Datasetdouble_gel_and_single_gel_rma_expression_values_collapsed_to_symbols.class.cls
#double_gel_48h_versus_single_gel_48h.class.cls
#double_gel_48h_versus_single_gel_48h_repos
Phenotypeclass.cls#double_gel_48h_versus_single_gel_48h_repos
Upregulated in classdouble_gel_48h
GeneSetHSIAO_LIVER_SPECIFIC_GENES
Enrichment Score (ES)0.61493653
Normalized Enrichment Score (NES)2.7632456
Nominal p-value0.0
FDR q-value0.0
FWER p-Value0.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HSIAO_LIVER_SPECIFIC_GENES   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1SLC10A1SLC10A1
Entrez,  Source
solute carrier family 10 (sodium/bile acid cotransporter family), member 150.4570.0240Yes
2FABP1FABP1
Entrez,  Source
fatty acid binding protein 1, liver100.4110.0457Yes
3HRGHRG
Entrez,  Source
histidine-rich glycoprotein110.3980.0669Yes
4ACAT2ACAT2
Entrez,  Source
acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase)140.3770.0869Yes
5G6PCG6PC
Entrez,  Source
glucose-6-phosphatase, catalytic subunit260.3370.1040Yes
6CDO1CDO1
Entrez,  Source
cysteine dioxygenase, type I540.2790.1169Yes
7AADACAADAC
Entrez,  Source
arylacetamide deacetylase (esterase)590.2690.1309Yes
8FBP1FBP1
Entrez,  Source
fructose-1,6-bisphosphatase 1670.2550.1440Yes
9KLKB1KLKB1
Entrez,  Source
kallikrein B, plasma (Fletcher factor) 1770.2450.1564Yes
10C4BPAC4BPA
Entrez,  Source
complement component 4 binding protein, alpha790.2430.1693Yes
11SERPIND1SERPIND1
Entrez,  Source
serpin peptidase inhibitor, clade D (heparin cofactor), member 1830.2400.1819Yes
12SC4MOLSC4MOL
Entrez,  Source
sterol-C4-methyl oxidase-like900.2360.1940Yes
13CES1CES1
Entrez,  Source
carboxylesterase 1 (monocyte/macrophage serine esterase 1)930.2340.2063Yes
14ARG1ARG1
Entrez,  Source
arginase, liver1170.2090.2157Yes
15PLGPLG
Entrez,  Source
plasminogen1200.2060.2266Yes
16TDO2TDO2
Entrez,  Source
tryptophan 2,3-dioxygenase1330.1990.2363Yes
17CFBCFB
Entrez,  Source
complement factor B1400.1960.2463Yes
18PCK1PCK1
Entrez,  Source
phosphoenolpyruvate carboxykinase 1 (soluble)1480.1930.2561Yes
19SERPINA7SERPINA7
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 71500.1920.2662Yes
20ACAA2ACAA2
Entrez,  Source
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)1630.1870.2753Yes
21DHCR24DHCR24
Entrez,  Source
24-dehydrocholesterol reductase1670.1850.2850Yes
22CRPCRP
Entrez,  Source
C-reactive protein, pentraxin-related1790.1790.2937Yes
23OTCOTC
Entrez,  Source
ornithine carbamoyltransferase1830.1780.3029Yes
24CFHR1CFHR1
Entrez,  Source
complement factor H-related 11840.1770.3124Yes
25ASGR2ASGR2
Entrez,  Source
asialoglycoprotein receptor 21850.1760.3218Yes
26GSTA2GSTA2
Entrez,  Source
glutathione S-transferase A21880.1750.3310Yes
27HMGCS2HMGCS2
Entrez,  Source
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)1900.1750.3403Yes
28CPS1CPS1
Entrez,  Source
carbamoyl-phosphate synthetase 1, mitochondrial2360.1620.3455Yes
29BHMTBHMT
Entrez,  Source
betaine-homocysteine methyltransferase2370.1620.3542Yes
30MTTPMTTP
Entrez,  Source
microsomal triglyceride transfer protein2390.1620.3627Yes
31DPYSDPYS
Entrez,  Source
dihydropyrimidinase2420.1610.3712Yes
32F9F9
Entrez,  Source
coagulation factor IX (plasma thromboplastic component, Christmas disease, hemophilia B)2430.1610.3797Yes
33LCATLCAT
Entrez,  Source
lecithin-cholesterol acyltransferase2590.1570.3870Yes
34ASLASL
Entrez,  Source
