-containing 4 | 11256 | -0.061 | -0.4844 | Yes |
| 40 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 11401 | -0.065 | -0.4817 | Yes |
| 41 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 11510 | -0.069 | -0.4756 | Yes |
| 42 | CDKN1B | CDKN1B Entrez, Source | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 11651 | -0.074 | -0.4708 | Yes |
| 43 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 11925 | -0.084 | -0.4738 | Yes |
| 44 | NFKB2 | NFKB2 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 12192 | -0.096 | -0.4738 | Yes |
| 45 | CDK4 | CDK4 Entrez, Source | cyclin-dependent kinase 4 | 12294 | -0.103 | -0.4600 | Yes |
| 46 | PIAS3 | PIAS3 Entrez, Source | protein inhibitor of activated STAT, 3 | 12301 | -0.103 | -0.4390 | Yes |
| 47 | LAMB2 | LAMB2 Entrez, Source | laminin, beta 2 (laminin S) | 12523 | -0.119 | -0.4309 | Yes |
| 48 | IKBKB | IKBKB Entrez, Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 12540 | -0.121 | -0.4070 | Yes |
| 49 | ITGA6 | ITGA6 Entrez, Source | integrin, alpha 6 | 12716 | -0.137 | -0.3917 | Yes |
| 50 | BIRC3 | BIRC3 Entrez, Source | baculoviral IAP repeat-containing 3 | 12722 | -0.137 | -0.3636 | Yes |
| 51 | PIK3CA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 12788 | -0.146 | -0.3382 | Yes |
| 52 | E2F1 | E2F1 Entrez, Source | E2F transcription factor 1 | 13022 | -0.195 | -0.3151 | Yes |
| 53 | LAMC1 | LAMC1 Entrez, Source | laminin, gamma 1 (formerly LAMB2) | 13024 | -0.196 | -0.2745 | Yes |
| 54 | LAMB3 | LAMB3 Entrez, Source | laminin, beta 3 | 13233 | -0.329 | -0.2218 | Yes |
| 55 | CCND1 | CCND1 Entrez, Source | cyclin D1 | 13250 | -0.352 | -0.1500 | Yes |
| 56 | APAF1 | APAF1 Entrez, Source | apoptotic peptidase activating factor | 13256 | -0.365 | -0.0745 | Yes |
| 57 | LAMC2 | LAMC2 Entrez, Source | laminin, gamma 2 | 13270 | -0.390 | 0.0054 | Yes |