argininosuccinate lyase2730.1540.3942Yes
35ALAS1ALAS1
Entrez,  Source
aminolevulinate, delta-, synthase 13000.1490.4002Yes
36ALDH6A1ALDH6A1
Entrez,  Source
aldehyde dehydrogenase 6 family, member A13140.1480.4071Yes
37HSD11B1HSD11B1
Entrez,  Source
hydroxysteroid (11-beta) dehydrogenase 13180.1470.4148Yes
38SEPHS2SEPHS2
Entrez,  Source
selenophosphate synthetase 23560.1410.4195Yes
39GYS2GYS2
Entrez,  Source
glycogen synthase 2 (liver)3700.1390.4259Yes
40NR1H4NR1H4
Entrez,  Source
nuclear receptor subfamily 1, group H, member 43900.1370.4318Yes
41CATCAT
Entrez,  Source
catalase3910.1370.4391Yes
42AZGP1AZGP1
Entrez,  Source
alpha-2-glycoprotein 1, zinc3920.1370.4463Yes
43RBP4RBP4
Entrez,  Source
retinol binding protein 4, plasma4090.1340.4523Yes
44VTNVTN
Entrez,  Source
vitronectin4200.1330.4586Yes
45TATTAT
Entrez,  Source
tyrosine aminotransferase4280.1320.4651Yes
46GCH1GCH1
Entrez,  Source
GTP cyclohydrolase 1 (dopa-responsive dystonia)4410.1310.4712Yes
47ACOX2ACOX2
Entrez,  Source
acyl-Coenzyme A oxidase 2, branched chain4420.1300.4782Yes
48TSTTST
Entrez,  Source
thiosulfate sulfurtransferase (rhodanese)4460.1300.4849Yes
49HGDHGD
Entrez,  Source
homogentisate 1,2-dioxygenase (homogentisate oxidase)4570.1290.4910Yes
50IGFBP1IGFBP1
Entrez,  Source
insulin-like growth factor binding protein 14590.1290.4978Yes
51FGBFGB
Entrez,  Source
fibrinogen beta chain4610.1290.5046Yes
52FGL1FGL1
Entrez,  Source
fibrinogen-like 14840.1270.5097Yes
53FAHFAH
Entrez,  Source
fumarylacetoacetate hydrolase (fumarylacetoacetase)4890.1260.5161Yes
54ACSL1ACSL1
Entrez,  Source
acyl-CoA synthetase long-chain family member 15640.1210.5169Yes
55TFTF
Entrez,  Source
transferrin5750.1200.5226Yes
56AGXTAGXT
Entrez,  Source
alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase)5910.1180.5277Yes
57SERPINF2SERPINF2
Entrez,  Source
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 26210.1170.5318Yes
58APOA2APOA2
Entrez,  Source
apolipoprotein A-II6780.1130.5336Yes
59HALHAL
Entrez,  Source
histidine ammonia-lyase7050.1120.5375Yes
60PZPPZP
Entrez,  Source
pregnancy-zone protein7610.1080.5391Yes
61SLC38A3SLC38A3
Entrez,  Source
solute carrier family 38, member 37790.1080.5436Yes
62SERPINC1SERPINC1
Entrez,  Source
serpin peptidase inhibitor, clade C (antithrombin), member 18640.1040.5428Yes
63ALDOBALDOB
Entrez,  Source
aldolase B, fructose-bisphosphate9410.1000.5423Yes
64ASGR1ASGR1
Entrez,  Source
asialoglycoprotein receptor 19700.0990.5455Yes
65CYP3A4CYP3A4
Entrez,  Source
cytochrome P450, family 3, subfamily A, polypeptide 49750.0990.5504Yes
66PBEF1PBEF1
Entrez,  Source
pre-B-cell colony enhancing factor 110740.0940.5480Yes
67GJB1GJB1
Entrez,  Source
gap junction protein, beta 1, 32kDa (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked)11070.0930.5505Yes
68CBSCBS
Entrez,  Source
cystathionine-beta-synthase11270.0920.5540Yes
69SULT2A1SULT2A1
Entrez,  Source
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 111530.0910.5570Yes
70GHRGHR
Entrez,  Source
growth hormone receptor12150.0890.5571Yes
71FGAFGA
Entrez,  Source
fibrinogen alpha chain12530.0880.5590Yes
72HRSP12HRSP12
Entrez,  Source
heat-responsive protein 1212670.0870.5626Yes
73ACAT1ACAT1
Entrez,  Source
acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)12950.0860.5652Yes
74HPNHPN
Entrez,  Source
hepsin (transmembrane protease, serine 1)13030.0860.5692Yes
75SERPINA5SERPINA5
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 513110.0860.5732Yes
76F10F10
Entrez,  Source
coagulation factor X13120.0860.5778Yes
77LBPLBP
Entrez,  Source
lipopolysaccharide binding protein13380.0850.5804Yes
78AOX1AOX1
Entrez,  Source
aldehyde oxidase 113650.0840.5829Yes
79MTHFD1MTHFD1
Entrez,  Source
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase13920.0830.5854Yes
80HMGCLHMGCL
Entrez,  Source
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)13940.0830.5897Yes
81APOHAPOH
Entrez,  Source
apolipoprotein H (beta-2-glycoprotein I)14310.0820.5913Yes
82SAA4SAA4
Entrez,  Source
serum amyloid A4, constitutive14570.0810.5937Yes
83FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 414730.0800.5969Yes
84ABCC6ABCC6
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 615370.0780.5963Yes
85APOBAPOB
Entrez,  Source
apolipoprotein B (including Ag(x) antigen)15600.0780.5988Yes
86FGGFGG
Entrez,  Source
fibrinogen gamma chain15720.0780.6021Yes
87BAATBAAT
Entrez,  Source
bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)16250.0770.6022Yes
88SERPINA4SERPINA4
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 416440.0760.6049Yes
89ALDH1A1ALDH1A1
Entrez,  Source
aldehyde dehydrogenase 1 family, member A116530.0760.6083Yes
90IL13IL13
Entrez,  Source
interleukin 1316580.0750.6120Yes
91C3C3
Entrez,  Source
complement component 317310.0740.6105Yes
92NR0B2NR0B2
Entrez,  Source
nuclear receptor subfamily 0, group B, member 217320.0740.6144Yes
93CYP2C9CYP2C9
Entrez,  Source
cytochrome P450, family 2, subfamily C, polypeptide 917770.0730.6149Yes
94PROCPROC
Entrez,  Source
protein C (inactivator of coagulation factors Va and VIIIa)18810.0700.6109No
95CFICFI
Entrez,  Source
complement factor I19360.0690.6105No
96KCNH2KCNH2
Entrez,  Source
potassium voltage-gated channel, subfamily H (eag-related), member 219710.0690.6115No
97AKR1D1AKR1D1
Entrez,  Source
aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)20980.0660.6055No
98CDH2CDH2
Entrez,  Source
cadherin 2, type 1, N-cadherin (neuronal)21630.0650.6041No
99CYP4F2CYP4F2
Entrez,  Source
cytochrome P450, family 4, subfamily F, polypeptide 222910.0620.5977No
100CPCP
Entrez,  Source
ceruloplasmin (ferroxidase)24380.0600.5898No
101F2F2
Entrez,  Source
coagulation factor II (thrombin)24830.0590.5896No
102PORPOR
Entrez,  Source
P450 (cytochrome) oxidoreductase25610.0580.5868No
103DDTDDT
Entrez,  Source
D-dopachrome tautomerase27620.0540.5745No
104SERPINA1SERPINA1
Entrez,  Source
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 128240.0530.5727No
105HPHP
Entrez,  Source
haptoglobin28290.0530.5752No
106PCSK6PCSK6
Entrez,  Source
proprotein convertase subtilisin/kexin type 628920.0520.5733No
107ASS1ASS1
Entrez,  Source
argininosuccinate synthetase 130630.0490.5630No
108APOA1APOA1
Entrez,  Source
apolipoprotein A-I30810.0490.5643No
109PON3PON3
Entrez,  Source
paraoxonase 331240.0480.5637No
110SERPING1SERPING1
Entrez,  Source
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)32320.0470.5580No
111APOC3APOC3
Entrez,  Source
apolipoprotein C-III33240.0450.5535No
112SEPP1SEPP1
Entrez,  Source
selenoprotein P, plasma, 134230.0440.5484No
113TOMM40TOMM40
Entrez,  Source
translocase of outer mitochondrial membrane 40 homolog (yeast)34710.0430.5472No
114ACADSBACADSB
Entrez,  Source
acyl-Coenzyme A dehydrogenase, short/branched chain35260.0430.5453No
115SDSSDS
Entrez,  Source
serine dehydratase36840.0410.5356No
116KYNUKYNU
Entrez,  Source
kynureninase (L-kynurenine hydrolase)40610.0350.5089No
117F12F12
Entrez,  Source
coagulation factor XII (Hageman factor)41310.0350.5055No
118PCCBPCCB
Entrez,  Source
propionyl Coenzyme A carboxylase, beta polypeptide42120.0340.5012No
119GATMGATM
Entrez,  Source
glycine amidinotransferase (L-arginine:glycine amidinotransferase)42290.0330.5018No
120FMO3FMO3
Entrez,  Source
flavin containing monooxygenase 343480.0320.4945No
121HSD17B4HSD17B4
Entrez,  Source
hydroxysteroid (17-beta) dehydrogenase 443700.0320.4946No
122MGST1MGST1
Entrez,  Source
microsomal glutathione S-transferase 144920.0300.4870No
123ACSM3ACSM3
Entrez,  Source
acyl-CoA synthetase medium-chain family member 346530.0280.4763No
124BDH1BDH1
Entrez,  Source
3-hydroxybutyrate dehydrogenase, type 146790.0280.4759No
125SHMT1SHMT1
Entrez,  Source
serine hydroxymethyltransferase 1 (soluble)47380.0270.4730No
126MST1MST1
Entrez,  Source
macrophage stimulating 1 (hepatocyte growth factor-like)47700.0270.4720No
127GSTO1GSTO1
Entrez,  Source
glutathione S-transferase omega 147850.0260.4724No
128PYGLPYGL
Entrez,  Source
phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)51600.0220.4451No
129ITIH3ITIH3
Entrez,  Source
inter-alpha (globulin) inhibitor H352290.0210.4411No
130CPB2CPB2
Entrez,  Source
carboxypeptidase B2 (plasma, carboxypeptidase U)53350.0200.4341No
131SERPINF1SERPINF1
Entrez,  Source
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 153980.0190.4305No
132HPXHPX
Entrez,  Source
hemopexin54760.0190.4256No
133ORM1ORM1
Entrez,  Source
orosomucoid 154860.0190.4259No
134PCBD1PCBD1
Entrez,  Source
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)55910.0170.4189No
135PROS1PROS1
Entrez,  Source
protein S (alpha)56630.0160.4144No
136GGCXGGCX
Entrez,  Source
gamma-glutamyl carboxylase58210.0150.4032No
137ADFPADFP
Entrez,  Source
adipose differentiation-related protein59420.0130.3948No
138HNMTHNMT
Entrez,  Source
histamine N-methyltransferase60100.0130.3904No
139ADH4ADH4
Entrez,  Source
alcohol dehydrogenase 4 (class II), pi polypeptide62350.0110.3739No
140CES2CES2
Entrez,  Source
carboxylesterase 2 (intestine, liver)65010.0080.3542No
141PGRMC1PGRMC1
Entrez,  Source
progesterone receptor membrane component 165420.0070.3515No
142AHSGAHSG
Entrez,  Source
alpha-2-HS-glycoprotein66520.0060.3436No
143SLC2A2SLC2A2
Entrez,  Source
solute carrier family 2 (facilitated glucose transporter), member 267010.0050.3402No
144CYP27A1CYP27A1
Entrez,  Source
cytochrome P450, family 27, subfamily A, polypeptide 167290.0050.3384No
145DECR1DECR1
Entrez,  Source
2,4-dienoyl CoA reductase 1, mitochondrial67460.0050.3375No
146SPP2SPP2
Entrez,  Source
secreted phosphoprotein 2, 24kDa67770.0040.3354No
147HGFACHGFAC
Entrez,  Source
HGF activator68250.0040.3320No
148ALBALB
Entrez,  Source
albumin68880.0030.3275No
149LTB4DHLTB4DH
Entrez,  Source
leukotriene B4 12-hydroxydehydrogenase69090.0030.3261No
150APCSAPCS
Entrez,  Source
amyloid P component, serum71220.0010.3101No
151FN1FN1
Entrez,  Source
fibronectin 17215-0.0000.3031No
152IL13RA1IL13RA1
Entrez,  Source
interleukin 13 receptor, alpha 17219-0.0000.3029No
153CYB5ACYB5A
Entrez,  Source
cytochrome b5 type A (microsomal)7424-0.0030.2875No
154APOC1APOC1
Entrez,  Source
apolipoprotein C-I7456-0.0030.2853No
155SORDSORD
Entrez,  Source
sorbitol dehydrogenase7900-0.0080.2521No
156AGTAGT
Entrez,  Source
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)7909-0.0080.2519No
157TAF6TAF6
Entrez,  Source
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa8224-0.0120.2287No
158HPDHPD
Entrez,  Source
4-hydroxyphenylpyruvate dioxygenase8248-0.0120.2276No
159GLUD1GLUD1
Entrez,  Source
glutamate dehydrogenase 18367-0.0140.2194No
160EPHX1EPHX1
Entrez,  Source
epoxide hydrolase 1, microsomal (xenobiotic)8371-0.0140.2199No
161SSRP1SSRP1
Entrez,  Source
structure specific recognition protein 18553-0.0160.2070No
162ALDH2ALDH2
Entrez,  Source
aldehyde dehydrogenase 2 family (mitochondrial)8630-0.0170.2021No
163FMO5FMO5
Entrez,  Source
flavin containing monooxygenase 58756-0.0190.1936No
164MBL2MBL2
Entrez,  Source
mannose-binding lectin (protein C) 2, soluble (opsonic defect)8903-0.0210.1836No
165TFPITFPI
Entrez,  Source
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)8929-0.0210.1828No
166NAT2NAT2
Entrez,  Source
N-acetyltransferase 2 (arylamine N-acetyltransferase)8962-0.0210.1815No
167SOD1SOD1
Entrez,  Source
superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult))9099-0.0230.1724No
168IL8RBIL8RB
Entrez,  Source
interleukin 8 receptor, beta9103-0.0230.1735No
169CASC3CASC3
Entrez,  Source
cancer susceptibility candidate 39112-0.0230.1741No
170BZW1BZW1
Entrez,  Source
basic leucine zipper and W2 domains 19170-0.0240.1710No
171LAMP2LAMP2
Entrez,  Source
lysosomal-associated membrane protein 29376-0.0270.1569No
172LGALS4LGALS4
Entrez,  Source
lectin, galactoside-binding, soluble, 4 (galectin 4)9392-0.0270.1572No
173CRHBPCRHBP
Entrez,  Source
corticotropin releasing hormone binding protein9669-0.0320.1379No
174AGTR1AGTR1
Entrez,  Source
angiotensin II receptor, type 19880-0.0350.1238No
175CYP2E1CYP2E1
Entrez,  Source
cytochrome P450, family 2, subfamily E, polypeptide 110268-0.0410.0965No
176ABCB4ABCB4
Entrez,  Source
ATP-binding cassette, sub-family B (MDR/TAP), member 411113-0.0580.0355No
177PRDX4PRDX4
Entrez,  Source
peroxiredoxin 411241-0.0610.0291No
178C1RC1R
Entrez,  Source
complement component 1, r subcomponent11719-0.076-0.0031No
179C2C2
Entrez,  Source
complement component 211739-0.077-0.0005No
180LSRLSR
Entrez,  Source
lipolysis stimulated lipoprotein receptor11762-0.0780.0020No
181RNASE4RNASE4
Entrez,  Source
ribonuclease, RNase A family, 411851-0.081-0.0004No
182ABCC2ABCC2
Entrez,  Source
ATP-binding cassette, sub-family C (CFTR/MRP), member 212612-0.126-0.0514No
183TM4SF4TM4SF4
Entrez,  Source
transmembrane 4 L six family member 412767-0.144-0.0555No
184GPTGPT
Entrez,  Source
glutamic-pyruvate transaminase (alanine aminotransferase)12858-0.158-0.0539No
185RGL2RGL2
Entrez,  Source
ral guanine nucleotide dissociation stimulator-like 212966-0.180-0.0524No
186RGNRGN
Entrez,  Source
regucalcin (senescence marker protein-30)13030-0.199-0.0466No
187DAB2DAB2
Entrez,  Source
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)13130-0.247-0.0409No
188FSTFST
Entrez,  Source
follistatin13176-0.277-0.0296No
189LIPCLIPC
Entrez,  Source
lipase, hepatic13211-0.304-0.0160No
190SERPINE1SERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 113308-0.4840.0026No
Table: GSEA details [plain text format]



Fig 2: HSIAO_LIVER_SPECIFIC_GENES   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HSIAO_LIVER_SPECIFIC_GENES: Random ES distribution   
Gene set null distribution of ES for HSIAO_LIVER_SPECIFIC_GENES